Hong Xu

Proteomics, pathway array and signaling network-based medicine in cancer (2009)

Zhang, David Y, Ye, Fei, Gao, Ling, Liu, Xiaoliang, Zhao, Xin, Che, Yufang, ...

Abstract Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering...

Tuning parameter selection for penalized likelihood estimation of inverse covariance matrix (2009)

Gao, Xin, Pu, Daniel Q., Wu, Yuehua, Xu, Hong

In a Gaussian graphical model, the conditional independence between two variables are characterized by the corresponding zero entries in the inverse covariance matrix. Maximum likelihood method using...

Behavioral/Systems/Cognitive Adaptation across the Cortical Hierarchy: Low-Level Curve Adaptation Affects High-Level Facial-Expression Judgments (2009)

Hong Xu, Peter Dayan, Richard M. Lipkin, Ning Qian

Adaptation is ubiquitous in sensory processing. Although sensory processing is hierarchical, with neurons at higher levels exhibiting greater degrees of tuning complexity and invariance than those at...

Contributions to Adatpive Web Sampling Designs (2009)

Xu, Hong

Investigation of the characteristics and estimation of quantities of hidden and hard-to-access population are of interest to scientists. Such populations are difficult to target because of their...

Asymmetric Composite Nanoparticles with Anisotropic Surface Functionalities (2009)

Yilong Wang, Hong Xu, Weili Qiang, Hongchen Gu, Donglu Shi

Asymmetric inorganic/organic composite nanoparticles with anisotropic surface functionalities represent a new approach for creating smart materials, requiring the selective introduction of chemical...

{6,6′-Dimethoxy-2,2′-[4-bromo-o-phenylenebis(nitrilomethylidyne)]diphenolato}nickel(II) methanol solvate (2009)

Ming-Ming Yu, Hong Xu, Qiu-Zhi Shi, Ying-Nai Wei, Zhan-Xian Li

In the title compound, [Ni(C22H17BrN2O4)]·CH3OH, the NiII ion is in a slightly distorted square-planar geometry involving an N2O2 atom set of the tetradentate Schiff base ligand. The asymmetric...

(E)-5-(2-Nitroprop-1-enyl)-2,3-dihydro-1-benzofuran (2009)

Hong Xu, Hongshun Sun, Ning Xu

The asymmetric unit of the title compound, C11H11NO3, contains two crystallographically independent molecules. The aromatic rings are oriented at a dihedral angle of 56.17 (5)°. The furan...

Asymptotic Behavior of Tail Density for Sum of Correlated Lognormal Variables (2009)

Xin Gao, Hong Xu, Dong Ye

We consider the asymptotic behavior of a probability density function for the sum of any two lognormally distributed random variables that are nontrivially correlated. We show that both the left and...

Human DNA polymerase {beta} polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity (2009)

Guo, Zhigang, Zheng, Li, Dai, Huifang, Zhou, Mian, Xu, Hong, Shen, Binghui

DNA polymerase β (Pol β) is a key enzyme in DNA base excision repair, and an important factor for maintaining genome integrity and stability. More than 30% of human tumors characterized to date...

Asymmetric Composite Nanoparticles with Anisotropic Surface Functionalities (2009)

Yilong Wang, Hong Xu, Weili Qiang, Hongchen Gu, Donglu Shi

Asymmetric inorganic/organic composite nanoparticles with anisotropic surface functionalities represent a new approach for creating smart materials, requiring the selective introduction of chemical...

Asymptotic Behavior of Tail Density for Sum of Correlated Lognormal Variables (2009)

Xin Gao, Hong Xu, Dong Ye

We consider the asymptotic behavior of a probability density function for the sum of any two lognormally distributed random variables that are nontrivially correlated. We show that both the left and...

BIOINFORMATICS ORIGINAL PAPER SNPselector: a web tool for selecting SNPs for genetic association studies (2008)

Hong Xu, Simon G. Gregory, Elizabeth R. Hauser, Judith E. Stenger, Margaret A. Pericak, Jeffery M. Vance, ...

Summary: Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology,...

Cinnamomin––a Versatile Type II Ribosome-inactivating Protein (2008)

Hong Xu, Wang-yi Liu

Abstract Ribosome-inactivating proteins (RIPs) are a group of toxic proteins that can specifically act on the universally conserved sarcin/ricin domain (S/R domain) of the largest RNA in ribosome and...

Monolayer self-assembly at liquid-solid interfaces: chirality and electronic properties of molecules at surfaces (2008)

Lazzaroni, Roberto, Gomar-Nadal, Elba, Veciana, Jaume, Rovira, Concepcio, ...

The spontaneous formation of supramolecular assemblies at the boundary between solids and liquids is a process which encompasses a variety of systems with diverse characteristics: chemisorbed systems...

Abstract (2008)

Jianqing Chen, Andrew B. Whinston, Hong Xu

Online communities provide a social sphere for people to share information and knowledge. While information sharing is becoming a ubiquitous online phenomenon, how to ensure information quality or...

Nonlinear Approximation and the Space BV(R 2) 1 (2008)

Albert Cohen, Ronald Devore, Pencho Petrushev, Hong Xu

Abstract. Given a function f 2 L2(Q), Q: = [0; 1) 2 and a real number t>0, let U(f; t):= inf g2BV(Q) kf, gk 2 L2(I) + t VQ(g); where the in mum is taken over all functions g 2 BV of bounded...

808 RESEARCH ARTICLE Global Mapping of the Yeast Genetic Interaction Network (2008)

Amy Hin, Yan Tong, Guillaume Lesage, Gary D. Bader, Huiming Ding, Hong Xu, ...

A genetic interaction network containing �1000 genes and �4000 interactions was mapped by crossing mutations in 132 different query genes into a set of �4700 viable gene yeast deletion mutants...

Locking of helicity and shape complementarity in diarylethene dimers on graphite (2008)

Minoia, Andrea, Mutai, Toshiki, Xu, Hong, ...

Upon deposition of an achiral solution of diarylethene 1 on the achiral surface of graphite, a highly ordered monolayer with large homachiral domains is formed by self-assembly. Scanning tunneling...

A compatible exon-exon junction database for the identification of exon skipping events using tandem mass spectrum data (2008)

Mo Fan, Hong Xu, Gao Feng, Du Lin, Wang Jun, Omenn Gilbert, ...

Abstract Background Alternative splicing is an important gene regulation mechanism. It is estimated that about 74% of multi-exon human genes have alternative splicing. High throughput tandem (MS/MS)...

Star-shaped oligo(p-phenylenevinylene) substituted hexaarylbenzene: Purity, stability, and chiral self-assembly (2007)

Van Dongen, Joost, George, Subi J, Xu, Hong, Pisula, Wojciech, Leclere, Philippe, ...

An oligo(p-phenylenevinylene) (OPV)-substituted hexaarylbenzene has been synthesized and fully characterized. Recycling gel permeation chromatography appeared to be a powerful technique to obtain the...

Best-Effort Bandwidth Reservation in High Speed LANs using Wormhole Routing (2007)

Bruce Kwan, Po-chi Hu, Nicholas Bambos, Leonard Kleinrock, Hong Xu, ...

Current quality of service schemes require switching nodes to identify and manipulate packets within large switch buffers. These methods are effective for networks with switching nodes that contain...

Best-Effort Bandwidth Reservation in High Speed LANs using Wormhole Routing (2007)

Using Wormhole Routing, Bruce Kwan, Po-Chi Hu, Nicholas Bambos, Leonard Kleinrock, Hong Xu, ...

Current quality of service schemes require switching nodes to identify and manipulate packets within large switch buffers. These methods are effective for networks with switching nodes that contain...

Developing daily precipitation scenarios for climate change impact studies in the Guadiana and the Tejo basins (2007)

Xu, Hong, Corte-Real, J., Qian, Budong

Hydrological models to evaluate the impacts of climate change in the water resources sector require spatially correlated daily precipitation scenarios as model inputs. This paper presents a practical...

Developing daily precipitation scenarios for climate change impact studies in the Guadiana and the Tejo basins (2007)

Xu, Hong, Corte-Real, J., Qian, Budong

Hydrological models to evaluate the impacts of climate change in the water resources sector require spatially correlated daily precipitation scenarios as model inputs. This paper presents a practical...

Strain and age-related changes in the localization of intestinal CD161+ natural killer cells and CD8+ intraepithelial lymphocytes along the longitudinal crypt axis in inbred rats. (2005)

Xu, Hong, Imanishi, Syunsuke, Yamada, Kazuhiko, Hara, Hiroshi, Ishizuka, Satoshi

Using a cell position approach, this study indicates that the frequency of CD161+ natural killer (NK) cells in the epithelia of DA rats was greater than that of WKAH and F344 rats. We further divided...

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain (2005)

Mo, Xianming, Kowenz-Leutz, Elisabeth, Laumonnier, Yves, Xu, Hong, Leutz, Achim

The c-Myb transcription factor coordinates proliferation and differentiation of hematopoietic precursor cells. Myb has three consecutive N-terminal SANT-type repeat domains (R1, R2, R3), two of which...

SNPselector: a web tool for selecting SNPs for genetic association studies (2005)

Xu, Hong, Gregory, Simon G., Hauser, Elizabeth R., Stenger, Judith E., Pericak-Vance, Margaret A., Vance, Jeffery M., ...

Summary: Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology,...

SNPselector: a web tool for selecting SNPs for genetic association studies (2005)

Xu, Hong, Gregory, Simon G., Hauser, Elizabeth R., Stenger, Judith E., Pericak-Vance, Margaret A., Vance, Jeffery M., ...

Summary: Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology,...

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain (2005)

Mo, Xianming, Kowenz-Leutz, Elisabeth, Laumonnier, Yves, Xu, Hong, Leutz, Achim

The c-Myb transcription factor coordinates proliferation and differentiation of hematopoietic precursor cells. Myb has three consecutive N-terminal SANT-type repeat domains (R1, R2, R3), two of which...

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain (2005)

Mo, Xianming, Kowenz-Leutz, Elisabeth, Laumonnier, Yves, Xu, Hong, Leutz, Achim

The c-Myb transcription factor coordinates proliferation and differentiation of hematopoietic precursor cells. Myb has three consecutive N-terminal SANT-type repeat domains (R1, R2, R3), two of which...

BMC Bioinformatics BioMed Central (2005)

Judith E Stenger, Hong Xu, Carol Haynes, Elizabeth R Hauser, Margaret Pericak-vance, ...

Software Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser

Development of a two-stage flexible fibre biofilm reactor for treatment of food processing wastewater (2003)

Yu, Jimmy, Xu, Hong, Yao, Deli, Williams, Philip

Biofilm (or attached growth) reactors can be effectively used to treat organic wastewater from various industries such as food processing industry. They have a number of advantages including high...

Development of a two-stage flexible fibre biofilm reactor for treatment of food processing wastewater (2003)

Yu, Jimmy, Xu, Hong, Yao, Deli, Williams, Philip

Biofilm (or attached growth) reactors can be effectively used to treat organic wastewater from various industries such as food processing industry. They have a number of advantages including high...

Acknowledgments (2003)

Xu Hong, Hong Xu, My Mr, John Birchall, Ms Helen Georgiou

I hereby certify that the work embodied in this thesis is the result of original research and has not been submitted for a higher degree to any other university or institution.

Effects of Exercise and Traditional Chinese Medical Modalities on Bone Structure and Function (2003)

Xu, Hong

Bone loss often leads to osteoporosis. This is a disease characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent...

Effects of Exercise and Traditional Chinese Medical Modalities on Bone Structure and Function (2003)

Xu, Hong

Bone loss often leads to osteoporosis. This is a disease characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a...

Development of Flexible Fibre Biofilm Reactor for Treatment of Food Processing Wastewater (2003)

Yu, Jimmy, Xu, Hong, Williams, Philip

Biological treatment methods are usually effective and commonly used in the treatment of organic wastewater. However, there are a number of problems for conventional biological treatment methods in...

Development of a two-stage flexible fibre biofilm reactor for treatment of food processing wastewater (2003)

Yu, Jimmy, Xu, Hong, Yao, Deli, Williams, Philip

Biofilm (or attached growth) reactors can be effectively used to treat organic wastewater from various industries such as food processing industry. They have a number of advantages including high...

Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage (2003)

Hauser, Michael A., Li, Yi-Ju, Takeuchi, Satoshi, Walters, Robert, Noureddine, Maher, Maready, Melinda, ...

We present a multifactorial, multistep approach called genomic convergence that combines gene expression with genomic linkage analysis to identify and prioritize candidate susceptibility genes for...

Effects of Exercise and Traditional Chinese Medical Modalities on Bone Structure and Function (2003)

Xu, Hong

Bone loss often leads to osteoporosis. This is a disease characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a...

Effects of Exercise and Traditional Chinese Medical Modalities on Bone Structure and Function (2002)

Xu, Hong

Bone loss often leads to osteoporosis. This is a disease characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent...

Nonlinear Approximation and the Space BV(R²) (1999)

Albert Cohen, Ronald Devore, Pencho Petrushev, Hong Xu

. Given a function f 2 L 2 (Q), Q := [0; 1) 2 and a real number t ? 0, let U(f; t) := inf g2BV(Q) kf \Gamma gk 2 L 2 (I) + t VQ (g); where the infimum is taken over all functions g 2 BV of bounded...

Optimal Software Multicast in Wormhole-Routed Multistage Networks (1997)

Hong Xu, Ya-Dong Gui, Lionel Ni

Multistage interconnection networks are a popular class of interconnection architecture for constructing scalable parallel computers (SPCs). The focus of this paper is on wormhole routed multistage...

Optimal Software Multicast in Wormhole-Routed Multistage Networks (1997)

Hong Xu, Ya-Dong Gui, Lionel M. Ni

Multistage interconnection networks are a popular class of interconnection architecture for constructing scalable parallel computers (SPCs). The focus of this paper is on the multistage network...

Transferable belief Model for Decision Making in the Valuation-Based Systems (1995)

Hong Xu, Yen-teh Hsia, Philippe Smets

In this paper, we present a decision support system which is based on the transferable belief model(TBM), a model that quantifies someone's degree of belief using belief functions. The system...

Generating Explanations for Evidential Reasoning (1995)

Hong Xu, Philippe Smets

In this paper, we present two methods to provide explanations for reasoning with belief functions in the valuation-based systems. One approach, inspired by Strat's method, is based on...

Improving PVM Performance Using ATOMIC User-Level Protocol (1995)

Hong Xu, Tom W. Fisher

Parallel virtual machine (PVM) software system provides a programming environment that allows a collection of networked workstations to appear as a single concurrent computational resource. The...

Reasoning in Evidential Networks with Conditional Belief Functions (1994)

Hong Xu, Philippe Smets, Service D'automatique

In the existing evidential networks applicable to belief functions, the relations among the variables are always represented by joint belief functions on the product space of the involved variables....

Evidential Reasoning with Conditional Belief Functions (1994)

Hong Xu Philippe, Hong Xu

In the existing evidential networks with belief functions, the relations among the variables are always represented by joint belief functions on the product space of the involved variables. In this...

Some Strategies for Explanations in Evidential Reasoning (1994)

Hong Xu, Philippe Smets

We present two methods to provide explanations for reasoning with belief functions. One approach, inspired by Strat's method, is based on sensitivity analysis, but its computation is simpler...

Optimizing Data Decomposition for Data Parallel Programs (1994)

Hong Xu, Lionel M. Ni

A critical issue in achieving the performance of data parallel programs is how to efficiently decompose data across processors. On distributed-memory machines, a good data decomposition should...

Optimizing Data Alignment for Data Parallel Programs (1994)

Hong Xu, Lionel M. Ni

Data decomposition across processors is critical to the performance of data parallel programs on distributedmemory machines. The data decomposition problem involves data alignment and data...

Issues in Scalable Library Design for Massively Parallel Computers (1993)

Lionel Ni, Lionel M. Ni, Hong Xu, Hong Xu, Edgar T. Kalns, Edgar T. Kalns

Providing a rich set of libraries offers many advantages in the programming of massively parallel computers (MPCs). This paper examines some critical issues raised in the design of libraries for...

Evaluation of Data Distribution Patterns in Distributed-Memory Machines (1993)

Edgar Kalns, Edgar T. Kalns, Hong Xu, Hong Xu, Lionel M. Ni, Lionel M. Ni

Determining an appropriate data distribution among different memories is critical to the performance of data-parallel programs on distributed-memory machines. By analyzing the computational load of...

Evaluation of Data Distribution Patterns in Distributed-Memory Machines (1993)

Edgar Kalns, Hong Xu, Lionel M. Ni

Determining an appropriate data distribution among different memories is critical to the performance of data-parallel programs on distributedmemory machines. By analyzing the computational load of...

Unicast-Based Multicast Communication in Wormhole-Routed Networks (1993)

Philip K. Mckinley, Philip K. Mckinley, Hong Xu, Hong Xu, Abdol-hossein Esfahanian, Abdol-hossein Esfahanian, ...

Multicast communication, in which the same message is delivered from a source node to an arbitrary number of destination nodes, is being increasingly demanded in parallel computing. System supported...

ComPaSS: Efficient Communication Services for Scalable Architectures (1992)

Philip Mckinley, Hong Xu, Edgar T. Kalns, Lionel M. Ni

In massively parallel computers (MPCs), efficient communication among processors is critical to performance. This paper describes the initial implementation of the ComPaSS communication library to...

Efficient Implementation of Barrier Synchronization in Wormhole-Routed Hypercube Multicomputers (1992)

Hong Xu, Philip K. Mckinley, Lionel M. Ni

This paper addresses efficient implementation of barrier synchronization in wormhole-routed hypercube multicomputers. For those systems supporting only unicast communication in hardware, a novel...

A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen

Xu, Hong, Lee, Seung-Jae, Suzuki, Emiko, Dugan, Katherine D, Stoddard, Alexander, Li, Hong-Sheng, ...

The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted a...

Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization

Xu, Hong, Yan, Jun, Huang, Yiming, Chilton, Paula M., Ding, Chuanlin, Schanie, Carrie L., ...

Sensitization is a critical unresolved challenge in transplantation. We show for the first time that blockade of CD154 alone or combined with T-cell depletion prevents sensitization. Allogeneic skin...

Nonlinear Approximation and the Space

Albert Cohen, Ronald Devore, Pencho Petrushev, Hong Xu

. Given a function f 2 L 2 (Q), Q := [0; 1) 2 and a real number t ? 0, let U(f; t) := inf g2BV(Q) kf \Gamma gk 2 L 2 (I) + t VQ (g); where the infimum is taken over all functions g 2 BV of bounded...

The Synthetic Genetic Network around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Saccharomyces cerevisiae▿

Krause, Sue A., Xu, Hong, Gray, Joseph V.

Budding yeast Saccharomyces cerevisiae contains one protein kinase C (PKC) isozyme encoded by the essential gene PKC1. Pkc1 is activated by the small GTPase Rho1 and plays a central role in the cell...

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

Guo, Guang-Hua, Chen, Su-Zuan, Yu, Jing, Zhang, Juan, Luo, Li-Li, Xie, Li-Hua, ...

AIM: To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells (DC) and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 (EC109).

Molecular mechanism for the umami taste synergism

Zhang, Feng, Klebansky, Boris, Fine, Richard M., Xu, Hong, Pronin, Alexey, Liu, Haitian, ...

Umami is one of the 5 basic taste qualities. The umami taste of L-glutamate can be drastically enhanced by 5′ ribonucleotides and the synergy is a hallmark of this taste quality. The umami taste...

Human DNA polymerase β polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity

Guo, Zhigang, Zheng, Li, Dai, Huifang, Zhou, Mian, Xu, Hong, Shen, Binghui

DNA polymerase β (Pol β) is a key enzyme in DNA base excision repair, and an important factor for maintaining genome integrity and stability. More than 30% of human tumors characterized to date...

Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function : Are They a Component of Diabetes Pathogenesis?

Huang, Yiming, Fugier-Vivier, Isabelle J., Miller, Thomas, Elliott, Mary J., Xu, Hong, Bozulic, Larry D., ...

OBJECTIVE—Plasmacytoid precursor dendritic cell facilitating cells (p-preDC FCs) play a critical role in facilitation of syngeneic and allogeneic hematopoietic stem cell (HSC) engraftment. Here, we...

Moderated Online Communities and User-Generated Content

Jianqing Chen, Hong Xu, Andrew B. Whinston

Online communities provide a social sphere for people to share information and knowledge. While information sharing is becoming a ubiquitous online phenomenon, how to ensure information quality or...

Proteomics, pathway array and signaling network-based medicine in cancer

Zhang, David Y, Ye, Fei, Gao, Ling, Liu, Xiaoliang, Zhao, Xin, Che, Yufang, ...

Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the...