Hiroyuki Nakagawa

Comparison in bone turnover markers during early healing of femoral neck fracture and trochanteric fracture in elderly patients (2009)

Shota Ikegami, Mikio Kamimura, Hiroyuki Nakagawa, Kenji Takahara, Hiroyuki Hashidate, Shigeharu Uchiyama, ...

Healing of fractures is different for each bone and bone turnover markers may reflect the fracture healing process. The purpose of this study was to determine the characteristic changes in bone...

Analysis of Multi-Agent Systems based on KAOS Modeling (2008)

Hiroyuki Nakagawa

Agent technology offers a solution for producing complex software systems characterized by autonomous behavior, a high degree of distribution, and mobility support. Particularly, a considerable...

Cerebral Sinus and Venous Thrombosis Associated with von Willebrand Factor, Independently of Factor VIII (2008)

Mari Terashima, Hiroshi Kataoka, Hirosei Horikawa, Hiroyuki Nakagawa, Toshiaki Taoka, Masanori Matsumoto, ...

Background and purpose: Previous studies have linked procoagulant factor VIII (F VIII) to an increased risk of venous thrombosis, whereas the relation between plasma von Willebrand factor (VWF) and...

Aggregation of Partially Unfolded Myosin Subfragment-1 into Spherical Oligomers with Amyloid-Like Dye-Binding Properties (2006)

Komatsu, Hideyuki, Shinotani, Nami, Kimori, Yoshitaka, Tokuoka, Jun-ichiro, Kaseda, Kuniyoshi, Nakagawa, Hiroyuki, ...

Proteolytic myosin subfragment 1 (S1) is known to be partially unfolded in its 50-kDa subdomain by mild heat treatment at 35°C [Burke et al. (1987) Biochemistry 26, 1492–1496]. Here, we report...

Flexible Foraging of Ants under Unsteadily Varying Environment (2004)

Tao, Tomomi, Nakagawa, Hiroyuki, Yamasaki, Masato, Nishimori, Hiraku

Using a simple model for the trail formation of ants, the relation between i)the schedule of feeding which represents the unsteady natural environment, ii)emerging patterns of trails connecting a...

Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines (2001)

Nakagawa, Hiroyuki, Tsuta, Koji, Kiuchi, Katsuji, Senzaki, Hideto, Tanaka, Kanji, Hioki, Koshiro, ...

Diallyl disulfide (DADS) is an oil-soluble organosulfur compound found in garlic. The effect of synthetic DADS on the growth of estrogen receptor (ER)-positive (KPL-1 and MCF-7) and -negative...

Nitric Oxide Underlies the Differentiation of PC 12 Cells Induced by Depolarization with High KCl (2000)

Nakagawa, Hiroyuki, Yoshida, Masaru, Miyamoto, Shigeaki

Nitric oxide (NO) acts as a cytostatic agent to induce neuronal differentiation of PC12 cells after nerve growth factor (NGF) treatment. We newly subcloned PC12K cells that extended neurites after...

A 260-kDa Filamin/ABP-Related Protein in Chicken Gizzard Smooth Muscle Cells Is a New Component of the Dense Plaques and Dense Bodies of Smooth Muscle (1997)

Tachikawa, Masaji, Nakagawa, Hiroyuki, Terasaki, Asako G., Mori, Hajime, Ohashi, Kazuyo

A 260-kDa protein, termed cgABP260, which localized in the dense plaques and dense bodies of smooth muscle cells, was found in a low-salt alkaline extract of chicken gizzard smooth muscle. An...

Cytochrome c Electronic Structure Characterization toward the Analysis of Electron Transfer Mechanism (1994)

Nakagawa, Hiroyuki, Koyama, Yasushi, Okada, Takashi

Seventy-four kinds of cytochrome c sequences have been compared in order to determine the conserved residues and residues of which the characters are conserved. Twenty-three residues are invariant...

A 36-kDa Protein of the Dense Bodies of Smooth Muscle Cells (1994)

Ohashi, Kazuyo, Nishimura, Mari, Terasaki, Asako Goi, Nakagawa, Hiroyuki

We purified a 36-kDa protein from a low-salt, alkaline extract of chicken gizzard smooth muscle by sequential column chromatography using DEAE-Cellurofine A-800 m, hydrox-ylapatite, and...

33-kDa Peptides Prepared from Chicken Gizzard Smooth Muscle Bundle Both Actin and Desmin Filaments In Vitro (1993)

Nakagawa, Hiroyuki, Ishihara, Mitsuaki, Ohashi, Kazuyo

A group of 33-kDa peptides was prepared from chicken gizzard. Gizzard smooth muscle was extracted with Hasselbach-Schneider's high ionic strength solution. The extract was fractionated by ammonium...

Cyclo(l-Leucyl-l-Prolyl) Produced by Achromobacter xylosoxidans Inhibits Aflatoxin Production by Aspergillus parasiticus

Yan, Pei-Sheng, Song, Yuan, Sakuno, Emi, Nakajima, Hiromitsu, Nakagawa, Hiroyuki, Yabe, Kimiko

Aflatoxins are potent carcinogenic and toxic substances that are produced primarily by Aspergillus flavus and Aspergillus parasiticus. We found that a bacterium remarkably inhibited production of...

The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein

Takenaka, Kei, Nakagawa, Hiroyuki, Miyamoto, Shigeaki, Miki, Hiroaki

SF3a (splicing factor 3a) complex is an essential component of U2 snRNPs (small nuclear ribonucleoprotein particles), which are involved in pre-mRNA splicing. This complex consists of three subunits:...

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...

Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...

Cyclo(l-Leucyl-l-Prolyl) Produced by Achromobacter xylosoxidans Inhibits Aflatoxin Production by Aspergillus parasiticus

Yan, Pei-Sheng, Song, Yuan, Sakuno, Emi, Nakajima, Hiromitsu, Nakagawa, Hiroyuki, Yabe, Kimiko

Aflatoxins are potent carcinogenic and toxic substances that are produced primarily by Aspergillus flavus and Aspergillus parasiticus. We found that a bacterium remarkably inhibited production of...

The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein

Takenaka, Kei, Nakagawa, Hiroyuki, Miyamoto, Shigeaki, Miki, Hiroaki

SF3a (splicing factor 3a) complex is an essential component of U2 snRNPs (small nuclear ribonucleoprotein particles), which are involved in pre-mRNA splicing. This complex consists of three subunits:...

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...

Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...

Contribution of the LIM Domain and Nebulin-Repeats to the Interaction of Lasp-2 with Actin Filaments and Focal Adhesions

Nakagawa, Hiroyuki, Suzuki, Hiroshi, Machida, Satoshi, Suzuki, Junko, Ohashi, Kazuyo, Jin, Mingyue, ...

Lasp-2 binds to actin filaments and concentrates in the actin bundles of filopodia and lamellipodia in neural cells and focal adhesions in fibroblastic cells. Lasp-2 has three structural regions: a...