Holger Erfle

Automated Analysis of siRNA Screens of Virus Infected Cells based on Immunofluorescence Microscopy (2009)

Petr Matula, Anil Kumar, Ilka Wörz, Nathalie Harder, Holger Erfle, Ralf Bartenschlager, ...

Abstract. We present an image analysis approach as part of a highthroughput microscopy screening system based on cell arrays for the identification of genes involved in Hepatitis C and Dengue virus...

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase (2008)

Tegha-Dunghu, Justus, Neumann, Beate, Krause, Roland, Erfle, Holger, Walter, Thomas, Held, Michael, ...

Assembly of the mitotic spindle requires a global change in the activity and constitution of the microtubule-binding-protein array at mitotic onset. An important subset of mitotic microtubule-binding...

Automatic Identification of Subcellular Phenotypes on Human Cell Arrays (2004)

Conrad, Christian, Erfle, Holger, Warnat, Patrick, Daigle, Nathalie, Lörch, Thomas, Ellenberg, Jan, ...

Light microscopic analysis of cell morphology provides a high-content readout of cell function and protein localization. Cell arrays and microwell transfection assays on cultured cells have made cell...

High-Content Screening Microscopy Identifies Novel Proteins With a Putative Role in Secretory Membrane Traffic (2004)

Starkuviene, Vytaute, Liebel, Urban, Simpson, Jeremy C., Erfle, Holger, Poustka, Annemarie, Wiemann, Stefan, ...

Here we describe the establishment of microscope-based functional screening assays in intact cells that allow us to systematically identify new proteins involved in secretory membrane traffic, and...

Untersuchung von Membran-DNA Komplexen in äußeren elektrischen Feldern (2002)

Erfle, Holger

Untersuchung von Membran-DNA Komplexen in äußeren elektrischen FeldernDie vorliegende Arbeit beschreibt die Entwicklung, Optimierung und Automatisierung einer neuartigen Methode zum Transferieren...

Untersuchung von Membran-DNA Komplexen in äußeren elektrischen Feldern (2002)

Erfle, Holger

Untersuchung von Membran-DNA Komplexen in äußeren elektrischen Feldern Die vorliegende Arbeit beschreibt die Entwicklung, Optimierung und Automatisierung einer neuartigen Methode zum Transferieren...

Automatic Identification of Subcellular Phenotypes on Human Cell Arrays

Conrad, Christian, Erfle, Holger, Warnat, Patrick, Daigle, Nathalie, Lörch, Thomas, Ellenberg, Jan, ...

Light microscopic analysis of cell morphology provides a high-content readout of cell function and protein localization. Cell arrays and microwell transfection assays on cultured cells have made cell...

High-Content Screening Microscopy Identifies Novel Proteins With a Putative Role in Secretory Membrane Traffic

Starkuviene, Vytaute, Liebel, Urban, Simpson, Jeremy C., Erfle, Holger, Poustka, Annemarie, Wiemann, Stefan, ...

Here we describe the establishment of microscope-based functional screening assays in intact cells that allow us to systematically identify new proteins involved in secretory membrane traffic, and...

Automatic Identification of Subcellular Phenotypes on Human Cell Arrays

Conrad, Christian, Erfle, Holger, Warnat, Patrick, Daigle, Nathalie, Lörch, Thomas, Ellenberg, Jan, ...

Light microscopic analysis of cell morphology provides a high-content readout of cell function and protein localization. Cell arrays and microwell transfection assays on cultured cells have made cell...

High-Content Screening Microscopy Identifies Novel Proteins With a Putative Role in Secretory Membrane Traffic

Starkuviene, Vytaute, Liebel, Urban, Simpson, Jeremy C., Erfle, Holger, Poustka, Annemarie, Wiemann, Stefan, ...

Here we describe the establishment of microscope-based functional screening assays in intact cells that allow us to systematically identify new proteins involved in secretory membrane traffic, and...

A Systems Biology Approach To Identify the Combination Effects of Human Herpesvirus 8 Genes on NF-κB Activation▿

Konrad, Andreas, Wies, Effi, Thurau, Mathias, Marquardt, Gaby, Naschberger, Elisabeth, Hentschel, Sonja, ...

Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma. Activation of the cellular transcription factor nuclear factor-kappa B (NF-κB) is essential for...