Hiroshi Mukae

Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin (2009)

Ishimoto, Hiroshi, Mukae, Hiroshi, Sakamoto, Noriho, Amenomori, Misato, Kitazaki, Takeshi, Imamura, Yoshifumi, ...

Objectives Mucus hypersecretion is a prominent feature in patients with chronic respiratory tract infections such as cystic fibrosis and diffuse panbronchiolitis, and the clinical effectiveness of...

High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis (2008)

Kakugawa, Tomoyuki, Yokota, Shin-ichi, Mukae, Hiroshi, Kubota, Hiroshi, Sakamoto, Noriho, Mizunoe, Syunji, ...

Abstract Background The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less...

Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection (2005)

Yanagi, Shigehisa, Ashitani, Jun-ichi, Ishimoto, Hiroshi, Date, Yukari, Mukae, Hiroshi, Chino, Naoyoshi, ...

Abstract Background Human β-defensin-4 (hBD-4), a new member of the β-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4...

Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment (2005)

Ishii, Hiroshi, Hayashi, Shizu, Hogg, James C, Fujii, Takeshi, Goto, Yukinobu, Sakamoto, Noriho, ...

Abstract Background Studies from our laboratory have shown that human alveolar macrophages (AM) and bronchial epithelial cells (HBEC) exposed to ambient particles (PM 10 ) in vitro increase their...

Expression of HSP47 in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia (2005)

Kakugawa, Tomoyuki, Mukae, Hiroshi, Hayashi, Tomayoshi, Ishii, Hiroshi, Nakayama, Seiko, Sakamoto, Noriho, ...

Abstract Background Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagens, and its expression is increased in various...

Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4 (2005)

Yoshida, Kayo, Yamamoto, Kazuo, Kohno, Tomoko, Hironaka, Noriko, Yasui, Kiyoshi, Kojima, Chojiro, ...

IFN regulatory factor-4 (IRF-4) is a transcription factor that is involved in the development and the functions of lymphocytes, macrophages and dendritic cells. Despite their critical roles in immune...

Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4 (2005)

Yoshida, Kayo, Yamamoto, Kazuo, Kohno, Tomoko, Hironaka, Noriko, Yasui, Kiyoshi, Kojima, Chojiro, ...

IFN regulatory factor-4 (IRF-4) is a transcription factor that is involved in the development and the functions of lymphocytes, macrophages and dendritic cells. Despite their critical roles in immune...

Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model (2002)

Yanagihara, Katsunori, Tomono, Kazunori, Imamura, Yoshifumi, Kaneko, Yukihiro, Kuroki, Misuzu, Sawai, Toyomitsu, ...

Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that...

Merozoite Surface Protein 1-Specific Immune Response Is Protective against Exoerythrocytic Forms of Plasmodium yoelii

Kawabata, Yuko, Udono, Heiichiro, Honma, Kiri, Ueda, Masakatsu, Mukae, Hiroshi, Kadota, Jun-ichi, ...

One of the difficulties in developing an effective malaria vaccine is the antigenic change of the parasite during the life cycle. It is desirable that vaccine-induced protective immunity be effective...

Effect of Erythromycin on Chronic Respiratory Infection Caused by Pseudomonas aeruginosa with Biofilm Formation in an Experimental Murine Model

Nagata, Towako, Mukae, Hiroshi, Kadota, Junichi, Hayashi, Tomayoshi, Fujii, Takeshi, Kuroki, Misuzu, ...

Diffuse panbronchiolitis (DPB) is a chronic lower respiratory tract infection commonly associated with persistent late-stage Pseudomonas aeruginosa infection. However, low-dose long-term therapy with...

Merozoite Surface Protein 1-Specific Immune Response Is Protective against Exoerythrocytic Forms of Plasmodium yoelii

Kawabata, Yuko, Udono, Heiichiro, Honma, Kiri, Ueda, Masakatsu, Mukae, Hiroshi, Kadota, Jun-ichi, ...

One of the difficulties in developing an effective malaria vaccine is the antigenic change of the parasite during the life cycle. It is desirable that vaccine-induced protective immunity be effective...

Effect of Erythromycin on Chronic Respiratory Infection Caused by Pseudomonas aeruginosa with Biofilm Formation in an Experimental Murine Model

Nagata, Towako, Mukae, Hiroshi, Kadota, Junichi, Hayashi, Tomayoshi, Fujii, Takeshi, Kuroki, Misuzu, ...

Diffuse panbronchiolitis (DPB) is a chronic lower respiratory tract infection commonly associated with persistent late-stage Pseudomonas aeruginosa infection. However, low-dose long-term therapy with...