Huang, Linda H., Cheng, Hong, Pardi, Arthur, Tam, James P., Sweeney, William V.
It has been shown that there is no epidermal growth factor (EGF)-receptor binding nor mitogenic activity in the synthetic first EGF-like domain of factor IX(45-87). However, the Gla-independent...
A Deformable Local Image Descriptor (2009)
Hong Cheng, Zicheng Liu, Nanning Zheng, Jie Yang
This paper presents a novel local image descriptor that is robust to general image deformations. A limitation with traditional image descriptors is that they use a single support region for each...
Semantic Annotation of Frequent Patterns (2008)
Qiaozhu Mei, Dong Xin, Hong Cheng, Jiawei Han, Chengxiang Zhai
Using frequent patterns to analyze data has been one of the fundamental approaches in many data mining applications. Research in frequent pattern mining has so far mostly focused on developing...
ScudWare: A Semantic and Adaptive Middleware Platform for Smart Vehicle Space (2008)
Zhaohui Wu, Senior Member, Qing Wu, Hong Cheng, Gang Pan, Minde Zhao, ...
Abstract—Compared with smart spaces addressed previously, the smart vehicle space is quite special. First, unlike room, it is a high mobile space. Second, it requires frequent information exchange...
A Study on the Performance and Mechanism of Soil-reinforcement by Herb Root System (2008)
Hong Cheng, Xiaojie Yang, Aiping Liu, Hengsheng Fu, Ming Wan
Abstract: A study is carried out on the mechanic function and the mechanism of soil reinforcement by herb root systems is discussed, in which there are four primary functions analyzed and four sorts...
Near-optimal supervised feature selection among frequent subgraphs (2008)
Thoma, Marisa, Cheng, Hong, Gretton, Arthur, Han, Jiawei, Kriegel, Hans-Peter, Smola, Alex, ...
Graph classification is an increasingly important step in numerous application domains, such as function prediction of molecules and proteins, computerised scene analysis, and anomaly detection in...
Approximate Frequent Pattern Mining (2008)
Philip S. Yu, Xifeng Yan, Jiawei Han, Hong Cheng, Feida Zhu
Frequent pattern mining has been a focused theme in data mining research and an important first step in the analysis of data arising in a broad range of applications. The traditional exact model for...
On Compressing Frequent Patterns ⋆ (2008)
Dong Xin, Jiawei Han, Xifeng Yan, Hong Cheng
A major challenge in frequent-pattern mining is the sheer size of its mining results. To compress the frequent patterns, we propose to cluster frequent patterns with a tightness measure δ (called...
ABSTRACT Extracting Redundancy-Aware Top-K Patterns ∗ (2008)
Dong Xin, Hong Cheng, Xifeng Yan, Jiawei Han
Observed in many applications, there is a potential need of extracting a small set of frequent patterns having not only high significance but also low redundancy. The significance is usually defined...
Research Interests. My primary research interests are in the fields of data mining, machine learning and database systems. With the enormous amounts of data accumulated in business, industry, Web,...
RESEARCH INTERESTS I have broad interests in data mining, machine learning and database systems. My primary interests include: discriminative frequent pattern-based classification, frequent pattern...
ABSTRACT Extracting Redundancy-Aware Top-K Patterns ∗ (2008)
Dong Xin, Hong Cheng, Xifeng Yan, Jiawei Han
Observed in many applications, there is a potential need of extracting a small set of frequent patterns having not only high significance but also low redundancy. The significance is usually defined...
Mapping the Epitope of an Inhibitory Monoclonal Antibody to the (2008)
Jizu Yi, Hong Cheng, Mark D. Andrake, L. Dunbrack, Heinrich Roder, ...
this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate...
Direct Evidence for the Cooperative Unfolding of (2008)
Cytochrome In Lipid, Hong Cheng, Steven H. Seeholzer, Heinrich Roder, Coventry Cv Al
ing *Corresponding author Introduction The interaction of water-soluble proteins with membranes is a common event occurring during the course of various cellular processes. Examples include the...
Early Events in Protein Folding Explored (2008)
Rapid Mixing Methods, Heinrich Roder, Kosuke Maki, Ramil F. Latypov, Hong Cheng, M. C. Ramach, ...
ructure. In contrast, the time course of protein folding monitored by optical and other experimental probes generally shows relaxation kinetics with one or a few exponential phases, which are...
Structural Characterization of an Equilibrium Unfolding Intermediate in Cytochrome c (2008)
Ramil Latypov Hong, Hong Cheng, Navid A. Roder, Jiaru Zhang, Heinrich Roder
al features, including a well-structured a-helical subdomain, a short Trp59--heme distance and solvent-shielded heme environment, but lacks the native Met80 sulfur--iron linkage and shows major...
Ding Yuan, Kyuhyung Lee, Hong Cheng, Gopal Krishna, Zhenmin Li, Xiao Ma, ...
Recently, frequent sequential pattern mining algorithms have been widely used in software engineering field to mine various source code or specification patterns. In practice, software evolves from...
Direct discriminative pattern mining for effective classification (2008)
Hong Cheng, Xifeng Yan, Philip S. Yu
Classification
Discriminative frequent pattern analysis for effective classification (2007)
Hong Cheng, Xifeng Yan, Jiawei Han, Chih-wei Hsu
The application of frequent patterns in classification appeared in sporadic studies and achieved initial success in the classification of relational data, text documents and graphs. In this paper, we...
Mining colossal frequent patterns by core pattern fusion (2007)
Feida Zhu, Xifeng Yan, Jiawei Han, Philip S. Yu, Hong Cheng
Extensive research for frequent-pattern mining in the past decade has brought forth a number of pattern mining algorithms that are both effective and efficient. However, the existing frequent-pattern...
Chinese St. Louis: From Enclave to Cultural Community (review) (2006)
Journal of Chinese Overseas - Volume 2, Number 2, November 2006
Turbulence over urban-type roughness: deductions from wind-tunnel measurements (2006)
Castro, Ian P., Cheng, Hong, Reynolds, Ryan
Turbulence data from experiments conducted over a staggered cube array, modelling a neutrally stable atmospheric boundary layer in an urban environment, are presented. The results support the...
Abstract On compressing frequent patterns q (2006)
Dong Xin, Jiawei Han, Xifeng Yan, Hong Cheng
A major challenge in frequent-pattern mining is the sheer size of its mining results. To compress the frequent patterns, we propose to cluster frequent patterns with a tightness measure d (called...
Generating semantic annotations for frequent patterns with context analysis (2006)
Qiaozhu Mei, Dong Xin, Hong Cheng, Jiawei Han, Chengxiang Zhai
As a fundamental data mining task, frequent pattern mining has widespread applications in many different domains. Research in frequent pattern mining has so far mostly focused on developing efficient...
AC-Close: efficiently mining approximate closed itemsets by core pattern recovery (2006)
Hong Cheng, Philip S. Yu, Jiawei Han
Recent studies have proposed methods to discover approximate frequent itemsets in the presence of random noise. By relaxing the rigid requirement of exact frequent pattern mining, some interesting...
Answering top-k queries with multi-dimensional selections: The ranking cube approach (2006)
Dong Xin, Jiawei Han, Hong Cheng, Xiaolei Li
Observed in many real applications, a top-k query often consists of two components to reflect a user’s preference: a selection condition and a ranking function. A user may not only propose ad hoc...
Answering top-k queries with multi-dimensional selections: The ranking cube approach (2006)
Dong Xin, Jiawei Han, Hong Cheng, Xiaolei Li
Observed in many real applications, a top-k query often consists of two components to reflect a user’s preference: a selection condition and a ranking function. A user may not only propose ad hoc...
Generating semantic annotations for frequent patterns with context analysis (2006)
Qiaozhu Mei, Dong Xin, Hong Cheng, Jiawei Han, Chengxiang Zhai
As a fundamental data mining task, frequent pattern mining has widespread applications in many different domains. Research in frequent pattern mining has so far mostly focused on developing efficient...
Generating semantic annotations for frequent patterns with context analysis (2006)
Qiaozhu Mei, Dong Xin, Hong Cheng, Jiawei Han, Chengxiang Zhai
As a fundamental data mining task, frequent pattern mining has widespread applications in many different domains. Research in frequent pattern mining has so far mostly focused on developing efficient...
Answering top-k queries with multi-dimensional selections: The ranking cube approach (2006)
Dong Xin, Jiawei Han, Hong Cheng, Xiaolei Li
Observed in many real applications, a top-k query often consists of two components to reflect a user’s preference: a selection condition and a ranking function. A user may not only propose ad hoc...
Cheng, Hong, Aleman, Tomas S., Cideciyan, Artur V., Khanna, Ritu, Jacobson, Samuel G., Swaroop, Anand
Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor...
Chang, Bo, Khanna, Hemant, Hawes, Norman, Jimeno, David, He, Shirley, Lillo, Concepcion, ...
Centrosome- and cilia-associated proteins play crucial roles in establishing polarity and regulating intracellular transport in post-mitotic cells. Using genetic mapping and positional candidate...
Cheng, Hong, Aleman, Tomas S., Cideciyan, Artur V., Khanna, Ritu, Jacobson, Samuel G., Swaroop, Anand
Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor...
Network constrained clustering for gene microarray data (2005)
Gene Expression, Dongxiao Zhu, Alfred O Hero, Hong Cheng, Ritu Khanna
doi:10.1093/bioinformatics/bti655
Mining compressed frequent-pattern sets (2005)
Dong Xin, Jiawei Han, Xifeng Yan, Hong Cheng
A major challenge in frequent-pattern mining is the sheer size of its mining results. In many cases, a high min sup threshold may discover only commonsense patterns but a low one may generate an...
Masayuki Akimoto, Hong Cheng, Dongxiao Zhu, Joseph A. Brzezinski, Ritu Khanna, ...
doi:10.1073/pnas.0508214103 This information is current as of June 2007. High-resolution figures, a citation map, links to PubMed and Google Scholar, etc., can be found at:...
Mining Compressed Frequent-Pattern Sets (2005)
Dong Xin Jiawei, Dong Xin, Jiawei Han, Xifeng Yan, Hong Cheng
A major challenge in frequent-pattern mining is the sheer size of its mining results. In many cases, a high min sup threshold may discover only commonsense patterns but a low one may generate an...
Early Events in Protein Folding Explored by Rapid Mixing Methods (2005)
Heinrich Roder Kosuke, Kosuke Maki, Hong Cheng
this documents the accuracy of the continuous-flow measurement. Instrumental dead times can be substantially longer if one or both of the solutions contains a denaturant, such as guanidine...
Summarizing itemset patterns: a profile-based approach (2005)
Xifeng Yan, Hong Cheng, Jiawei Han, Dong Xin
Frequent-pattern mining has been studied extensively on scalable methods for mining various kinds of patterns including itemsets, sequences, and graphs. However, the bottleneck of frequent-pattern...
Recruitment of the human TREX complex to mRNA during splicing (2005)
Masuda, Seiji, Das, Rita, Cheng, Hong, Hurt, Ed, Dorman, Nijsje, Reed, Robin
In yeast, the TREX complex contains the THO transcription elongation complex, which functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 to nascent transcripts....
Network constrained clustering for gene microarray data (2005)
Zhu, Dongxiao, Hero, Alfred O., Cheng, Hong, Khanna, Ritu, Swaroop, Anand
Many bioinformatics problems can be tackled from a fresh angle offered by the network perspective. Directly inspired by metabolic network structural studies, we propose an improved gene clustering...
Network constrained clustering for gene microarray data (2005)
Zhu, Dongxiao, Hero, Alfred O, Cheng, Hong, Khanna, Ritu, Swaroop, Anand
Many bioinformatics problems can be tackled from a fresh angle offered by the network perspective. Directly inspired by metabolic network structural studies, we propose an improved gene clustering...
Incspan: incremental mining of sequential patterns in large database (2004)
Many real life sequence databases grow incrementally. It is undesirable to mine sequential patterns from scratch each time when a small set of sequences grow, or when some new sequences are added...
Rapid Mixing Methods for Exploring the Kinetics of Protein Folding (2004)
Heinrich Roder Kosuke, Kosuke Maki, Hong Cheng, M. C. Ramach, Ra Shastry A
Information on the time-dependence of molecular species is critical for elucidating reaction mechanisms in chemistry and biology. Rapid flow experiments involving turbulent mixing of two or more...
Early Events During Folding of Wild-type (2004)
Staphylococcal Nuclease And, Kosuke Maki, Hong Cheng, Dimitry A. Dolgikh, M. C. Ramach, Ra Shastry, ...
uring the final stages of folding. The fact that both variants exhibit the same number of kinetic phases with very similar rates confirms that the folding mechanism is not perturbed by the F76W/W140H...
Incspan: incremental mining of sequential patterns in large database (2004)
Hong Cheng, Xifeng Yan, Jiawei Han
Many real life sequence databases grow incrementally. It is undesirable to mine sequential patterns from scratch each time when a small set of sequences grow, or when some new sequences are added...
Cheng, Hong, Khanna, Hemant, Oh, Edwin C. T., Hicks, David, Mitton, Kenneth P., Swaroop, Anand
NR2E3, a photoreceptor-specific orphan nuclear receptor, is believed to play a pivotal role in the differentiation of photoreceptors. Mutations in the human NR2E3 gene and its mouse ortholog are...
Cheng, Hong, Khanna, Hemant, Oh, Edwin C.T., Hicks, David, Mitton, Kenneth P., Swaroop, Anand
NR2E3, a photoreceptor-specific orphan nuclear receptor, is believed to play a pivotal role in the differentiation of photoreceptors. Mutations in the human NR2E3 gene and its mouse ortholog are...
Cheng, Hong, Khanna, Hemant, Oh, Edwin C. T., Hicks, David, Mitton, Kenneth P., Swaroop, Anand
NR2E3, a photoreceptor-specific orphan nuclear receptor, is believed to play a pivotal role in the differentiation of photoreceptors. Mutations in the human NR2E3 gene and its mouse ortholog are...
Mining high-utility plans from plan databases / (2003)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.
Mining high-utility plans from plan databases / (2003)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.
Mining high-utility plans from plan databases / (2003)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.
Case Mining from Large Databases (2003)
Abstract. This paper presents an approach of case mining to automatically discover case bases from large datasets in order to improve both the speed and the quality of case based reasoning. Case...
Mining high-utility plans from plan databases (2003)
Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2003
Near wall flow over urban-like roughness (2002)
In this study, comprehensive measurements over a number of urban-type surfaces with the same area density of 25% have been performed in a wind tunnel. The experiments were conducted at a free stream...
Latent variable analysis and application in bio-informatics / (2001)
Thesis (M.S.)--University of Louisiana at Lafayette, 2001.
Thesis (Ph. D.)--University of Alabama at Birmingham, School of Public Health, 2000.
Adaptive and splitting computation on the quenching type problems / (2000)
Thesis (Ph. D.)--University of Louisiana at Lafayette, 2000.
Adaptive and splitting computation on the quenching type problems [microform] / (2000)
Thesis (Ph. D.)--University of Louisiana at Lafayette, 2000.
Thesis (Ph. D.)--East Tennessee State University, 1998.
Research paper, Faculty of Commerce and Administration, International Aviation M.B.A. Programme--Concordia University, 1998.
SeqIndex: Indexing sequences by sequential pattern analysis (1998)
Hong Cheng, Xifeng Yan, Jiawei Han
In this paper, we study the issues related to the design and construction of high-performance sequence index structures in large sequence databases. To build effective indices, a novel method, called...
Publications Conferences (1996)
Ding Yuan, Ding Yuan, Kyuhyung Lee, Hong Cheng, Gopal Krishna, Zhenmin Li, ...
Research Interests I’m interested in various aspects in computer systems and program analysis, especially using data
Vita.
Solution structure and dynamics of a de novo designed three-helix bundle protein
Walsh, Scott T. R., Cheng, Hong, Bryson, James W., Roder, Heinrich, DeGrado, William F.
Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed...
Cheng, Hong, Macaluso, Maurizio, Vermund, Sten H., Hook, Edward W.
Published estimates of the sensitivity and specificity of PCR and ligase chain reaction (LCR) for detecting Chlamydia trachomatis are potentially biased because of study design limitations...
Cheng, Hong, Sugiura, Reiko, Wu, Wenlian, Fujita, Masaaki, Lu, Yabin, Sio, Susie O., ...
A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the...
Kuwata, Kazuo, Matumoto, Tomoharu, Cheng, Hong, Nagayama, Kuniaki, James, Thomas L., Roder, Heinrich
PrP106–126, a peptide corresponding to residues 107–127 of the human prion protein, induces neuronal cell death by apoptosis and causes proliferation and hypertrophy of glia, reproducing the main...
Recruitment of the human TREX complex to mRNA during splicing
Masuda, Seiji, Das, Rita, Cheng, Hong, Hurt, Ed, Dorman, Nijsje, Reed, Robin
In yeast, the TREX complex contains the THO transcription elongation complex, which functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 to nascent transcripts....
Akimoto, Masayuki, Cheng, Hong, Zhu, Dongxiao, Brzezinski, Joseph A., Khanna, Ritu, Filippova, Elena, ...
The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the Nrl gene in mice leads to functional cones at the expense of rods. We show that...
Solution structure and dynamics of a de novo designed three-helix bundle protein
Walsh, Scott T. R., Cheng, Hong, Bryson, James W., Roder, Heinrich, DeGrado, William F.
Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed...
Cheng, Hong, Macaluso, Maurizio, Vermund, Sten H., Hook, Edward W.
Published estimates of the sensitivity and specificity of PCR and ligase chain reaction (LCR) for detecting Chlamydia trachomatis are potentially biased because of study design limitations...
Cheng, Hong, Sugiura, Reiko, Wu, Wenlian, Fujita, Masaaki, Lu, Yabin, Sio, Susie O., ...
A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the...
Kuwata, Kazuo, Matumoto, Tomoharu, Cheng, Hong, Nagayama, Kuniaki, James, Thomas L., Roder, Heinrich
PrP106–126, a peptide corresponding to residues 107–127 of the human prion protein, induces neuronal cell death by apoptosis and causes proliferation and hypertrophy of glia, reproducing the main...
Recruitment of the human TREX complex to mRNA during splicing
Masuda, Seiji, Das, Rita, Cheng, Hong, Hurt, Ed, Dorman, Nijsje, Reed, Robin
In yeast, the TREX complex contains the THO transcription elongation complex, which functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 to nascent transcripts....
Akimoto, Masayuki, Cheng, Hong, Zhu, Dongxiao, Brzezinski, Joseph A., Khanna, Ritu, Filippova, Elena, ...
The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the Nrl gene in mice leads to functional cones at the expense of rods. We show that...
Soravia, Claudio, Sugg, Sonia L., Berk, Terri, Mitri, Angela, Cheng, Hong, Gallinger, Steven, ...
We report two familial adenomatous polyposis (FAP) kindreds with thyroid cancer, harboring two apparently novel germline APC mutations. The clinical phenotype in the first kindred was typical of...
Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation
Samuel, Dharmaraj, Cheng, Hong, Riley, Paul W., Canutescu, Adrian A., Nagaswami, Chandrasekaran, Weisel, John W., ...
Factor XI (FXI) is a homodimeric blood coagulation protein. Each monomer comprises four tandem apple-domain repeats (A1–A4) and a serine protease domain. We report here the NMR solution structure...
AIM: To compare the efficacy and side effect profiles of three furazolidone and amoxicillin-based quadruple rescue therapies for the eradication of Helicobacter pylori (H pylori).
Longitudinal Trends in Use of Bone Mass Measurement Among Older Americans, 1999–2005
Curtis, Jeffrey R, Carbone, Laura, Cheng, Hong, Hayes, Burton, Laster, Andrew, Matthews, Robert, ...
Bone mass measurement (BMM) is useful to identify persons with low bone mass who are at increased risk for fracture. Given the increased emphasis that is being placed on preventive services such as...
Curtis, Jeffrey R, Westfall, Andrew O, Cheng, Hong, Lyles, Kenneth, Saag, Kenneth G, Delzell, Elizabeth
The relationship between high adherence to oral bisphosphonates and the risk of different types of fractures has not been well studied among adults of different ages. Using claims data from a large...
Nucleic Acid Amplification Tests for Diagnosis of Neisseria gonorrhoeae Oropharyngeal Infections▿
Bachmann, Laura H., Johnson, Robert E., Cheng, Hong, Markowitz, Lauri E., Papp, John R., Hook, Edward W.
The optimal methods for the diagnosis of pharyngeal Neisseria gonorrhoeae infection are uncertain. The objective of this study was to define the performance of culture and nucleic acid amplification...