Okada, Hiroyuki, Zhang, Xianfeng, Ben Fofana, Ismael, Nagai, Mika, Suzuki, Hajime, Ohashi, Takashi, ...
Abstract Background In vivo studies of HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to...
Okada, Hiroyuki, Zhang, Xianfeng, Ben Fofana, Ismael, Nagai, Mika, Suzuki, Hajime, Ohashi, Takashi, ...
Background: In vivo studies of HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1...
Kiyoshi Ayada, Kenji Yokota, Yoshiro Kawahara, Yumiko Yamamoto, Kazuyuki Hirai, Tomoki Inaba, ...
Helicobacter pylori (H. pylori) infection is a definite causative factor for gastric ulcers (GUs). In the present study we detected a specific antigen of gastric epithelial cells (HGC-27) using cell...
Kiyoshi Ayada, Kenji Yokota, Yoshiro Kawahara, Yumiko Yamamoto, Kazuyuki Hirai, Tomoki Inaba, ...
Helicobacter pylori (H. pylori) infection is a definite causative factor for gastric ulcers (GUs). In the present study we detected a specific antigen of gastric epithelial cells (HGC-27) using cell...
Ohashi, Takashi, Nagai, Mika, Okada, Hiroyuki, Takayanagi, Ryo, Shida, Hisatoshi
Abstract Background Human T cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in infected individuals after a long incubation period. Immunological studies have suggested that...
B. Babu Madhavan, Kikuo Tachibana, Tadashi Sasagawa, Hiroyuki Okada, Yasuke Shimozuma
Due to high object density and high proportion of shadow-covered areas, it is usually quite difficult to extract information in urban high-resolution airborne images from Leica Geosystems '...
The role of object labels and familiarity in Japanese children’s verb learning (2008)
Mutsumi Imai, Etsuko Haryu, Hiroyuki Okada
In order to learn a new word, children first need to determine what form class the word belongs to, and find an appropriate referent in the situation in which the word is introduced. They then must...
Ishikawa, Shigenao, Inaba, Tomoki, Mizuno, Motowo, Okada, Hiroyuki, Kuwaki, Kenji, Kuzume, Toshiaki, ...
Upper gastrointestinal bleeding is a major adverse event of non-steroidal anti-inflammatory drugs (NSAIDs), and co-administration of proton pump inhibitors and H2 receptor antagonists has been...
Hiroyuki Okada, Atsushi Tajima, Kazuyoshi Shichiri, Atsushi Tanaka, Kenichi Tanaka, Ituro Inoue
Infertility affects about one in six couples attempting pregnancy, with the man responsible in approximately half of the cases. Because the pathophysiology underlying azoospermia is not elucidated,...
Mifune, Hirofumi, Akaki, Shiro, Ida, Kentaro, Sei, Tetsuro, Kanazawa, Susumu, Okada, Hiroyuki
To evaluate the ability of multidetector-row CT (MDCT) to predict a risk of hemorrhage in patients with esophageal varices, a total of 40 MDCT scans were performed in 29 patients who had been...
Kawabata, Mihoko, Hirao, Kenzo, Higuchi, Kouji, Sasaki, Takeshi, Furukawa, Toshiyuki, Okada, Hiroyuki, ...
Aims The purpose of this retrospective study was to assess characteristics of patients who had suffered atrial flutter (AFL) with 1:1 atrioventricular (AV) conduction (1:1 AFL). Methods and results...
Matsushima, Ayami, Kakuta, Yoshimitsu, Teramoto, Takamasa, Koshiba, Takumi, Liu, Xiaohui, Okada, Hiroyuki, ...
Many lines of evidence reveal that bisphenol A (BPA) functions at very low doses as an endocrine disruptor. The human estrogen-related receptor γ (ERRγ) behaves as a constitutive activator of...
Ikeda, Nobumasa, Mizuno, Motowo, Okada, Hiroyuki, Tomoda, Jun, Tsuji, Takao
To identify diffuse mucosal changes which may precede the development of colorectal cancer and a possible indicator for detecting high-risk populations, we immunohistochemically studied cell-cycle...
Mikami, Yuichirou, Mizuno, Motowo, Maga, Toshirou, Kihara, Yasuhiro, Yoshinaga, Fumiya, Tanaka, Shouichi, ...
UDP-galactosyltransferase (UDP-Gal-T) is a key enzyme in the synthesis of mucus glycoprotein which plays an important role in gastric mucosal defensive mechanisms. Analysis of gastric UDP-Gal-T...
Okada, Hiroyuki, Mizuno, Motowo, Yamamoto, Kazuhide, Tsuji, Takao
To characterize primary sclerosing cholangitis (PSC) in Japanese patients and its association with inflammatory bowel disease (IBD), 155 reported cases of PSC, including 6 cases of our own, were...
Ariyoshi, Masanori, MIzuno, Motowo, Morisue, Yoshiko, Shimada, Morizou, Fujita, Shirou, Nasu, Junichirou, ...
We developed a monoclonal antibody (MoAb) (clone 5E8) against an antigen on the bile canalicular membrane of rat hepatocyte. By immunoblotting, MoAb 5E8 detected a band of 110 kD. In this study, we...
Ohya, Shogen, Mizuno, Motowo, Kawada, Mikihiro, Nasu, Junichirou, Okada, Hiroyuki, Shimomura, Hiroyuki, ...
We have previously developed an enzyme-linked immunosorbent assay (ELISA) to measure stool decay-accelerating factor (DAF) and found that stool DAF concentrations were significantly elevated in...
Hirai, Michio, Mizuno, Motowo, Morisue, Yoshiko, Yoshioka, Masao, Shimada, Morizou, Nasu, Junichirou, ...
Anti-idiotype antibodies (Ab2) play an important role in the homeostasis of immune responses and are related to the development and the disease activity of certain autoimmune diseases. The...
Yoshioka, Masao, Mizuno, Motowo, Morisue, Yoshiko, Shimada, Morizou, Hirai, Michio, Nasu, Junichirou, ...
In autoimmune chronic active hepatitis (AIH) and primary biliary cirrhosis (PBC), various autoantibodies including anti-asialoglycoprotein receptor (ASGPR) antibodies have been found in patients'...
ISHIBASHI, Koichiro, FUJIMOTO, Tetsuya, YAMASHITA, Takahiro, OKADA, Hiroyuki, ARIMA, Yukio, HASHIMOTO, Yasuyuki, ...
Circuit techniques for realizing low-voltage and low-power SoCs for 90-nm CMOS technology and beyond are described. A proposed SAFBB (self-adjusted forward body bias techniques), ATC (Asymmetric...
Two dimensional evaluation reinforcement learning (2001)
Hiroyuki Okada, Hiroshi Yamakawa, Takashi Omori
Abstract. To solve the problem of tradeo between exploration and exploitation actions in reinforcement learning, the authors have proposed two-dimensional evaluation reinforcement learning, which...
Ouchi, Yasuomi, Kanno, Toshihiko, Okada, Hiroyuki, Yoshikawa, Etsuji, Futatsubashi, Masami, Nobezawa, Shuji, ...
The basal ganglia play a role in controlling movement during gait. The aim of the present study was to investigate changes in dopamine transporter (DAT) availability in the striatum and extrastriatal...
KONNO, Akihiro, SUKEGAWA, Akihiro, KUSANO, Michio, KARIYA, Kazuhiro, ISHIDA, Takuo, OKADA, Hiroyuki
We evaluated the expression of parathyroid hormone-related protein (PTHrP) by immunohistochemistry in eight benign and malignant mammary mixed tumors of dogs with (n=4) and without (n=4)...
Brain activation during maintenance of standing postures in humans (1999)
Ouchi, Yasuomi, Okada, Hiroyuki, Yoshikawa, Etsuji, Nobezawa, Shuji, Futatsubashi, Masami
The regulatory mechanism of bipedal standing in humans remains to be elucidated. We investigated neural substrates for maintaining standing postures in humans using PET with our mobile gantry PET...
Secretion of parathyroid hormone-related protein by bovine mammary cells in vitro (1994)
Okada, Hiroyuki, Rosol, Thomas J., Capen, Charles C., McCauley, Laurie K., Weckmann, Michelle T., Schanbacher, Floyd L.
Mammary cells were isolated from lactating cows at 1 to 6 weeks after calving and evaluated for their ability to secrete PTHrP in vitro. The tissue was enzymatically digested to release glandular...
Yunoki, Naoko, Yokota, Kenji, Mizuno, Motowo, Kawahara, Yoshiro, Adachi, Masayasu, Okada, Hiroyuki, ...
Infection with Helicobacter pylori induces humoral immune responses against various antigens of the bacterium. Heat shock proteins (hsps) are immunodominant antigens in various diseases including H....
Yunoki, Naoko, Yokota, Kenji, Mizuno, Motowo, Kawahara, Yoshiro, Adachi, Masayasu, Okada, Hiroyuki, ...
Infection with Helicobacter pylori induces humoral immune responses against various antigens of the bacterium. Heat shock proteins (hsps) are immunodominant antigens in various diseases including H....
Iwamaru, Yoshifumi, Takenouchi, Takato, Ogihara, Kazumasa, Hoshino, Megumi, Takata, Masuhiro, Imamura, Morikazu, ...
Several lines of evidence suggest that microglia have important roles in the pathogenesis of prion diseases. Here, we establish a novel microglial cell line (MG20) from neonatal tga20 mice that...
Okada, Hiroyuki, Tokunaga, Takatoshi, Liu, Xiaohui, Takayanagi, Sayaka, Matsushima, Ayami, Shimohigashi, Yasuyuki
Okada, Hiroyuki, Tajima, Atsushi, Shichiri, Kazuyoshi, Tanaka, Atsushi, Tanaka, Kenichi, Inoue, Ituro
Infertility affects about one in six couples attempting pregnancy, with the man responsible in approximately half of the cases. Because the pathophysiology underlying azoospermia is not elucidated,...
Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages
Okada, Hiroyuki, Zhang, Xianfeng, Ben Fofana, Ismael, Nagai, Mika, Suzuki, Hajime, Ohashi, Takashi, ...
Masujin, Kentaro, Shu, Yujing, Yamakawa, Yoshio, Hagiwara, Ken'ichi, Sata, Tetsutaro, Matsuura, Yuichi, ...
A case of L-type-like atypical bovine spongiform encephalopathy was detected in 14-year-old Japanese black beef cattle (BSE/JP24). To clarify the biological and biochemical properties of the prion in...
Ayada, Kiyoshi, Yokota, Kenji, Kawahara, Yoshiro, Yamamoto, Yumiko, Hirai, Kazuyuki, Inaba, Tomoki, ...
Helicobacter pylori (H. pylori) infection is a definite causative factor for gastric ulcers (GUs). In the present study we detected a specific antigen of gastric epithelial cells (HGC-27) using cell...
Isolation of two distinct prion strains from a scrapie-affected sheep
Masujin, Kentaro, Shu, Yujing, Okada, Hiroyuki, Matsuura, Yuichi, Iwamaru, Yoshifumi, Imamura, Morikazu, ...
We performed a transmission study using mice to clarify the characteristics of the most recent case of scrapie in Japan. The mice that were inoculated with the brain homogenate from a...