Hiroshi Watanabe

Dynamical Study of Polydisperse Hard-Sphere System (2009)

Nogawa, Tomoaki, Ito, Nobuyasu, Watanabe, Hiroshi

We study the phase diagram and the phase transitions of a polydisperse hard-sphere system by nonequilibrium molecular dynamics simulations. It is clarified that the width of the coexistence phase...

Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia (2009)

川口, 辰哉, 濱田, 哲暢, 南部, 健, 山川, 裕司, 渡邊, 博志, 堀川, 健太郎, ...

The standard dose of imatinib for the treatment of chronic-phase chronic myeloid leukemia (CML) is 400 mg/day. Some patients receive reduced doses of imatinib because of serious adverse effects....

Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca2+ entry via non-selective cation channels (2009)

Asai, Masayoshi, Takeuchi, Kazuhiko, Saotome, Masao, Urushida, Tsuyoshi, Katoh, Hideki, Satoh, Hiroshi, ...

Aims Hypoxia, ischaemia, and exogenous chemicals can induce extracellular and intracellular acidosis, but it is not clear which of these types of acidosis affects endothelial cell function. The...

Mapping functions and critical behavior of percolation on rectangular domains (2008)

Watanabe, Hiroshi, Hu, Chin-Kun

The existence probability $E_p$ and the percolation probability $P$ of the bond percolation on rectangular domains with different aspect ratios $R$ are studied via the mapping functions between...

Fermi-Surface Reconstruction in the Periodic Anderson Model (2008)

Watanabe, Hiroshi, Ogata, Masao

We study ground state properties of periodic Anderson model in a two-dimensional square lattice with variational Monte Carlo method. It is shown that there are two different types of quantum phase...

Multiphysics simulation of left ventricular filling dynamics uding fluid-structure interaction finite element method (2008)

Hiroshi Watanabe, Seiryo Sugiura, Hidenobu Kafuku, Toshiaki Hisada

ABSTRACT To relate the subcellular molecular events to organ level physiology in heart, we have developed a threedimensional finite-element-based simulation program incorporating the cellular...

Efficiency of Rejection-Free Methods for Dynamic Monte Carlo Studies of Off-lattice Interacting Particles (2008)

Guerra, Marta L., Novotny, M. A., Watanabe, Hiroshi, Ito, Nobuyasu

We calculate the efficiency of a rejection-free dynamic Monte Carlo method for $d$-dimensional off-lattice homogeneous particles interacting through a repulsive power-law potential $r^{-p}$....

Markovian Approximation for the Nos\'e--Hoover method and H-theorem (2008)

Watanabe, Hiroshi

A Langevin equation with state-dependent random force is considered. When the Helmholtz free energy is a nonincreasing function of time (the H-theorem), a generalized Einstein relation is obtained. A...

Non-equilibrium Relaxation Analysis on Two-dimensional Melting (2008)

Watanabe, Hiroshi

The melting transition in the hard-disk system is considered. Non-equilibrium relaxation analysis of the six-fold bond-orientational order parameter has been carried out. The critical point between...

Shear small-angle light scattering studies of shear-induced concentration fluctuations and steady state viscoelastic properties (2008)

Endoh, Maya K., Takenaka, Mikihito, Inoue, Tadashi, Watanabe, Hiroshi, Hashimoto, Takeji

We aimed at elucidating the influence of shear-induced structures (shear-enhanced concentration fluctuations and/or shear-induced phase separation), as observed by rheo-optical methods with...

Statics, linear, and nonlinear dynamics of entangled polystyrene melts simulated through the primitive chain network model (2008)

Yaoita, Takatoshi, Isaki, Takeharu, Masubuchi, Yuichi, Watanabe, Hiroshi, Ianniruberto, Giovanni, Greco, Francesco, ...

Simulation results of the primitive chain network (PCN) model for entangled polymers are compared here to existing data of diffusion coefficient, linear and nonlinear shear and elongational rheology...

A Coalgebraic Representation of Reduction by Cone of Influence (2008)

Hiroshi Watanabe, Koki Nishizawa, Osamu Takaki

The Cone of Influence Reduction is a fundamental abstraction technique for reducing the size of models used in symbolic model checking. We develop coalgebraic representations of systems as composites...

Efficiency Analysis of Model-based Review in Actual Software Design (2008)

Hitoshi Furusawa, Hitoshi Furusawa, Hitoshi Furusawa, Eun-hye Choi, Hiroshi Watanabe

In this paper, we quantitatively analyze the efficiency of the Model-Based Review (MBR) method in an actual software design from the two points of view; one is cost and the other is reviewability....

Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries (2008)

Hirao, Akiko, Kondo, Kazunao, Takeuchi, Kazuhiko, Inui, Naoki, Umemura, Kazuo, Ohashi, Kyoichi, ...

Aims Denudation and regeneration of the vascular endothelium are important in the pathogenesis of atherosclerosis. The aim of this study is to clarify the mechanisms of functional alterations in...

SPORT: An Algorithm for Divisible Load Scheduling with Result Collection on Heterogeneous Systems (2008)

GHATPANDE, Abhay, NAKAZATO, Hidenori, BEAUMONT, Olivier, WATANABE, Hiroshi

Divisible Load Theory (DLT) is an established mathematical framework to study Divisible Load Scheduling (DLS). However, traditional DLT does not address the scheduling of results back to source...

A Design of HEMT Comparators for Ultrahigh-Speed A/D Conversion (2008)

WATANABE, Hiroshi, NAKAMURA, Shunsuke, WAHO, Takao

HEMT comparators for ultrahigh-speed A/D converters have been investigated. In particular, the transition times of the D-latch used in the comparator have been analyzed by assuming a 0.1-μm HEMT...

A Functorial Approach to Refinement (2007)

Yoshiki Kinoshita, Hiroshi Watanabe

We introduce -algebras and -algebras as a semantic domain for data renement of imperative programming languages. The functorial semantics of -calculus is given by using the adjunction between the...

Combining a Monad and a Comonad (2007)

John Power, Hiroshi Watanabe

We give a systematic treatment of distributivity for a monad and a comonad as arises in giving category theoretic accounts of operational and denotational semantics, and in giving an intensional...

A Functorial Approach to Refinement (2007)

Yoshiki Kinoshita, Hiroshi Watanabe

We introduce -algebras and -algebras as semantic domains for data refinement of imperative programming languages. The functorial semantics of -calculus is given by using the adjunction between the...

Effect of predictive sign of acceleration on heart rate variability in passive translation situation: preliminary evidence using visual and vestibular stimuli in VR environment (2007)

Watanabe, Hiroshi, Teramoto, Wataru, Umemura, Hiroyuki

Abstract Objective We studied the effects of the presentation of a visual sign that warned subjects of acceleration around the yaw and pitch axes in virtual reality (VR) on their heart rate...

Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates (2007)

Chopra, Sameer S, Watanabe, Hiroshi, Zhong, Tao P, Roden, Dan M

Abstract Background Action potential generation in excitable cells such as myocytes and neurons critically depends on voltage-gated sodium channels. In mammals, sodium channels exist as...

How do we manage the gastrectomy for gastric cancer after coronary artery bypass grafting using the right gastroepiploic artery? Report of two cases and a review of the literature (2007)

Konishi, Yukiko, Suzuki, Koichi, Wada, Hidetoshi, Watanabe, Hiroshi, Ogura, Hiroyuki, Sugamori, Yuno, ...

Abstract Background Recently, the right gastroepiploic artery (RGEA) has been used in coronary artery bypass grafting (CABG) as an alternative arterial graft. Unfortunately, an increased incidence of...

Fermi Surface Reconstruction without Breakdown of Kondo Screening at Quantum Critical Point (2007)

Watanabe, Hiroshi, Ogata, Masao

Motivated by recent Hall-effect experiment in YbRh$_2$Si$_2$, we study ground state properties of a Kondo lattice model in a two-dimensional square lattice using variational Monte Carlo method. We...

Ergodicity of a thermostat family of the Nosé-Hoover type (2007)

Watanabe, Hiroshi, Kobayashi, Hiroto

One-variable thermostats are studied as a generalization of the Nosé-Hoover method, which is aimed at achieving Gibbs’ canonical distribution while conserving the time reversibility. A condition...

Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma (2007)

Asakage, Takahiro, Yokoyama, Akira, Haneda, Tatsumasa, Yamazaki, Mitsuo, Muto, Manabu, Yokoyama, Tetsuji, ...

The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol. The...

Desmoplastic Melanoma Arising in The Ankle (2007)

Hatori, Masahito, Watanabe, Mika, Watanabe, Hiroshi, Hosaka, Masami, Kokubun, Shoichi

Desmoplastic melanoma (DM) is an uncommon but potentially devastating malignancy that can be cured with early recognition and surgery. DM often occurs in elderly men and develops on sun-exposed areas...

Ergodicity of Thermostat Family of Nos\'e--Hoover type (2006)

Watanabe, Hiroshi, Kobayashi, Hiroto

One-variable thermostats are studied as a generalization of the Nos\'e--Hoover method which is aimed to achieve Gibbs' canonical distribution with conserving the time-reversibility. A condition for...

Positional order and diffusion processes in particle systems (2006)

Watanabe, Hiroshi, Yukawa, Satoshi, Ito, Nobuyasu

The relaxation of a nonequilibrium solid to a fluid is determined by observing the positional order parameter in Monte Carlo simulations, and discussed based on diffusion processes in the...

Efficiency of rejection-free dynamic Monte Carlo methods for homogeneous spin models, hard disk systems, and hard sphere systems (2006)

Watanabe, Hiroshi, Yukawa, Satoshi, Novotny, M. A., Ito, Nobuyasu

We construct asymptotic arguments for the relative efficiency of rejection-free Monte Carlo (MC) methods compared to the standard MC method. We find that the efficiency is proportional to...

Ergodicity of the Nos\'e-Hoover method (2006)

Watanabe, Hiroshi, Kobayashi, Hiroto

Ergodicity of the systems with Nos\'e-Hoover thermostat are studied. The dynamics of the heatbath variables are investigated and they can be periodic when the system has quick oscillation. The...

Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL (2006)

Oota, Sayako, Shibuya, Hitoshi, Yoshimura, Ryo-ichi, Watanabe, Hiroshi, Miura, Masahiko

Abstract Background There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a...

Positional Order and Diffusion Processes in Particle Systems (2006)

Watanabe, Hiroshi, Yukawa, Satoshi, Ito, Nobuyasu

Nonequilibrium behaviors of positional order are discussed based on diffusion processes in particle systems. With the cumulant expansion method up to the second order, we obtain a relation between...

Novel Charge Order and Superconductivity in Two-Dimensional Frustrated Lattice at Quarter Filling (2006)

Watanabe, Hiroshi, Ogata, Masao

Motivated by the various physical properties observed in $\theta$-(BEDT-TTF)$_2$X, we study the ground state of extended Hubbard model on two-dimensional anisotropic triangular lattice at 1/4-filling...

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and drinking, smoking, and diet in Japanese men with oral and pharyngeal squamous cell carcinoma (2006)

Asakage, Takahiro, Yokoyama, Akira, Haneda, Tatsumasa, Yamazaki, Mitsuo, Muto, Manabu, Yokoyama, Tetsuji, ...

The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol. The...

Endoplasmic reticulum Ca2+ depletion induces endothelial cell apoptosis independently of caspase-12 (2006)

Nakano, Tomoyasu, Watanabe, Hiroshi, Ozeki, Mariko, Asai, Masayoshi, Katoh, Hideki, Satoh, Hiroshi, ...

Objective: Apoptosis of endothelial cells is considered an initial step in the development of atherosclerosis. Recent studies have indicated that depletion of the endoplasmic reticulum (ER) Ca2+...

Watanabe and Hu Reply (2005)

Watanabe, Hiroshi, Hu, Chin-Kun

The article is an reply to comments on the paper [H. Watanabe, S. Yukawa, N. Ito, and C.-K. Hu, Phys. Rev. Lett. vol. 93, 19601 (2004)] by G. Pruessner and N. R. Moloney published in [Phys. Rev....

Charge order and superconductivity in a two-dimensional triangular lattice at n=2/3 (2005)

Watanabe, Hiroshi, Ogata, Masao

To investigate the possibility of charge order and superconductivity in a doped two-dimensional triangular lattice, we study the extended Hubbard model with variational Monte Carlo method. At n=2/3,...

Irradiation of Mammalian Cultured Cells with a Collimated Heavy-Ion Microbeam (2005)

Tomoo Funayama, Seiichi Wada, Yasuhiko Kobayashi, Hiroshi Watanabe

Funayama, T., Wada, S., Kobayashi, Y. and Watanabe, H. Irradiation of Mammalian Cultured Cells with a Collimated Heavy-Ion Microbeam. Radiat. Res. 163, 241–246 (2005). As the first step for the...

Size-dispersity effects in two-dimensional melting (2005)

Watanabe, Hiroshi, Yukawa, Satoshi, Ito, Nobuyasu

In order to investigate the effect of size dispersity on two-dimensional melting transitions, hard-disk systems with equimolar bidispersity are studied by means of particle dynamics simulations. From...

Analysis of mutations induced by carbon ions in Arabidopsis thaliana (2005)

Shikazono, Naoya, Suzuki, Chihiro, Kitamura, Satoshi, Watanabe, Hiroshi, Tano, Shigemitsu, Tanaka, Atsushi

To investigate the nature of mutations induced by accelerated ions in higher plants, the effects of carbon-ion-irradiation were compared with those of electron-irradiation in Arabidopsis thaliana....

Analysis of mutations induced by carbon ions in Arabidopsis thaliana (2005)

Shikazono, Naoya, Suzuki, Chihiro, Kitamura, Satoshi, Watanabe, Hiroshi, Tano, Shigemitsu, Tanaka, Atsushi

To investigate the nature of mutations induced by accelerated ions in higher plants, the effects of carbon-ion-irradiation were compared with those of electron-irradiation in Arabidopsis thaliana....

Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis (2005)

Yoshida, Tsuyoshi, Hanawa, Haruo, Toba, Ken, Watanabe, Hiroshi, Watanabe, Ritsuo, Yoshida, Kaori, ...

Background: In a heart with myocarditis, there are cardiomyocytes, inflammatory cells, and non-inflammatory interstitial cells. Immunological molecules are thought to influence not only inflammatory...

Analysis of mutations induced by carbon ions in Arabidopsis thaliana (2005)

Shikazono, Naoya, Suzuki, Chihiro, Kitamura, Satoshi, Watanabe, Hiroshi, Tano, Shigemitsu, Tanaka, Atsushi

To investigate the nature of mutations induced by accelerated ions in higher plants, the effects of carbon-ion-irradiation were compared with those of electron-irradiation in Arabidopsis thaliana....

Evaluation of the Resistance of Euglena gracilis to Ion Beam Radiation (2004)

HIROTAKA HAYASHI, SEIICHI WADA, TOMOO FUNAYAMA, ISSAY NARUMI, YASUHIKO KOBAYASHI, HIROSHI WATANABE, ...

The resistance of Euglena (E.) gracilis to ionizing radiation was investigated using seven kinds of ion beams each with different energy characteristics. The minimum effective dose of the most lethal...

Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression (2004)

Takeuchi, Kazuhiko, Watanabe, Hiroshi, Tran, Quang-Kim, Ozeki, Mariko, Sumi, Daigo, Hayashi, Toshio, ...

Objective: Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase exerts many harmful effects such as stimulation of inflammation and induction of apoptosis. The effects of...

Triviality of hierarchical O(N) spin model in four dimensions with large N (2003)

Watanabe, Hiroshi

The renormalization group transformation for the hierarchical O(N) spin model in four dimensions is studied by means of characteristic functions of single-site measures, and convergence of the...

A study on Vector Representation of Binary Images Containing Halftone Dots (2003)

Kei Kawamura, Hiroshi Watanabe, Hideyoshi Tominaga

Vector representation of graphics has an advantage of being displayed at any size. When resolution of a bitmap image is changed, lack of a line segment arises. In addition, moire occurs when...

Well-behaved translations between structural operational semantics (2002)

Hiroshi Watanabe

We examine two versions of maps between distributive laws as candidates for wellbehaved translations between structural operational semantics, and validate that by using simple coalgebraic arguments....

Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma (2002)

Yokoyama, Akira, Kato, Hoichi, Yokoyama, Tetsuji, Tsujinaka, Toshimasa, Muto, Manabu, Omori, Tai, ...

The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-2 (ADH2), ADH3, and glutathione S-transferase M1 (GSTM1) influence the metabolism of alcohol and other...

Positional effect of cell inactivation on root gravitropism using heavy-ion microbeams (2002)

Tanaka, Atsushi, Kobayashi, Yasuhiko, Hase, Yoshihiro, Watanabe, Hiroshi

When primary root apical tissues of Arabidopsis thaliana were irradiated by heavy‐ion microbeams with 120 μm diameter, strong inhibition of root elongation and curvature were observed at...

Characterization of RecA424 and RecA670 Proteins from Deinococcus radiodurans (2002)

Satoh, Katsuya, Narumi, Issay, Kikuchi, Masahiro, Kitayama, Shigeru, Yanagisawa, Tadashi, Yamamoto, Kazuo, ...

RecA protein is considered to be the most important participant in the radiation resistance of Deinococcus radiodurans. However, it is still unclear how RecA contributes to the resistance. In this...

Viscoelasticity and Morphology of Soft Polycarbonate as a Substitute for Poly(vinyl chloride) (FUNDAMENTAL MATERIAL PROPERTIES-Molecular Rheology) (2001)

Inoue, Tadashi, Watanabe, Hiroshi, Osaki, Kunihiro

The soft polycarbonate resins, SPC, were newly developed as a substitute for soft poly(vinyl chloride). The soft polycarbonates are multiblock copolymers composed of bisphenol A polycarbonate, PC,...

Phase II Evaluation of Protracted Infusion of Cisplatin and 5-Fluorouracil in Advanced Squamous Cell Carcinoma of the Esophagus: a Japan Esophageal Oncology Group (JEOG) Trial (JCOG9407) (2001)

Hayashi, Kazuhiko, Ando, Nobutoshi, Watanabe, Hiroshi, Ide, Hiroko, Nagai, Kagami, Aoyama, Norio, ...

Background: Surgery for advanced esophageal carcinoma has its limits as regards aggressiveness and therapeutic effect, therefore effective multimodality treatment is required to obtain better...

Biological Response to Ionizing Radiation in Mouse Embryo Fibroblasts with a Targeted Disruption of the DNA Polymerase β Gene (2000)

Masahiko Miura, Hiroshi Watanabe, Kiyoshi Okochi, Takehito Sasaki, Hitoshi Shibuya

Miura, M., Watanabe, H., Okochi, K., Sasaki, T. and Shibuya, H. Biological Response to Ionizing Radiation in Mouse Embryo Fibroblasts with a Targeted Disruption of the DNA Polymerase β Gene. Base...

Nonlinear Rheology and Flow-Induced Structure in a Concentrated Spherical Silica Suspension (FUNDAMENTAL MATERIAL PROPERTIES-Molecular Rheology) (2000)

Watanabe, Hiroshi, Inoue, Tadashi, Osaki, Kunihiro

In hard-sphere suspensions of solid particles, the stress has the Brownian (thermodynamic) and hydrodynamic components σB and σH, the former reflecting the anisotropy of the particle distribution...

Distributivity for Endofunctors, Pointed and Co-Pointed Endofunctors, Monads and Comonads (2000)

Marina Lenisa, John Power, Hiroshi Watanabe

We generalise the notion of a distributive law between a monad and a comonad to consider weakened structures such as pointed or co-pointed endofunctors, or endofunctors. We investigate...

Distributivity for Endofunctors, Pointed and Co-Pointed Endofunctors, Monads and Comonads (2000)

Marina Lenisa, John Power, Hiroshi Watanabe

We generalise the notion of a distributive law between a monad and a comonad to consider weakened structures such as pointed or co-pointed endofunctors, or endofunctors. We investigate...

Calcium signalling in endothelial cells (2000)

Tran, Quang-Kim, Ohashi, Kyoichi, Watanabe, Hiroshi

Vascular endothelial cells are ubiquitous for their presence in each and every vessel and unique for their multifunctional nature. A large number of endothelial functions depend to various extents on...

Rheo-Dielectric Behavior of Oligostyrene and Polyisoprene (FUNDAMENTAL MATERIAL PROPERTIES-Molecular Rheology) (1999)

Watanabe, Hiroshi, Inoue, Tadashi, Osaki, Kunihiro

Flow effects were examined for dielectric behavior of oligostyrene (OS; M = 950) and cis-polyisoprene (PI; M = 8200). OS-1 has monomeric dipoles perpendicular to its backbone and the terminal...

Nonlinear Viscoelasticity of Amorphous Polymers in the Vicinity of the Glass Transition Temperature (FUNDAMENTAL MATERIAL PROPERTIES-Molecular Rheology) (1998)

Inoue, Tadashi, Watanabe, Hiroshi, Osaki, Kunihiro

Nonlinear viscoelasticity of atactic polystyrene around the glass transition was studied by means of constant rate elongation. The strain-induced birefringence and the stress were simultaneously...

An Axiomatics for Categories of Coalgebras (1998)

John Power, Hiroshi Watanabe

We give an axiomatic account of what structure on a category C and an endofunctor H on C yield similar structure on the category H0Coalg of H-coalgebras. We give conditions under which completeness,...

The Subobject Classifier of the Category of Functional Bisimulations (1998)

Hiroshi Watanabe

We show the existence of subobject classifier in the category of nondeterministic dynamical systems and functional bisimulations. Keywords: nondeterministic dynamical system, functional bisimulation,...

A Criterion for the Existence of Subobject Classifiers (1998)

Hiroshi Watanabe

We give a criterion for the existence of subobject classifiers of cocomplete categories with a small, dense subcategory. (key word: subobject classifier, cocomplete, dense, topos, AMS...

Mathematical Derivation of Chiral Anomaly in Lattice Gauge Theory with Wilson's Action (1997)

Hattori, Tetsuya, Watanabe, Hiroshi

Chiral U(1) anomaly is derived with mathematical rigor for a Euclidean fermion coupled to a smooth external U(1) gauge field on an even dimensional torus as a continuum limit of lattice regularized...

Molecular Rheology of Glassy Polymers (FUNDAMENTAL MATERIAL PROPERTIES-Molecular Rheology) (1997)

Inoue, Tadashi, Matsui, Hiroto, Watanabe, Hiroshi, Osaki, Kunihiro

Molecular origin of the viscoelasticity around the glass transition zone is investigated by means of dynamic birefringence and dynamic viscoelasticity measurements. The present study show that the...

Restoration of isotropy on fractals (1995)

Barlow, Martin T., Hattori, Kumiko, Hattori, Tetsuya, Watanabe, Hiroshi

We report a new type of restoration of macroscopic isotropy (homogenization) in fractals with microscopic anisotropy. The phenomenon is observed in various physical setups, including diffusions,...

Con A Receptive Sites on the Surface of Photoreceptor Outer Segments of Lampetra japonica: TEM Quantification by Thin-Sectioning and Freeze-Etching (1993)

Ishikawa, Makoto, Watanabe, Hiroshi, Tonosaki, Akira

Lamprey photoreceptor outer segments were labeled with ferritin-Con A by pre-embedding labeling. Based on the ferritin particles associated with the membrane on the TEM of thin sections, Con A...

Gap Junction of Stratum Granulosum Cells of Mouse Follicles: Immunohistochemistry and Electron Microscopy (1993)

Koike, Kazutomo, Watanabe, Hiroshi, Hiroi, Masahiko, Tonosaki, Akira

The gap junction (GJ) of stratum granulosum cells was investigated in growing and mature follicles of the mouse by means of light- and electron-microscopic immunohistochemistry, freeze-fracturing and...

Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-{alpha} (1993)

Takeda, Yuji, Watanabe, Hiroshi, Yonehara, Shin, Yamashita, Takao, Salto, Susumu, Sendo, Fujiro, ...

We demonstrate here that human necrosis factor-α, a potent neutrophil activator, induces rapid (within 3 h) apoptosis of these cells, i.e. neutrophils treated with this cytokine exhibit (I) light...

Primary Malignant Melanoma of the Esophagus: Report of Four Cases (1991)

Kato, Hoichi, Watanabe, Hidejirou, Tachimori, Yuji, Watanabe, Hiroshi, Iizuka, Toshifumi, Yamaguchi, Hajime, ...

We report four cases of malignant melanoma of the esophagus treated at the National Cancer Center Hospital in Tokyo over a period of 28 years. There were three men and one woman. One patient had been...

Carcinosarcoma of the Esophagus: a Twenty-case Study (1990)

Iyomasa, Shinsuke, Kato, Hoichi, Tachimori, Yuji, Watanabe, Hiroshi, Yamaguchi, Hajime, Itabashi, Masayuki

The present report reviews results from 20 carcinosarcoma patients, and compares them with 773 cases of squamous cell carcinoma of the esophagus treated surgically at the National Cancer Center...

Left Pneumonectomy Associated with Subtotal Esophagectomy for Carcinoma of the Esophagus Invading the Left Main Bronchus (1989)

Tachimori, Yuji, Watanabe, Hiroshi, Kato, Hoichi

A case of squamous cell carcinoma of the mid-thoracic esophagus invading the left main bronchus, and synchronous gastric cancer was successfully treated with subtotal esophagectomy, left...

A new type of the manifestation of colony specificity in the compound ascidian, Botrylloides violaceus (1988)

Euichi Hirose, Yasunori Saito, Hiroshi Watanabe

Abstract. A new type ofcobony specificity ( = albogeneic recognition) is shown for Botryioides violaceus. All bo tryllid ascidians previously studied for colony specificity show albo-recognition...

Mediastinal Malignant Lymphoma Complicated with Esophagobronchial Fistula: Successfully Treated Case (1987)

Tachimori, Yuji, Kato, Hoichi, Watanabe, Hiroshi, Lizuka, Toshifumi, Minato, Keisuke, Yamaguchi, Hajime, ...

A 64-year-old man presented with medlastinal and bilateral hilar adenopatl and a biopsy of a scalene node revealed non-Hodgkin's lymphoma. One week after a cycle of combination chemotherapy, he...

Primary Esophageal Reconstruction After Resection of the Cancer in the Hypopharynx or Cervical Esophagus: Comparision of Free Forearm Skin Tube Flap, Free Jejunal Transplantation and Pull-through Esophagectomy (1987)

Kato, Hoichi, Watanabe, Hiroshi, Iizuka, Toshihumi, Ebihara, Satoshi, Ono, Isamu, Terui, Shoji, ...

Sixty-six patients with carcinoma of the hypopharynx or cervical esophagus received esophageal extraction and primary reconstruction. The methods of reconstruction were free forearm skin tube...

One-Hundred-and-Two 5-Year Survivors of Esophageal Carcinoma after Resective Surgery (1985)

LIZUKA, TOSHIFUMI, KATO, HOICHE, WATANABE, HIROSHI

Among 492 patients with esophageal carcinoma who received resective surgery, 102 survived over 5 years. These 5-year survivors were analyzed according to many factors. Females had a better prognosis...

Reconstruction of the Esophagus by Microvascular Surgery (1984)

KATO, HOICHI, IIZUKA, TOSHIFUMI, WATANABE, HIROSHI, TERUI, SHOJI, ONO, ISAMU, EBIHARA, SATOSHI, ...

After esophagectomy, free jejunal autografts were used for reconstruction in 11 patients and pedunculated colons in two patients. A microvascular technique was applied immediately after the...

Superficial Carcinoma of the Esophagus Coexisting with Esophageal Leiomyoma: A Case Report and Review of the Japanese Literature (1984)

IIZUKA, TOSHIFUMI, KATO, HOICHI, WATANABE, HIROSHI, ITABASHI, MASAYUKI, HIROTA, TERUYUKI

A case of superficial spreading squamous cell carcinoma located just over a leiomyoma is presented. The patient complained of slight dysphagia and an esophagogram showed an elevated tumor in the...

Pull-Through Esophagectomy Without Thoracotomy (1983)

KATO, HOICHI, IIZUKA, TOSHIFUMI, WATANABE, HIROSHI, HIRATA, KATSUJI, ONO, ISAMU, EBIHARA, SATOSHI, ...

Twenty patients with carcinoma of the hypopharynx, esophagus and thyroid underwent pull-through esophagectomy. Seventeen of them received combined resection of the larynx and trachea. Dissection of...

Self or Non--self Recognition in Compound Ascidians (1982)

WATANABE, HIROSHI, TANEDA, YASUHO

SYNOPSIS. Certain species of compound ascidians have an ability to distinguish self colonies from non—self colonies within the same species. This ability, called colony specificity, is manifested...

Purification and Properties of a Copper-Containing Nitrite Reductase from a Denitrifying Bacterium, Alcaligenes faecalis Strain S-6 (1981)

KAKUTANI, Tetsu, WATANABE, Hiroshi, ARIMA, Kei, BEPPU, Teruhiko

A copper-containing nitrite reductase was purified and crystallized from a potent denitrifying bacterium, Alcaligenes faecalis strain S-6. The enzyme was composed of 4 subunits with a molecular...

A Blue Protein as an Inactivating Factor for Nitrite Reductase from Alcaligenes faecalis Strain S-6 (1981)

KAKUTANI, Tetsu, WATANABE, Hiroshi, ARIMA, Kei, BEPPU, Teruhiko

A blue protein with a molecular weight of 12,000 containing 1 atom of type I Cu2+ was purified and crystallized from a denitrifying bacterium, Alcaligenes faecalis strain S-6, as an inactivating...

Double Adenocarcinoma in Barrett's Esophagus: A Case Report (1981)

KATO, HOICHI, IIZUKA, TOSHIFUMI, WATANABE, HIROSHI, HIRATA, KATSUJI, HIRASHIMA, TOSHIO, MATSUE, HIROTO, ...

At the National Cancer Center Hospital in Tokyo, a patient with Barrett's esophagus developed double adenocarcinoma of the esophagus. One carcinoma was located in the midesophagus and the other just...

A Case of Esophageal Carcinoma and Collision Tumor of the Stomach (1981)

SAITO, TAKAO, IIZUKA, TOSHIFUMI, HIRATA, KATSUJI, WATANABE, HIROSHI, KATO, HOICHI

A case of double primary cancer of the esophagus and stomach with metastasis of the esophageal cancer to the stomach is reported. The entire stomach and the lower part of the esophagus were...

A Case of Concomitant Association of Early Esophageal Carcinoma, Early Gastric Carcinoma and Malignant Lymphoma of the Stomach (1980)

IIZUKA, TOSHIFUMI, WATANABE, HIROSHI, HIRATA, KATSUJI, KATO, HOICHI, MATSUSHIMA, SHINJI, HIROTA, TERUYUKI, ...

A case of concomitant association of early esophageal carcinoma, cancer of the early gastric carcinoma and malignant lymphoma of the stomach was reported. The intrathoracic esophagus was resected...

Primary Adenocarcinoma of the Esophagus Report of Six Cases (1980)

KATO, HOICHI, IIZUKA, TOSHIFUMI, WATANABE, HIROSHI, HIRATA, KATSUJI, SAITO, TAKAO, HIRASHIMA, TOSHIO, ...

Six primary adenocarcinomas were found among 1,346 cases of esophageal carcinoma, an incidence of 0.45%. Three of the adenocarcinomas were the “type ordinaire” of Lortat-Jacob, two were...

Factors Controlling Five-Year Survival in Patients with Esophageal Carcinoma (1979)

IIZUKA, TOSHIFUMI, HIRATA, KATSUJI, WATANABE, HIROSHI, SEMBA, TAKESHI

Sixty-two out of 310 patients with esophageal carcinoma, who had undergone resective surgery at the National Cancer Center Hospital, Tokyo, survived more than five years. These cases were studied by...

Six Cases of So-Called Carcinosarcoma of the Esophagus -- Histological and Ultrastructural Study on its Histogenesis -- (1979)

ITABASHI, MASAYUKI, HIROTA, TERUYUKI, YAMAMOTO, MITSUE, OHNUKI, TAKASHI, IIZUKA, TOSHIFIMI, HIRATA, KATSUJI, ...

Histopathological aspects of six cases of so-called carcinosarcoma of the esophagus are reported. Four of the patients had polypoid tumors and the other two had ulcerated lesions. Histologically,...

Six Cases of Carcinosarcoma of the Esophagus (1977)

IIZUKA, TOSHIFUMI, HIRATA, KATSUJI, WATANABE, HIROSHI, INUKAI, HIDENORI, HIROTA, TERUYUKI, ITABASHI, MASAYUKI

Clinical aspects of six cases of esophageal carcinosarcoma were reported. They were all male in their sixties. Although almost all cases of carcinosarcoma of the esophagus reported in the literatures...

IDENTIFICATION OF IMMUNOGLOBULINS IN CHICKEN EGGS AND THEIR ANTIBODY ACTIVITY (1975)

YAMAMOTO, Hiroshi, WATANABE, Hiroshi, SATO, Gihei, MIKAMI, Takeshi

The presence of immunoglobulins and a secretory component (SC) in the hen's egg and oviduct washings was investigated. In addition, the existence of transferred antibodies in the yolk and white of...

CHICKEN IMMUNOGLOBULINS IN SERUM AND ASCITIC FLUID (1973)

WATANABE, Hiroshi, ISAYAMA, Yasuro

Three subclasses of chicken IgG were found, each of them contained in chicken serum and ascitic fluid. IgG1 was the main subclass of serum IgG, but only a very small quantity of IgG1 was present in...

INFECTION TO COLOSTRUM-DEPRIVED BABY PIGS WITH A PORCINE ENTEROVIRUS (Kr 69TC STRAIN) ISOLATED FROM THE LUNG (1971)

WATANABE, Hiroshi, POSPISIL, Zdenek, MENSIK, Jarmir

The pathogen-free, colostrum-deprived pigs infected intranasally with a lung-isolated enterovirus showed pneumonitis in the early stage of infection and viremia was recognized 2 days after infection...

STUDY ON THE PIGS INFECTED WITH VIRULENT TESCHEN DISEASE VIRUS (KNM STRAIN) WITH SPECIAL REFERENCE TO IMMUNOFLUORESCENCE (1971)

WATANABE, Hiroshi, POSPISIL, Zdenek, MENSIK, Jarmir

Conventional pigs of 4-week-old were infected with KNM strain of virulent Teschen disease virus by intracerebral (IC), intranasal (IN) and contact (CT) routes. The pigs of the IC group showed a very...

FLUORESCENT ANTIBODY TECHNIQUE IN CULTURED CELLS INFECTED WITH PORCINE ENTEROVIRUSES (1971)

WATANABE, Hiroshi

The indirect method of the fluorescent antibody (FA) technique was applied to observe primary porcine kidney cultured cells infected with porcine enterovirusess (V 76 and Kr 69 TC strains). Halo-like...

Removal of the Outer Membrane from Brain Mitochondria (1971)

WATANABE, Hiroshi

1. The outer membrane of pig brain mitochondria was removed by treatment with digitonin at a concentration of 2.0 mg/10 mg protein. 2. The denuded mitochondria showed loss of monoamine oxidase...

A Liquid Helium Cooled Stage for Electron Microscope and Its Application (1968)

WATANABE, Hiroshi, ISHIKAWA, Isao

Two types of liquid helium cooled stage have been developed, one is for use in HU-11 electron microscope and another in the 1MeV electron microscope. In the former model, liquid helium circulates...

Analysis and Performance of Triode Biased Electron Gun (1966)

MUNAKATA, Chusuke, WATANABE, Hiroshi

A circuit of a triode biased tri-electrode electron gun was analysed using the triode equation, and an equation for emission current was proposed. The validity of the present equation was checked...

g- value of Fe3+ in II-VI cubic crystals (1964)

Watanabe, Hiroshi

A theory of g-shift is developed of Fe3+ in II-VI cubic crystals. Electron-transfer through spin-orbit interaction to Fe3+ from the surrounding ligands is shown to be a reasonable mechanism for the...

A Self-Oscillating Electron Gun (1964)

MUNAKATA, Chusuke, WATANABE, Hiroshi

A blocking oscillator is constructed with a tri-electrode electron gun to get pulse beam. The period of the pulse beam obtained is from the order of msec, to sec. . The pulse width is from a few to a...

A New Bias Method of an Electron Gun (1962)

MUNAKATA, Chusuke, WATANABE, Hiroshi

It is well known that the “self-bias” system in an ordinary tri-electrode electron gun forms a negative feed back loop for the beam current of the gun, and stabilizes the current. The better...

Energy Analysis of Electrons Scattered by Solids (1960)

WATANABE, Hiroshi

The detail of the designing of the electron velocity analyser of Möllenstedt type is described. The analyser consists of three stage electron lens system with a condenser lens and of the analyser...

Velocity Analyzer and Electron Microscope (1956)

WATANABE, Hiroshi

Experimental results on the energy analysis of electrons passing through various materials are given, and using the results some considerations are given about the image formation in an electron...

有限要素法プログラミング演習(fortran, C のソースコードつき)(開発版)

渡辺, 浩志, ワタナベ, ヒロシ, Watanabe, Hiroshi

非線形有限要素法解析コードをゼロから作成できることを目指した自習書。PDFファイルサイズ867KB。

Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

Dong, Erbo, Matsumoto, Kinzo, Uzunova, Veska, Sugaya, Ikuko, Takahata, Hiroki, Nomura, Hiroaki, ...

Allopregnanolone (ALLO), is a brain endogenous neurosteroid that binds with high affinity to γ-aminobutyric acid type A (GABAA) receptors and positively modulates the action of GABA at these...

Molecular Analysis of Methicillin-Resistant Staphylococcus aureus as a Causative Agent of Bronchopulmonary Infection: Relation to Colonization in the Upper Respiratory Tract

Watanabe, Hiroshi, Masaki, Hironori, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, Kobayashi, Shinobu, ...

Using five diagnostic markers, we compared the types of 72 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated simultaneously from the nasal cavity, pharynx, and sputum from 24...

Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

Watanabe, Hiroshi, Masaki, Hironori, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, Kobayashi, Shinobu, ...

We describe a patient with methicillin-resistant Staphylococcus aureus (MRSA) colonizing the pharynx. The MIC of mupirocin was 0.25 μg/ml before treatment and increased after treatment to 8 μg/ml....

The LexA Protein from Deinococcus radiodurans Is Not Involved in RecA Induction following γ Irradiation

Narumi, Issay, Satoh, Katsuya, Kikuchi, Masahiro, Funayama, Tomoo, Yanagisawa, Tadashi, Kobayashi, Yasuhiko, ...

The involvement of LexA in induction of RecA was investigated in Deinococcus radiodurans. As in the wild-type strain, an increase in RecA protein synthesis following γ irradiation was detected in a...

High Rate of Transmission of Penicillin-Resistant Streptococcus pneumoniae between Parents and Children

Hoshino, Kazuhiko, Watanabe, Hiroshi, Sugita, Rinya, Asoh, Norichika, Ntabaguzi, Simon Angelo, Watanabe, Kiwao, ...

Transmission of Streptococcus pneumoniae between children and their parents was evaluated in 29 pairs from 25 families. The serotypes of 35 pneumococcal isolates from 18 (62.1%) of 29 child-parent...

An Ultraviolet-B-Resistant Mutant with Enhanced DNA Repair in Arabidopsis

Tanaka, Atsushi, Sakamoto, Ayako, Ishigaki, Yasuhito, Nikaido, Osamu, Sun, Guakin, Hase, Yoshihiro, ...

An ultraviolet-B (UV-B)-resistant mutant, uvi1 (UV-B insensitive 1), of Arabidopsis was isolated from 1,280 M1 seeds that had been exposed to ion beam irradiation. The fresh weight of uvi1 under...

Emergence of Rifampin-Resistant Rhodococcus equi with Several Types of Mutations in the rpoB Gene among AIDS Patients in Northern Thailand

Asoh, Norichika, Watanabe, Hiroshi, Fines-Guyon, Marguerite, Watanabe, Kiwao, Oishi, Kazunori, Kositsakulchai, Weerayut, ...

The antimicrobial susceptibilities of 30 Rhodococcus equi isolates obtained from 30 patients between 1993 and 2001 in northern Thailand were investigated. The MICs showed a tendency toward resistance...

Antimicrobial Susceptibility and Serotype Distribution of Streptococcus pneumoniae and Molecular Characterization of Multidrug-Resistant Serotype 19F, 6B, and 23F Pneumococci in Northern Thailand

Watanabe, Hiroshi, Asoh, Norichika, Hoshino, Kazuhiko, Watanabe, Kiwao, Oishi, Kazunori, Kositsakulchai, Weerayut, ...

Penicillin-resistant Streptococcus pneumoniae is widely spread worldwide. Our study was undertaken to examine the susceptibility and serotypes of S. pneumoniae in northern Thailand. Ninety-three S....

Chemical chaperone therapy for brain pathology in GM1-gangliosidosis

Matsuda, Junichiro, Suzuki, Osamu, Oshima, Akihiro, Yamamoto, Yoshie, Noguchi, Akira, Takimoto, Kazuhiro, ...

We synthesized a galactose derivative, N-octyl-4-epi-β-valienamine (NOEV), for a molecular therapy (chemical chaperone therapy) of a human neurogenetic disease, β-galactosidosis (GM1-gangliosidosis...

Possible High Rate of Transmission of Nontypeable Haemophilus influenzae, Including β-Lactamase-Negative Ampicillin-Resistant Strains, between Children and Their Parents

Watanabe, Hiroshi, Hoshino, Kazuhiko, Sugita, Rinya, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, ...

The possible transmission of nontypeable Haemophilus influenzae between children and their parents was evaluated in 18 pairs of subjects from 15 families. Of the 33 isolates, 31 were found to be...

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

Mohan, Chandra, Morel, Laurence, Yang, Ping, Watanabe, Hiroshi, Croker, Byron, Gilkeson, Gary, ...

Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has shown that B6.NZMc1 mice, congenic for Sle1, exhibit loss of tolerance to...

Role of Sialic Acid and Complex Carbohydrate Biosynthesis in Biofilm Formation by Nontypeable Haemophilus influenzae in the Chinchilla Middle Ear

Jurcisek, Joseph, Greiner, Laura, Watanabe, Hiroshi, Zaleski, Anthony, Apicella, Michael A., Bakaletz, Lauren O.

Nontypeable Haemophilus influenzae (NTHI) is an important pathogen in respiratory tract infections, including otitis media (OM). NTHI forms biofilms in vitro as well as in the chinchilla middle ear,...

Characterization of Pathways Dependent on the uvsE, uvrA1, or uvrA2 Gene Product for UV Resistance in Deinococcus radiodurans

Tanaka, Masashi, Narumi, Issay, Funayama, Tomoo, Kikuchi, Masahiro, Watanabe, Hiroshi, Matsunaga, Tsukasa, ...

The genome of a radiation-resistant bacterium, Deinococcus radiodurans, contains one uvsE gene and two uvrA genes, uvrA1 and uvrA2. Using a series of mutants lacking these genes, we determined the...

Comparative Molecular Analysis of Haemophilus influenzae Isolates from Young Children with Acute Lower Respiratory Tract Infections and Meningitis in Hanoi, Vietnam

Watanabe, Hiroshi, Kaji, Chiharu, Anh, Dang Duc, Huong, Phan Le Thanh, Anh, Nguyen Thi Hien, Huong, Vu Thi, ...

Thirty-seven Haemophilus influenzae strains from nasopharyngeal swabs (NP) and 44 H. influenzae strains from cerebrospinal fluid (CSF) were investigated. Of the 37 H. influenzae isolates from NP, the...

Multiphysics Simulation of Left Ventricular Filling Dynamics Using Fluid-Structure Interaction Finite Element Method

Watanabe, Hiroshi, Sugiura, Seiryo, Kafuku, Hidenobu, Hisada, Toshiaki

To relate the subcellular molecular events to organ level physiology in heart, we have developed a three-dimensional finite-element-based simulation program incorporating the cellular mechanisms of...

Deletion of the CaBIG1 Gene Reduces β-1,6-Glucan Synthesis, Filamentation, Adhesion, and Virulence in Candida albicans

Umeyama, Takashi, Kaneko, Aki, Watanabe, Hiroshi, Hirai, Asuka, Uehara, Yoshimasa, Niimi, Masakazu, ...

The human fungal pathogen Candida albicans is able to change its shape in response to various environmental signals. We analyzed the C. albicans BIG1 homolog, which might be involved in β-1,6-glucan...

Mutation rate and novel tt mutants of Arabidopsis thaliana induced by carbon ions.

Shikazono, Naoya, Yokota, Yukihiko, Kitamura, Satoshi, Suzuki, Chihiro, Watanabe, Hiroshi, Tano, Shigemitsu, ...

Irradiation of Arabidopsis thaliana by carbon ions was carried out to investigate the mutational effect of ion particles in higher plants. Frequencies of embryonic lethals and chlorophyll-deficient...

Elimination of atretic follicles from the mouse ovary: a TEM and immunohistochemical study in mice

INOUE, SATOKO, WATANABE, HIROSHI, SAITO, HIDEKAZU, HIROI, MASAHIKO, TONOSAKI, AKIRA

We examined numerous ovarian follicles from 32–35 d virgin mice by transmission electron microscopy and light microscopic immunohistochemistry. No macrophages were seen, but various stages of...

Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

Dong, Erbo, Matsumoto, Kinzo, Uzunova, Veska, Sugaya, Ikuko, Takahata, Hiroki, Nomura, Hiroaki, ...

Allopregnanolone (ALLO), is a brain endogenous neurosteroid that binds with high affinity to γ-aminobutyric acid type A (GABAA) receptors and positively modulates the action of GABA at these...

Molecular Analysis of Methicillin-Resistant Staphylococcus aureus as a Causative Agent of Bronchopulmonary Infection: Relation to Colonization in the Upper Respiratory Tract

Watanabe, Hiroshi, Masaki, Hironori, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, Kobayashi, Shinobu, ...

Using five diagnostic markers, we compared the types of 72 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated simultaneously from the nasal cavity, pharynx, and sputum from 24...

Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

Watanabe, Hiroshi, Masaki, Hironori, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, Kobayashi, Shinobu, ...

We describe a patient with methicillin-resistant Staphylococcus aureus (MRSA) colonizing the pharynx. The MIC of mupirocin was 0.25 μg/ml before treatment and increased after treatment to 8 μg/ml....

The LexA Protein from Deinococcus radiodurans Is Not Involved in RecA Induction following γ Irradiation

Narumi, Issay, Satoh, Katsuya, Kikuchi, Masahiro, Funayama, Tomoo, Yanagisawa, Tadashi, Kobayashi, Yasuhiko, ...

The involvement of LexA in induction of RecA was investigated in Deinococcus radiodurans. As in the wild-type strain, an increase in RecA protein synthesis following γ irradiation was detected in a...

High Rate of Transmission of Penicillin-Resistant Streptococcus pneumoniae between Parents and Children

Hoshino, Kazuhiko, Watanabe, Hiroshi, Sugita, Rinya, Asoh, Norichika, Ntabaguzi, Simon Angelo, Watanabe, Kiwao, ...

Transmission of Streptococcus pneumoniae between children and their parents was evaluated in 29 pairs from 25 families. The serotypes of 35 pneumococcal isolates from 18 (62.1%) of 29 child-parent...

An Ultraviolet-B-Resistant Mutant with Enhanced DNA Repair in Arabidopsis

Tanaka, Atsushi, Sakamoto, Ayako, Ishigaki, Yasuhito, Nikaido, Osamu, Sun, Guakin, Hase, Yoshihiro, ...

An ultraviolet-B (UV-B)-resistant mutant, uvi1 (UV-B insensitive 1), of Arabidopsis was isolated from 1,280 M1 seeds that had been exposed to ion beam irradiation. The fresh weight of uvi1 under...

Emergence of Rifampin-Resistant Rhodococcus equi with Several Types of Mutations in the rpoB Gene among AIDS Patients in Northern Thailand

Asoh, Norichika, Watanabe, Hiroshi, Fines-Guyon, Marguerite, Watanabe, Kiwao, Oishi, Kazunori, Kositsakulchai, Weerayut, ...

The antimicrobial susceptibilities of 30 Rhodococcus equi isolates obtained from 30 patients between 1993 and 2001 in northern Thailand were investigated. The MICs showed a tendency toward resistance...

Antimicrobial Susceptibility and Serotype Distribution of Streptococcus pneumoniae and Molecular Characterization of Multidrug-Resistant Serotype 19F, 6B, and 23F Pneumococci in Northern Thailand

Watanabe, Hiroshi, Asoh, Norichika, Hoshino, Kazuhiko, Watanabe, Kiwao, Oishi, Kazunori, Kositsakulchai, Weerayut, ...

Penicillin-resistant Streptococcus pneumoniae is widely spread worldwide. Our study was undertaken to examine the susceptibility and serotypes of S. pneumoniae in northern Thailand. Ninety-three S....

Chemical chaperone therapy for brain pathology in GM1-gangliosidosis

Matsuda, Junichiro, Suzuki, Osamu, Oshima, Akihiro, Yamamoto, Yoshie, Noguchi, Akira, Takimoto, Kazuhiro, ...

We synthesized a galactose derivative, N-octyl-4-epi-β-valienamine (NOEV), for a molecular therapy (chemical chaperone therapy) of a human neurogenetic disease, β-galactosidosis (GM1-gangliosidosis...

Possible High Rate of Transmission of Nontypeable Haemophilus influenzae, Including β-Lactamase-Negative Ampicillin-Resistant Strains, between Children and Their Parents

Watanabe, Hiroshi, Hoshino, Kazuhiko, Sugita, Rinya, Asoh, Norichika, Watanabe, Kiwao, Oishi, Kazunori, ...

The possible transmission of nontypeable Haemophilus influenzae between children and their parents was evaluated in 18 pairs of subjects from 15 families. Of the 33 isolates, 31 were found to be...

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

Mohan, Chandra, Morel, Laurence, Yang, Ping, Watanabe, Hiroshi, Croker, Byron, Gilkeson, Gary, ...

Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has shown that B6.NZMc1 mice, congenic for Sle1, exhibit loss of tolerance to...

Role of Sialic Acid and Complex Carbohydrate Biosynthesis in Biofilm Formation by Nontypeable Haemophilus influenzae in the Chinchilla Middle Ear

Jurcisek, Joseph, Greiner, Laura, Watanabe, Hiroshi, Zaleski, Anthony, Apicella, Michael A., Bakaletz, Lauren O.

Nontypeable Haemophilus influenzae (NTHI) is an important pathogen in respiratory tract infections, including otitis media (OM). NTHI forms biofilms in vitro as well as in the chinchilla middle ear,...

Characterization of Pathways Dependent on the uvsE, uvrA1, or uvrA2 Gene Product for UV Resistance in Deinococcus radiodurans

Tanaka, Masashi, Narumi, Issay, Funayama, Tomoo, Kikuchi, Masahiro, Watanabe, Hiroshi, Matsunaga, Tsukasa, ...

The genome of a radiation-resistant bacterium, Deinococcus radiodurans, contains one uvsE gene and two uvrA genes, uvrA1 and uvrA2. Using a series of mutants lacking these genes, we determined the...

Comparative Molecular Analysis of Haemophilus influenzae Isolates from Young Children with Acute Lower Respiratory Tract Infections and Meningitis in Hanoi, Vietnam

Watanabe, Hiroshi, Kaji, Chiharu, Anh, Dang Duc, Huong, Phan Le Thanh, Anh, Nguyen Thi Hien, Huong, Vu Thi, ...

Thirty-seven Haemophilus influenzae strains from nasopharyngeal swabs (NP) and 44 H. influenzae strains from cerebrospinal fluid (CSF) were investigated. Of the 37 H. influenzae isolates from NP, the...

Multiphysics Simulation of Left Ventricular Filling Dynamics Using Fluid-Structure Interaction Finite Element Method

Watanabe, Hiroshi, Sugiura, Seiryo, Kafuku, Hidenobu, Hisada, Toshiaki

To relate the subcellular molecular events to organ level physiology in heart, we have developed a three-dimensional finite-element-based simulation program incorporating the cellular mechanisms of...

Deletion of the CaBIG1 Gene Reduces β-1,6-Glucan Synthesis, Filamentation, Adhesion, and Virulence in Candida albicans

Umeyama, Takashi, Kaneko, Aki, Watanabe, Hiroshi, Hirai, Asuka, Uehara, Yoshimasa, Niimi, Masakazu, ...

The human fungal pathogen Candida albicans is able to change its shape in response to various environmental signals. We analyzed the C. albicans BIG1 homolog, which might be involved in β-1,6-glucan...

Mutation rate and novel tt mutants of Arabidopsis thaliana induced by carbon ions.

Shikazono, Naoya, Yokota, Yukihiko, Kitamura, Satoshi, Suzuki, Chihiro, Watanabe, Hiroshi, Tano, Shigemitsu, ...

Irradiation of Arabidopsis thaliana by carbon ions was carried out to investigate the mutational effect of ion particles in higher plants. Frequencies of embryonic lethals and chlorophyll-deficient...

Elimination of atretic follicles from the mouse ovary: a TEM and immunohistochemical study in mice

INOUE, SATOKO, WATANABE, HIROSHI, SAITO, HIDEKAZU, HIROI, MASAHIKO, TONOSAKI, AKIRA

We examined numerous ovarian follicles from 32–35 d virgin mice by transmission electron microscopy and light microscopic immunohistochemistry. No macrophages were seen, but various stages of...

有限要素法プログラミング演習(fortran, C のソースコードつき)(開発版)

渡辺, 浩志, ワタナベ, ヒロシ, Watanabe, Hiroshi

非線形有限要素法解析コードをゼロから作成できることを目指した自習書。PDFファイルサイズ867KB。

Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery

Fukao, Mitsuhiro, Hattori, Yuichi, Sato, Atsushi, Liu, Ming-Yue, Watanabe, Hiroshi, Kim, Tran Quang, ...

In isolated rat mesenteric artery with endothelium, NaF caused slowly developing hyperpolarization. The hyperpolarizing effect was unchanged in the presence of NG-nitro-L-arginine (L-NOARG) and...

Antimicrobial Susceptibility and Genetic Characteristics of Streptococcus pneumoniae Isolates Indicating Possible Nosocomial Transmission Routes in a Community Hospital in Japan▿

Qin, Liang, Masaki, Hironori, Watanabe, Kiwao, Furumoto, Akitsugu, Watanabe, Hiroshi

A clinical study was designed to study Streptococcus pneumoniae isolates recovered from a community hospital in Japan from April 2001 to November 2002. A total of 73 isolates were defined as derived...

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α

Sasaki, Junko, Sasaki, Takehiko, Yamazaki, Masakazu, Matsuoka, Kunie, Taya, Choji, Shitara, Hiroshi, ...

The membrane phospholipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2] is a critical signal transducer in eukaryotic cells. However, the physiological roles of the type I phosphatidylinositol...

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

Watanabe, Hiroshi, Koopmann, Tamara T., Le Scouarnec, Solena, Yang, Tao, Ingram, Christiana R., Schott, Jean-Jacques, ...

Brugada syndrome is a genetic disease associated with sudden cardiac death that is characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-function...

Distributivity for a Monad and a Comonad

John Power, Hiroshi Watanabe

We give a systematic treatment of distributivity for a monad and a comonad as arises in incorporating category theoretic accounts of operational and denotational semantics, and in giving an...

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Urano, Yasuomi, Watanabe, Hiroshi, Murphy, Stephanie R., Shibuya, Yohei, Geng, Yong, Peden, Andrew A., ...

Mammalian cells acquire cholesterol mainly from LDL. LDL enter the endosomes, allowing cholesteryl esters to be hydrolyzed by acid lipase. The hydrolyzed cholesterol (LDL-CHOL) enters the...

Wnt/β-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra

Philipp, Isabelle, Aufschnaiter, Roland, Özbek, Suat, Pontasch, Stefanie, Jenewein, Marcell, Watanabe, Hiroshi, ...

In and evaginations of 2D cell sheets are major shape generating processes in animal development. They result from directed movement and intercalation of polarized cells associated with cell shape...

Maintenance time of sedative effects after an intravenous infusion of diazepam: A guide for endoscopy using diazepam

Sugimoto, Mitsushige, Furuta, Takahisa, Nakamura, Akiko, Shirai, Naohito, Ikuma, Mutsuhiro, Misaka, Shingen, ...

AIM: To examine whether the sedative effects assessed by psychomotor tests would depend on the cytochrome P450 (CYP) 2C19 genotypes after an infusion regimen of diazepam commonly used for...