New Approach for M-Cell-Specific Molecules Screening by Comprehensive Transcriptome Analysis (2009)
Nakato, Gaku, Fukuda, Shinji, Hase, Koji, Goitsuka, Ryo, Cooper, Max D., Ohno, Hiroshi
A minor population of M cells within the follicle-associated epithelium (FAE) of intestinal Peyer's patches (PPs) serves as a major portal for entry of exogenous antigens. Characterization of the...
Search for the Charmonium Dissociation Temperature with Variational Analysis in Lattice QCD (2008)
Ohno, Hiroshi, Umeda, Takashi, Kanaya, Kazuyuki
Charmonium dissociation temperatures are studied in a quenched anisotropic lattice QCD with standard plaquette gauge action and O(a) improved Wilson fermion action. Simulations are carried out at...
Morita, Hidetoshi, Toh, Hidehiro, Fukuda, Shinji, Horikawa, Hiroshi, Oshima, Kenshiro, Suzuki, Takehito, ...
Lactobacillus reuteri is a heterofermentative lactic acid bacterium that naturally inhabits the gut of humans and other animals. The probiotic effects of L. reuteri have been proposed to be largely...
A New Approach to Acquisition of Comprehensible Fuzzy Rules (2007)
Hiroshi Ohno, Takeshi Furuhashi
This paper presents a new approach to acquisition of comprehensible fuzzy rules for fuzzy modeling from data using evolutionary programming(EP). For the accuracy of the model, it is effective to...
Magnetic Field Spectrum at Cosmological Recombination (2007)
Ichiki, Kiyotomo, Takahashi, Keitaro, Sugiyama, Naoshi, Hanayama, Hidekazu, Ohno, Hiroshi
A generation of magnetic fields from cosmological density perturbations is investigated. In the primordial plasma before cosmological recombination, all of the materials except dark matter in the...
Hijikata, Atsushi, Kitamura, Hiroshi, Kimura, Yayoi, Yokoyama, Ryo, Aiba, Yuichi, Bao, Yanyuan, ...
Motivation: Although a huge amount of mammalian genomic data does become publicly available, there are still hurdles for biologists to overcome before such data can be fully exploited. One of the...
Characteristics of salt inclusions in polar ice from Dome Fuji, East Antarctica (2006)
Ohno, Hiroshi, Igarashi, Makoto, Hondoh, Takeo
We studied the depth profile of the chemical properties, number concentration and average diameter of micro-inclusions in Antarctic ice from Dome Fuji. Analysis of the data indicated that the...
Characteristics of salt inclusions in polar ice from Dome Fuji, East Antarctica (2006)
Ohno, Hiroshi, Igarashi, Makoto, Hondoh, Takeo
We studied the depth profile of the chemical properties, number concentration and average diameter of micro-inclusions in Antarctic ice from Dome Fuji. Analysis of the data indicated that the...
Characteristics of salt inclusions in polar ice from Dome Fuji, East Antarctica (2006)
Ohno, Hiroshi, Igarashi, Makoto, Hondoh, Takeo
We studied the depth profile of the chemical properties, number concentration and average diameter of micro-inclusions in Antarctic ice from Dome Fuji. Analysis of the data indicated that the...
Cosmological Magnetic Field: a fossil of density perturbations in the early universe (2006)
Ichiki, Kiyotomo, Takahashi, Keitaro, Ohno, Hiroshi, Hanayama, Hidekazu, Sugiyama, Naoshi
The origin of the substantial magnetic fields that are found in galaxies and on even larger scales, such as in clusters of galaxies, is yet unclear. If the second-order couplings between photons and...
Generation of magnetic field from cosmological perturbations (2006)
Takahashi, Keitaro, Ichiki, Kiyotomo, Ohno, Hiroshi, Hanayama, Hidekazu, Sugiyama, Naoshi
We discuss generation of magnetic field from cosmological perturbations. We consider the evolution of three component plasma (electron, proton and photon) evaluating the collision term between...
Fujimoto, Masanori, Takatsu, Hiroyuki, Ohno, Hiroshi
The murine CMRF-35-like molecule (CLM) family belongs to the Ig superfamily, and consists of nine mapped genes. Here we report that CLM-5 and CLM-1 constitute novel paired Ig-like receptors (PIRs)....
Overview: Membrane Traffic in Multicellular Systems: More than Just a Housekeeper (2006)
Membrane traffic is a fundamental cellular function by which molecules are transported between organelles in the post-Golgi network. Accumulating evidence supports the notion that membrane traffic is...
Physiological Roles of Clathrin Adaptor AP Complexes: Lessons from Mutant Animals (2006)
Clathrin-associated adaptor protein (AP) complexes play a key role in the transport of proteins, by regulating the formation of transport vesicles as well as cargo selection, between organelles of...
Fujimoto, Masanori, Takatsu, Hiroyuki, Ohno, Hiroshi
The murine CMRF-35-like molecule (CLM) family belongs to the Ig superfamily, and consists of nine mapped genes. Here we report that CLM-5 and CLM-1 constitute novel paired Ig-like receptors (PIRs)....
Biermann Mechanism in Primordial Supernova Remnant and Seed Fields (2005)
Hanayama, Hidekazu, Takahashi, Keitaro, Kotake, Kei, Oguri, Masamune, Ichiki, Kiyotomo, Ohno, Hiroshi
We have studied the generation of magnetic fields by the Biermann mechanism in the pair-instability supernovae explosions of the first stars. The Biermann mechanism produces magnetic fields in the...
Magnetic field generation from cosmological perturbations (2005)
Takahashi, Keitaro, Ichiki, Kiyotomo, Ohno, Hiroshi, Hanayama, Hidekazu
In this letter, we discuss generation of magnetic field from cosmological perturbations. We consider the evolution of three component plasma (electron, proton and photon) evaluating the collision...
Biermann Mechanism in Primordial Supernova Remnant and Seed Magnetic Fields (2005)
Hanayama, Hidekazu, Takahashi, Keitaro, Kotake, Kei, Oguri, Masamune, Ichiki, Kiyotomo, Ohno, Hiroshi
We study generation of magnetic fields by the Biermann mechanism in the pair-instability supernovae explosions of first stars. The Biermann mechanism produces magnetic fields in the shocked region...
Hase, Koji, Ohshima, Sayaka, Kawano, Kazuya, Hashimoto, Noriko, Matsumoto, Kenji, Saito, Hirohisa, ...
Follicle-associated epithelium (FAE) covering Peyer's patches contains specialized epithelial M cells that take up ingested macromolecules and microorganisms from the lumen of the gut by...
Patchy He II reionization and the physical state of the IGM (2004)
Gleser, Liron, Nusser, Adi, Benson, Andrew J., Ohno, Hiroshi, Sugiyama, Naoshi
We present a Monte-Carlo model of He II reionization by QSOs and its effect on the thermal state of the clumpy intergalactic medium (IGM). The model assumes that patchy reionization develops as a...
An Analytic Model of Superclusters (2004)
Oguri, Masamune, Takahashi, Keitaro, Ichiki, Kiyotomo, Ohno, Hiroshi
We construct an analytic model for the mass distributions of superclusters and clusters in each supercluster. Our model is a modification of the Press-Schechter theory, and defines superclusters as...
Yoh, Kanji, Ohno, Hiroshi, Sueoka, Kazuhisa, Ramsteiner, Manfred E.
We have investigated Fe/InAs interfaces for two different growth temperatures of Fe and the effect on the spin injection properties through an Fe/InAs junction. Secondary ion mass spectroscopy and...
Dynamics of Golgi Matrix Proteins after the Blockage of ER to Golgi Transport (2004)
Yoshimura, Shin-ichiro, Yamamoto, Akitsugu, Misumi, Yoshio, Sohda, Miwa, Barr, Francis A., Fujii, Gourou, ...
When the ER to Golgi transport is blocked by a GTP-restricted mutant of Sar1p (H79G) in NRK-52E cells, most Golgi resident proteins are transported back into the ER. In contrast, the cis-Golgi matrix...
Decaying Cold Dark Matter and the Evolution of the Cluster Abundance (2003)
Oguri, Masamune, Takahashi, Keitaro, Ohno, Hiroshi, Kotake, Kei
The cluster abundance and its redshift evolution are known to be a powerful tool to constrain the amplitude of mass fluctuations \sigma_8 and the mass density parameter \Omega_m0. We study the impact...
Multiday Variations in Flow Velocity at Glaciar Soler, Northern Patagonia, Chile (2003)
Satoru Yamaguchi, Renji Naruse, Takane Matsumoto, Hiroshi Ohno
Physical properties of the Dome Fuji deep ice core (2003)
Hondoh, Takeo, Narita, Hideki, Hori, Akira, Ikeda-Fukazawa, Tomoko, Fujii-Miyamoto, Michiko, Ohno, Hiroshi, ...
Recent results of physical analyses of the Dome Fuji ice core are summarized with special attention to new methods introduced in the present studies．Microphysical processes which affect the ice...
Spin-Polarized Electron Injection through an Fe/InAs Junction (2003)
Ohno, Hiroshi, Yoh, Kanji, Sueoka, Kazuhisa, Mukasa, Koichi, Kawaharazuka, Atsushi, Ramsteiner, Manfred E.
We report on the spin-polarized electron injection through an Fe(100)/InAs(100) junction. The circularly polarized electroluminescence of injected electrons from epitaxially grown Fe thin film into...
Probing intracluster magnetic fields with cosmic microwave background polarization (2003)
Ohno, Hiroshi, Takada, Masahiro, Dolag, Klaus, Bartelmann, Matthias, Sugiyama, Naoshi
Radio Halo Formation through Magneto-turbulent Particle Acceleration in Clusters of Galaxies (2002)
Ohno, Hiroshi, Takizawa, Motokazu, Shibata, Shinpei
We developed a magneto-turbulent model for the cosmic ray (CR) electrons seen in the radio halo clusters of galaxies. Steady state momentum distribution functions of the CR electrons are calculated...
Probing Intracluster Magnetic Fields with Cosmic Microwave Background Polarization (2002)
Ohno, Hiroshi, Takada, Masahiro, Dolag, Klaus, Bartelmann, Matthias, Sugiyama, Naoshi
Intracluster magnetic fields with $ \sim \mu G $ strength induce Faraday rotation on the cosmic microwave background (CMB) polarization. Measurements of this effect can potentially probe the detailed...
Takada, Masahiro, Ohno, Hiroshi, Sugiyama, Naoshi
The observed magnetic field of microgauss strength in clusters of galaxies should induce the Faraday rotation effect on the linearly polarized cosmic microwave background (CMB) radiation when the CMB...
OHNO, HIROSHI, NOMURA, MAMORU, WATANABE, KAZUO
A previous study revealed that DQ-2511, a new gastroprokietic drug, induced hemolytic anemia together with increased Heinz body formation, preceded by a marked decrease in erythrocyte reduced...
Aoe, Tomohiko, Okamoto, Yasuhiro, Arase, Hisashi, Ikuta, Koichi, Miyazaki, Jun-ichi, Ono, Satoru, ...
Antigen recognition signals by the TCR are transduced through activation motifs present in the cytoplasmic region of CD3 chains. In vitro analysis has suggested that the CD3ζ chain mediates...
Aoe, Tomohiko, Goto, Shigemasa, Ohno, Hiroshi, Saito, Takashi
The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3γδϵ chains and ζ, dimers within the complex. We have investigated functional...
Ohno, Hiroshi, Aoe, Tomohiko, Ra, Chisel, Yamamoto, Tadashi, Saito, Takashi, Arai, K.
The structure and function of the TCR-CD3 complex containing a homodimer of the gamma chain of the high affinity receptor for IgE (FcRγ) (FcRγ+ TCR) was investigated by transfecting the FcRγ...
Heinz Body Hemolytic Anemia Induced by DQ-2511, a New Anti-ulcer Drug, in Dogs (1993)
OHNO, HIROSHI, TOJO, HIROKO, KAKIHATA, KOJI, NOMURA, MAMORU, TAKAYAMA, SATOSHI
DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with...
Aoe, Tomohiko, Ohno, Hiroshi, Sonta, Shin-ichi, Saito, Takashi, Watanebe, T.
Specific inactivation of the CD3ζ or CD3&eegr;; gene was introduced into a murine T cell hybridoma cell line by homologous recombination to elucidate the role of the CD3ζ chain in the assembly of...
Concerning the above article, the authors found that the Clone λ 10-3 had a deletion of approximately 1.4 kb inlength within intron 8, which resulted in the misestimation of the length of intron 8....
CD3{zeta} and {eta} chains are produced by alternative splicing from a common gene (1990)
We have analyzed the genomlc organization of the murlne CD3&eegr; gene. As suggested from the sequence of CD3&eegr; cDNA, exons I-VII are identical to those of CD3ζ and exon VIII Is a unique exon...
Sugimoto, Hisashi, Sugahara, Masayuki, Fölsch, Heike, Koide, Yasuhiro, Nakatsu, Fubito, Tanaka, Naotaka, ...
To investigate the importance of tyrosine recognition by the AP-1B clathrin adaptor subunit μ1B for basolateral sorting of integral membrane proteins in polarized epithelial cells, we have produced...
Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms
Tabuchi, Mitsuaki, Tanaka, Naotaka, Nishida-Kitayama, Junko, Ohno, Hiroshi, Kishi, Fumio
Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral...
The polarized epithelia-specific µ1B-adaptin complements µ1A-deficiency in fibroblasts
Eskelinen, Eeva-Liisa, Meyer, Christoph, Ohno, Hiroshi, Von Figura, Kurt, Schu, Peter
The heterotetrameric AP-1A adaptor complex of clathrin-coated vesicles is ubiquitously expressed. The µ1-adaptin subunit of the complex exists as the ubiquitous µ1A and the polarized...
Ito, Mikiko, Iidawa, Sachi, Izuka, Michiyo, Haito, Sakiko, Segawa, Hiroko, Kuwahata, Masashi, ...
Treatment with PTH (parathyroid hormone) or a high-P(i) diet causes internalization of the type IIa sodium-dependent phosphate (Na/P(i) IIa) co-transporter from the apical membrane and its...
Clathrin Adaptor AP-2 Is Essential for Early Embryonal Development
Mitsunari, Takashi, Nakatsu, Fubito, Shioda, Noriko, Love, Paul E., Grinberg, Alexander, Bonifacino, Juan S., ...
The heterotetrameric adaptor protein (AP) complexes AP-1, AP-2, AP-3, and AP-4 play key roles in transport vesicle formation and cargo sorting in post-Golgi trafficking pathways. Studies on cultured...
Sugimoto, Hisashi, Sugahara, Masayuki, Fölsch, Heike, Koide, Yasuhiro, Nakatsu, Fubito, Tanaka, Naotaka, ...
To investigate the importance of tyrosine recognition by the AP-1B clathrin adaptor subunit μ1B for basolateral sorting of integral membrane proteins in polarized epithelial cells, we have produced...
Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms
Tabuchi, Mitsuaki, Tanaka, Naotaka, Nishida-Kitayama, Junko, Ohno, Hiroshi, Kishi, Fumio
Divalent metal transporter 1 (DMT1) is responsible for dietary-iron absorption from apical plasma membrane in the duodenum and iron acquisition from the transferrin cycle endosomes in peripheral...
The polarized epithelia-specific µ1B-adaptin complements µ1A-deficiency in fibroblasts
Eskelinen, Eeva-Liisa, Meyer, Christoph, Ohno, Hiroshi, Von Figura, Kurt, Schu, Peter
The heterotetrameric AP-1A adaptor complex of clathrin-coated vesicles is ubiquitously expressed. The µ1-adaptin subunit of the complex exists as the ubiquitous µ1A and the polarized...
Ito, Mikiko, Iidawa, Sachi, Izuka, Michiyo, Haito, Sakiko, Segawa, Hiroko, Kuwahata, Masashi, ...
Treatment with PTH (parathyroid hormone) or a high-P(i) diet causes internalization of the type IIa sodium-dependent phosphate (Na/P(i) IIa) co-transporter from the apical membrane and its...
Clathrin Adaptor AP-2 Is Essential for Early Embryonal Development
Mitsunari, Takashi, Nakatsu, Fubito, Shioda, Noriko, Love, Paul E., Grinberg, Alexander, Bonifacino, Juan S., ...
The heterotetrameric adaptor protein (AP) complexes AP-1, AP-2, AP-3, and AP-4 play key roles in transport vesicle formation and cargo sorting in post-Golgi trafficking pathways. Studies on cultured...
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor
Nakatsu, Fubito, Okada, Motohiro, Mori, Fumiaki, Kumazawa, Noriko, Iwasa, Hiroto, Zhu, Gang, ...
AP-3 is a member of the adaptor protein (AP) complex family that regulates the vesicular transport of cargo proteins in the secretory and endocytic pathways. There are two isoforms of AP-3: the...
Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex
Wild, Martin K., Cambiaggi, Anna, Brown, Marion H., Davies, Elizabeth A., Ohno, Hiroshi, Saito, Takashi, ...
The T cell antigen receptor (TCR) and its ligand peptide–major histocompatibility complex (MHC) are small (∼7 nm) compared with other abundant cell surface molecules such as integrins, CD43, and...
Nakaseko, Chiaki, Miyatake, Shoichiro, Iida, Tomohiko, Hara, Satoru, Abe, Ryo, Ohno, Hiroshi, ...
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a T cell costimulation receptor that delivers inhibitory signals upon activation. Although the tyrosine-based motif (165YVKM) within its cytoplasmic tail...
Arase, Noriko, Arase, Hisashi, Park, Seung Yong, Ohno, Hiroshi, Ra, Chisei, Saito, Takashi
Natural killer (NK) cells exhibit cytotoxicity against variety of tumor cells and virus-infected cells without prior sensitization and represent unique lymphocytes involved in primary host defense....
Uekita, Takamasa, Itoh, Yoshifumi, Yana, Ikuo, Ohno, Hiroshi, Seiki, Motoharu
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that degrades the pericellular extracellular matrix (ECM) and is expressed in many migratory cells, including...
Splenic CD19−CD35+B220+ cells function as an inducer of follicular dendritic cell network formation
Murakami, Takaya, Chen, Xin, Hase, Koji, Sakamoto, Ayako, Nishigaki, Chie, Ohno, Hiroshi
Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune...
Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease
Hase, Koji, Takahashi, Daisuke, Ebisawa, Masashi, Kawano, Sayaka, Itoh, Kikuji, Ohno, Hiroshi
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR). Humans with AID mutations...
Morita, Hidetoshi, Toh, Hidehiro, Fukuda, Shinji, Horikawa, Hiroshi, Oshima, Kenshiro, Suzuki, Takehito, ...
Lactobacillus reuteri is a heterofermentative lactic acid bacterium that naturally inhabits the gut of humans and other animals. The probiotic effects of L. reuteri have been proposed to be largely...
New Approach for M-Cell-Specific Molecules Screening by Comprehensive Transcriptome Analysis
Nakato, Gaku, Fukuda, Shinji, Hase, Koji, Goitsuka, Ryo, Cooper, Max D., Ohno, Hiroshi
A minor population of M cells within the follicle-associated epithelium (FAE) of intestinal Peyer's patches (PPs) serves as a major portal for entry of exogenous antigens. Characterization of the...