Hiroshi Furukawa

A Feasibility Study of UFT/LV and Irinotecan (TEGAFIRI) in Advanced or Metastatic Colorectal Cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) PROG 0304 (2009)

Ishida, Hideyuki, Miyake, Yasuhiro, Fukunaga, Mutsumi, Watanabe, Yasunori, Kato, Takeshi, Takemoto, Hiroyoshi, ...

Objective This is a feasibility trial of oral uracil/tegafur (UFT)/oral leucovorin (LV) and irinotecan (TEGAFIRI) with maximum dose confirmed in Japan. To document the toxicity and define the...

Multi-Center Phase II Study for Combination Therapy with Paclitaxel/Doxifluridine to Treat Advanced/Recurrent Gastric Cancer Showing Resistance to S-1 (OGSG 0302) (2008)

Takiuchi, Hiroya, Goto, Masahiro, Imamura, Hiroshi, Furukawa, Hiroshi, Imano, Motohiro, Imamoto, Haruhiko, ...

Background A pre-clinical study demonstrated that paclitaxel induced thymidine phosphorylase in the tumor tissues. The combination of paclitaxel and doxifluridine is expected to exert extra...

Experimental Evaluations of Wireless Multihop Networks Associated with Intermittent Periodic Transmit (2007)

HIGA, Yukinori, FURUKAWA, Hiroshi

Intermittent periodic transmit (IPT forwarding) has been proposed as a highly efficient packet forwarding method for wireless multihop networks. With IPT forwarding, packets are intermittently...

Phase I/II Study of CPT-11 plus UFT in Patients with Advanced/Recurrent Colorectal Cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG): Protocol 0102 (2007)

Tomita, Naohiro, Fukunaga, Mutsumi, Okamura, Shu, Narahara, Hiroyuki, Uedo, Noriya, Ishihara, Ryu, ...

Objective The primary objective of this study was to explore the efficacy and safety of combined chemotherapy with CPT-11 and UFT in patients with advanced/metastatic colorectal cancer. Methods...

Risk Factors for Para-aortic Lymph Node Metastasis of Gastric Cancer from a Randomized Controlled Trial of JCOG9501 (2007)

Nomura, Eiji, Sasako, Mitsuru, Yamamoto, Seiichiro, Sano, Takeshi, Tsujinaka, Toshimasa, Kinoshita, Taira, ...

Background No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we...

Phase I Study of S-1 Combined with Irinotecan (CPT-11) in Patients with Advanced Gastric Cancer (OGSG 0002) (2005)

Takiuchi, Hiroya, Narahara, Hiroyuki, Tsujinaka, Toshimasa, Gotoh, Masahiro, Kawabe, Sei-ichiro, Katsu, Ken-ichi, ...

Objective: A dose-escalation study of irinotecan (CPT-11) combined with S-1, a novel oral fluoropyrimidine, was performed to determine the maximum-tolerated dose (MTD), recommended dose (RD) and...

Phase I Study of S-1 Combined with Irinotecan (CPT-11) in Patients with Advanced Gastric Cancer (OGSG 0002) (2005)

Takiuchi, Hiroya, Narahara, Hiroyuki, Tsujinaka, Toshimasa, Gotoh, Masahiro, Kawabe, Sei-ichiro, Katsu, Ken-ichi, ...

Objective: A dose-escalation study of irinotecan (CPT-11) combined with S-1, a novel oral fluoropyrimidine, was performed to determine the maximum-tolerated dose (MTD), recommended dose (RD) and...

Phase I Study of S-1 Combined with Irinotecan (CPT-11) in Patients with Advanced Gastric Cancer (OGSG 0002) (2005)

Takiuchi, Hiroya, Narahara, Hiroyuki, Tsujinaka, Toshimasa, Gotoh, Masahiro, Kawabe, Sei-ichiro, Katsu, Ken-ichi, ...

Objective: A dose-escalation study of irinotecan (CPT-11) combined with S-1, a novel oral fluoropyrimidine, was performed to determine the maximum-tolerated dose (MTD), recommended dose (RD) and...

The Novel Germline Mutation of hMSH2 Gene in a Case of a Colon Cancer Patient Without Family History (2002)

Ishida, Hideyuki, Furukawa, Hiroshi, Tatsuta, Masayuki, Masutani, Seizo, Imamura, Hiroshi, Shimizu, Junzo, ...

Hereditary non-polyposis colorectal cancer (HNPCC) is generally found from the patient’s family history. The functional disorder of mismatch repair genes has been reported to be responsible for...

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

Smith, Hamish R. C., Heusel, Jonathan W., Mehta, Indira K., Kim, Sungjin, Dorner, Brigitte G., Naidenko, Olga V., ...

Natural killer (NK) cells express inhibitory and activation receptors that recognize MHC class I-like molecules on target cells. These receptors may be involved in the critical role of NK cells in...

Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome

Furukawa, Hiroshi, Murata, Shigeo, Yabe, Toshio, Shimbara, Naoki, Keicho, Naoto, Kashiwase, Kouichi, ...

Expression of histocompatibility leukocyte antigen (HLA) class I molecules on the cell surface depends on the heterodimer of the transporter associated with antigen processing 1 and 2 (TAP1 and...

High Incidence of Thrombosis of the Portal Venous System After Laparoscopic Splenectomy: A Prospective Study With Contrast-Enhanced CT Scan

Ikeda, Masataka, Sekimoto, Mitsugu, Takiguchi, Shuji, Kubota, Masaru, Ikenaga, Masakazu, Yamamoto, Hirofumi, ...

This study compares the incidence of portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy (LS) using contrast-enhanced CT scan with open splenectomy (OS). PSVT occurred in...

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

Smith, Hamish R. C., Heusel, Jonathan W., Mehta, Indira K., Kim, Sungjin, Dorner, Brigitte G., Naidenko, Olga V., ...

Natural killer (NK) cells express inhibitory and activation receptors that recognize MHC class I-like molecules on target cells. These receptors may be involved in the critical role of NK cells in...

Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome

Furukawa, Hiroshi, Murata, Shigeo, Yabe, Toshio, Shimbara, Naoki, Keicho, Naoto, Kashiwase, Kouichi, ...

Expression of histocompatibility leukocyte antigen (HLA) class I molecules on the cell surface depends on the heterodimer of the transporter associated with antigen processing 1 and 2 (TAP1 and...

High Incidence of Thrombosis of the Portal Venous System After Laparoscopic Splenectomy: A Prospective Study With Contrast-Enhanced CT Scan

Ikeda, Masataka, Sekimoto, Mitsugu, Takiguchi, Shuji, Kubota, Masaru, Ikenaga, Masakazu, Yamamoto, Hirofumi, ...

This study compares the incidence of portal or splenic vein thrombosis (PSVT) after elective laparoscopic splenectomy (LS) using contrast-enhanced CT scan with open splenectomy (OS). PSVT occurred in...

Keloid-Derived Fibroblasts Are Refractory to Fas-Mediated Apoptosis and Neutralization of Autocrine Transforming Growth Factor-β1 Can Abrogate this Resistance

Chodon, Thinle, Sugihara, Tsuneki, Igawa, Hiroharu H., Funayama, Emi, Furukawa, Hiroshi

The pathogenesis of keloid remains poorly understood. As no effective therapy for keloid is as yet available, an insight into its pathogenesis may lead to novel approaches. Apoptosis has been found...