Toyama, Tatsuya, Yamashita, Hiroko, Sugiura, Hiroshi, Kondo, Naoto, Iwase, Hirotaka, Fujii, Yoshitaka
Objective The CYP2D6 enzyme plays a major role in converting tamoxifen to its active metabolites. We investigated whether there is an association between the CYP2D6*10 allele and clinical outcome in...
Toyama, Tatsuya, Yamashita, Hiroko, Kondo, Naoto, Okuda, Katsuhiro, Takahashi, Satoru, Sasaki, Hidefumi, ...
Abstract Background Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these...
Identification of biomarkers in ductal carcinoma in situof the breast with microinvasion (2008)
Okumura, Yasuhiro, Yamamoto, Yutaka, Zhang, Zhenhuan, Toyama, Tatsuya, Kawasoe, Teru, Ibusuki, Mutsuko, ...
Abstract Background Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS). DCIS of the breast...
Kai, Kazuharu, Zhang, Zhenhuan, Yamashita, Hiroko, Yamamoto, Yutaka, Miura, Yutaka, Iwase, Hirotaka
Abstract Background Loss of heterozygosity (LOH) on the long arm of chromosome 16 is one of the most frequent genetic events in solid tumors. Recently, the AT-motif binding factor 1 ( ATBF1 )- A...
Hamaguchi, Maho, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Kondo, Naoto, Fujii, Yoshitaka, ...
Objective Genetic polymorphisms associated with breast cancer risk are likely to differ among ethnic and molecular subtypes. The ability to identify genetic polymorphisms affecting the risk of...
Mita, Keiko, Zhang, Zhenhuan, Ando, Yoshiaki, Toyama, Tatsuya, Hamaguchi, Maho, Kobayashi, Shunzo, ...
Background Expression of estrogen-regulated genes has been considered as potential predictive markers for endocrine therapy. We focused on two insulin-like growth factor binding proteins (IGFBPs):...
Sugiura, Hiroshi, Toyama, Tatsuya, Hara, Yasuo, Zhang, Zhenhuan, Kobayashi, Shunzo, Fujii, Yoshitaka, ...
Background The clinical value of estrogen receptor (ER) β and its variants has been investigated. However, reported results have frequently been discordant. Methods We investigated mRNA and protein...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial-mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial- mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer
Kai, Kazuharu, Zhang, Zhenhuan, Yamashita, Hiroko, Yamamoto, Yutaka, Miura, Yutaka, Iwase, Hirotaka