Janes, Holly, Pepe, Margaret S.
Recent scientific and technological innovations have produced an abundance of potential markers that are being investigated for their use in disease screening and diagnosis. In evaluating these...
Accommodating Covariates in ROC Analysis (2008)
Janes, Holly, Longton, Gary M., Pepe, Margaret
Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is commonly summarized using the receiver operating...
Estimation and Comparison of Receiver Operating Characteristic Curves (2008)
Pepe, Margaret, Longton, Gary M., Janes, Holly
The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a...
Accommodating Covariates in ROC Analysis (2008)
Janes, Holly, Longton, Gary M., Pepe, Margaret
Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is commonly summarized using the receiver operating...
Estimation and Comparison of Receiver Operating Characteristic Curves (2008)
Pepe, Margaret, Longton, Gary M., Janes, Holly
The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a...
Accommodating Covariates in ROC Analysis (2008)
Janes, Holly, Longton, Gary M., Pepe, Margaret
Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is commonly summarized using the receiver operating...
Estimation and Comparison of Receiver Operating Characteristic Curves (2008)
Pepe, Margaret, Longton, Gary M., Janes, Holly
The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a...
Accommodating Covariates in ROC Analysis (2008)
Janes, Holly, Longton, Gary M., Pepe, Margaret
Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is commonly summarized using the receiver operating...
Estimation and Comparison of Receiver Operating Characteristic Curves (2008)
Pepe, Margaret, Longton, Gary M., Janes, Holly
The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a...
Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.
Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...
Janes, Holly, Pepe, Margaret S.
The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the...
The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the...
The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the...
The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the...
The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the...
Janes, Holly, Dominici, Francesca, Zeger, Scott
We propose a method for diagnosing confounding bias under a model which links a spatially and temporally varying exposure and health outcome. We decompose the association into orthogonal components,...
Janes, Holly, Dominici, Francesca, Zeger, Scott
We propose a method for diagnosing confounding bias under a model which links a spatially and temporally varying exposure and health outcome. We decompose the association into orthogonal components,...
Janes, Holly, Dominici, Francesca, Zeger, Scott
We propose a method for diagnosing confounding bias under a model which links a spatially and temporally varying exposure and health outcome. We decompose the association into orthogonal components,...
Janes, Holly, Dominici, Francesca, Zeger, Scott
We propose a method for diagnosing confounding bias under a model which links a spatially and temporally varying exposure and health outcome. We decompose the association into orthogonal components,...
Insights into latent class analysis of diagnostic test performance (2007)
Pepe, Margaret Sullivan, Janes, Holly
Latent class analysis is used to assess diagnostic test accuracy when a gold standard assessment of disease is not available but results of multiple imperfect tests are. We consider the simplest...
Statistical Analysis of Air Pollution Panel Studies: An Illustration (2006)
Janes, Holly, Sheppard, Lianne, Shepherd, Kristen
The panel study design is commonly used to evaluate the short-term health effects of air pollution. Standard statistical methods for analyzing longitudinal data are available, but the literature...
Statistical Analysis of Air Pollution Panel Studies: An Illustration (2006)
Janes, Holly, Sheppard, Lianne, Shepherd, Kristen
The panel study design is commonly used to evaluate the short-term health effects of air pollution. Standard statistical methods for analyzing longitudinal data are available, but the literature...
Statistical Analysis of Air Pollution Panel Studies: An Illustration (2006)
Janes, Holly, Sheppard, Lianne, Shepherd, Kristen
The panel study design is commonly used to evaluate the short-term health effects of air pollution. Standard statistical methods for analyzing longitudinal data are available, but the literature...
Statistical Analysis of Air Pollution Panel Studies: An Illustration (2006)
Janes, Holly, Sheppard, Lianne, Shepherd, Kristen
The panel study design is commonly used to evaluate the short-term health effects of air pollution. Standard statistical methods for analyzing longitudinal data are available, but the literature...
A Comparative Analysis of the Chronic Effects of Fine Particulate Matter (2006)
Eftim, Sorina E, Janes, Holly, McDermott, Aidan, Samet, Jonathan M, Dominici, Francesca
The American Cancer Society study (ACS) and the Harvard Six Cities study (SCS) are the two landmark cohort studies for estimating the chronic effects of fine particulate matter PM2.5 on mortality. To...
A Comparative Analysis of the Chronic Effects of Fine Particulate Matter (2006)
Eftim, Sorina E, Janes, Holly, McDermott, Aidan, Samet, Jonathan M, Dominici, Francesca
The American Cancer Society study (ACS) and the Harvard Six Cities study (SCS) are the two landmark cohort studies for estimating the chronic effects of fine particulate matter PM2.5 on mortality. To...
A Comparative Analysis of the Chronic Effects of Fine Particulate Matter (2006)
Eftim, Sorina E, Janes, Holly, McDermott, Aidan, Samet, Jonathan M, Dominici, Francesca
The American Cancer Society study (ACS) and the Harvard Six Cities study (SCS) are the two landmark cohort studies for estimating the chronic effects of fine particulate matter PM2.5 on mortality. To...
A Comparative Analysis of the Chronic Effects of Fine Particulate Matter (2006)
Eftim, Sorina E, Janes, Holly, McDermott, Aidan, Samet, Jonathan M, Dominici, Francesca
The American Cancer Society study (ACS) and the Harvard Six Cities study (SCS) are the two landmark cohort studies for estimating the chronic effects of fine particulate matter PM2.5 on mortality. To...
Janes, Holly, Pepe, Margaret S.
Recent scientific and technological innovations have produced an abundance of potential markers which are being investigated for their use in disease screen- ing and diagnosis. In evaluating these...
Janes, Holly, Pepe, Margaret S.
Recent scientific and technological innovations have produced an abundance of potential markers which are being investigated for their use in disease screen- ing and diagnosis. In evaluating these...
Janes, Holly, Pepe, Margaret S.
Recent scientific and technological innovations have produced an abundance of potential markers which are being investigated for their use in disease screen- ing and diagnosis. In evaluating these...
Janes, Holly, Pepe, Margaret S.
Recent scientific and technological innovations have produced an abundance of potential markers which are being investigated for their use in disease screen- ing and diagnosis. In evaluating these...
Margaret Sullivan Pepe, Holly Janes, Gary Longton, Wendy Leisenring
A marker strongly associated with outcome (or disease) is often assumed to be effective for classifying persons according to their current or future outcome. However, for this assumption to be true,...
The case-control design is frequently used to study the discriminatory accuracy of a screening or diagnostic biomarker. Yet, the appropriate ratio in which to sample cases and controls has never been...
Insights into Latent Class Analysis of Diagnostic Test Performance (2006)
Pepe, Margaret Sullivan, Janes, Holly
Latent class analysis is used to assess diagnostic test accuracy when a gold standard assessment of disease is not available but results of multiple imperfect tests are. We consider the simplest...
The case–control design is frequently used to study the discriminatory accuracy of a screening or diagnostic biomarker. Yet, the appropriate ratio in which to sample cases and controls has never...
Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker (2005)
Pepe, Margaret S., Janes, Holly, Longton, Gary M., Leisenring, Wendy, Newcomb, Polly
A marker that is strongly associated with outcome (or disease) is often assumed to be effective for classifying individuals according to their current or future outcome. However, for this to be true,...
Insights into Latent Class Analysis (2005)
Pepe, Margaret S., Janes, Holly
Latent class analysis is a popular statistical technique for estimating disease prevalence and test sensitivity and specificity. It is used when a gold standard assessment of disease is not available...
Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker (2005)
Pepe, Margaret S., Janes, Holly, Longton, Gary M., Leisenring, Wendy, Newcomb, Polly
A marker that is strongly associated with outcome (or disease) is often assumed to be effective for classifying individuals according to their current or future outcome. However, for this to be true,...
Insights into Latent Class Analysis (2005)
Pepe, Margaret S., Janes, Holly
Latent class analysis is a popular statistical technique for estimating disease prevalence and test sensitivity and specificity. It is used when a gold standard assessment of disease is not available...
Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker (2005)
Pepe, Margaret S., Janes, Holly, Longton, Gary M., Leisenring, Wendy, Newcomb, Polly
A marker that is strongly associated with outcome (or disease) is often assumed to be effective for classifying individuals according to their current or future outcome. However, for this to be true,...
Insights into Latent Class Analysis (2005)
Pepe, Margaret S., Janes, Holly
Latent class analysis is a popular statistical technique for estimating disease prevalence and test sensitivity and specificity. It is used when a gold standard assessment of disease is not available...
Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker (2005)
Pepe, Margaret S., Janes, Holly, Longton, Gary M., Leisenring, Wendy, Newcomb, Polly
A marker that is strongly associated with outcome (or disease) is often assumed to be effective for classifying individuals according to their current or future outcome. However, for this to be true,...
Insights into Latent Class Analysis (2005)
Pepe, Margaret S., Janes, Holly
Latent class analysis is a popular statistical technique for estimating disease prevalence and test sensitivity and specificity. It is used when a gold standard assessment of disease is not available...
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design has been widely used to study the association between short term air pollution exposure and the risk of an acute adverse health event. The design uses cases only, and, for...
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design has been widely used to study the association between short term air pollution exposure and the risk of an acute adverse health event. The design uses cases only, and, for...
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design has been widely used to study the association between short term air pollution exposure and the risk of an acute adverse health event. The design uses cases only, and, for...
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design has been widely used to study the association between short term air pollution exposure and the risk of an acute adverse health event. The design uses cases only, and, for...
Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures (2004)
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or "referent" times, in order to assess the effect of short-term...
Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures (2004)
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or "referent" times, in order to assess the effect of short-term...
Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures (2004)
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or "referent" times, in order to assess the effect of short-term...
Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures (2004)
Janes, Holly, Sheppard, Lianne, Lumley, Thomas
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or "referent" times, in order to assess the effect of short-term...
Pepe, Margaret Sullivan, Janes, Holly, Longton, Gary, Leisenring, Wendy, Newcomb, Polly
A marker strongly associated with outcome (or disease) is often assumed to be effective for classifying persons according to their current or future outcome. However, for this assumption to be true,...
Identifying Target Populations for Screening or Not Screening Using Logic Regression (2003)
Janes, Holly, Pepe, Margaret S., Kooperberg, Charles, Newcomb, Polly
Colorectal cancer remains a significant public health concern despite the fact that effective screening procedures exist and that the disease is treatable when detected at early stages. Numerous risk...
Identifying Target Populations for Screening or Not Screening Using Logic Regression (2003)
Janes, Holly, Pepe, Margaret S., Kooperberg, Charles, Newcomb, Polly
Colorectal cancer remains a significant public health concern despite the fact that effective screening procedures exist and that the disease is treatable when detected at early stages. Numerous risk...
Identifying Target Populations for Screening or Not Screening Using Logic Regression (2003)
Janes, Holly, Pepe, Margaret S., Kooperberg, Charles, Newcomb, Polly
Colorectal cancer remains a significant public health concern despite the fact that effective screening procedures exist and that the disease is treatable when detected at early stages. Numerous risk...
Identifying Target Populations for Screening or Not Screening Using Logic Regression (2003)
Janes, Holly, Pepe, Margaret S., Kooperberg, Charles, Newcomb, Polly
Colorectal cancer remains a significant public health concern despite the fact that effective screening procedures exist and that the disease is treatable when detected at early stages. Numerous risk...
Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures
Holly Janes, Lianne Sheppard, Thomas Lumley
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or "referent" times, in order to assess the effect of short-term...
Assessing the Health Effects of Air Pollution Using the Case-Crossover Design
Holly Janes, Lianne Sheppard, Thomas Lumley
The case-crossover design has been widely used to study the association between short term air pollution exposure and the risk of an acute adverse health event. The design uses cases only, and...
Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker
Margaret Pepe, Holly Janes, Gary Longton, Wendy Leisenring, Polly Newcomb
A marker that is strongly associated with outcome (or disease) is often assumed to be effective for classifying individuals according to their current or future outcome. However, for this to be true,...
Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.
Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...
Accommodating covariates in receiver operating characteristic analysis
Holly Janes, Gary Longton, Margaret S. Pepe
Classification accuracy is the ability of a marker or diagnostic test to discriminate between two groups of individuals, cases and controls, and is com- monly summarized by using the receiver...
Estimation and comparison of receiver operating characteristic curves
Margaret S. Pepe, Gary Longton, Holly Janes
The receiver operating characteristic (ROC) curve displays the capacity of a marker or diagnostic test to discriminate between two groups of subjects, cases versus controls. We present a...
Recent scientific and technological innovations have produced an abundance of potential markers that are being investigated for their use in disease screening and diagnosis. In evaluating these...