Exact model reduction of combinatorial reaction networks (2008)
Conzelmann, Holger, Fey, Dirk, Gilles, Ernst D
Abstract Background Receptors and scaffold proteins usually possess a high number of distinct binding domains inducing the formation of large multiprotein signaling complexes. Due to combinatorial...
Mathematical models of biological processes are becoming more and more important in biology. The goal of mathematical modeling is a holistic understanding of how biological processes like cellular...
Reduced modeling of signal transduction – a modular approach (2007)
Koschorreck, Markus, Conzelmann, Holger, Ebert, Sybille, Ederer, Michael, Gilles, Ernst
Abstract Background Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively and a lot...
Reduced modeling of signal transduction – a modular approach (2007)
Bmc Bioinformatics, Markus Koschorreck, Holger Conzelmann, Sybille Ebert, Michael Ederer, Ernst Dieter Gilles
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N, Gilles, Ernst D
Abstract Background: Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial...
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N., Gilles, Ernst D.
Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of...
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Bullinger, Eric, Allgöwer, Frank, Gilles, Ernst Dieter
Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain...
Bistability analyses of a caspase activation model for receptor-induced apoptosis (2004)
Eissing, Thomas, Conzelmann, Holger, Gilles, Ernst Dieter, Allgöwer, Frank, Bullinger, Eric, Scheurich, Peter
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed...