Nishibori, Masahiro, Takahashi, Hide K., Katayama, Hiroshi, Mori, Shuji, Saito, Shinya, Iwagaki, Hiromi, ...
Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been...
Otani, Satoru, Kuinose, Masahiko, Murakami, Takashi, Saito, Shinya, Iwagaki, Hiromi, Tanaka, Noriaki, ...
Activation of inflammatory response during cardiopulmonary bypass (CPB) may lead to considerable post-operative mortality. Recently, pentoxifylline (PTX), a methylxanthine derivative, has been...
Surgical treatment for Crohn's disease. (2007)
Perdomo, Jose Antonio, Iwagaki, Hiromi, Hizuta, Akio, Mizuno, Motowo, Nakagawa, Hitoshi, Tanaka, Noriaki, ...
The medical records of 16 consecutive patients with Crohn's disease surgically treated in our department from 1978 to 1993 were retrospectively reviewed. The indication for surgery was obstructive...
Okamoto, Ko, Hamazaki, Keisuke, Iwagaki, Hiromi, Orita, Kunzo, Mori, Akitane
We administered a biological response modifier Picibanil (OK-432), attenuated Streptococcus pyogenes, via the dorsal vein of the penis after 70% hepatectomy in rats, and clarified the scavenging...
The importance of family study in the patients with familial adenomatous polyposis. (2007)
Perdomo, Jose Antonio, Iwagaki, Hiromi, Hizuta, Akio, Tanaka, Noriaki, Orita, Kunzo
Familial adenomatous polyposis (FAP) is a well-known autosomal dominant disorder characterized by the formation of multiple adenomatous polyps of the colon. Gardner's syndrome is a variant of...
Clinical value of soluble interleukin-2 receptor in infectious complications. (2007)
Iwagaki, Hiromi, Hizuta, Akio, Iwadou, Hironori, Perdomo, Jose Antonio, Tanaka, Noriaki, Orita, Kunzo
In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations...
Ariki, Norifumi, Iwagaki, Hiromi, Yoshino, Tadashi, Nonaka, Yasuyuki, Fujiki, Shigeatsu, Perdomo, Jose Antonio, ...
Endoscopical segmental piecemeal tumorectomy (ESPT) for nodular elevation of colorectal tumor is advantageous in terms of minimizing both surgical invasion and postoperative burden to the patients....
Ovarian Metastasis in Patients with Colorectal Carcinoma (2007)
Perdomo, Jose A, Hizuta, Akio, Iwagaki, Hiromi, Takasu, Shinji, Nonaka, Yasuyuki, Kimura, Toshikazu, ...
The records of 159 patients who underwent surgical resection of colorectal cancer were reviewed to assess the incidence of ovarian metastasis and to define the role of oophorectomy. Four of these...
Lipid peroxidation in hepatocellular carcinoma. (2007)
Iwagaki, Hiromi, Hamazaki, Keisuke, Matsubara, Nagahide, Hiramatsu, Midori, Orita, Kunzo, Mori, Akitane
In this study, we measured free radicals and thiobarbituric acid-reactive substances (TBARS) in hepatocellular carcinoma and in non-cancerous liver parenchyma. There was a higher concentration of...
Cancer cachexia and depressive states: a neuro-endocrine-immunological disease? (2007)
Iwagaki, Hiromi, Hizuta, Akio, Uomoto, Masashi, Takeuchi, Yoshiaki, Saito, Shinya, Tanaka, Noriaki
Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period....
Iwagaki, Hiromi, Hizuta, Akio, Fujiwara, Toshiyushi, Perdomo, Jose Antonio, Tanaka, Noriaki, Orita, Kunzo
Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a...
Iwagaki, Hiromi, Marutaka, Masahito, Mizukawa, Kiminao, Kooka, Hideo, Tanaka, Noriaki, Orita, Kunzo
We report here the time-course of electron microscopic changes induced by gamma-interferon (IFN-gamma) in the human erythromyeloid leukemia cell line K562. In K562 cells treated with IFN-gamma for...
Hyperthermotherapy for postoperative local recurrences of rectal cancer. (2007)
Kuroda, Masahiro, Hizuta, Akio, Iwagaki, Hiromi, Makihata, Eiichi, Asaumi, Junichi, Nishikawa, Koji, ...
Between November 1984 and August 1992 we used hyperthermotherapy in six cases of local recurrence of rectal cancer. Hyperthermotherapy was performed on the average 8.7 times (range: 3-18) for each...
Occlusion of a postoperative rectoabdominocutaneous fistula with fibrin clot: a case report. (2007)
Iwagaki, Hiromi, Hizuta, Akio, Nezu, Masashi, Nonaka, Yasuyuki, Kimura, Toshikazu, Marutaka, Masahito, ...
A 56 year-old rectal cancer patient who developed a chronic rectoabdominocutaneous fistula postoperatively was treated with fibrin clot, and the fistula healed completely. Occlusion of chronic...
Acute superior mesenteric artery syndrome following left hemicolectomy: a case report. (2007)
Yerdel, Mehmet Ali, Moreira, Luis Fernando, Iwagaki, Hiromi, Kamikawa, Yasuaki, Tanaka, Noriaki, Orita, Kunzo
Acute superior mesenteric artery syndrome (SMAS) following a major surgical procedure is extremely rare, and represents an iatrogenic cause of postoperative upper gastrointestinal obstruction. In...
Assessment of lymph node metastasis and vessel invasion in early rectal cancer. (2007)
Moreira, Luis Fernando, Iwagaki, Hiromi, Inoguchi, Kazuhito, Hizuta, Akio, Sakagami, Keinichi, Orita, Kunzo
Thirteen patients with rectal carcinoma seen between December 1980 and December 1990 have been reviewed to determine the risk of lymph node metastasis and its implication for subsequent treatment....
Shiiki, Sigeo, Fuchimoto, Sadanori, Iwagaki, Hiromi, Akazai, Yoshihiro, Matsubara, Nagahide, Watanabe, Tetsuya, ...
We investigated the antitumor activities of 5-fluorouracil (5-FU), 5'-deoxy-5-fluorouridine (5'-DFUR), 1-hexylcarbamoyl-5-fluorouracil (HCFU) and 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) in...
Primary non-Hodgkin's lymphoma of the rectum: a case report. (2007)
Moreira, Luis Fernando, Iwagaki, Hiromi, Watanabe, Kazuhiko, Yoshino, Tadashi, Fuchimoto, Sadanori, Orita, Kunzo
A rare gastrointestinal tract neoplasm, primary non-Hodgkin's B-cell lymphoma in a 39-year-old, asymptomatic woman is described. The tumor was originally localized in the rectum without evidence of...
Iwagaki, Hiromi, Fuchimoto, Sadanori, Orita, Kunzo
The same chemotherapeutic agents were tested against fresh surgical explants of solid tumors obtained from 50 patients using the in vivo subrenal capsule (SRC) assay and the in vitro succinate...
Gotohda, Naoto, Iwagaki, Hiromi, Itano, Satoshi, Horiki, Sadayuki, Fujiwara, Toshiya, Saito, Shinya, ...
POSSUM, a Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity, is a scoring system which assesses perioperative surgical risks (Copeland GP et al.: Br J Surg,...
Nakao, Atsunori, Iwagaki, Hiromi, Notohara, Kenji, Morimoto, Yushinori, Ariki, Norifumi, Kanagawa, Taiichiro, ...
A 69-year-old woman was admitted to our hospital because of anal bleeding and fatigue. The patient was previously diagnosed as having Evans' syndrome on the basis of hematological examination and had...
Funaki, Masato, Gouchi, Akira, Iwagaki, Hiromi, Morimoto, Yoshinori, Shimamura, Hiroshi, Ariki, Norifumi, ...
Conventional therapy for colorectal carcinoma using 5-fluorouracil (5-FU) has shown limited antitumor action. The purpose of our study was to investigate synergistic antitumor effects of the...
Kuinose, Masahiko, Iwagaki, Hiromi, Morimoto, Yoshinori, Kohka, Hideo, Kobashi, Kenta, Sadamori, Hiroshi, ...
Tacrolimus (FK-506) and cyclosporin A (CsA) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on the production of interleukin-18 (IL-18) remains...
Nakagawa, Kazuhiko, Matsuno, Tsuyoshi, Iwagaki, Hiromi, Fujiwara, Takuzo, Tanaka, Noriaki
The immune status of thirteen living and related kidney transplant recipients with stable allografts were examined. The immunological assays consisted of a mixed lymphocyte reaction (MLR),...
Iwagaki, Hiromi, Yagi, Takahito, Urushihara, Naoto, Kobashi, Kenta, Morimoto, Yoshinori, Isozaki, Hiroshi, ...
The relationship between endogenous cytokine antagonists and surgical stress is poorly understood. Surgical stress induces immunosuppression, and the reversed therapy of postoperative...
Kohka, Hideo, Iwagaki, Hiromi, Yoshino, Tadashi, Kobashi, Kenta, Saito, Shinnya, Isozaki, Hiroshi, ...
Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis...
Effect of Ciprofloxacin-Induced Prostaglandin E2 on Interleukin-18-Treated Monocytes
Takahashi, Hideo Kohka, Iwagaki, Hiromi, Xue, Dong, Katsuno, Goutarou, Sugita, Sachi, Mizuno, Kenji, ...
Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from...
Effect of Ciprofloxacin-Induced Prostaglandin E2 on Interleukin-18-Treated Monocytes
Takahashi, Hideo Kohka, Iwagaki, Hiromi, Xue, Dong, Katsuno, Goutarou, Sugita, Sachi, Mizuno, Kenji, ...
Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from...