Hiroyuki Shimada

ABCC6 Mutation in Patients with Angioid Streaks (2006)

Yoshihiro Mizutani, Tomohiro Nakayama, Satoshi Asai, Hiroyuki Shimada, Mitsuko Yuzawa

Angioid streaks (AS) are hereditary eye conditions caused by breaks in the elastic layer of Bruch's membrane. Patients with AS are also frequently affected with pseudoxanthoma elasticum (PXE). The...

Outer Membrane Protein A-Promoted Actin Condensation of Brain Microvascular Endothelial Cells Is Required for Escherichia coli Invasion

Prasadarao, Nemani V., Wass, Carol A., Stins, Monique F., Shimada, Hiroyuki, Kim, Kwang Sik

Escherichia coli is the most common gram-negative bacterium that causes meningitis during the neonatal period. We have previously shown that the entry of circulating E. coli organisms into the...

Citrobacter koseri Brain Abscess in the Neonatal Rat: Survival and Replication within Human and Rat Macrophages

Townsend, Stacy M., Pollack, Harvey A., Gonzalez-Gomez, Ignacio, Shimada, Hiroyuki, Badger, Julie L.

A unique feature of Citrobacter koseri is the extremely high propensity to initiate brain abscesses during neonatal meningitis. Previous clinical reports and studies on infant rats have documented...

Entry and Intracellular Replication of Escherichia coli K1 in Macrophages Require Expression of Outer Membrane Protein A

Sukumaran, Sunil K., Shimada, Hiroyuki, Prasadarao, Nemani V.

Interactions between Escherichia coli K1, which causes meningitis in neonates, and macrophages have not been explored well. In this study we found that E. coli K1 was able to enter, survive, and...

TraJ-Dependent Escherichia coli K1 Interactions with Professional Phagocytes Are Important for Early Systemic Dissemination of Infection in the Neonatal Rat

Hill, Val T., Townsend, Stacy M., Arias, Robyn S., Jenabi, Jasmine M., Gomez-Gonzalez, Ignacio, Shimada, Hiroyuki, ...

Escherichia coli is a major cause of neonatal bacterial sepsis and meningitis. We recently identified a gene, traJ, which contributes to the ability of E. coli K1 to penetrate the blood-brain barrier...

Outer Membrane Protein A-Promoted Actin Condensation of Brain Microvascular Endothelial Cells Is Required for Escherichia coli Invasion

Prasadarao, Nemani V., Wass, Carol A., Stins, Monique F., Shimada, Hiroyuki, Kim, Kwang Sik

Escherichia coli is the most common gram-negative bacterium that causes meningitis during the neonatal period. We have previously shown that the entry of circulating E. coli organisms into the...

Citrobacter koseri Brain Abscess in the Neonatal Rat: Survival and Replication within Human and Rat Macrophages

Townsend, Stacy M., Pollack, Harvey A., Gonzalez-Gomez, Ignacio, Shimada, Hiroyuki, Badger, Julie L.

A unique feature of Citrobacter koseri is the extremely high propensity to initiate brain abscesses during neonatal meningitis. Previous clinical reports and studies on infant rats have documented...

Entry and Intracellular Replication of Escherichia coli K1 in Macrophages Require Expression of Outer Membrane Protein A

Sukumaran, Sunil K., Shimada, Hiroyuki, Prasadarao, Nemani V.

Interactions between Escherichia coli K1, which causes meningitis in neonates, and macrophages have not been explored well. In this study we found that E. coli K1 was able to enter, survive, and...

TraJ-Dependent Escherichia coli K1 Interactions with Professional Phagocytes Are Important for Early Systemic Dissemination of Infection in the Neonatal Rat

Hill, Val T., Townsend, Stacy M., Arias, Robyn S., Jenabi, Jasmine M., Gomez-Gonzalez, Ignacio, Shimada, Hiroyuki, ...

Escherichia coli is a major cause of neonatal bacterial sepsis and meningitis. We recently identified a gene, traJ, which contributes to the ability of E. coli K1 to penetrate the blood-brain barrier...

Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways

Erdreich-Epstein, Anat, Tran, Linda B., Cox, Órla T., Huang, Elaine Y., Laug, Walter E., Shimada, Hiroyuki, ...

Matrix ligation of integrins αvβ3/αvβ5 is critical for endothelial survival and angiogenesis. We have previously shown that ceramide, a proapoptotic lipid second messenger, increases during...