Hong Zheng

SHP-2 tyrosine phosphatase in human diseases. (2009)

Zheng, Hong, Alter, Shawn, Qu, Cheng-Kui

SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be...

3′,6′-Bis(diethylamino)-2-phenylspiro[isoindoline-1,9′-xanthen]-3-one (2009)

Wu-Jian Deng, Di Sun, Bing-Yuan Su, Shu-Ping Wang, Hong Zheng

The title compound, C34H35O2N3, was synthesized by the reaction of 2-[3,6-bis(diethylamino)-9H-xanthen-9-yl]benzoyl chloride with aniline. In the molecular structure, the dihedral angles between the...

Effect of Prosodic Structure on Segmental Variants (2008)

Yiqing Zu, Hong Zheng

There is a large amount of segmental variants in a natural speech corpus. It is very important to label those variants correctly for a corpus based TTS system. We successfully applied automatic...

Evaluating Regional Contra-Flow and Phased Evacuation Strategies for Texas Using a Large-Scale Dynamic Traffic Simulation and Assignment Approach (2008)

Chiu, Yi-Chang, Zheng, Hong, Villalobos, Jorge A, Peacock, Walter, Henk, Russell

After Hurricane Rita, the need for systematic and quantitative assessments of evacuation planning and operations strategies was recognized. Both contra-flow operation and phased evacuation were put...

Evaluating Regional Contra-Flow and Phased Evacuation Strategies for Texas Using a Large-Scale Dynamic Traffic Simulation and Assignment Approach (2008)

Chiu, Yi-Chang, Zheng, Hong, Villalobos, Jorge A, Peacock, Walter, Henk, Russell

After Hurricane Rita, the need for systematic and quantitative assessments of evacuation planning and operations strategies was recognized. Both contra-flow operation and phased evacuation were put...

Evaluating Regional Contra-Flow and Phased Evacuation Strategies for Texas Using a Large-Scale Dynamic Traffic Simulation and Assignment Approach (2008)

Chiu, Yi-Chang, Zheng, Hong, Villalobos, Jorge A, Peacock, Walter, Henk, Russell

After Hurricane Rita, the need for systematic and quantitative assessments of evacuation planning and operations strategies was recognized. Both contra-flow operation and phased evacuation were put...

Evaluating Regional Contra-Flow and Phased Evacuation Strategies for Texas Using a Large-Scale Dynamic Traffic Simulation and Assignment Approach (2008)

Chiu, Yi-Chang, Zheng, Hong, Villalobos, Jorge A, Peacock, Walter, Henk, Russell

After Hurricane Rita, the need for systematic and quantitative assessments of evacuation planning and operations strategies was recognized. Both contra-flow operation and phased evacuation were put...

Image Matching using TI Multi-Wavelet Transform (2008)

Asim Bhatti, Saeid Nahav, Hong Zheng

Abstract. A multi-resolution image matching technique based on multiwavelets followed by a coarse to fine strategy is presented. The technique addresses the estimation of optimal corresponding points...

Disparity Estimation Using TI Multi-Wavelet Transform (2008)

Asim Bhatti, Saeid Nahavandi, Hong Zheng

A multi-resolution image matching technique based on translation invariant discrete multi-wavelet transform followed by a coarse to fine matching strategy is presented. The technique addresses the...

Nucleocapsid Amino Acids 211 to 254, in Particular, Tetrad Glutamines, are Essential for the Interaction Between the Nucleocapsid and Membrane Proteins of SARS-Associated Coronavirus (2008)

Fang, Xiaonan, Ye, Lin-Bai, Zhang, Yijuan, Li, Baozong, Li, Shanshan, Kong, Lingbao, ...

GST pull-down assays were used to characterize the SARS-CoV membrane (M) and nucleocapsid (N) interaction, and it was found that the amino acids 211-254 of N protein were essential for this...

Three Dimensional Simulation of Viscoelastic Polymer Melts Flow in a Cast Film Process (2008)

Zheng, Hong, Yu, Wei, Zhou, Chixing, Zhang, Hongbin

Three-dimensional simulation of the cast film process for viscoelastic polymer materials was carried out using the finite element method. The flow between the extrusion die and chill roll was assumed...

Modeling Non-Repudiation in Distributed Systems (2008)

Hong Zheng, Yu Yue Du, Yu ShuXia

As an important security service in distributed systems, non-repudiation is required to implement evidence generating or validating in the application layer. Formal methods are powerful tools to...

Analysis and Verification of Dynamic Stock Trading Systems (2008)

Yuyue Du, Hong Zheng, Shuxia Yu

A dynamic stock trading system with a distributed shared memory is analyzed formally based on its temporal Petri net model. The functional correctness of the system is formally verified and some...

3′,6′-Bis(diethylamino)-3H-spiro[2-benzothiophene-1,9′-xanthene]-3-thione (2008)

Bing-Yuan Su, Xin-Qi Zhan, Jian-Nan Guo, Yue-Feng Zhou, Hong Zheng

The title compound, C28H30N2OS2, was obtained by thionation of 3′,6′-bis(diethylamino)-3H-spiro[isobenzofuran-1,9′-xanthene]-3-one with...

Pro-oxidant effect of transforming growth factor- 1 mediates contractile dysfunction in rat ventricular myocytes (2008)

Li, Shumin, Li, Xun, Zheng, Hong, Xie, Bin, Bidasee, Keshore R., Rozanski, George J.

Aims Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact...

Pro-oxidant Effect of Transforming Growth Factor-{beta}1 Mediates Contractile Dysfunction in Rat Ventricular Myocytes (2007)

Li, Shumin, Li, Xun, Zheng, Hong, Xie, Bin, Bidasee, Keshore R., Rozanski, George J.

Aims Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact...

Pro-oxidant effect of transforming growth factor-{beta}1 mediates contractile dysfunction in rat ventricular myocytes (2007)

Li, Shumin, Li, Xun, Zheng, Hong, Xie, Bin, Bidasee, Keshore R., Rozanski, George J.

Aims Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact...

CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine (2006)

Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...

Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...

Thermal Decomposition of Li(NTO)·2H2O and Na(NTO)·H2O (NTO = Anion of 3-Nitro-1,2,4-triazol-5-one): Kinetics Derived from T-jump/FTIR Spectroscopy (2006)

Sun, Yuanhua, Zhang, Tonglai, Zhang, Jianguo, Qiao, Xiaojing, Yang, Li, Zheng, Hong

A "snapshot" simulation of the surface reaction zone is captured by a thin film of material heated rapidly to temperatures characteristic of the burning surface by using the T-jump/FTIR spectroscopy....

Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits (2006)

Li, Yu-Long, Xia, Xiao-Hong, Zheng, Hong, Gao, Lie, Li, Yi-Fan, Liu, Dongmei, ...

Objectives We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF). Methods We measured renal...

Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation (2004)

Sussman, Steve, McCuller, William J, Zheng, Hong, Pfingston, Yvonne M, Miyano, James, Dent, Clyde W

Abstract This paper presents the Project EX research program. The historical background for Project EX is presented, including a brief summary of reasons youth fail to quit tobacco use, the...

Blind separation of cyclostationary signals from instantaneous mixtures (2004)

Xiang, Yong, Yu, Wensheng, Zheng, Hong, Nahavandi, Saeid

This paper presents a new approach for blind separation of unknown cyclostationary signals from instantaneous mixtures. The proposed method can perfectly separate the mixed source signals so long as...

Blind separation of cyclostationary signals from instantaneous mixtures (2004)

Xiang, Yong, Yu, Wensheng, Zheng, Hong, Nahavandi, Saeid

This paper presents a new approach for blind separation of unknown cyclostationary signals from instantaneous mixtures. The proposed method can perfectly separate the mixed source signals so long as...

Learning to detect texture objects by artificial immune approaches (2004)

Zheng, Hong, Zhang, Jingxin, Nahavandi, Saeid

This paper introduces a novel method to detect texture objects from satellite images. First, a hierarchical strategy is developed to extract texture objects according to their roughness. Then, an...

Learning to detect texture objects by artificial immune approaches (2004)

Zheng, Hong, Zhang, Jingxin, Nahavandi, Saeid

This paper introduces a novel method to detect texture objects from satellite images. First, a hierarchical strategy is developed to extract texture objects according to their roughness. Then, an...

Machine vision system for automatic inspection of surface defects in aluminium die casting (2004)

Frayman, Yakov, Zheng, Hong, Nahavandi, Saeid

A machine vision system is presented for the automatic inspection of surface defects in aluminium die casting. The system uses a hybrid image processing algorithm based on mathematic morphology to...

Blind separation of cyclostationary signals from instantaneous mixtures (2004)

Xiang, Yong, Yu, Wensheng, Zheng, Hong, Nahavandi, Saeid

This paper presents a new approach for blind separation of unknown cyclostationary signals from instantaneous mixtures. The proposed method can perfectly separate the mixed source signals so long as...

Machine vision system for automatic inspection of surface defects in aluminium die casting (2004)

Frayman, Yakov, Zheng, Hong, Nahavandi, Saeid

A machine vision system is presented for the automatic inspection of surface defects in aluminium die casting. The system uses a hybrid image processing algorithm based on mathematic morphology to...

Learning to detect texture objects by artificial immune approaches (2004)

Zheng, Hong, Zhang, Jingxin, Nahavandi, Saeid

This paper introduces a novel method to detect texture objects from satellite images. First, a hierarchical strategy is developed to extract texture objects according to their roughness. Then, an...

Heat shock proteins in dendritic cell activation and antigen cross-presentation (2003)

Zheng, Hong

Heat shock proteins (HSPs) have been observed on surface of a variety of cells, and their levels are up-regulated under conditions of stress. However, the immunological consequences of surface HSP...

Image matching using TI multi-wavelet transform (2003)

Bhatti, Asim, Nahavandi, Saeid, Zheng, Hong

A multi-resolution image matching technique based on multiwavelets followed by a coarse to fine strategy is presented. The technique addresses the estimation of optimal corresponding points and the...

Image matching using TI multi-wavelet transform (2003)

Bhatti, Asim, Nahavandi, Saeid, Zheng, Hong

A multi-resolution image matching technique based on multiwavelets followed by a coarse to fine strategy is presented. The technique addresses the estimation of optimal corresponding points and the...

Research on seismic signals for vehicle targets and recognition by data fusion (2003)

Lan, Jinhui, Nahavandi, Saeid, Zhang, Jingxin, Zheng, Hong, Lan, Tian

This paper researches seismic signals of typical vehicle targets in order to extract features and to recognize vehicle targets. As a data fusion method, the technique of artificial neural networks...

Research on seismic signals for vehicle targets and recognition by data fusion (2003)

Lan, Jinhui, Nahavandi, Saeid, Zhang, Jingxin, Zheng, Hong, Lan, Tian

This paper researches seismic signals of typical vehicle targets in order to extract features and to recognize vehicle targets. As a data fusion method, the technique of artificial neural networks...

Application of rough set and Kohonen network to feature selection for object extraction (2003)

Pan, Li, Zheng, Hong, Nahavandi, Saeid

Selecting a set of features which is optimal for a given task is a problem which plays an important role in a wide variety of contexts including pattern recognition, images understanding and machine...

Application of rough set and Kohonen network to feature selection for object extraction (2003)

Pan, Li, Zheng, Hong, Nahavandi, Saeid

Selecting a set of features which is optimal for a given task is a problem which plays an important role in a wide variety of contexts including pattern recognition, images understanding and machine...

Application of ant colony systems to image texture classification (2003)

Zheng, Hong, Zheng, Zheng, Xiang, Yiang

This paper presents a novel ant system based optimisation method which integrates genetic algorithms and simplex algorithms. This method is able to not only speed up the search process for solutions,...

Image Matching using TI Multi-Wavelet Transform (2003)

Asim Bhatti, Saeid Nahavandi, Hong Zheng

A multi-resolution image matching technique based on multiwavelets followed by a coarse to fine strategy is presented. The technique addresses the estimation of optimal corresponding points and the...

Disparity estimation using TI multi-wavelet transform (2003)

Bhatti, Asim, Nahavandi, Saeid, Zheng, Hong

A multi-resolution image matching technique based on translation invariant discrete multi-wavelet transform followed by a coarse to fine matching strategy is presented. The technique addresses the...

The transcription factor Net regulates the angiogenic switch (2003)

Zheng, Hong, Wasylyk, Christine, Ayadi, Abdelkader, Abecassis, Joseph, Schalken, Jack A, Rogatsch, Hermann, ...

Angiogenesis is fundamental to physiological and pathological processes. Despite intensive efforts, little is known about the intracellular circuits that regulate angiogenesis. The transcription...

The application of ant colony systems to image texture classification (2003)

Zheng, Hong, Zheng, Zheng, Xiang, Yiang

This paper presents a novel ant system based optimisation method which integrates genetic algorithms and simplex algorithms. This method is able to not only speed up the search process for solutions,...

Image matching using TI multi-wavelet transform (2003)

Bhatti, Asim, Nahavandi, Saeid, Zheng, Hong

A multi-resolution image matching technique based on multiwavelets followed by a coarse to fine strategy is presented. The technique addresses the estimation of optimal corresponding points and the...

Research on seismic signals for vehicle targets and recognition by data fusion (2003)

Lan, Jinhui, Nahavandi, Saeid, Zhang, Jingxin, Zheng, Hong, Lan, Tian

This paper researches seismic signals of typical vehicle targets in order to extract features and to recognize vehicle targets. As a data fusion method, the technique of artificial neural networks...

Disparity estimation using TI multi-wavelet transform (2003)

Bhatti, Asim, Nahavandi, Saeid, Zheng, Hong

A multi-resolution image matching technique based on translation invariant discrete multi-wavelet transform followed by a coarse to fine matching strategy is presented. The technique addresses the...

The application of rough set and Kohonen network to feature selection for object extraction (2003)

Pan, Li, Zheng, Hong, Nahavandi, Saeid

Selecting a set of features which is optimal for a given task is a problem which plays an important role in a wide variety of contexts including pattern recognition, images understanding and machine...

Synthesis and Stoichiometry of MgB2 (2002)

Hinks, D. G., Jorgensen, J. D., Zheng, Hong, Short, S.

The system MgxB2 has been investigated to investigate possible nonstoichiometry in MgB2. When synthesized at 850oC, MgB2 is a line compound with a possible Mg vacancy content of about 1%. Small...

Automatic inspection of metallic surface defects using genetic algorithms (2002)

Zheng, Hong, Kong, Lingxue, Nahavandi, Saeid

This paper is concerned with the problem of automatic inspection of metallic surface using machine vision. An experimental system has been developed to take images of external metallic surfaces and...

Automatic inspection of metallic surface defects using genetic algorithms (2002)

Zheng, Hong, Kong, Lingxue, Nahavandi, Saeid

This paper is concerned with the problem of automatic inspection of metallic surface using machine vision. An experimental system has been developed to take images of external metallic surfaces and...

Effect of Prosodic Structure on Segmental Variants (2002)

Yiqing Zu Hong, Hong Zheng

There is a large amount of segmental variants in a natural speech corpus. It is very important to label those variants correctly for a corpus based TTS system. We successfully applied automatic...

Object extraction using genetic algorithms and morphological processing (2002)

Zheng, Hong, Pan, Li, Nahavandi, Saeid

This paper introduces a novel methodology for object detection using genetic algorithms and morphological processing. The method employs a kind of object oriented structuring element, which are...

Automatic inspection of metallic surface defects using genetic algorithms (2002)

Zheng, Hong, Kong, Lingxue, Nahavandi, Saeid

This paper is concerned with the problem of automatic inspection of metallic surface using machine vision. An experimental system has been developed to take images of external metallic surfaces and...

Object extraction using genetic algorithms and morphological processing (2002)

Zheng, Hong, Pan, Li, Nahavandi, Saeid

This paper introduces a novel methodology for object detection using genetic algorithms and morphological processing. The method employs a kind of object oriented structuring element, which are...

Magnetoconductivity due to Quantum Interference in Strongly Underdoped YBa_2Cu_3O_x (2001)

Cimpoiasu, E., Levin, G. A., Almasan, C. C., Zheng, Hong, Veal, B. W.

We report magnetoconductivity measurements on YBa_2Cu_3O_x (x=6.25 and 6.36) single crystals. Our main result is that both the in-plane Delta_sigma_ab and out-of-plane Delta_sigma_c...

Relationship Between Conductivity and Phase Coherence Length in Cuprates (1999)

Almasan, C. C., Levin, G. A., Cimpoiasu, E., Stein, T., Zhang, C. L., Deandrade, M. C., ...

The large ($10^2 - 10^5$) and strongly temperature dependent resistive anisotropy $\eta = (\sigma_{ab}/\sigma_c)^{1/2}$ of cuprates perhaps holds the key to understanding their normal state in-plane...

Induction of Cytotoxic Oxidative Stress by d-Alanine in Brain Tumor Cells Expressing Rhodotorula gracilis d-Amino Acid Oxidase: A Cancer Gene Therapy Strategy (1998)

Stegman, Lauren D., Zheng, Hong, Neal, Eric R., Ben-Yoseph, Oded, Pollegioni, Loredano, Pilone, Mirella S., ...

Overview summary Gene-directed enzyme prodrug therapy (GDEPT) is an antineoplastic treatment strategy designed to overcome the systemic toxicity of chemotherapy by specifically expressing a foreign...

Construction of Human Factor IX Expression Vectors in Retroviral Vector Frames Optimized for Muscle Cells (1996)

Wang, Jian-Min, Zheng, Hong, Sugahara, Yuichi, Tan, Jun, Yao, Shou-Nan, Olson, Eric, ...

Overview summary Skeletal muscle cells may serve as an efficient medium for systemic production of transgene products in a gene therapy. Retroviral vector constructs were prepared using human factor...

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1

Ayadi, Abdelkader, Zheng, Hong, Sobieszczuk, Peter, Buchwalter, Gilles, Moerman, Philippe, Alitalo, Kari, ...

The ternary complex factors (TCFs) Net, Elk-1 and Sap-1 regulate immediate early genes through serum response elements (SREs) in vitro, but, surprisingly, their in vivo roles are unknown. Net is a...

The transcription factor Net regulates the angiogenic switch

Zheng, Hong, Wasylyk, Christine, Ayadi, Abdelkader, Abecassis, Joseph, Schalken, Jack A, Rogatsch, Hermann, ...

Angiogenesis is fundamental to physiological and pathological processes. Despite intensive efforts, little is known about the intracellular circuits that regulate angiogenesis. The transcription...

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

Sengupta, Sagar, Vonesch, Jean-Luc, Waltzinger, Caroline, Zheng, Hong, Wasylyk, Bohdan

The tumour suppressor p53 and the glucocorticoid receptor (GR) respond to different types of stress. We found that dexamethasone-activated endogenous and exogenous GR inhibit p53-dependent functions,...

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

Liu, Bei, Dai, Jie, Zheng, Hong, Stoilova, Diliana, Sun, Shaoli, Li, Zihai

Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Without tissue distress or death, these intracellular molecules are inaccessible to surface receptor(s) on...

The Forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-β guidance factor in C. elegans

Nash, Bruce, Colavita, Antonio, Zheng, Hong, Roy, Peter J., Culotti, Joseph G.

Secreted proteins required for cellular movements along the circumference of the body wall in Caenorhabditis elegans include UNC-6/netrin and the novel TGF-β UNC-129. Expression of these proteins is...

The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling

Nakade, Koji, Zheng, Hong, Ganguli, Gitali, Buchwalter, Gilles, Gross, Christian, Wasylyk, Bohdan

The tumor suppressor function of p53 is linked to its ability to repress gene expression, but the mechanisms of specific gene repression are poorly understood. We report that wild-type p53 inhibits...

CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine

Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...

Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...

Identification, Cloning, Expression, and Characterization of the Gene for Plasmodium knowlesi Surface Protein Containing an Altered Thrombospondin Repeat Domain

Mahajan, Babita, Jani, Dewal, Chattopadhyay, Rana, Nagarkatti, Rana, Zheng, Hong, Majam, Victoria, ...

Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the...

Identification and Preliminary Characterization of Two cDNAs Encoding Unique Carbonic Anhydrases from the Marine Alga Emiliania huxleyi

Soto, Amelia R., Zheng, Hong, Shoemaker, Dorinda, Rodriguez, Jason, Read, Betsy A., Wahlund, Thomas M.

Marine coccolithophorid algae are thought to play a significant role in carbon cycling due to their ability to incorporate dissolved inorganic carbon (DIC) into both calcite and photosynthetic...

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1

Ayadi, Abdelkader, Zheng, Hong, Sobieszczuk, Peter, Buchwalter, Gilles, Moerman, Philippe, Alitalo, Kari, ...

The ternary complex factors (TCFs) Net, Elk-1 and Sap-1 regulate immediate early genes through serum response elements (SREs) in vitro, but, surprisingly, their in vivo roles are unknown. Net is a...

The transcription factor Net regulates the angiogenic switch

Zheng, Hong, Wasylyk, Christine, Ayadi, Abdelkader, Abecassis, Joseph, Schalken, Jack A, Rogatsch, Hermann, ...

Angiogenesis is fundamental to physiological and pathological processes. Despite intensive efforts, little is known about the intracellular circuits that regulate angiogenesis. The transcription...

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

Sengupta, Sagar, Vonesch, Jean-Luc, Waltzinger, Caroline, Zheng, Hong, Wasylyk, Bohdan

The tumour suppressor p53 and the glucocorticoid receptor (GR) respond to different types of stress. We found that dexamethasone-activated endogenous and exogenous GR inhibit p53-dependent functions,...

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

Liu, Bei, Dai, Jie, Zheng, Hong, Stoilova, Diliana, Sun, Shaoli, Li, Zihai

Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Without tissue distress or death, these intracellular molecules are inaccessible to surface receptor(s) on...

The Forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-β guidance factor in C. elegans

Nash, Bruce, Colavita, Antonio, Zheng, Hong, Roy, Peter J., Culotti, Joseph G.

Secreted proteins required for cellular movements along the circumference of the body wall in Caenorhabditis elegans include UNC-6/netrin and the novel TGF-β UNC-129. Expression of these proteins is...

The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling

Nakade, Koji, Zheng, Hong, Ganguli, Gitali, Buchwalter, Gilles, Gross, Christian, Wasylyk, Bohdan

The tumor suppressor function of p53 is linked to its ability to repress gene expression, but the mechanisms of specific gene repression are poorly understood. We report that wild-type p53 inhibits...

CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine

Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...

Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...

Identification, Cloning, Expression, and Characterization of the Gene for Plasmodium knowlesi Surface Protein Containing an Altered Thrombospondin Repeat Domain

Mahajan, Babita, Jani, Dewal, Chattopadhyay, Rana, Nagarkatti, Rana, Zheng, Hong, Majam, Victoria, ...

Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the...

Identification and Preliminary Characterization of Two cDNAs Encoding Unique Carbonic Anhydrases from the Marine Alga Emiliania huxleyi

Soto, Amelia R., Zheng, Hong, Shoemaker, Dorinda, Rodriguez, Jason, Read, Betsy A., Wahlund, Thomas M.

Marine coccolithophorid algae are thought to play a significant role in carbon cycling due to their ability to incorporate dissolved inorganic carbon (DIC) into both calcite and photosynthetic...

A Novel Chimeric Plasmodium vivax Circumsporozoite Protein Induces Biologically Functional Antibodies That Recognize both VK210 and VK247 Sporozoites▿

Yadava, Anjali, Sattabongkot, Jetsumon, Washington, Michael A., Ware, Lisa A., Majam, Victoria, Zheng, Hong, ...

A successful vaccine against Plasmodium vivax malaria would significantly improve the health and quality of the lives of more than 1 billion people around the world. A subunit vaccine is the only...

Molecular Factors and Biochemical Pathways Induced by Febrile Temperature in Intraerythrocytic Plasmodium falciparum Parasites▿ †

Oakley, Miranda S. M., Kumar, Sanjai, Anantharaman, Vivek, Zheng, Hong, Mahajan, Babita, Haynes, J. David, ...

Intermittent episodes of febrile illness are the most benign and recognized symptom of infection with malaria parasites, although the effects on parasite survival and virulence remain unclear. In...

The Ternary Complex Factor Net Is Downregulated by Hypoxia and Regulates Hypoxia-Responsive Genes▿ †

Gross, Christian, Buchwalter, Gilles, Dubois-Pot, Hélène, Cler, Emilie, Zheng, Hong, Wasylyk, Bohdan

Hypoxia and the Net ternary complex factor (TCF) regulate similar processes (angiogenesis, wound healing, and cellular migration) and genes (PAI-1, c-fos, erg-1, NOS-2, HO-1, and vascular endothelial...

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases▿

Zheng, Hong, Ye, Linbai, Fang, Xiaonan, Li, Baozong, Wang, Yuhua, Xiang, Xiaoxiao, ...

Since the first discovery of Torque teno virus (TTV) in 1997, many researchers focused on its epidemiology and transcriptional regulation, but the function of TTV-encoded proteins remained unknown....

Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease

Zheng, Hong, Matte-Martone, Catherine, Li, Hongmei, Anderson, Britt E., Venketesan, Srividhya, Sheng Tan, Hung, ...

Much of the efficacy of allogeneic hematopoietic stem cell transplantation (alloSCT) in curing hematologic malignancies is due to a graft-versus-leukemia (GVL) effect mediated by donor T cells that...

Host Biomarkers and Biological Pathways That Are Associated with the Expression of Experimental Cerebral Malaria in Mice▿ †

Oakley, Miranda S., McCutchan, Thomas F., Anantharaman, Vivek, Ward, Jerrold M., Faucette, Laurence, Erexson, Cindy, ...

Cerebral malaria (CM) is a primary cause of malaria-associated deaths among young African children. Yet no diagnostic tools are available that could be used to predict which of the children infected...

Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation

Sussman, Steve, McCuller, William J, Zheng, Hong, Pfingston, Yvonne M, Miyano, James, Dent, Clyde W

This paper presents the Project EX research program. The historical background for Project EX is presented, including a brief summary of reasons youth fail to quit tobacco use, the disappointing...

Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation

Sussman, Steve, McCuller, William J, Zheng, Hong, Pfingston, Yvonne M, Miyano, James, Dent, Clyde W

This paper presents the Project EX research program. The historical background for Project EX is presented, including a brief summary of reasons youth fail to quit tobacco use, the disappointing...

SHP-2 tyrosine phosphatase in human diseases

Zheng, Hong, Alter, Shawn, Qu, Cheng-Kui

SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be...

Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice

Oakley, Miranda S., Majam, Victoria, Mahajan, Babita, Gerald, Noel, Anantharaman, Vivek, Ward, Jerrold M., ...

An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and...

Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of β-adrenoceptors

Bidasee, Keshore R., Zheng, Hong, Shao, Chun-Hong, Parbhu, Sheeva K., Rozanski, George J., Patel, Kaushik P.

The present study was undertaken to assess cardiac function and characterize β-adrenoceptor subtypes in hearts of diabetic rats that underwent exercise training (ExT) after the onset of diabetes....