Kawasaki, Aya, Ito, Ikue, Hikami, Koki, Ohashi, Jun, Hayashi, Taichi, Goto, Daisuke, ...
Abstract Introduction Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded...
Tougan, Takahiro, Onda, Hiroaki, Okuzaki, Daisuke, Kobayashi, Shigeto, Hashimoto, Hiroshi, Nojima, Hiroshi
DNA diagnostics are useful but are hampered by difficult ethical issues. Moreover, it cannot provide enough information on the environmental factors that are important for pathogenesis of certain...
Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients (2008)
Kobayashi, Shigeto, Ito, Akihiko, Okuzaki, Daisuke, Onda, Hiroaki, Yabuta, Norikazu, Nagamori, Ippei, ...
Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also other...
Watts, Richard A., Scott, David G. I., Jayne, David R. W., Ito-Ihara, Toshiko, Muso, Eri, Fujimoto, Shouichi, ...
Background. The epidemiology of renal vasculitis in different populations is poorly understood. A recent study from Japan suggests that whilst the overall incidence is similar to that reported from...
Azumi, Makoto, Hou, Kyokushin, Numata, Atsushi, Taniguchi, Narumi, Saga, Yoji, Hashimoto, Hiroshi, ...
A 68-year-old man underwent left side simple nephrectomy for symptomatic severe hydronephrosis with decreased function due to a renal stone. Because of severe adhesion around the kidney, the renal...
Infantile fibrosarcoma of thigh - a case report - (2007)
Himori, Ko, Hatori, Masahito, Wantanabe, Mika, Moriya, Takuya, Ogose, Akira, Hashimoto, Hiroshi, ...
Infantile fibrosarcoma is a rare soft tissue malignant tumor, when it occurs, it is usually seen in the first year of life. The clinical course of infantile fibrosarcoma is more favorable and...
Wang, Biao, Morinobu, Akio, Kanagawa, Sugayo, Nakamura, Tomoko, Kawano, Seiji, Koshiba, Masahiro, ...
To determine the role of transforming growth factor beta 1 (TGFβ1) genepolymorphisms in the pathogenesis of systemic lupus erythematosus (SLE), weinvestigated the polymorphisms of T869C of the...
A case of metastatic renal cell carcinoma to the ovary (2006)
Kato, Yuji, Numata, Atsushi, Wada, Naoki, Iwata, Tatsuya, Saga, Yuji, Hashimoto, Hiroshi, ...
A 52-year-old woman had a pathological fracture of the right femur. On histopathological examination bone metastasis from renal cell carcinoma was suspected. Abdominal computed tomography showed a...
Yoshimitsu Mori, Hiroshi Saruwatari, Tomoya Takatani, Satoshi Ukai, Kiyohiro Shikano, Takashi Hiekata, ...
A new two-stage blind source separation (BSS) method for convolutive mixtures of speech is proposed, in which a single-input multiple-output (SIMO)-model-based independent component analysis (ICA)...
Morimoto, Koichi, Furuta, Erino, Hashimoto, Hiroshi, Inouye, Kuniyo
Effects of salts on the activity and stability of actinidain were examined. With increasing salt concentration up to 0.5 M, the activity (kcat/Km) for N-α-Cbz-l-lysine p-nitrophenyl ester...
Whole genome association study of rheumatoid arthritis using 27,039 microsatellites (2005)
Tamiya, Gen, Shinya, Minori, Imanishi, Tadashi, Ikuta, Tomoki, Makino, Satoshi, Okamoto, Koichi, ...
A major goal of current human genome-wide studies is to identify the genetic basis of complex disorders. However, the availability of an unbiased, reliable, cost efficient and comprehensive...
Kuroki, Kimiko, Tsuchiya, Naoyuki, Shiroishi, Mitsunori, Rasubala, Linda, Yamashita, Yumi, Matsuta, Kunio, ...
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1/LIR1/ILT2), is an inhibitory receptor broadly expressed on leukocytes, and recognizes HLA-class I and human cytomegalovirus UL18....
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites (2005)
Tamiya, Gen, Shinya, Minori, Imanishi, Tadashi, Ikuta, Tomoki, Makino, Satoshi, Okamoto, Koichi, ...
A major goal of current human genome-wide studies is to identify the genetic basis of complex disorders. However, the availability of an unbiased, reliable, cost efficient and comprehensive...
Kuroki, Kimiko, Tsuchiya, Naoyuki, Shiroishi, Mitsunori, Rasubala, Linda, Yamashita, Yumi, Matsuta, Kunio, ...
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1/LIR1/ILT2) is an inhibitory receptor broadly expressed on leukocytes and recognizes HLA-class I and human cytomegalovirus UL18....
Hitomi, Yuki, Tsuchiya, Naoyuki, Kawasaki, Aya, Kyogoku, Chieko, Ohashi, Jun, Suzuki, Takeshi, ...
We previously reported association of FCGR2B-Ile232Thr with systemic lupus erythematosus (SLE) in three Asian populations. Because polymorphism of CD72, another inhibitory receptor of B cells, was...
Takasaki, Yoshinari, Kaneda, Kazuhiko, Matsushita, Masakazu, Yamada, Hirofumi, Nawata, Masuyuki, Matsudaira, Ran, ...
Using 2-dimensional electrophoresis and ion-pair chromatography, we have identified elements of proliferating cell nuclear antigen (PCNA) multiprotein complexes that are reactive to antibodies in...
Hitomi, Yuki, Tsuchiya, Naoyuki, Kawasaki, Aya, Ohashi, Jun, Suzuki, Takeshi, Kyogoku, Chieko, ...
We previously reported association of FCGR2B-Ile232Thr with systemic lupus erythematosus (SLE) in three Asian populations. Because polymorphism of CD72, another inhibitory receptor of B cells, was...
Hitomi, Yuki, Tsuchiya, Naoyuki, Kawasaki, Aya, Kyogoku, Chieko, Ohashi, Jun, Suzuki, Takeshi, ...
We previously reported association of FCGR2B-Ile232Thr with systemic lupus erythematosus (SLE) in three Asian populations. Because polymorphism of CD72, another inhibitory receptor of B cells, was...
Nakamura, Takahiro, Furuhashi, Yumiko, Hasegawa, Keiko, Hashimoto, Hiroshi, Watanabe, Kazufumi, Obokata, Junichi, ...
The plastid genome of higher plants includes about 120 genes. We adopted genomic array technologies to the tobacco plastid genome. A microarray was constructed, consisting of 220 DNA fragments that...
Akira Fujimori, Hiroshi Hashimoto, Ryoko Araki, Toshiyuki Saito, Shinji Sato, Yasuji Kasama, ...
Fujimori, A., Hashimoto, H., Araki, R., Saito, T., Sato, S., Kasama, Y., Tsutsumi, Y., Mori, M., Fukumura, R., Ohhata, T., Tatsumi, K. and Abe, M. Sequence Analysis of 193.4 and 83.9 kbp of Mouse and...
Hashimoto, Hiroshi, Matsumoto, Tomoya, Nishioka, Motomu, Yuasa, Toru, Takeuchi, Shoko, Inoue, Tsuyoshi, ...
A hyperthermostable family B DNA polymerase from the hyperthermophilic archaeon, Pyrococcus kodakaraensis strain KOD1, has been crystallized by the hanging-drop vapor diffusion method at 293 K with...
Expression and function of fibronectin binding integrins on rat mast cells (1995)
Yasuda, Masahiko, Hasunuma, Yukihito, Adachi, Hiroyasu, Sekine, Chiyoko, Sakanishi, Tamami, Hashimoto, Hiroshi, ...
Adhesion molecules of the integrin family are implicated not only in leukocyte migration but also in leukocyte activation. Here we characterize the expression and function of fibronectin receptor...
A case control study of female systemic lupus erythematosus in Japan (1993)
NAGAI, MASAKI, HIROHATA, TOMIO, MATSUMOTO, YOSHIFUJI, HASHIMOTO, HIROSHI, KONDO, MASAKAZU, OZASA, KOTARO, ...
In a multi-institutional case-control study, we investigated risk factors for systemic lupus erythematosus (SLE) in 151 Japanese women treated for SLE during the period September 1988 to August 1990....
The soluble CD40 ligand sCD154 in systemic lupus erythematosus
Kato, Kazunori, Santana-Sahagún, Ernesto, Rassenti, Laura Z., Weisman, Michael H., Tamura, Naoto, Kobayashi, Shigeto, ...
We found that the plasma of patients with active systemic lupus erythematosus (SLE) could induce a human B-cell line (Ramos) to express high levels of immune accessory molecules that are commonly...
Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Arita, Kyouhei, Shimizu, Toshiyuki, Hashimoto, Hiroshi, Hidaka, Yuji, Yamada, Michiyuki, Sato, Mamoru
Histone arginine methylation is a posttranslational modification linked to the regulation of gene transcription. Unlike other posttranslational modifications, methylation has generally been regarded...
The soluble CD40 ligand sCD154 in systemic lupus erythematosus
Kato, Kazunori, Santana-Sahagún, Ernesto, Rassenti, Laura Z., Weisman, Michael H., Tamura, Naoto, Kobayashi, Shigeto, ...
We found that the plasma of patients with active systemic lupus erythematosus (SLE) could induce a human B-cell line (Ramos) to express high levels of immune accessory molecules that are commonly...
Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Arita, Kyouhei, Shimizu, Toshiyuki, Hashimoto, Hiroshi, Hidaka, Yuji, Yamada, Michiyuki, Sato, Mamoru
Histone arginine methylation is a posttranslational modification linked to the regulation of gene transcription. Unlike other posttranslational modifications, methylation has generally been regarded...
Tsuji, Seiji, Hisaoka, Masanori, Morimitsu, Yosuke, Hashimoto, Hiroshi, Shimajiri, Shohei, Komiya, Setsuro, ...
The reciprocal translocation t(X;18)(p11;q11) is known to be highly characteristic of synovial sarcoma, and its consequence, an SYT-SSX fusion gene, is expected to be a diagnostic molecular marker....
COL1A1-PDGFB Fusion Transcripts in Fibrosarcomatous Areas of Six Dermatofibrosarcomas Protuberans
Wang, Jian, Morimitsu, Yosuke, Okamoto, Sumika, Hisaoka, Masanori, Ishida, Tsuyoshi, Sheng, Weiqi, ...
The fibrosarcomatous transformation of dermatofibrosarcoma protuberans (DFSP) has been considered for some time to be associated with an adverse clinical outcome. However, the molecular and cellular...
Naoe, Youichi, Arita, Kyouhei, Hashimoto, Hiroshi, Kanazawa, Hiroshi, Sato, Mamoru, Shimizu, Toshiyuki
Calcineurin B homologous protein 1 from rat was expressed in E. coli, purified and crystallized. A full set of X-ray diffraction data has been collected to 2.2 Å resolution using a...
Imasaki, Tsuyoshi, Shimizu, Toshiyuki, Hashimoto, Hiroshi, Hidaka, Yuji, Yamada, Michiyuki, Sato, Mamoru
Transportin 1 was cocrystallized with nucleocytoplasmic shuttling fragments of JKTBP and hnRNP D and a nuclear localization fragment of TAP. X-ray diffraction data were collected using synchrotron...
Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients
Kobayashi, Shigeto, Ito, Akihiko, Okuzaki, Daisuke, Onda, Hiroaki, Yabuta, Norikazu, Nagamori, Ippei, ...
Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also other...
Tougan, Takahiro, Onda, Hiroaki, Okuzaki, Daisuke, Kobayashi, Shigeto, Hashimoto, Hiroshi, Nojima, Hiroshi
DNA diagnostics are useful but are hampered by difficult ethical issues. Moreover, it cannot provide enough information on the environmental factors that are important for pathogenesis of certain...