Hiroshi Mitani

Dual control by a single gene of secondary sexual characters and mating preferences in medaka (2009)

Fukamachi, Shoji, Kinoshita, Masato, Aizawa, Kouichi, Oda, Shoji, Meyer, Axel, Mitani, Hiroshi

Abstract Background Animals utilize a wide variety of tactics to attract reproductive partners. Behavioral experiments often indicate an important role for visual cues in fish, but their molecular...

Medaka: a promising model animal for comparative population genomics (2009)

Matsumoto, Yoshifumi, Oota, Hiroki, Asaoka, Yoichi, Nishina, Hiroshi, Watanabe, Koji, Bujnicki, Janusz M, ...

Abstract Background Within-species genome diversity has been best studied in humans. The international HapMap project has revealed a tremendous amount of single-nucleotide polymorphisms (SNPs) among...

Rescue From Oculocutaneous Albinism Type 4 Using Medaka slc45a2 cDNA Driven by Its Own Promoter (2008)

Fukamach, Shoji, Kinoshita, Masato, Tsujimura, Taro, Shimada, Atsuko, Oda, Shoji, Shima, Akihiro, ...

Patients and vertebrate mutants with oculocutaneous albinism type 4 (OCA4) have mutations in the solute carrier family 45 member 2 (slc45a2) gene. However, there is no empirical evidence for this...

WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development (2008)

Iwanami, Norimasa, Higuchi, Tomokazu, Sasano, Yumi, Fujiwara, Toshinobu, Hoa, Vu Q., Okada, Minoru, ...

The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened...

Radiation Hybrid Maps of Medaka Chromosomes LG 12, 17, and 22 (2007)

Su, Feng, Osada, Yumi, Ekker, Marc, Chevrette, Mario, Shimizu, Atsushi, Asakawa, Shuichi, ...

The Medaka is an excellent genetic system for studies of vertebrate development and disease and environmental and evolutionary biology studies. To facilitate the mapping of markers or the cloning of...

The DNA sequence of medaka chromosome LG22 (2007)

Sasaki, Takashi, Shimizu, Atsushi, Ishikawa, Sabine K., Imai, Shuichiro, Asakawa, Shuichi, Murayama, Yuji, ...

We report the genomic DNA sequence of a single chromosome (linkage group 22; LG22) of the small teleost fish medaka (Oryzias latipes) as a first whole chromosome sequence from a non-mammalian...

Generation of medaka gene knockout models by target-selected mutagenesis (2006)

Taniguchi, Yoshihito, Takeda, Shunichi, Furutani-Seiki, Makoto, Kamei, Yasuhiro, Todo, Takeshi, Sasado, Takao, ...

Abstract We have established a reverse genetics approach for the routine generation of medaka ( Oryzias latipes ) gene knockouts. A cryopreserved library of N -ethyl- N -nitrosourea (ENU) mutagenized...

A novel membrane guanylyl cyclase expressed in medaka (Oryzias latipes) intestine. (2005)

Iio, Kaori, Nakauchi, Mina, Yamagami, Sayaka, Tsutsumi, Makiko, Hori, Hiroshi, Naruse, Kiyoshi, ...

A novel membrane guanylyl cyclase (GC), OlGC9, was identified in the intestine of the medaka fish Oryzias latipes by the isolation of a full-length cDNA clone (3783 bp). Phylogenetic analysis...

A novel membrane guanylyl cyclase expressed in medaka (Oryzias latipes) intestine. (2005)

Iio, Kaori, Nakauchi, Mina, Yamagami, Sayaka, Tsutsumi, Makiko, Hori, Hiroshi, Naruse, Kiyoshi, ...

A novel membrane guanylyl cyclase (GC), OlGC9, was identified in the intestine of the medaka fish Oryzias latipes by the isolation of a full-length cDNA clone (3783 bp). Phylogenetic analysis...

A novel membrane guanylyl cyclase expressed in medaka (Oryzias latipes) intestine. (2005)

Iio, Kaori, Nakauchi, Mina, Yamagami, Sayaka, Tsutsumi, Makiko, Hori, Hiroshi, Naruse, Kiyoshi, ...

A novel membrane guanylyl cyclase (GC), OlGC9, was identified in the intestine of the medaka fish Oryzias latipes by the isolation of a full-length cDNA clone (3783 bp). Phylogenetic analysis...

A first generation physical map of the medaka genome in BACs essential for positional cloning and clone-by-clone based genomic sequencing (2004)

Khorasani,Maryam Zadeh, Hennig,Steffen, Imre,Gabriele, Asakawa,Shuichi, Palczewski,Stefanie, Berger,Anja, ...

In order to realize the full potential of the medaka as a model system for developmental biology and genetics, characterized genomic resources need to be established, culminating in the sequence of...

A first generation physical map of the medaka genome in BACs essential for positional cloning and clone-by-clone based genomic sequencing (2004)

Khorasani, Maryam Zadeh, Hennig, Steffen, Imre, Gabriele, Asakawa, Shuichi, Palczewski, Stefanie, Berger, Anja, ...

In order to realize the full potential of the medaka as a model system for developmental biology and genetics, characterized genomic resources need to be established, culminating in the sequence of...

A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping (2004)

Naruse, Kiyoshi, Tanaka, Minoru, Mita, Kazuei, Shima, Akihiro, Postlethwait, John, Mitani, Hiroshi

The mapping of Hox clusters and many duplicated genes in zebrafish indicated an extra whole-genome duplication in ray-fined fish. However, to reconstruct the preduplication chromosomes...

A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping (2004)

Naruse, Kiyoshi, Tanaka, Minoru, Mita, Kazuei, Shima, Akihiro, Postlethwait, John, Mitani, Hiroshi

The mapping of Hox clusters and many duplicated genes in zebrafish indicated an extra whole-genome duplication in ray-fined fish. However, to reconstruct the preduplication chromosomes...

Genomic Structure and Expression of the Soluble Guanylyl Cyclase α2 Subunit Gene in the Medaka Fish Oryzias latipes (2003)

Yao, Yuko, Yamamoto, Takehiro, Tsutsumi, Makiko, Matsuda, Masaru, Hori, Hiroshi, Naruse, Kiyoshi, ...

A cDNA clone encoding the soluble guanylyl cyclase α2 subunit was isolated from medaka fish (Oryzias latipes) and designated as OIGCS-α2. The OIGCS-α2 cDNA was 3192 bp in length and the open...

A Critical Stage in Spermatogenesis for Radiation-Induced Cell Death in the Medaka Fish, Oryzias latipes (2002)

Yoshikazu Kuwahara, Atsuko Shimada, Hiroshi Mitani, Akihiro Shima

Kuwahara, Y., Shimada, A., Mitani, H. and Shima, A. A Critical Stage in Spermatogenesis for Radiation-Induced Cell Death in the Medaka Fish, Oryzias latipes. Radiat. Res. 157, 386–392 (2002). To...

5-Azacytidine-induced recovery of O6 alkyltransferase activity in mouse Ha821 cells (1989)

Mitani, Hiroshi, Yagi, Takashi, Leiler, Clara Y. M., Takebe, Hiraku

Mouse 11a821 cells, Harvey murine sarcoma virus-trans formed NIH3T3 cells, have extremely low O6-alkyguanine- DNA alkyltransferase (O6AGTase) activity and are hyper sensitive to an anti-tumor...

Determination of Pyrimidine Dimers in Escherichia coli and Cryptosporidium parvum during UV Light Inactivation, Photoreactivation, and Dark Repair

Oguma, Kumiko, Katayama, Hiroyuki, Mitani, Hiroshi, Morita, Shigemitsu, Hirata, Tsuyoshi, Ohgaki, Shinichiro

UV inactivation, photoreactivation, and dark repair of Escherichia coli and Cryptosporidium parvum were investigated with the endonuclease sensitive site (ESS) assay, which can determine UV-induced...

Four functionally distinct C-type natriuretic peptides found in fish reveal evolutionary history of the natriuretic peptide system

Inoue, Koji, Naruse, Kiyoshi, Yamagami, Sayaka, Mitani, Hiroshi, Suzuki, Norio, Takei, Yoshio

Natriuretic peptides (NPs) are major cardiovascular and osmoregulatory hormones in vertebrates. Although tetrapods generally have three subtypes, atrial NP (ANP), B-type NP (BNP), and C-type NP...

Construction of a Linkage Map of the Medaka (Oryzias latipes) and Mapping of the Da Mutant Locus Defective in Dorsoventral Patterning

Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...

Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...

A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping

Naruse, Kiyoshi, Tanaka, Minoru, Mita, Kazuei, Shima, Akihiro, Postlethwait, John, Mitani, Hiroshi

The mapping of Hox clusters and many duplicated genes in zebrafish indicated an extra whole-genome duplication in ray-fined fish. However, to reconstruct the preduplication chromosomes...

Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka

Fukamachi, Shoji, Sugimoto, Masazumi, Mitani, Hiroshi, Shima, Akihiro

Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display...

Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers

Nishimura, Yoshiki, Yoshinari, Tomoya, Naruse, Kiyoshi, Yamada, Takeshi, Sumi, Kazuyoshi, Mitani, Hiroshi, ...

In almost all eukaryotes, mitochondrial (mt) genes are transmitted to progeny mainly from the maternal parent. The most popular explanation for this phenomenon is simple dilution of paternal mtDNA,...

Conserved Function of Medaka pink-eyed dilution in Melanin Synthesis and Its Divergent Transcriptional Regulation in Gonads Among Vertebrates

Fukamachi, Shoji, Asakawa, Shuichi, Wakamatsu, Yuko, Shimizu, Nobuyoshi, Mitani, Hiroshi, Shima, Akihiro

Medaka is emerging as a model organism for the study of vertebrate development and genetics, and its effectiveness in forward genetics should prove equal to that of zebrafish. Here, we identify by...

Medaka Receptors for Somatolactin and Growth Hormone: Phylogenetic Paradox Among Fish Growth Hormone Receptors

Fukamachi, Shoji, Yada, Takashi, Mitani, Hiroshi

Somatolactin (SL) in fish belongs to the growth hormone/prolactin family. Its ortholog in tetrapods has not been identified and its function(s) remains largely unknown. The SL-deficient mutant of...

Determination of Pyrimidine Dimers in Escherichia coli and Cryptosporidium parvum during UV Light Inactivation, Photoreactivation, and Dark Repair

Oguma, Kumiko, Katayama, Hiroyuki, Mitani, Hiroshi, Morita, Shigemitsu, Hirata, Tsuyoshi, Ohgaki, Shinichiro

UV inactivation, photoreactivation, and dark repair of Escherichia coli and Cryptosporidium parvum were investigated with the endonuclease sensitive site (ESS) assay, which can determine UV-induced...

Four functionally distinct C-type natriuretic peptides found in fish reveal evolutionary history of the natriuretic peptide system

Inoue, Koji, Naruse, Kiyoshi, Yamagami, Sayaka, Mitani, Hiroshi, Suzuki, Norio, Takei, Yoshio

Natriuretic peptides (NPs) are major cardiovascular and osmoregulatory hormones in vertebrates. Although tetrapods generally have three subtypes, atrial NP (ANP), B-type NP (BNP), and C-type NP...

Construction of a Linkage Map of the Medaka (Oryzias latipes) and Mapping of the Da Mutant Locus Defective in Dorsoventral Patterning

Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...

Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...

A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping

Naruse, Kiyoshi, Tanaka, Minoru, Mita, Kazuei, Shima, Akihiro, Postlethwait, John, Mitani, Hiroshi

The mapping of Hox clusters and many duplicated genes in zebrafish indicated an extra whole-genome duplication in ray-fined fish. However, to reconstruct the preduplication chromosomes...

Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka

Fukamachi, Shoji, Sugimoto, Masazumi, Mitani, Hiroshi, Shima, Akihiro

Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display...

Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers

Nishimura, Yoshiki, Yoshinari, Tomoya, Naruse, Kiyoshi, Yamada, Takeshi, Sumi, Kazuyoshi, Mitani, Hiroshi, ...

In almost all eukaryotes, mitochondrial (mt) genes are transmitted to progeny mainly from the maternal parent. The most popular explanation for this phenomenon is simple dilution of paternal mtDNA,...

Conserved Function of Medaka pink-eyed dilution in Melanin Synthesis and Its Divergent Transcriptional Regulation in Gonads Among Vertebrates

Fukamachi, Shoji, Asakawa, Shuichi, Wakamatsu, Yuko, Shimizu, Nobuyoshi, Mitani, Hiroshi, Shima, Akihiro

Medaka is emerging as a model organism for the study of vertebrate development and genetics, and its effectiveness in forward genetics should prove equal to that of zebrafish. Here, we identify by...

Medaka Receptors for Somatolactin and Growth Hormone: Phylogenetic Paradox Among Fish Growth Hormone Receptors

Fukamachi, Shoji, Yada, Takashi, Mitani, Hiroshi

Somatolactin (SL) in fish belongs to the growth hormone/prolactin family. Its ortholog in tetrapods has not been identified and its function(s) remains largely unknown. The SL-deficient mutant of...

Generation of medaka gene knockout models by target-selected mutagenesis

Taniguchi, Yoshihito, Takeda, Shunichi, Furutani-Seiki, Makoto, Kamei, Yasuhiro, Todo, Takeshi, Sasado, Takao, ...

A reverse genetics approach for the routine generation of medaka (Oryzias latipes) gene knockouts is described and applied to create a cryopreserved resource containing knockouts for most medaka...

The hotei mutation of medaka in the anti-Müllerian hormone receptor causes the dysregulation of germ cell and sexual development

Morinaga, Chikako, Saito, Daisuke, Nakamura, Shuhei, Sasaki, Takashi, Asakawa, Shuichi, Shimizu, Nobuyoshi, ...

We previously performed mutant screens in the medaka for defects in gonadal development and identified a mutant of interest in this regard, which was designated as hotei (hot). This mutant manifests...

Genetic Analysis of Craniofacial Traits in the Medaka

Kimura, Tetsuaki, Shimada, Atsuko, Sakai, Noriyoshi, Mitani, Hiroshi, Naruse, Kiyoshi, Takeda, Hiroyuki, ...

Family and twin studies suggest that a substantial genetic component underlies individual differences in craniofacial morphology. In the current study, we quantified 444 craniofacial traits in 100...

Rescue From Oculocutaneous Albinism Type 4 Using Medaka slc45a2 cDNA Driven by Its Own Promoter

Fukamachi, Shoji, Kinoshita, Masato, Tsujimura, Taro, Shimada, Atsuko, Oda, Shoji, Shima, Akihiro, ...

Patients and vertebrate mutants with oculocutaneous albinism type 4 (OCA4) have mutations in the solute carrier family 45 member 2 (slc45a2) gene. However, there is no empirical evidence for this...

WDR55 Is a Nucleolar Modulator of Ribosomal RNA Synthesis, Cell Cycle Progression, and Teleost Organ Development

Iwanami, Norimasa, Higuchi, Tomokazu, Sasano, Yumi, Fujiwara, Toshinobu, Hoa, Vu Q., Okada, Minoru, ...

The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened...

Radiation Hybrid Maps of Medaka Chromosomes LG 12, 17, and 22

Su, Feng, Osada, Yumi, Ekker, Marc, Chevrette, Mario, Shimizu, Atsushi, Asakawa, Shuichi, ...

The Medaka is an excellent genetic system for studies of vertebrate development and disease and environmental and evolutionary biology studies. To facilitate the mapping of markers or the cloning of...