Scientific Commons: Hirotaka Iwase

No Association Between CYP2D6*10 Genotype and Survival of Node-negative Japanese Breast Cancer Patients Receiving Adjuvant Tamoxifen Treatment (2009)

Toyama, Tatsuya, Yamashita, Hiroko, Sugiura, Hiroshi, Kondo, Naoto, Iwase, Hirotaka, Fujii, Yoshitaka

Objective The CYP2D6 enzyme plays a major role in converting tamoxifen to its active metabolites. We investigated whether there is an association between the CYP2D6*10 allele and clinical outcome in...

Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers (2008)

Toyama, Tatsuya, Yamashita, Hiroko, Kondo, Naoto, Okuda, Katsuhiro, Takahashi, Satoru, Sasaki, Hidefumi, ...

Abstract Background Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these...

Identification of biomarkers in ductal carcinoma in situof the breast with microinvasion (2008)

Okumura, Yasuhiro, Yamamoto, Yutaka, Zhang, Zhenhuan, Toyama, Tatsuya, Kawasoe, Teru, Ibusuki, Mutsuko, ...

Abstract Background Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS). DCIS of the breast...

Loss of heterozygosity at the ATBF1-Alocus located in the 16q22 minimal region in breast cancer (2008)

Kai, Kazuharu, Zhang, Zhenhuan, Yamashita, Hiroko, Yamamoto, Yutaka, Miura, Yutaka, Iwase, Hirotaka

Abstract Background Loss of heterozygosity (LOH) on the long arm of chromosome 16 is one of the most frequent genetic events in solid tumors. Recently, the AT-motif binding factor 1 ( ATBF1 )- A...

Prognostic Significance of Insulin-like Growth Factor Binding Protein (IGFBP)-4 and IGFBP-5 Expression in Breast Cancer (2007)

Mita, Keiko, Zhang, Zhenhuan, Ando, Yoshiaki, Toyama, Tatsuya, Hamaguchi, Maho, Kobayashi, Shunzo, ...

Background Expression of estrogen-regulated genes has been considered as potential predictive markers for endocrine therapy. We focused on two insulin-like growth factor binding proteins (IGFBPs):...

Association of TP53codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients (2007)

Toyama, Tatsuya, Zhang, Zhenhuan, Nishio, Mariko, Hamaguchi, Maho, Kondo, Naoto, Iwase, Hirotaka, ...

Abstract Introduction Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 (also known as p53 ) gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been...

Expression of Estrogen Receptor Wild-type and its Variant ER cx/ 2 is Correlated with Better Prognosis in Breast Cancer (2007)

Sugiura, Hiroshi, Toyama, Tatsuya, Hara, Yasuo, Zhang, Zhenhuan, Kobayashi, Shunzo, Fujii, Yoshitaka, ...

Background The clinical value of estrogen receptor (ER) β and its variants has been investigated. However, reported results have frequently been discordant. Methods We investigated mRNA and protein...

p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer (2006)

Yamashita, Hiroko, Toyama, Tatsuya, Nishio, Mariko, Ando, Yoshiaki, Hamaguchi, Maho, Zhang, Zhenhuan, ...

Abstract Introduction Endocrine therapy is the most important treatment option for women with hormone receptor-positive breast cancer. The potential mechanisms for endocrine resistance involve...

Low Expression of the Snail Gene is a Good Prognostic Factor in Node-Negative Invasive Ductal Carcinomas (2006)

Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...

Background: While Snail is a zinc-finger transcription factor that triggers the epithelial-mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...

Low Expression of the Snail Gene is a Good Prognostic Factor in Node-Negative Invasive Ductal Carcinomas (2006)

Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...

Background: While Snail is a zinc-finger transcription factor that triggers the epithelial- mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...

Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer (2005)

Yamashita, Hiroko, Nishio, Mariko, Kobayashi, Shunzo, Ando, Yoshiaki, Sugiura, Hiroshi, Zhang, Zhenhuan, ...

Abstract Introduction Endocrine therapy is the most important treatment option for women with hormone-receptor-positive breast cancer. The potential mechanisms for endocrine resistance involve...

Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer (2003)

Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...

Abstract Introduction Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although...

Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast (2003)

Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...

Abstract Background Estrogen is a mitogenic factor that is implicated in the genesis and progression of breast cancer via its binding to estrogen receptor (ER)-α. Synthesis of estrogen in situ is...

Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast

Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...

Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...

Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer

Yamashita, Hiroko, Nishio, Mariko, Kobayashi, Shunzo, Ando, Yoshiaki, Sugiura, Hiroshi, Zhang, Zhenhuan, ...

Quantitative determination, by real-time reverse transcription polymerase chain reaction, of aromatase mRNA in invasive ductal carcinoma of the breast

Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...

Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...

Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer

Yamashita, Hiroko, Nishio, Mariko, Kobayashi, Shunzo, Ando, Yoshiaki, Sugiura, Hiroshi, Zhang, Zhenhuan, ...