Hiroshi Masumoto

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing (2009)

Kim, Jung-Hyun, Ebersole, Thomas, Kouprina, Natalay, Noskov, Vladimir N., Ohzeki, Jun-Ichirou, Masumoto, Hiroshi, ...

The role of repetitive DNA sequences in pericentromeric regions with respect to kinetochore/heterochromatin structure and function is poorly understood. Here, we use a mouse erythroleukemia cell...

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation (2005)

Ebersole, Tom, Okamoto, Yasuhide, Noskov, Vladimir N., Kouprina, Natalay, Kim, Jung-Hyun, Leem, Sun-Hee, ...

Human artificial chromosomes (HACs) provide a unique opportunity to study kinetochore formation and to develop a new generation of vectors with potential in gene therapy. An investigation into the...

The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein (2005)

Kouprina, Natalay, Pavlicek, Adam, Collins, N. Keith, Nakano, Megumi, Noskov, Vladimir N., Ohzeki, Jun-Ichirou, ...

The most common cause of primary autosomal recessive microcephaly (MCPH) appears to be mutations in the ASPM gene which is involved in the regulation of neurogenesis. The predicted gene product...

The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein (2005)

Kouprina, Natalay, Pavlicek, Adam, Keith Collins, N., Nakano, Megumi, Noskov, Vladimir N., Ohzeki, Jun-Ichirou, ...

The most common cause of primary autosomal recessive microcephaly (MCPH) appears to be mutations in the ASPM gene which is involved in the regulation of neurogenesis. The predicted gene product...

Long-term clinical performance of AAI pacing in patients with sick sinus syndrome: a comparison with dual-chamber pacing (2004)

Masumoto, Hiroshi, Ueda, Yuichi, Kato, Rinya, Usui, Akihiko, Maseki, Takashi, Takagi, Yasushi, ...

Aims In this clinical study, we compared two groups of age-matched patients, AAI and DDD, to evaluate the clinical benefits of AAI pacing in patients with sick sinus syndrome (SSS) and normal...

Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes (2000)

Sugata, Naoko, Li, Shulan, Earnshaw, William C., Yen, Tim J., Yoda, Kinya, Masumoto, Hiroshi, ...

Centromere and kinetochore proteins have a pivotal role in centromere structure, kinetochore formation and sister chromatid separation. However, the molecular architecture and the precise dynamic...

Preparation of Bismuth Titanate Films by Chemical Vapor Deposition. (1998)

Masumoto, Hiroshi, Namerikawa, Masahiko, Hirai, Toshio

Bismuth titanate (Bi4Ti3O12) thin films were prepared on sapphire substrates (A(1 1 -2 0), R(1 -1 0 2) and C(0001) planes) by chemical vapor deposition using...

Distribution of CENP-B boxes reflected in CREST centromere antigenic sites on long-range {alpha}-satellite DNA arrays of human chromosome 21 (1994)

Ikeno, Masashi, Masumoto, Hiroshi, Okazaki, Tuneko

The long-range organization of alphold DNA arrays of human chromosome 21 was investigated using a mouse - human somatic cell hybrid. Two distinct long alphoid DNA arrays, the loci α21-l and α21-ll,...

Molecular Analyses of Centromere in Human Chromosome (1989)

Masumoto, Hiroshi, 舛本, 寛

名古屋大学博士学位論文 学位の種類:理学博士 (課程) 学位授与年月日:平成1年10月11日

Molecular Analyses of Centromere in Human Chromosome (1989)

Masumoto, Hiroshi, 舛本, 寛

名古屋大学博士学位論文 学位の種類:理学博士 (課程) 学位授与年月日:平成1年10月11日

名古屋大学大学院理学研究科染色体機能

舛本, 寛(1957-), マスモト, ヒロシ, Masumoto, Hiroshi

名古屋大学大学院理学研究科生命理学専攻情報機構学講座染色体機能舛本グループのホームページ。研究内容の概要、メンバー紹介など。

Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

Masumoto, Hiroshi, Sugino, Akio, Araki, Hiroyuki

Dpb11 is required for chromosomal DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Here, we report detection of a physical complex containing Dpb11 and DNA polymerase ɛ...

Sld2, Which Interacts with Dpb11 in Saccharomyces cerevisiae, Is Required for Chromosomal DNA Replication

Kamimura, Yoichiro, Masumoto, Hiroshi, Sugino, Akio, Araki, Hiroyuki

The DPB11 gene, which genetically interacts with DNA polymerase II (ɛ), one of three replicative DNA polymerases, is required for DNA replication and the S phase checkpoint in Saccharomyces...

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation

Ebersole, Tom, Okamoto, Yasuhide, Noskov, Vladimir N., Kouprina, Natalay, Kim, Jung-Hyun, Leem, Sun-Hee, ...

Human artificial chromosomes (HACs) provide a unique opportunity to study kinetochore formation and to develop a new generation of vectors with potential in gene therapy. An investigation into the...

Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

Masumoto, Hiroshi, Sugino, Akio, Araki, Hiroyuki

Dpb11 is required for chromosomal DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Here, we report detection of a physical complex containing Dpb11 and DNA polymerase ɛ...

Sld2, Which Interacts with Dpb11 in Saccharomyces cerevisiae, Is Required for Chromosomal DNA Replication

Kamimura, Yoichiro, Masumoto, Hiroshi, Sugino, Akio, Araki, Hiroyuki

The DPB11 gene, which genetically interacts with DNA polymerase II (ɛ), one of three replicative DNA polymerases, is required for DNA replication and the S phase checkpoint in Saccharomyces...

Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation

Ebersole, Tom, Okamoto, Yasuhide, Noskov, Vladimir N., Kouprina, Natalay, Kim, Jung-Hyun, Leem, Sun-Hee, ...

Human artificial chromosomes (HACs) provide a unique opportunity to study kinetochore formation and to develop a new generation of vectors with potential in gene therapy. An investigation into the...

名古屋大学大学院理学研究科染色体機能

舛本, 寛(1957-), マスモト, ヒロシ, Masumoto, Hiroshi

名古屋大学大学院理学研究科生命理学専攻情報機構学講座染色体機能舛本グループのホームページ。研究内容の概要、メンバー紹介など。

An Artificially Constructed De Novo Human Chromosome Behaves Almost Identically to Its Natural Counterpart during Metaphase and Anaphase in Living Cells†

Tsuduki, Tomohiro, Nakano, Megumi, Yasuoka, Nao, Yamazaki, Saeko, Okada, Teruaki, Okamoto, Yasuhide, ...

Human artificial chromosomes (HACs) are promising reagents for the analysis of chromosome function. While HACs are maintained stably, the segregation mechanisms of HACs have not been investigated in...

Left Atrial Myxosarcoma with Previously Detected Intestinal Metastasis

Takami, Yoshiyuki, Masumoto, Hiroshi, Terasawa, Akihiro, Kanai, Michio, Sugiura, Hiroshi

Primary cardiac myxosarcoma is a rare disease; it is exceedingly rare for symptoms of systemic metastasis to precede diagnosis of the primary cardiac tumor. We describe the case of a previously...

A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere

Okamoto, Yasuhide, Nakano, Megumi, Ohzeki, Jun-ichirou, Larionov, Vladimir, Masumoto, Hiroshi

Chromatin clusters containing CENP-A, a histone H3 variant, are found in centromeres of multicellular eukaryotes. This study examines the ability of alpha-satellite (alphoid) DNA arrays in different...

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

Nakano, Megumi, Cardinale, Stefano, Noskov, Vladimir N., Gassmann, Reto, Vagnarelli, Paola, Kandels-Lewis, Stefanie, ...

We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kinetochore. The HAC has a dimeric α-satellite repeat containing one natural monomer...

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA

Ohzeki, Jun-ichirou, Nakano, Megumi, Okada, Teruaki, Masumoto, Hiroshi

Centromere protein (CENP) B boxes, recognition sequences of CENP-B, appear at regular intervals in human centromeric α-satellite DNA (alphoid DNA). In this study, to determine whether information...

Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing

Kim, Jung-Hyun, Ebersole, Thomas, Kouprina, Natalay, Noskov, Vladimir N., Ohzeki, Jun-Ichirou, Masumoto, Hiroshi, ...

The role of repetitive DNA sequences in pericentromeric regions with respect to kinetochore/heterochromatin structure and function is poorly understood. Here, we use a mouse erythroleukemia cell...