Aberrant promoter hypermethylation in serum DNA from patients with silicosis (2008)
Umemura, Shigeki, Fujimoto, Nobukazu, Hiraki, Akio, Gemba, Kenichi, Takigawa, Nagio, Fujiwara, Keiichi, ...
It is well established that patients with silicosis are at high risk for lung cancer; however, it is difficult to detect lung cancer by chest radiography during follow-up treatment of patients with...
Ohnoshi, Taisuke, Oka, Akira, Hayashi, Kyoichi, Ueoka, Hiroshi, Sato, Masaharu, Nishihara, Ryuji, ...
Eighteen patients with advanced non-Hodgkin's lymphoma other than the diffuse histiocytic type were treated with a combination of adriamycin, vincristine, ifosfamide and prednisolone (AVIP). The...
Matsuo, Keisuke, Kiura, Katsuyuki, Ueoka, Hiroshi, Tabata, Masahiro, Shibayama, Takuo, Matsumura, Tadashi, ...
We have established an Adriamycin (ADM) -resistant small cell lung cancer (SCLC) cell line, SBC-3/ADM100, which shows multifactorial mechanisms of resistance to ADM, such as overexpression of...
Segawa, Yoshihiko, Ohnoshi, Taisuke, Ueoka, Hiroshi, Kimura, Ikuro
The neural cell adhesion molecule (NCAM) is a family of cell surface sialoglycoproteins mediating homotypic and heterotypic cell-cell adhesion. In tumors, NCAM is supposed to be involved with the...
Tabata, Masahiro, Ohnoshi, Taisuke, Ueoka, Hiroshi, Kiura, Katsuyuki, Kimura, Ikuro
We report a preliminary study to determine whether MDR1 gene expression level in small cell lung cancer (SCLC) tumors is a useful predictor of tumor response to chemotherapy and patient survival in...
Yonei, Toshiro, Ohnoshi, Taisuke, Hiraki, Shunkichi, Ueoka, Hiroshi, Kiura, Katsuyuki, Moritaka, Tomonori, ...
Antitumor activities of five platinum analogs, including cisplatin, carboplatin, 254-S, DWA2114R, and NK121, were compared using five human lung cancer cell lines and 19 tumor specimens obtained from...
Ohnoshi, Taisuke, Hiraki, Shunkichi, Fujii, Masafumi, Ueoka, Hiroshi, Yonei, Toshiro, Tamura, Makoto, ...
We evaluated the long-term outcome of 148 patients with small cell lung cancer (SCLC) who had been entered into clinical trials of chemotherapy with or without thoracic and prophylactic cranial...
Segawa, Yoshihiko, Ohnoshi, Taisuke, Hiraki, Shunkichi, Ueoka, Hiroshi, Kiura, Katsuyuki, Kamei, Haruhito, ...
In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen...
Takigawa, Nagio, Ohnoshi, Taisuke, Ueoka, Hiroshi, Kiura, Katsuyuki, Kimura, Ikuro
In an attempt to predict the clinical activity of newly developed anthracycline analogues, ME2303, KRN8602, and SM5887 in the treatment of lung cancer, we compared antitumor activity of these drugs...
Takigawa, Nagio, Ohnoshi, Taisuke, Ueoka, Hiroshi, Kiura, Katsuyuki, Kimura, Ikuro
An etoposide-resistant subline, SBC-3/ETP, from a human small cell lung cancer cell line, SBC-3, was developed by continuous exposure to increasing concentrations of etoposide in culture. The...
Hosoya, Shigee, Kataoka, Mikio, Nakata, Yasunari, Maeda, Tsuyoshi, Nishizaki, Hiroshi, Hioka, Tohru, ...
Clinical features were studied in 125 patients with sarcoidosis (72 females and 53 males) diagnosed at Okayama University Hospital during a recent 10-year period. The age distribution had two peaks...
Ohnoshi, Taisuke, Hiraki, Shunkichi, Ueda, Nobuo, Fujii, Masafumi, Machida, Ken-ichi, Ueoka, Hiroshi, ...
Twenty-seven previously untreated patients with unresectable non-small cell lung cancer were treated with a 3-drug combination of ifosfamide, cisplatin, and vindesine as a phase II study. Patients...
Prognostic factors of small-cell lung cancer in Okayama Lung Cancer Study Group Trials. (2007)
Tamura, Makoto, Ueoka, Hiroshi, Kiura, Katsuyuki, Tabata, Masahiro, Shibayama, Takuo, Miyatake, Kazuyo, ...
In order to elucidate factors influencing the prognosis of small-cell lung cancer (SCLC), we reviewed the records of 253 patients with SCLC and evaluated 20 pretreatment prognostic factors by...
Suzaki, Noriyuki, Hiraki, Akio, Takigawa, Nagio, Ueoka, Hiroshi, Tanimoto, Yasushi, Kozuki, Toshiyuki, ...
A 71-year-old Japanese man with adenocarcinoma of the lung developed interstitial pneumonia after treatment with paclitaxel. The patient had acute chills and fever on the fourth day after the second...
Takata, Ichiro, Ueoka, Hiroshi, Kiura, Katsuyuki, Tabata, Masahiro, Takigawa, Nagio, Katayama, Hideki, ...
A pilot study was conducted to assess the efficacy and feasibility of daily low-dose cisplatin with concurrent thoracic irradiation for clinically unresectable non-small-cell lung cancer (NSCLC)....
Comparison of chemosensitivity tests: clonogenic assay versus MTT assay. (2006)
Kawada, Kazuhiko, Yonei, Toshiro, Ueoka, Hiroshi, Kiura, Katsuyuki, Tabata, Masahiro, Takigawa, Nagio, ...
When the development of chemotherapeutic agents reaches the clinical trial stage, it is necessary to perform drug sensitivity tests quickly in order to select the most promising agents for the...
Hiraki, Akio, Murakami, Tomoyuki, Aoe, Keisuke, Matsuda, Eisuke, Maeda, Tadashi, Umemori, Yoshiki, ...
We describe here a patient with a recurrent hemangiopericytoma of the superior mediastinum 23 years after an initial complete resection. In the current biopsy specimen, the tumor cells were much more...
Kitajima, Takuji, Nishii, Kenji, Ueoka, Hiroshi, Shibayama, Takuo, Gemba, Kenichi, Kodani, Tsuyoshi, ...
To evaluate recent improvements in lung cancer screening, we compared the results of recently conducted lung cancer screening with those of a previous screening. This study compared the survival of...
Establishment of a Drug Sensitivity Panel Using Human Lung Cancer Cell Lines (2006)
Matsushita, Akio, Tabata, Masahiro, Ueoka, Hiroshi, Kiura, Katsuyuki, Shibayama, Takuo, Aoe, Keisuke, ...
We established a drug sensitivity panel consisting of 24 human lung cancer cell lines. Using this panel, we evaluated 26 anti-cancer agents: three alkylators, three platinum compounds, four...
Uchida, Akiko, Tabata, Masahiro, Kiura, Katsuyuki, Tanimoto, Yasushi, Kanehiro, Arihiko, Aoe, Motoi, ...
We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a...
Uchida, Akiko, Tabata, Masahiro, Kiura, Katsuyuki, Tanimoto, Yasushi, Kanehiro, Arihiko, Aoe, Motoi, ...
We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a...
Uchida, Akiko, Tabata, Masahiro, Kiura, Katsuyuki, Tanimoto, Yasushi, Kanehiro, Arihiko, Aoe, Motoi, ...
We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a...
(-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice (2000)
Mimoto, Junko, Kiura, Katsuyuki, Matsuo, Keisuke, Yoshino, Tadashi, Takata, Ichiro, Ueoka, Hiroshi, ...
Risks of secondary lung cancer in patients with non-small cell lung cancer and small cell lung cancer are estimated to be 1–2% and 2–10% per patient per year, respectively. Cisplatin is widely...
Maeda, Tadashi, Ueoka, Hiroshi, Tabata, Masahiro, Kiura, Katsuyuki, Shibayama, Takuo, Gemba, Kenichi, ...
Background: Non-small cell lung cancer (NSCLC) is resistant to chemotherapy and prognosis of advanced NSCLC patients is considered to be dependent on various prognostic factors. Methods: We analyzed...
KATSUHIRO, INOUE, UEOKA, HIROSHI, FUJIMOTO, SHUICHI, INAGAKI, JIRO, HORIKOSHI, NOBORU, TAKANO, YASUO, ...
An evaluation of the effectiveness of ifosfamide against a xenograft of a mammary breast carcinoma and clinical evaluation in patients with advanced malignant tumors refractory to previous chemo- and...