Hiroshi Hara

Chemical specificity in short-chain fatty acids and their analogues in increasing osmotic fragility in rat erythrocytes in vitro. (2007)

Mineo, Hitoshi, Hara, Hiroshi

We examined the role of the chemical specificity of short-chain fatty acids (SCFAs) and their derivatives in increasing osmotic fragility (OF) in rat red blood cells (RBCs). Except for formic acid,...

Chemical specificity in short-chain fatty acids and their analogues in increasing osmotic fragility in rat erythrocytes in vitro. (2007)

Mineo, Hitoshi, Hara, Hiroshi

We examined the role of the chemical specificity of short-chain fatty acids (SCFAs) and their derivatives in increasing osmotic fragility (OF) in rat red blood cells (RBCs). Except for formic acid,...

Soybean phosphatidylcholine-induced enhancement of lymphatic absorption of triglyceride depends on chylomicron formation in rats. (2007)

Nishimukai, Megumi, Hara, Hiroshi

We investigated whether chylomicron formation is involved in the dietary phosphatidylcholine (PC)-induced increase in triglyceride (TG) absorption using an inhibitor of chylomicron formation,...

Soybean phosphatidylcholine-induced enhancement of lymphatic absorption of triglyceride depends on chylomicron formation in rats. (2007)

Nishimukai, Megumi, Hara, Hiroshi

We investigated whether chylomicron formation is involved in the dietary phosphatidylcholine (PC)-induced increase in triglyceride (TG) absorption using an inhibitor of chylomicron formation,...

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats. (2006)

Tamura, Akiko, Nishimukai, Megumi, Shigematsu, Norihiro, Hara, Hiroshi

Equol, a derivative of daidzein produced by enterobacteria, has greater activity as a phyto-oestrogen compared with daidzein. Difructose anhydride III (DFAIII) is a newly manufactured non-digestible...

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats. (2006)

Tamura, Akiko, Nishimukai, Megumi, Shigematsu, Norihiro, Hara, Hiroshi

Equol, a derivative of daidzein produced by enterobacteria, has greater activity as a phyto-oestrogen compared with daidzein. Difructose anhydride III (DFAIII) is a newly manufactured non-digestible...

Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine. (2006)

Minamida, Kimiko, Tanaka, Michiko, Abe, Ayumi, Sone, Teruo, Tomita, Fusao, Hara, Hiroshi, ...

Isoflavones (mainly daidzein and genistin) belong to the flavonoid group of compounds and are classified as phytoestrogens. In the intestine, daidzin is converted to daidzein by β-glucosidase, and...

Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine. (2006)

Minamida, Kimiko, Tanaka, Michiko, Abe, Ayumi, Sone, Teruo, Tomita, Fusao, Hara, Hiroshi, ...

Isoflavones (mainly daidzein and genistin) belong to the flavonoid group of compounds and are classified as phytoestrogens. In the intestine, daidzin is converted to daidzein by β-glucosidase, and...

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats. (2006)

Tamura, Akiko, Nishimukai, Megumi, Shigematsu, Norihiro, Hara, Hiroshi

Equol, a derivative of daidzein produced by enterobacteria, has greater activity as a phyto-oestrogen compared with daidzein. Difructose anhydride III (DFAIII) is a newly manufactured non-digestible...

Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine. (2006)

Minamida, Kimiko, Tanaka, Michiko, Abe, Ayumi, Sone, Teruo, Tomita, Fusao, Hara, Hiroshi, ...

Isoflavones (mainly daidzein and genistin) belong to the flavonoid group of compounds and are classified as phytoestrogens. In the intestine, daidzin is converted to daidzein by β-glucosidase, and...

Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats. (2006)

SUFIAN, MKNB, HIRA, Tohru, MIYASHITA, Kyoko, NISHI, Takashi, ASANO, Kozo, HARA, Hiroshi

We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small...

Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats. (2006)

SUFIAN, MKNB, HIRA, Tohru, MIYASHITA, Kyoko, NISHI, Takashi, ASANO, Kozo, HARA, Hiroshi

We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small...

Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats. (2006)

SUFIAN, MKNB, HIRA, Tohru, MIYASHITA, Kyoko, NISHI, Takashi, ASANO, Kozo, HARA, Hiroshi

We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small...

Ingestion of difructose anhydride III, a non-digestible disaccharide, prevents gastrectomy-induced iron malabsorption and anemia in rats (2006)

Shiga, Kazuki, Nishimukai, Megumi, Tomita, Fusao, Hara, Hiroshi

Objective Total gastrectomy produces iron malabsorption and anemia, and several non-digestible carbohydrates promote mineral absorption. In this study, we examined the effects of feeding difructose...

Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells (2006)

Suzuki, Takuya, Hara, Hiroshi

A nondigestible disaccharide, difructose anhydride (DFA) III, is known to activate calcium transport via tight junctions (TJs); however, the characteristics of and mechanisms for the increase in...

Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells (2006)

Suzuki, Takuya, Hara, Hiroshi

A nondigestible disaccharide, difructose anhydride (DFA) III, is known to activate calcium transport via tight junctions (TJs); however, the characteristics of and mechanisms for the increase in...

Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells (2006)

Suzuki, Takuya, Hara, Hiroshi

A nondigestible disaccharide, difructose anhydride (DFA) III, is known to activate calcium transport via tight junctions (TJs); however, the characteristics of and mechanisms for the increase in...

Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen deficiency in rats (2006)

Mitamura, Rieko, Hara, Hiroshi

Background Vitamin D (VD) and estrogen deficiencies impair Ca absorption and bone mineralization, and the relevance of the interaction between these factors has not been fully understood. Aim of the...

Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen deficiency in rats (2006)

Mitamura, Rieko, Hara, Hiroshi

Background Vitamin D (VD) and estrogen deficiencies impair Ca absorption and bone mineralization, and the relevance of the interaction between these factors has not been fully understood.

Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen deficiency in rats (2006)

Mitamura, Rieko, Hara, Hiroshi

Background Vitamin D (VD) and estrogen deficiencies impair Ca absorption and bone mineralization, and the relevance of the interaction between these factors has not been fully understood.

Two-week feeding of difructose anhydride III enhances calcium absorptive activity with epithelial cell proliferation in isolated rat cecal mucosa (2006)

Mineo, Hitoshi, Amano, Midori, Minaminida, Kimiko, Chiji, Hideyuki, Shigematsu, Norihiro, Tomita, Fusao, ...

Objective Ingestion of difructose anhydride III (DFAIII) enhances calcium (Ca) absorption in rats. The present study investigated the mechanism involved in increased Ca transport by DFAIII ingestion....

Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans (2006)

Minamida, Kimiko, Asakawa, Chikako, Sujaya I., Nengah, Kaneko, Maki, Abe, Ayumi, Sone, Teruo, ...

Changes in the intestinal microbiota of 10 human subjects with long-term ingestion of 3 g/d difructose anhydride III (DFA III; 4 persons, 2 months; 3 persons, 6 months; and 3 persons, 12 months) were...

Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2006)

Minamida, Kimiko, Ohashi, Midori, Hara, Hiroshi, Asano, Kozo, Tomita, Fusao

We have isolated a difructose anhydride III (DFA III)-assimilating bacterium, Ruminococcus productus AHU1760, from human. After an acclimation period of 1 week, male Sprague-Dawley rats (5 weeks old)...

Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2006)

Minamida, Kimiko, Ohashi, Midori, Hara, Hiroshi, Asano, Kozo, Tomita, Fusao

We have isolated a difructose anhydride III (DFA III)-assimilating bacterium, Ruminococcus productus AHU1760, from human. After an acclimation period of 1 week, male Sprague-Dawley rats (5 weeks old)...

Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans (2006)

Minamida, Kimiko, Asakawa, Chikako, Sujaya I., Nengah, Kaneko, Maki, Abe, Ayumi, Sone, Teruo, ...

Changes in the intestinal microbiota of 10 human subjects with long-term ingestion of 3 g/d difructose anhydride III (DFA III; 4 persons, 2 months; 3 persons, 6 months; and 3 persons, 12 months) were...

Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2006)

Minamida, Kimiko, Ohashi, Midori, Hara, Hiroshi, Asano, Kozo, Tomita, Fusao

We have isolated a difructose anhydride III (DFA III)-assimilating bacterium, Ruminococcus productus AHU1760, from human. After an acclimation period of 1 week, male Sprague-Dawley rats (5 weeks old)...

Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans (2006)

Minamida, Kimiko, Asakawa, Chikako, Sujaya I., Nengah, Kaneko, Maki, Abe, Ayumi, Sone, Teruo, ...

Changes in the intestinal microbiota of 10 human subjects with long-term ingestion of 3 g/d difructose anhydride III (DFA III; 4 persons, 2 months; 3 persons, 6 months; and 3 persons, 12 months) were...

Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. (2005)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Objective: We examined the effects of feeding non-digestible disaccharides, difructose anhydride III (DFAIII), maltitol, melibiose and, cellobiose, on calcium, magnesium, and iron absorption in...

Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats. (2005)

Matsumoto, Megumi, Chiji, Hideyuki, Hara, Hiroshi

A highly soluble quercetin glycoside, αG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of αG-rutin has not been known. We investigated the intestinal...

Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. (2005)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Objective: We examined the effects of feeding non-digestible disaccharides, difructose anhydride III (DFAIII), maltitol, melibiose and, cellobiose, on calcium, magnesium, and iron absorption in...

Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats. (2005)

Matsumoto, Megumi, Chiji, Hideyuki, Hara, Hiroshi

A highly soluble quercetin glycoside, αG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of αG-rutin has not been known. We investigated the intestinal...

Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. (2005)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Objective: We examined the effects of feeding non-digestible disaccharides, difructose anhydride III (DFAIII), maltitol, melibiose and, cellobiose, on calcium, magnesium, and iron absorption in...

Intestinal absorption and metabolism of a soluble flavonoid, alphaG-rutin, in portal cannulated rats. (2005)

Matsumoto, Megumi, Chiji, Hideyuki, Hara, Hiroshi

A highly soluble quercetin glycoside, αG-rutin, is a glucose adduct of insoluble rutin, and intestinal absorption and metabolism of αG-rutin has not been known. We investigated the intestinal...

Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2005)

Minamida, Kimiko, Kaneko, Maki, Ohashi, Midori, Sujaya I., Nengah, Sone, Teruo, Wada, Masaru, ...

The growth of DFA III-assimilating bacteria in the intestines of rats fed 3% DFA III for 2 weeks was examined. Sixty-four percent of the DFA III intake had been assimilated on day 3 of ingestion, and...

Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2005)

Minamida, Kimiko, Kaneko, Maki, Ohashi, Midori, Sujaya I., Nengah, Sone, Teruo, Wada, Masaru, ...

The growth of DFA III-assimilating bacteria in the intestines of rats fed 3% DFA III for 2 weeks was examined. Sixty-four percent of the DFA III intake had been assimilated on day 3 of ingestion, and...

Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine. (2005)

Minamida, Kimiko, Kaneko, Maki, Ohashi, Midori, Sujaya I., Nengah, Sone, Teruo, Wada, Masaru, ...

The growth of DFA III-assimilating bacteria in the intestines of rats fed 3% DFA III for 2 weeks was examined. Sixty-four percent of the DFA III intake had been assimilated on day 3 of ingestion, and...

Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine. (2005)

Hara, Hiroshi, Kondo, Kazuma

We examined the effects of di-D-fructose anhydride (DFA) III and IV on Ca absorption in luminally perfused segments of the small intestine in anesthetized rats. The calcium absorption rate with...

Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine. (2005)

Hara, Hiroshi, Kondo, Kazuma

We examined the effects of di-D-fructose anhydride (DFA) III and IV on Ca absorption in luminally perfused segments of the small intestine in anesthetized rats. The calcium absorption rate with...

Difructose anhydrides III and IV equally promote calcium absorption from the luminally perfused rat small intestine. (2005)

Hara, Hiroshi, Kondo, Kazuma

We examined the effects of di-D-fructose anhydride (DFA) III and IV on Ca absorption in luminally perfused segments of the small intestine in anesthetized rats. The calcium absorption rate with...

Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota. (2005)

Minamida, Kimiko, Shiga, Kazuki, Sujaya I., Nengah, Sone, Teruo, Yokota, Atsushi, Hara, Hiroshi, ...

The effects of difructose anhydride III (di-D-fructofuranose-1,2′:2,3′-dianhydride; DFA III) administration (3% DFA III for 4 weeks) on rat intestinal microbiota were examined using denaturing...

Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats. (2005)

Xu, Hong, Imanishi, Syunsuke, Yamada, Kazuhiko, Hara, Hiroshi, Ishizuka, Satoshi

Using a cell position approach, this study indicates that the frequency of CD161+ natural killer (NK) cells in the epithelia of DA rats was greater than that of WKAH and F344 rats. We further divided...

Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota. (2005)

Minamida, Kimiko, Shiga, Kazuki, Sujaya I., Nengah, Sone, Teruo, Yokota, Atsushi, Hara, Hiroshi, ...

The effects of difructose anhydride III (di-D-fructofuranose-1,2′:2,3′-dianhydride; DFA III) administration (3% DFA III for 4 weeks) on rat intestinal microbiota were examined using denaturing...

Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats. (2005)

Xu, Hong, Imanishi, Syunsuke, Yamada, Kazuhiko, Hara, Hiroshi, Ishizuka, Satoshi

Using a cell position approach, this study indicates that the frequency of CD161+ natural killer (NK) cells in the epithelia of DA rats was greater than that of WKAH and F344 rats. We further divided...

Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota. (2005)

Minamida, Kimiko, Shiga, Kazuki, Sujaya I., Nengah, Sone, Teruo, Yokota, Atsushi, Hara, Hiroshi, ...

The effects of difructose anhydride III (di-D-fructofuranose-1,2′:2,3′-dianhydride; DFA III) administration (3% DFA III for 4 weeks) on rat intestinal microbiota were examined using denaturing...

Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats. (2005)

Xu, Hong, Imanishi, Syunsuke, Yamada, Kazuhiko, Hara, Hiroshi, Ishizuka, Satoshi

Using a cell position approach, this study indicates that the frequency of CD161+ natural killer (NK) cells in the epithelia of DA rats was greater than that of WKAH and F344 rats. We further divided...

Disruption of the Structural Gene for Farnesyl Diphosphate Synthase in Escherichia coli (2005)

Fujisaki, Shingo, Takahashi, Isao, Hara, Hiroshi, Horiuchi, Kensuke, Nishino, Tokuzo, Nishimura, Yukinobu

The chromosomal ispA gene encoding farnesyl diphosphate synthase of Escherichia coli was disrupted by inserting a neo gene cassette. The null ispA mutants were viable. The growth yield of the mutants...

A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa. (2004)

Matsumoto, Megumi, Matsukawa, Noriko, Mineo, Hitoshi, Chiji, Hideyuki, Hara, Hiroshi

We investigated the absorption and metabolism of the highly soluble quercetin glycoside αG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines...

A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa. (2004)

Matsumoto, Megumi, Matsukawa, Noriko, Mineo, Hitoshi, Chiji, Hideyuki, Hara, Hiroshi

We investigated the absorption and metabolism of the highly soluble quercetin glycoside αG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines...

A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa. (2004)

Matsumoto, Megumi, Matsukawa, Noriko, Mineo, Hitoshi, Chiji, Hideyuki, Hara, Hiroshi

We investigated the absorption and metabolism of the highly soluble quercetin glycoside αG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines...

Inhibitory effects of psyllium on rat mineral absorption were abolished by reduction of viscosity with partial hydrolysis. (2004)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Psyllium husk, a highly viscous fiber, has beneficial effects for health, but has been reported to inhibit absorption of calcium. The present study found the effects of fiber viscosity on calcium,...

Inhibitory effects of psyllium on rat mineral absorption were abolished by reduction of viscosity with partial hydrolysis. (2004)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Psyllium husk, a highly viscous fiber, has beneficial effects for health, but has been reported to inhibit absorption of calcium. The present study found the effects of fiber viscosity on calcium,...

Inhibitory effects of psyllium on rat mineral absorption were abolished by reduction of viscosity with partial hydrolysis. (2004)

Asvarujanon, Patchana, Ishizuka, Satoshi, Hara, Hiroshi

Psyllium husk, a highly viscous fiber, has beneficial effects for health, but has been reported to inhibit absorption of calcium. The present study found the effects of fiber viscosity on calcium,...

Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats. (2004)

Hashimoto, Naoto, Hara, Hiroshi

Regulators for pancreatic amylase were examined. Rats were fed ad libitum a 20% amino acid (AA) mixture diet (Con), a 60% AA diet (HA), a branched-chain amino acid (BCAA)-rich diet (BC), or a diet...

Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats. (2004)

Hashimoto, Naoto, Hara, Hiroshi

Regulators for pancreatic amylase were examined. Rats were fed ad libitum a 20% amino acid (AA) mixture diet (Con), a 60% AA diet (HA), a branched-chain amino acid (BCAA)-rich diet (BC), or a diet...

Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats. (2004)

Hashimoto, Naoto, Hara, Hiroshi

Regulators for pancreatic amylase were examined. Rats were fed ad libitum a 20% amino acid (AA) mixture diet (Con), a 60% AA diet (HA), a branched-chain amino acid (BCAA)-rich diet (BC), or a diet...

Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. (2004)

Afsana, Kaosar, Shiga, Kazuki, Ishizuka, Satoshi, Hara, Hiroshi

Interest in the beneficial effects of polyphenols, including tannic acid (TA), is increasing, although, these compounds also have adverse effects; for example, on the absorption of iron (Fe), and...

Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. (2004)

Afsana, Kaosar, Shiga, Kazuki, Ishizuka, Satoshi, Hara, Hiroshi

Interest in the beneficial effects of polyphenols, including tannic acid (TA), is increasing, although, these compounds also have adverse effects; for example, on the absorption of iron (Fe), and...

Reducing effect of ingesting tannic acid on the absorption of iron, but not of zinc, copper and manganese by rats. (2004)

Afsana, Kaosar, Shiga, Kazuki, Ishizuka, Satoshi, Hara, Hiroshi

Interest in the beneficial effects of polyphenols, including tannic acid (TA), is increasing, although, these compounds also have adverse effects; for example, on the absorption of iron (Fe), and...

Ingestion of raffinose promotes calcium absorption in the large intestine of rats. (2004)

Mitamura, Rieko, Hara, Hiroshi, Aoyama, Yoritaka

We examined the effects of feeding raffinose on intestinal calcium absorption in ovariectomized rats by two separate experiments. In experiment 1, female Sprague-Dawley rats (6 wk old) were divided...

Ingestion of raffinose promotes calcium absorption in the large intestine of rats. (2004)

Mitamura, Rieko, Hara, Hiroshi, Aoyama, Yoritaka

We examined the effects of feeding raffinose on intestinal calcium absorption in ovariectomized rats by two separate experiments. In experiment 1, female Sprague-Dawley rats (6 wk old) were divided...

Ingestion of raffinose promotes calcium absorption in the large intestine of rats. (2004)

Mitamura, Rieko, Hara, Hiroshi, Aoyama, Yoritaka

We examined the effects of feeding raffinose on intestinal calcium absorption in ovariectomized rats by two separate experiments. In experiment 1, female Sprague-Dawley rats (6 wk old) were divided...

Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats. (2003)

Mineo, Hitoshi, Amano, Midori, Chiji, Hideyuki, Shigematsu, Norihiro, Tomita, Fusao, Hara, Hiroshi

We compared net Ca absorption and Lucifer Yellow (LY), a paracellular passage dye, permeability in the epithelium isolated from the rat small intestine, cecum, and colon after feeding with control...

Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats. (2003)

Mineo, Hitoshi, Amano, Midori, Chiji, Hideyuki, Shigematsu, Norihiro, Tomita, Fusao, Hara, Hiroshi

We compared net Ca absorption and Lucifer Yellow (LY), a paracellular passage dye, permeability in the epithelium isolated from the rat small intestine, cecum, and colon after feeding with control...

Absorptive activity of calcium in the isolated cecal epithelium adaptively increased by 2 week's feeding of difructose anhydride III in rats. (2003)

Mineo, Hitoshi, Amano, Midori, Chiji, Hideyuki, Shigematsu, Norihiro, Tomita, Fusao, Hara, Hiroshi

We compared net Ca absorption and Lucifer Yellow (LY), a paracellular passage dye, permeability in the epithelium isolated from the rat small intestine, cecum, and colon after feeding with control...

L-homoarginine suppresses exocrine pancreas in rats. (2003)

Hira, Tohru, Ohyama, Sumika, Hara, Hiroshi

Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined...

L-homoarginine suppresses exocrine pancreas in rats. (2003)

Hira, Tohru, Ohyama, Sumika, Hara, Hiroshi

Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined...

L-homoarginine suppresses exocrine pancreas in rats. (2003)

Hira, Tohru, Ohyama, Sumika, Hara, Hiroshi

Previously, we found that guanidinated casein, a l-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined...

Non-essential amino acids play an important role in adaptation of the rat exocrine pancreas to high nitrogen feeding. (2001)

Hara, Hiroshi, Akatsuka, Naoki, Aoyama, Yoritaka

We have previously demonstrated that feeding a diet with a high amino acid (60% AA diet) content, as a mixture simulating casein, induced pancreatic growth and pancreatic protease production in rats....

Non-essential amino acids play an important role in adaptation of the rat exocrine pancreas to high nitrogen feeding. (2001)

Hara, Hiroshi, Akatsuka, Naoki, Aoyama, Yoritaka

We have previously demonstrated that feeding a diet with a high amino acid (60% AA diet) content, as a mixture simulating casein, induced pancreatic growth and pancreatic protease production in rats....

Non-essential amino acids play an important role in adaptation of the rat exocrine pancreas to high nitrogen feeding. (2001)

Hara, Hiroshi, Akatsuka, Naoki, Aoyama, Yoritaka

We have previously demonstrated that feeding a diet with a high amino acid (60% AA diet) content, as a mixture simulating casein, induced pancreatic growth and pancreatic protease production in rats....

Characterization of Binding Between the Rat Small Intestinal Brush-border Membrane and Dietary Proteins in the Sensory Mechanism of Luminal Dietary Proteins. (2001)

Hira, Tohru, Hara, Hiroshi, Tomita, Fusao

Dietary proteins are recognized by the gastrointestinal tract to display physiological functions, however, the sensory mechanism of the intestinal mucosa is not known. We examined binding properties...

Characterization of Binding Between the Rat Small Intestinal Brush-border Membrane and Dietary Proteins in the Sensory Mechanism of Luminal Dietary Proteins. (2001)

Hira, Tohru, Hara, Hiroshi, Tomita, Fusao

Dietary proteins are recognized by the gastrointestinal tract to display physiological functions, however, the sensory mechanism of the intestinal mucosa is not known. We examined binding properties...

Characterization of Binding Between the Rat Small Intestinal Brush-border Membrane and Dietary Proteins in the Sensory Mechanism of Luminal Dietary Proteins. (2001)

Hira, Tohru, Hara, Hiroshi, Tomita, Fusao

Dietary proteins are recognized by the gastrointestinal tract to display physiological functions, however, the sensory mechanism of the intestinal mucosa is not known. We examined binding properties...

Intestinal absorption of zinc is promoted by low-level intake but inhibited by high-level intake of corn husk fiber in rats (2001)

Hara, Hiroshi, Hayashi, Kumiko, Aoyama, Yoritaka

We examined the effects of feeding several types of insoluble dietary fiber (100 g/kg diet), including cellulose (control), wheat bran (demineralized), sugar-beet fiber and corn husk fiber, on zinc...

Intestinal absorption of zinc is promoted by low-level intake but inhibited by high-level intake of corn husk fiber in rats (2001)

Hara, Hiroshi, Hayashi, Kumiko, Aoyama, Yoritaka

We examined the effects of feeding several types of insoluble dietary fiber (100 g/kg diet), including cellulose (control), wheat bran (demineralized), sugar-beet fiber and corn husk fiber, on zinc...

Intestinal absorption of zinc is promoted by low-level intake but inhibited by high-level intake of corn husk fiber in rats (2001)

Hara, Hiroshi, Hayashi, Kumiko, Aoyama, Yoritaka

We examined the effects of feeding several types of insoluble dietary fiber (100 g/kg diet), including cellulose (control), wheat bran (demineralized), sugar-beet fiber and corn husk fiber, on zinc...

Dietary Sugar Beet Fiber Ameliorates Diarrhea as an Acute Gamma-Radiation Injury in Rats (2000)

Satoshi Ishizuka, Satoshi Ito, Takanori Kasai, Hiroshi Hara

Ishizuka, S., Ito, S., Kasai, T. and Hara, H. Dietary Sugar Beet Fiber Ameliorates Diarrhea as an Acute Gamma-Radiation Injury in Rats. Gamma radiation induces diarrhea as an acute injury. We have...

Luminal dietary protein, not amino acids, induces pancreatic protease via CCK in pancreaticobiliary-diverted rats (2000)

Hara, Hiroshi, Ohyama, Sumika, Hira, Tohru

We determined whether pancreatic adaptation to a high-protein diet depends on ingested protein in the intestinal lumen and whether such adaptation depends on a CCK or capsaicin-sensitive vagal...

Effects of Bromo-Cyclic GMP and Bromo-Cyclic AMP on Embryonic Development of Xenopus laevis (2000)

Yuko Moroki, Shigeo Takeuchi, Kazuei Igarashi, Hiroshi Hara, Koichiro Shiokawa

Low molecular signalling molecules such as cAMP and cGMP are expected to have important functions in early morphogenetic processes in animal development. We examined the effect of 8-bromo-cyclic GMP...

Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition (1999)

Ishizuka, Satoshi, Ito, Satoshi, Onuma, Masashi, Kasai, Takanori, Aoyama, Yoritaka, Hara, Hiroshi

The induction of aberrant crypt foci (ACF) by irradiation of γ-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal...

Operation of Transversely Excited N2O Lasers. (1998)

Whitney,Wayne T., Hara,Hiroshi

This patent discloses an improved method and apparatus for producing high power, high efficiency pulsed TEA laser energy at N2O wavelengths by suppressing discharge arc formation with H2 or CO that...

Cloning and Nucleotide Sequence of the ispA Gene Responsible for Farnesyl Diphosphate Synthase Activity in Escherichia coli1 (1990)

Fujisaki, Shingo, Hara, Hiroshi, Nishimura, Yukinobu, Horiuchi, Kensuke, Nishino, Tokuzo

The molecular cloning and the determination of the nucleotide sequence of the ispA gene responsible for farnesyl diphosphate (FPP) synthase [EC 2.5.1.1] activity in Escherichia coli are described. E....

Trichosporon beigelii Pneumonia in a Patient with Malignant Histiocytosis (1986)

KOBAYASHI, MAKOTO, MATSUOKA, TOMOKO, TAGUCHI, HIROKUNI, MORIKI, TOSHIAKI, ENZAN, HIDEAKI, HARA, HIROSHI, ...

A 30-year-old previously healthy housewife presented with bilateral pulmonary infiltrates. She was treated with various antibiotics but died with disseminated intravascular coagulation. Cultures of...

Contribution of the Pmra Promoter to Expression of Genes in the Escherichia coli mra Cluster of Cell Envelope Biosynthesis and Cell Division Genes

Mengin-Lecreulx, Dominique, Ayala, Juan, Bouhss, Ahmed, Van Heijenoort, Jean, Parquet, Claudine, Hara, Hiroshi

Recently, a promoter for the essential gene ftsI, which encodes penicillin-binding protein 3 of Escherichia coli, was precisely localized 1.9 kb upstream from this gene, at the beginning of the mra...

Envelope Disorder of Escherichia coli Cells Lacking Phosphatidylglycerol

Suzuki, Motoo, Hara, Hiroshi, Matsumoto, Kouji

Phosphatidylglycerol, the most abundant acidic phospholipid in Escherichia coli, is considered to play specific roles in various cellular processes that are essential for cell viability. A null...

Cardiolipin Domains in Bacillus subtilis Marburg Membranes

Kawai, Fumitaka, Shoda, Momoko, Harashima, Rie, Sadaie, Yoshito, Hara, Hiroshi, Matsumoto, Kouji

Recently, use of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange (NAO) revealed CL-rich domains in the Escherichia coli membrane (E. Mileykovskaya and W. Dowhan, J....

Activation of the Rcs Signal Transduction System Is Responsible for the Thermosensitive Growth Defect of an Escherichia coli Mutant Lacking Phosphatidylglycerol and Cardiolipin

Shiba, Yasuhiro, Yokoyama, Yasuko, Aono, Yoshiko, Kiuchi, Takashi, Kusaka, Jin, Matsumoto, Kouji, ...

The lethal effect of an Escherichia coli pgsA null mutation, which causes a complete lack of the major acidic phospholipids, phosphatidylglycerol and cardiolipin, is alleviated by a lack of the major...

Phosphatidylethanolamine Domains and Localization of Phospholipid Synthases in Bacillus subtilis Membranes

Nishibori, Ayako, Kusaka, Jin, Hara, Hiroshi, Umeda, Masato, Matsumoto, Kouji

Application of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange has recently revealed CL-rich domains in the septal regions and at the poles of the Bacillus subtilis membrane...

Contribution of the Pmra Promoter to Expression of Genes in the Escherichia coli mra Cluster of Cell Envelope Biosynthesis and Cell Division Genes

Mengin-Lecreulx, Dominique, Ayala, Juan, Bouhss, Ahmed, Van Heijenoort, Jean, Parquet, Claudine, Hara, Hiroshi

Recently, a promoter for the essential gene ftsI, which encodes penicillin-binding protein 3 of Escherichia coli, was precisely localized 1.9 kb upstream from this gene, at the beginning of the mra...

Envelope Disorder of Escherichia coli Cells Lacking Phosphatidylglycerol

Suzuki, Motoo, Hara, Hiroshi, Matsumoto, Kouji

Phosphatidylglycerol, the most abundant acidic phospholipid in Escherichia coli, is considered to play specific roles in various cellular processes that are essential for cell viability. A null...

Cardiolipin Domains in Bacillus subtilis Marburg Membranes

Kawai, Fumitaka, Shoda, Momoko, Harashima, Rie, Sadaie, Yoshito, Hara, Hiroshi, Matsumoto, Kouji

Recently, use of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange (NAO) revealed CL-rich domains in the Escherichia coli membrane (E. Mileykovskaya and W. Dowhan, J....

Activation of the Rcs Signal Transduction System Is Responsible for the Thermosensitive Growth Defect of an Escherichia coli Mutant Lacking Phosphatidylglycerol and Cardiolipin

Shiba, Yasuhiro, Yokoyama, Yasuko, Aono, Yoshiko, Kiuchi, Takashi, Kusaka, Jin, Matsumoto, Kouji, ...

The lethal effect of an Escherichia coli pgsA null mutation, which causes a complete lack of the major acidic phospholipids, phosphatidylglycerol and cardiolipin, is alleviated by a lack of the major...

Phosphatidylethanolamine Domains and Localization of Phospholipid Synthases in Bacillus subtilis Membranes

Nishibori, Ayako, Kusaka, Jin, Hara, Hiroshi, Umeda, Masato, Matsumoto, Kouji

Application of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange has recently revealed CL-rich domains in the septal regions and at the poles of the Bacillus subtilis membrane...

Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia

Murayama, Takashi, Oba, Toshiharu, Hara, Hiroshi, Wakebe, Kikuo, Ikemoto, Noriaki, Ogawa, Yasuo

We have demonstrated recently that CICR (Ca2+-induced Ca2+ release) activity of RyR1 (ryanodine receptor 1) is held to a low level in mammalian skeletal muscle (‘suppression’ of the channel) and...

Gene Expression in Pre-MBT Embryos and Activation of Maternally-Inherited Program of Apoptosis to be Executed at around MBT as a Fail-Safe Mechanism in Xenopus Early Embryogenesis

Shiokawa, Koichiro, Aso, Mai, Kondo, Takeshi, Uchiyama, Hiroaki, Kuroyanagi, Shinsaku, Takai, Jun-Ichi, ...

S-adenosylmethionine decarboxylase (SAMDC) is an enzyme which converts S-adenosylmethione (SAM), a methyl donor, to decarboxylated SAM (dcSAM), an aminopropyl donor for polyamine biosynthesis. In our...