Semi-supervised protein subcellular localization (2009)
Xu, Qian, Hu, Derek, Xue, Hong, Yu, Weichuan, Yang, Qiang
Abstract Background Protein subcellular localization is concerned with predicting the location of a protein within a cell using computational method. The location information can indicate key...
Wan, Xiang, Yang, Can, Yang, Qiang, Xue, Hong, Tang, Nelson LS, Yu, Weichuan
Abstract Background The interactions of multiple single nucleotide polymorphisms (SNPs) are highly hypothesized to affect an individual's susceptibility to complex diseases. Although many works have...
Yang, Can, He, Zengyou, Wan, Xiang, Yang, Qiang, Xue, Hong, Yu, Weichuan
Motivation: Hundreds of thousands of single nucleotide polymorphisms (SNPs) are available for genome-wide association (GWA) studies nowadays. The epistatic interactions of SNPs are believed to be...
The Seventh Asia Pacific Bioinformatics Conference (APBC 2009) (2009)
Bmc Bioinformatics, Qian Xu, Derek Hao Hu, Hong Xue, Weichuan Yu, Qiang Yang, ...
endoplasmic reticulum, cell nucleus and Golgi apparatus. These compartments play different roles, for instance, mitochondria supply chemical energy ATP for cell survive; chloroplasts transform light...
BMC Bioinformatics BioMed Central Methodology article (2009)
Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Nelson Ls Tang, Weichuan Yu
MegaSNPHunter: a learning approach to detect disease predisposition SNPs and high level interactions in genome wide association study
Guo, Li-Tao, Chen, Xiang-Long, Zhao, Bo-Tao, Shi, Yi, Li, Wei, Xue, Hong, ...
For most aminoacyl-tRNA synthetases (aaRS), their cognate tRNA is not obligatory to catalyze amino acid activation, with the exception of four class I (aaRS): arginyl-tRNA synthetase, glutamyl-tRNA...
The Evolution of GABAA Receptor-Like Genes (2007)
Tsang, Shui-Ying, Ng, Siu-Kin, Xu, Zhiwen, Xue, Hong
The inhibitory ligand-gated ion channel family of receptors, including the type A γ-aminobutryic acid (GABAA) and glycine receptors, mediates inhibitory neurotransmissions in the central nervous...
Li, Wenming, Pi, Rongbiao, Chan, Hugh H. N., Fu, Hongjun, Lee, Nelson T. K., Tsang, Hing Wai, ...
The neuroprotective properties of bis(7)-tacrine, a novel dimeric acetylcholinesterase (AChE) inhibitor, on glutamate-induced excitotoxicity were investigated in primary cultured cerebellar granule...
Between the Hammer and the Block: China’s Intellectual Property Rights in the Network Age (2005)
Abstract : Since China adopted the policy of economic openness and reform in the late 1970s, developed countries have imposed tremendous pressure on Chinese intellectual property issues in order to...
Xu, Zhiwen, Fang, Shisong, Shi, Haifeng, Li, Hoiming, Deng, Yiqun, Liao, Yinglei, ...
Structural investigation of GABAA receptors has been limited by difficulties imposed by its trans-membrane-complex nature. In the present study, the topology of a membrane-proximal β-rich (MPB)...
The present invention is concerned with new, previously unsuggested, therapeutic uses of dl-THP (dl-tetrahydropalmatine) including anxiety disorders, seizures,and status epilepticus.
Shi, Haifeng, Tsang, Shui Ying, Tse, Man Kit, Xu, Zhiwen, Xue, Hong
The three most widely expressed subunits of the GABAA receptor are α1, β2, and γ2 subunits, and the major isoform in the human brain is a pentameric receptor composed of 2α12β21γ2. Previously,...
Topological structure analysis of the protein-protein interaction network in budding yeast (2003)
Bu, Dongbo, Zhao, Yi, Cai, Lun, Xue, Hong, Zhu, Xiaopeng, Lu, Hongchao, ...
Interaction detection methods have led to the discovery of thousands of interactions between proteins, and discerning relevance within large‐scale data sets is important to present‐day...
Wang, Ganggang, Guo, Rong, Bartlam, Mark, Yang, Haitao, Xue, Hong, Liu, Yiwei, ...
The Sac10b family consists of a group of highly conserved DNA binding proteins from both the euryarchaeotal and the crenarchaeotal branches of Archaea. The proteins have been suggested to play an...
Shi, Haifeng, Tsang, Shui Ying, Zheng, Hui, Sturgis, James N., Xue, Hong
The type A γ-aminobutyric acid (GABAA) receptor is a major inhibitory neurotransmitter-gated ion channel. Previously, we identified a membrane-proximal β-rich (MPBR) domain in fragment C166-L296 of...
An interactive pagoda broadcasting protocol for video-on-demand / (2000)
Thesis (M.S.)--University of Houston, 2000.
GABAagent: a system for integrating data on GABA receptors (2000)
Rachedi, Abdelkrim, Rebhan, Michael, Xue, Hong
Motivation: Scientific data pertaining to GABA receptors, which are of medical importance, are widely scattered throughout numerous heterogeneous Internet resources. This situation has made the...
Modified nucleotides in Bacillus subtilis tRNATrp hyperexpressed in Escherichia coli (1993)
Xue, Hong, Glasser, Anne-Lise, Desgres, Jean, Grosjean, Henri
In the present study, modified nucleotides in the B.subtilis tRNATrp cloned and hyperexpressed In E.coll have been identified by TLC and HPLC analyses. The modification patterns of the two...
Xue, Hong, Guo, Rong, Wen, Yunfei, Liu, Danxu, Huang, Li
The DNA binding protein Ssh10b, a member of the Sac10b family, has been purified from the hyperthermophilic archaeon Sulfolobus shibatae. Ssh10b constitutes about 4% of the cellular protein....
Topological structure analysis of the protein–protein interaction network in budding yeast
Bu, Dongbo, Zhao, Yi, Cai, Lun, Xue, Hong, Zhu, Xiaopeng, Lu, Hongchao, ...
Interaction detection methods have led to the discovery of thousands of interactions between proteins, and discerning relevance within large-scale data sets is important to present-day biology. Here,...
Xue, Hong, Guo, Rong, Wen, Yunfei, Liu, Danxu, Huang, Li
The DNA binding protein Ssh10b, a member of the Sac10b family, has been purified from the hyperthermophilic archaeon Sulfolobus shibatae. Ssh10b constitutes about 4% of the cellular protein....
Topological structure analysis of the protein–protein interaction network in budding yeast
Bu, Dongbo, Zhao, Yi, Cai, Lun, Xue, Hong, Zhu, Xiaopeng, Lu, Hongchao, ...
Interaction detection methods have led to the discovery of thousands of interactions between proteins, and discerning relevance within large-scale data sets is important to present-day biology. Here,...
Positive Selection within the Schizophrenia-Associated GABAA Receptor β2 Gene
Lo, Wing-Sze, Xu, Zhiwen, Yu, Zhiliang, Pun, Frank W., Ng, Siu-Kin, Chen, Jianhuan, ...
The gamma-aminobutyric acid type-A (GABAA) receptor plays a major role in inhibitory neurotransmissions. Intronic SNPs and haplotypes in GABRB2, the gene for GABAA receptor β2 subunit, are...
Guo, Li-Tao, Chen, Xiang-Long, Zhao, Bo-Tao, Shi, Yi, Li, Wei, Xue, Hong, ...
For most aminoacyl-tRNA synthetases (aaRS), their cognate tRNA is not obligatory to catalyze amino acid activation, with the exception of four class I (aaRS): arginyl-tRNA synthetase, glutamyl-tRNA...
Topology characterization of a benzodiazepine-binding β-rich domain of the GABAA receptor α1 subunit
Xu, Zhiwen, Fang, Shisong, Shi, Haifeng, Li, Hoiming, Deng, Yiqun, Liao, Yinglei, ...
Structural investigation of GABAA receptors has been limited by difficulties imposed by its trans-membrane-complex nature. In the present study, the topology of a membrane-proximal β-rich (MPB)...
Shi, Haifeng, Tsang, Shui Ying, Tse, Man Kit, Xu, Zhiwen, Xue, Hong
The three most widely expressed subunits of the GABAA receptor are α1, β2, and γ2 subunits, and the major isoform in the human brain is a pentameric receptor composed of 2α12β21γ2. Previously,...
Wang, Ganggang, Guo, Rong, Bartlam, Mark, Yang, Haitao, Xue, Hong, Liu, Yiwei, ...
The Sac10b family consists of a group of highly conserved DNA binding proteins from both the euryarchaeotal and the crenarchaeotal branches of Archaea. The proteins have been suggested to play an...
Shi, Haifeng, Tsang, Shui Ying, Zheng, Hui, Sturgis, James N., Xue, Hong
The type A γ-aminobutyric acid (GABAA) receptor is a major inhibitory neurotransmitter-gated ion channel. Previously, we identified a membrane-proximal β-rich (MPBR) domain in fragment C166-L296 of...
Rasmussen, Susanne, Parsons, Anthony J., Fraser, Karl, Xue, Hong, Newman, Jonathan A.
Lolium perenne cultivars differing in their capacity to accumulate water soluble carbohydrates (WSCs) were infected with three strains of fungal Neotyphodium lolii endophytes or left uninfected. The...
Semi-supervised protein subcellular localization
Xu, Qian, Hu, Derek Hao, Xue, Hong, Yu, Weichuan, Yang, Qiang
Nutrition Knowledge, Sensory Characteristics and Consumersâ Willingness to Pay for Pasture-Fed Beef
Xue, Hong, Mainville, Denise, You, Wen, Nayga, Rodolfo M. Jr.
Nutritional value is an important attribute of foods whose benefits can only be experienced by repetitive consumption in long run. Consumersâ knowledge about the importance and usefulness of...
Plant-endophyte-herbivore interactions: More than just alkaloids?
Rasmussen, Susanne, Parsons, Anthony J, Popay, Alison, Xue, Hong, Newman, Jonathan A
A recent paper by Rasmussen et al., (New Phytol 2007; 173:787–97) describes the interactions between Lolium perenne cultivars with contrasting carbohydrate content and the symbiotic fungal...