Okada, Soji, Miyai, Yooichiro, Masaki, Yoshitugu, Ichiki, Ken, Tanokuchi, So, Ishii, Keita, ...
The aim of this study is to obtain data for improving a training program for patients with diabetes mellitus. One hundred eighty-seven patients with non-insulin dependent diabetes mellitus were...
Significance of urinary albumin index in the urine collected arbitrarily in the morning. (2007)
Okada, Soji, Tanokuchi, So, Ichiki, Ken, Ishii, Keita, Hamada, Hiroshi, Ota, Zensuke
To evaluate urinary albumin index (UAI), the relationship between albumin excretion rate (AER) in the urine stored for 24 h and UAI in the urine collected arbitrarily on the morning of the same day...
Okada, Soji, Ichiki, Ken, Sato, Kimiaki, Tanakuchi, So, Ishii, Keita, Hamada, Hiroshi, ...
We studied the pathways of complement activation associated with the islet cell surface antibody (ICSA) obtained from sera of 7 patients (age less than 15 years) with insulin dependent diabetes...
Takeuchi, Jun K., Lickert, Heiko, Bisgrove, Brent W., Sun, Xin, Yamamoto, Masamichi, Chawengsaksophak, Kallayanee, ...
Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left–right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF...
Takeuchi, Jun K., Lickert, Heiko, Bisgrove, Brent W., Sun, Xin, Yamamoto, Masamichi, Chawengsaksophak, Kallayanee, ...
Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left–right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF...
Long-range action of Nodal requires interaction with GDF1 (2007)
Tanaka, Chinatsu, Sakuma, Rui, Nakamura, Tetsuya, Hamada, Hiroshi, Saijoh, Yukio
GDF1 (growth/differentiation factor 1), a Vg1-related member of the transforming growth factor-β superfamily, is required for left–right patterning in the mouse, but the precise function of GDF1...
Retinoid signaling determines germ cell fate in mice (2006)
Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, ...
Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes,...
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia (2005)
Shigenori Nonaka, Satoko Yoshiba, Daisuke Watanabe, Shingo Ikeuchi, Tomonobu Goto, Wallace F. Marshall, ...
Left-right asymmetry in the developing mouse embryo is established by leftward fluid flow. Here the authors demonstrate how a posterior tilt of beating cilia creates this unidirectional fluid flow.
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia (2005)
Shigenori Nonaka, Satoko Yoshiba, Daisuke Watanabe, Shingo Ikeuchi, Tomonobu Goto, Wallace F. Marshall, ...
In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines left–right (L-R) asymmetry. However, the mechanism by which the rotational movement of node cilia can...
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression (2003)
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression (2003)
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Sakai, Yasuo, Meno, Chikara, Fujii, Hideta, Nishino, Jinsuke, Shiratori, Hidetaka, Saijoh, Yukio, ...
Yamamoto, Masamichi, Meno, Chikara, Sakai, Yasuo, Shiratori, Hidetaka, Mochida, Kyoko, Ikawa, Yayoi, ...
Adachi, Hitoshi, Saijoh, Yukio, Mochida, Kyoko, Ohishi, Sachiko, Hashiguchi, Hiromi, Hirao, Akiko, ...
Imagawa, Masayoshi, Miyamoto, Aki, Shirakawa, Masahiro, Hamada, Hiroshi, Muramatsu, Masami
POU-specific and POU-homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence. POU domain protein Including A, B and H domains could bind to...
The Effects of Pole Piece Saturation on the Constants of Magnetic Lenses (1955)
SUGATA, Eizi, NISHITANI, Yoshio, HAMADA, Hiroshi
The measuring method of the field distribution of magnetic electron lenses by the electron image rotation has already been described.(1) Recently, we measured the magnetic field considering the pole...
Notch signaling regulates left–right asymmetry determination by inducing Nodal expression
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...
Yamamoto, Masamichi, Meno, Chikara, Sakai, Yasuo, Shiratori, Hidetaka, Mochida, Kyoko, Ikawa, Yayoi, ...
FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor–β, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and...
Saijoh, Yukio, Adachi, Hitoshi, Mochida, Kyoko, Ohishi, Sachiko, Hirao, Akiko, Hamada, Hiroshi
Both lefty-1 and lefty-2 genes are expressed on the left side of developing mouse embryos and are implicated in left–right (L–R) axis formation. With the use of transgenic analysis, the...
Adachi, Hitoshi, Saijoh, Yukio, Mochida, Kyoko, Ohishi, Sachiko, Hashiguchi, Hiromi, Hirao, Akiko, ...
The nodal gene is expressed on the left side of developing mouse embryos and is implicated in left/right (L-R) axis formation. The transcriptional regulatory regions of nodal have now been...
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension
Nishino, Jinsuke, Yamashita, Kimiyo, Hashiguchi, Hiromi, Fujii, Hideta, Shimazaki, Takuya, Hamada, Hiroshi
Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed...
Interplay of SOX and POU Factors in Regulation of the Nestin Gene in Neural Primordial Cells
Tanaka, Shinya, Kamachi, Yusuke, Tanouchi, Aki, Hamada, Hiroshi, Jing, Naihe, Kondoh, Hisato
Intermediate-filament Nestin and group B1 SOX transcription factors (SOX1/2/3) are often employed as markers for neural primordium, suggesting their regulatory link. We have identified adjacent and...
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia
Nonaka, Shigenori, Yoshiba, Satoko, Watanabe, Daisuke, Ikeuchi, Shingo, Goto, Tomonobu, Marshall, Wallace F, ...
In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines left–right (L-R) asymmetry. However, the mechanism by which the rotational movement of node cilia can...
Sakai, Yasuo, Meno, Chikara, Fujii, Hideta, Nishino, Jinsuke, Shiratori, Hidetaka, Saijoh, Yukio, ...
Retinoic acid (RA), a derivative of vitamin A, plays a pivotal role in vertebrate development. The level of RA may be determined by the balance between its synthesis and degradation. We have examined...
Notch signaling regulates left–right asymmetry determination by inducing Nodal expression
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...
Sakai, Yasuo, Meno, Chikara, Fujii, Hideta, Nishino, Jinsuke, Shiratori, Hidetaka, Saijoh, Yukio, ...
Retinoic acid (RA), a derivative of vitamin A, plays a pivotal role in vertebrate development. The level of RA may be determined by the balance between its synthesis and degradation. We have examined...
Yamamoto, Masamichi, Meno, Chikara, Sakai, Yasuo, Shiratori, Hidetaka, Mochida, Kyoko, Ikawa, Yayoi, ...
FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor–β, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and...
Saijoh, Yukio, Adachi, Hitoshi, Mochida, Kyoko, Ohishi, Sachiko, Hirao, Akiko, Hamada, Hiroshi
Both lefty-1 and lefty-2 genes are expressed on the left side of developing mouse embryos and are implicated in left–right (L–R) axis formation. With the use of transgenic analysis, the...
Adachi, Hitoshi, Saijoh, Yukio, Mochida, Kyoko, Ohishi, Sachiko, Hashiguchi, Hiromi, Hirao, Akiko, ...
The nodal gene is expressed on the left side of developing mouse embryos and is implicated in left/right (L-R) axis formation. The transcriptional regulatory regions of nodal have now been...
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension
Nishino, Jinsuke, Yamashita, Kimiyo, Hashiguchi, Hiromi, Fujii, Hideta, Shimazaki, Takuya, Hamada, Hiroshi
Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed...
Interplay of SOX and POU Factors in Regulation of the Nestin Gene in Neural Primordial Cells
Tanaka, Shinya, Kamachi, Yusuke, Tanouchi, Aki, Hamada, Hiroshi, Jing, Naihe, Kondoh, Hisato
Intermediate-filament Nestin and group B1 SOX transcription factors (SOX1/2/3) are often employed as markers for neural primordium, suggesting their regulatory link. We have identified adjacent and...
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia
Nonaka, Shigenori, Yoshiba, Satoko, Watanabe, Daisuke, Ikeuchi, Shingo, Goto, Tomonobu, Marshall, Wallace F, ...
In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines left–right (L-R) asymmetry. However, the mechanism by which the rotational movement of node cilia can...
Baf60c is a nuclear Notch signaling component required for the establishment of left–right asymmetry
Takeuchi, Jun K., Lickert, Heiko, Bisgrove, Brent W., Sun, Xin, Yamamoto, Masamichi, Chawengsaksophak, Kallayanee, ...
Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left–right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF...
Long-range action of Nodal requires interaction with GDF1
Tanaka, Chinatsu, Sakuma, Rui, Nakamura, Tetsuya, Hamada, Hiroshi, Saijoh, Yukio
GDF1 (growth/differentiation factor 1), a Vg1-related member of the transforming growth factor-β superfamily, is required for left–right patterning in the mouse, but the precise function of GDF1...
Yamamoto, Masamichi, Beppu, Hideyuki, Takaoka, Katsuyoshi, Meno, Chikara, Li, En, Miyazono, Kohei, ...
The anterior–posterior axis of the mouse embryo is established by formation of distal visceral endoderm (DVE) and its subsequent migration. The precise mechanism of DVE formation has remained...