Kamiya, Hiroyuki, Cadena-Amaro, Claudio, Dugué, Laurence, Yakushiji, Hiroyuki, Minakawa, Noriaki, Matsuda, Akira, ...
The MTH1 protein catalyzes hydrolysis of oxidatively damaged purine nucleotides including 8-hydroxy-dGTP to the monophosphates. The MTH1 protein seems to act as an important defense system against...
Kamiya, Hiroyuki, Cadena-Amaro, Claudio, Dugué, Laurence, Yakushiji, Hiroyuki, Minakawa, Noriaki, Matsuda, Akira, ...
The MTH1 protein catalyzes hydrolysis of oxidatively damaged purine nucleotides including 8-hydroxy-dGTP to the monophosphates. The MTH1 protein seems to act as an important defense system against...
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor (2005)
Erker, Laura, Schubert, Ralf, Yakushiji, Hiroyuki, Barlow, Carrolee, Larson, Denise, Mitchell, James B., ...
We previously demonstrated that the nitroxide antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) increased latency to tumorigenesis and doubled (100%) the lifespan of...
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Cancer chemoprevention by the antioxidant Tempol in Atm-deficient mice (2004)
Schubert, Ralf, Erker, Laura, Barlow, Carrolee, Yakushiji, Hiroyuki, Larson, Denise, Russo, Angelo, ...
Reactive oxygen species (ROS) are important endogenous etiological agents for DNA damage, and ROS perform critical signaling functions in apoptosis, stress responses and proliferation. The...
Substrate recognition by the human MTH1 protein (2002)
Kamiya, Hiroyuki, Dugué, Laurence, Yakushiji, Hiroyuki, Pochet, Sylvie, Nakabeppu, Yusaku, Harashima, Hideyoshi
Substrate recognition by the human MTH1 protein (2002)
Kamiya, Hiroyuki, Dugué, Laurence, Yakushiji, Hiroyuki, Pochet, Sylvie, Nakabeppu, Yusaku, Harashima, Hideyoshi
A nucleotide pool sanitizing enzyme, the human MIH1 protein, hydrolyses 2-hydroxy-dATP, 8-hydroxy-dATP, and 8-hydroxy-dGTP. To examine the substrate recognition mechanism of the MTH1 protein, ten...
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP (2001)
Fujikawa, Katsuyoshi, Kamiya, Hiroyuki, Yakushiji, Hiroyuki, Nakabeppu, Yusaku, Kasai, Hiroshi
The human nucleotide pool sanitization enzyme, MTH1, hydrolyzes 2-hydroxy-dATP and 8-hydroxy-dATP in addition to 8-hydroxy-dGTP. We report here that human MTH1 is highly specific for 2-hydroxy-ATP,...
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
Fujikawa, Katsuyoshi, Kamiya, Hiroyuki, Yakushiji, Hiroyuki, Nakabeppu, Yusaku, Kasai, Hiroshi
The human nucleotide pool sanitization enzyme, MTH1, hydrolyzes 2-hydroxy-dATP and 8-hydroxy-dATP in addition to 8-hydroxy-dGTP. We report here that human MTH1 is highly specific for 2-hydroxy-ATP,...
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
Fujikawa, Katsuyoshi, Kamiya, Hiroyuki, Yakushiji, Hiroyuki, Nakabeppu, Yusaku, Kasai, Hiroshi
The human nucleotide pool sanitization enzyme, MTH1, hydrolyzes 2-hydroxy-dATP and 8-hydroxy-dATP in addition to 8-hydroxy-dGTP. We report here that human MTH1 is highly specific for 2-hydroxy-ATP,...