Hisayuki Shigematsu

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers (2007)

Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, ...

BackgroundThe epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and...

The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non–small Cell Lung Cancer (2007)

Toyooka, Shinichi, Matsuo, Keitaro, Shigematsu, Hisayuki, Kosaka, Takayuki, Tokumo, Masaki, Yatabe, Yasushi, ...

Purpose: Mutation of epidermal growth factor receptor (EGFR) gene has been reported to be present in non–small cell lung cancer (NSCLC) and significantly associated with female sex and...

The Need for an Individual Approach to Lung Cancer Treatment (2006)

Hisayuki Shigematsu, Shinichi Toyooka, Makoto Suzuki

The Need for an Individual Approach to Lung Cancer Treatment (2006)

Hisayuki Shigematsu, Shinichi Toyooka, Makoto Suzuki

RESPONSE: Re: Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers (2006)

Shigematsu, Hisayuki, Minna, John D., Gazdar, Adi F.

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers (2005)

Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers (2005)

Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...

Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer (2004)

Yano, Masaaki, Ouchida, Mamoru, Shigematsu, Hisayuki, Tanaka, Noriyoshi, Ichimura, Koichi, Kobayashi, Kazuyasu, ...

In an attempt to identify tumor suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variants of the HELLS/ SMARCA6 gene transcripts. HELLS/SMARCA6 is a...

The Need for an Individual Approach to Lung Cancer Treatment

Shigematsu, Hisayuki, Toyooka, Shinichi, Suzuki, Makoto

The Need for an Individual Approach to Lung Cancer Treatment

Shigematsu, Hisayuki, Toyooka, Shinichi, Suzuki, Makoto

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers

Nomura, Masaharu, Shigematsu, Hisayuki, Li, Lin, Suzuki, Makoto, Takahashi, Takao, Estess, Pila, ...

Masaharu Nomura and colleagues examine the distribution ofEGFR polymorphisms in different populations and find differences that might explain different responses to tyrosine kinase inhibitors in lung...

Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines

Gandhi, Jeet, Zhang, Jianling, Xie, Yang, Soh, Junichi, Shigematsu, Hisayuki, Zhang, Wei, ...

Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, ...