Hirokazu Tanaka

Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking (2009)

Tanaka, Hirokazu, Kitakura, Saeko, De Rycke, Rita, De Groodt, Ruth, Friml, Jiri

Endocytic vesicle trafficking is crucial for regulating activity and localization of plasma membrane components, but the process Is still poorly genetically defined In plants. Membrane proteins of...

LETTER Communicated by Daniel Wolpert Different Predictions by the Minimum Variance and Minimum Torque-Change Models on the Skewness of Movement Velocity Profiles (2008)

Hirokazu Tanaka, Meihua Tai, Ning Qian

We investigated the differences between two well-known optimization principles for understanding movement planning: the minimum variance (MV) model of Harris and Wolpert (1998) and the minimum torque...

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions (2008)

Dhonukshe, Pankaj, Tanaka, Hirokazu, Goh, Tatsuaki, Ebine, Kazuo, Mähönen, Ari Pekka, Prasad, Kalika, ...

Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication - a vital feature of multicellular development. Efflux carriers for...

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation (2007)

Bermejo, Rodrigo, Doksani, Ylli, Capra, Thelma, Katou, Yuki-Mori, Tanaka, Hirokazu, Shirahige, Katsuhiko, ...

DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects...

Cell Cycle Regulation in Hematopoietic Stem/progenitor Cells (2005)

Hirokazu Tanaka, Itaru Matsumura, Yuzuru Kanakura

Hematopoietic Stem Cells (HSCs) are characterized by two distinct abilities, that is, self-renewal ability and multipotency. To keep the homeostasis of hematopoiesis and protect the exhaustion of...

Cell Cycle Regulation in Hematopoietic Stem/progenitor Cells (2005)

Hirokazu Tanaka, Itaru Matsumura, Yuzuru Kanakura

Hematopoietic Stem Cells (HSCs) are characterized by two distinct abilities, that is, self-renewal ability and multipotency. To keep the homeostasis of hematopoiesis and protect the exhaustion of...

An optimization principle for determining movement duration (2005)

Hirokazu Tanaka, Hirokazu Tanaka, John W. Krakauer, John W. Krakauer, Ning Qian, Ning Qian

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Experimental Gizzard Erosions in Specific-Pathogen-Free Chicks by Serotype 1 Group I Avian Adenoviruses from Broilers (2002)

Kikuyasu Nakamura, Takayuki Ohyama, Manabu Yamada, Toshiaki Abe, Hirokazu Tanaka, Masaji Mase

SUMMARY. The pathogenicity of serotype 1 group I avian adenovirus (GIAAV) strains isolated from gizzard erosions for 1-wk-old specific-pathogen-free (SPF) chickens was investigated. In Experiment 1,...

ACR4, a Putative Receptor Kinase Gene of Arabidopsis thaliana, that is Expressed in the Outer Cell Layers of Embryos and Plants, is Involved in Proper Embryogenesis (2002)

Tanaka, Hirokazu, Watanabe, Masaru, Watanabe, Daisuke, Tanaka, Toshihiro, Machida, Chiyoko, Machida, Yasunori

The surfaces of higher plants are characterized by epidermis, which usually consists of a single layer of cells. The epidermis is derived from the outer cell layer of the embryo or protoderm, which...

Maternal ophthalmic artery Doppler velocimetry in type 1 diabetes during pregnancy (2000)

Hata, Toshiyuki, Yanagihara, Toshihiro, Tanaka, Hirokazu, Yamashiro, Chizu, Kanenishi, Kenji

Our purpose was to evaluate whether maternal ophthalmic artery pulsatility index (PI) in normotensive pregnancies with type 1 diabetes is different from that in normal normotensive pregnancies. The...

Intrauterine sonographic measurement of embryonic brain vesicle (2000)

Tanaka, Hirokazu, Senoh, Daisaku, Yanagihara, Toshihiro, Hata, Toshiyuki

Our purpose was to evaluate embryonic brain vesicle measurements using intrauterine sonography in early first-trimester pregnancy. Fifty-one women about to undergo therapeutic abortion from 7–9.9...

Weyl Groups in AdS(3)/CFT(2) (1999)

Fukuma, Masafumi, Oota, Takeshi, Tanaka, Hirokazu

The system of D1 and D5 branes with a Kaluza-Klein momentum is re-investigated using the five-dimensional U-duality group E_{6(+6)}(Z). We show that the residual U-duality symmetry that keeps this...

Comments on T-dualities of Ramond-Ramond Potentials (1999)

Fukuma, Masafumi, Oota, Takeshi, Tanaka, Hirokazu

The type IIA/IIB effective actions compactified on T^d are known to be invariant under the T-duality group SO(d, d; Z) although the invariance of the R-R sector is not so direct to see. Inspired by a...

Laparoscopy-assisted intrapelvic sonography with a high-frequency, real-time miniature transducer for assessment of the Fallopian tube: a preliminary report (1999)

Senoh, Daisaku, Yanagihara, Toshihiro, Akiyama, Masashi, Ohnishi, Yohichi, Yamashiro, Chizu, Tanaka, Hirokazu, ...

Our purpose was to visualize normal and abnormal Fallopian tubes using laparoscopy-assisted intrapelvic sonography with a specially developed 20 MHz flexible catheter-based high-resolution, real-time...

Saline infusion contrast intrauterine sonographic assessment of the endometrium with high-frequency, real-time miniature transducer in normal menstrual cycle: a preliminary report (1999)

Senoh, Daisaku, Tanaka, Hirokazu, Akiyama, Masashi, Yanagihara, Toshihiro, Hata, Toshiyuki

Normal endometrial texture was visualized using saline infusion contrast intrauterine sonography with a specially developed 20 MHz flexible catheter-based high-resolution, real-time miniature (2.4 mm...

Comparison of alterations in fetal regional arterial vascular resistance in appropriate-for-gestational-age singleton, twin and triplet pregnancies (1999)

Akiyama, Masashi, Kuno, Atsushi, Tanaka, Yasuko, Tanaka, Hirokazu, Hayashi, Keiji, Yanagihara, Toshihiro, ...

The objective of this longitudinal study was to evaluate alterations in fetal vascular resistance of fetal peripheral arteries with advancing gestation in singleton appropriate-for-gestational-age...

Interaction of boundaries with heterogeneous matter states in matrix models (1997)

Anazawa, Masahiro, Ishikawa, Atushi, Tanaka, Hirokazu

We study disk amplitudes whose boundary conditions on matter configurations are not restricted to homogeneous ones. They are examined in the two-matrix model as well as in the three-matrix model for...

The Relation between Mixed Boundary States in Two- and Three- Matrix Models (1997)

Anazawa, Masahiro, Ishikawa, Atushi, Tanaka, Hirokazu

We discuss the relation among some disk amplitudes with non-trivial boundary conditions in two-dimensional quantum gravity. They are obtained by the two-matrix model as well as the three-matirx model...

In Vitro Activities of a New Lipopeptide Antifungal Agent, FK463, against a Variety of Clinically Important Fungi

Tawara, Shuichi, Ikeda, Fumiaki, Maki, Katsuyuki, Morishita, Yoshihiko, Otomo, Kazumi, Teratani, Noriko, ...

The in vitro antifungal activity and spectrum of FK463 were compared with those of amphotericin B, fluconazole, and itraconazole by using a broth microdilution method specified by National Committee...

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, ...

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function....

In Vitro Activities of a New Lipopeptide Antifungal Agent, FK463, against a Variety of Clinically Important Fungi

Tawara, Shuichi, Ikeda, Fumiaki, Maki, Katsuyuki, Morishita, Yoshihiko, Otomo, Kazumi, Teratani, Noriko, ...

The in vitro antifungal activity and spectrum of FK463 were compared with those of amphotericin B, fluconazole, and itraconazole by using a broth microdilution method specified by National Committee...

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

Tanaka, Hirokazu, Yoshida, Tetsuo, Miyamoto, Norimasa, Motoike, Toshiyuki, Kurosu, Hiroshi, Shibata, Kenji, ...

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function....

持続する多量の粘液性帯下により子宮摘出に至ったPeutz-Jeghers症候群の1例

小竹, 和美, 高野, 昇, 上杉, 健哲, 田中, 宏一, 鈴鹿, 清美, 漢那, 磨理意, ...

本症例(36歳, 2回経妊2回経産)は, 持続的な多量の粘液性帯下と下腹部痛を主徴とし,...

Analysis of two pharmacologically predicted endothelin B receptor subtypes by using the endothelin B receptor gene knockout mouse

Mizuguchi, Tadahiko, Nishiyama, Mariko, Moroi, Kayoko, Tanaka, Hirokazu, Saito, Toshihiro, Masuda, Yoshiaki, ...

This study was performed to clarify whether the endothelin (ET) receptor subtypes mediating two pharmacologically heterogeneous response to ETB receptor agonists in normal mice are the product(s) of...

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

Bermejo, Rodrigo, Doksani, Ylli, Capra, Thelma, Katou, Yuki-Mori, Tanaka, Hirokazu, Shirahige, Katsuhiko, ...

DNA topoisomerases solve topological problems during chromosome metabolism. We investigated where and when Top1 and Top2 are recruited on replicating chromosomes and how their inactivation affects...

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells

Kawasaki, Akira, Matsumura, Itaru, Miyagawa, Jun-ichiro, Ezoe, Sachiko, Tanaka, Hirokazu, Terada, Yasuhiko, ...

During the late phase of megakaryopoiesis, megakaryocytes undergo polyploidization, which is characterized by DNA duplication without concomitant cell division. However, it remains unknown by which...

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe, Yoko, Tanaka, Hirokazu, Yokomizo, Takehiko, Hashidate-Yoshida, Tomomi, Yanagisawa, Masashi, Sakurai, Takeshi

GPR109B (HM74) is a putative G protein-coupled receptor (GPCR) whose cognate ligands have yet to be characterized. GPR109B shows a high degree of sequence similarity to GPR109A, another GPCR that was...

AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells*

Satoh, Yusuke, Matsumura, Itaru, Tanaka, Hirokazu, Ezoe, Sachiko, Fukushima, Kentaro, Tokunaga, Masahiro, ...

In this study, we analyzed the roles for AML1/RUNX1 in the regulation of the c-mpl promoter. Wild-type AML1 activated the c-mpl promoter through the proximal AML-binding site in luciferase assays...