Hosahudya N. Gopi

Hybrid Peptide Hairpins Containing $\alpha$-and $\varpi$-Amino Acids: Conformational Analysis of Decapeptides with Unsubstituted $\beta$-, $\gamma$-, and $\delta$-Residues at Positions 3 and 8 (2006)

Roy, Rituparna S, Gopi, Hosahudya N, Raghothama, Srinivasa Rao, Karle, Isabella L, Balaram, Padmanabhan

The effects of inserting unsubstituted -amino acids into the strand segments of model -hairpin peptides was investigated by using four synthetic decapeptides,...

Hybrid Peptide Hairpins Containing $\alpha$-and $\varpi$-Amino Acids: Conformational Analysis of Decapeptides with Unsubstituted $\beta$-, $\gamma$-, and $\delta$-Residues at Positions 3 and 8 (2006)

Roy, Rituparna S, Gopi, Hosahudya N, Raghothama, Srinivasa Rao, Karle, Isabella L, Balaram, Padmanabhan

The effects of inserting unsubstituted -amino acids into the strand segments of model -hairpin peptides was investigated by using four synthetic decapeptides,...

Peptide Hairpins with Strand Segments Containing \alpha - and \beta - Amino Acid Residues: Cross- Strand Aromatic Interactions of Facing Phe Residues (2005)

Roy, Rituparna S, Gopi, Hosahudya N, Raghothama, S, Gilardi, Richard D, Karle, Isabella L, Balaram, Padmanabhan

The incporation of \beta -amino acid residues into the strand segments of designed \beta -hairpin leads to the formation of polar sheets, since in the case of \beta -peptide strands, all adjacent...

Peptide Hairpins with Strand Segments Containing \alpha - and \beta - Amino Acid Residues: Cross- Strand Aromatic Interactions of Facing Phe Residues (2005)

Roy, Rituparna S, Gopi, Hosahudya N, Raghothama, S, Gilardi, Richard D, Karle, Isabella L, Balaram, Padmanabhan

The incporation of \beta -amino acid residues into the strand segments of designed \beta -hairpin leads to the formation of polar sheets, since in the case of \beta -peptide strands, all adjacent...

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located D amino acids (2003)

Karle, Isabella L, Gopi, Hosahudya N, Balaram, Padmanabhan

The design of the synthetic 19-residue peptide Boc-Leu-Aib-Val-Ala-Leu5-Aib-Val-D-Ala-D-Leu-Leu10-Val-Phe-Val-Aib-D-Val15-Leu-Phe-Val-Val-OMe (Aib, alpha-aminoisobutyric acid; OMe, methyl ester) was...

Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate (2003)

Pattanaik, Priyaranjan, Jain, Bimba, Ravindra, Gudihal, Gopi, Hosahudya N, Pal, Prajna P, Balaram, Hemalatha, ...

Novel internally quenched fluorescence peptide substrates containing sequence specific sites for cleavage by multiple proteases were designed and synthesized. The 28 and 29 residue peptides contain...

Proteolytic stability of beta-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site (2003)

Gopi, Hosahudya N, Ravindra, Gudihal, Pal, Prajna P, Pattanaik, Priyaranjan, Balaram, Hemalatha, Balaram, Padmanabhan

A set of designed internally quenched fluorescence peptide substrates has been used to probe the e¡ects of insertion of beta-peptide bonds into peptide sequences. The test sequence chosen...

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located D amino acids (2003)

Karle, Isabella L, Gopi, Hosahudya N, Balaram, Padmanabhan

The design of the synthetic 19-residue peptide Boc-Leu-Aib-Val-Ala-Leu5-Aib-Val-D-Ala-D-Leu-Leu10-Val-Phe-Val-Aib-D-Val15-Leu-Phe-Val-Val-OMe (Aib, alpha-aminoisobutyric acid; OMe, methyl ester) was...

Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate (2003)

Pattanaik, Priyaranjan, Jain, Bimba, Ravindra, Gudihal, Gopi, Hosahudya N, Pal, Prajna P, Balaram, Hemalatha, ...

Novel internally quenched fluorescence peptide substrates containing sequence specific sites for cleavage by multiple proteases were designed and synthesized. The 28 and 29 residue peptides contain...

Proteolytic stability of beta-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site (2003)

Gopi, Hosahudya N, Ravindra, Gudihal, Pal, Prajna P, Pattanaik, Priyaranjan, Balaram, Hemalatha, Balaram, Padmanabhan

A set of designed internally quenched fluorescence peptide substrates has been used to probe the e¡ects of insertion of beta-peptide bonds into peptide sequences. The test sequence chosen...

A Crystalline beta-Hairpin Peptide Nucleated by a Type I’ Aib-D-Ala beta-Turn: Evidence for Cross-Strand Aromatic Interactions (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Rajkishore, Rai, Gopi, Hosahudya N, Balaram, Padmanabhan

Recent progress in the design of beta-hairpin peptides[1] and beta-sheet models has been based on the ability to nucleate reverse turns of the appropriate stereochemistry. D-Pro-Gly[2] and to a...

Infinite pleated beta-sheet formed by the beta-hairpin Boc-beta-Phe-beta-Phe-D-Pro-Gly-beta-Phe-beta-Phe-OMe (2002)

Karle, Isabella, Gopi, Hosahudya N, Balaram, Padmanabhan

A beta-hairpin conformation and extended beta-pleated sheet assembly have been characterized by single crystal x-ray diffraction for the synthetic peptide...

A Crystalline beta-Hairpin Peptide Nucleated by a Type I’ Aib-D-Ala beta-Turn: Evidence for Cross-Strand Aromatic Interactions (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Rajkishore, Rai, Gopi, Hosahudya N, Balaram, Padmanabhan

Recent progress in the design of beta-hairpin peptides[1] and beta-sheet models has been based on the ability to nucleate reverse turns of the appropriate stereochemistry. D-Pro-Gly[2] and to a...

Infinite pleated beta-sheet formed by the beta-hairpin Boc-beta-Phe-beta-Phe-D-Pro-Gly-beta-Phe-beta-Phe-OMe (2002)

Karle, Isabella, Gopi, Hosahudya N, Balaram, Padmanabhan

A beta-hairpin conformation and extended beta-pleated sheet assembly have been characterized by single crystal x-ray diffraction for the synthetic peptide...

Peptide hybrids containing alpha- and beta-amino acids: Structure of a decapeptide beta-hairpin with two facing beta-phenylalanine residues (2001)

Karle, Isabella L, Gopi, Hosahudya N, Balaram, Padmanabhan

A beta-hairpin conformation has been characterized in crystals of the decapeptide t-butoxycarbonyl-Leu-Val-betaPhe-Val-DPro-Gly-Leub Phe-Val-Val-methyl ester [bPhe; (S)-b3 homophenylalanine] by x-ray...

Peptide hybrids containing alpha- and beta-amino acids: Structure of a decapeptide beta-hairpin with two facing beta-phenylalanine residues (2001)

Karle, Isabella L, Gopi, Hosahudya N, Balaram, Padmanabhan

A beta-hairpin conformation has been characterized in crystals of the decapeptide t-butoxycarbonyl-Leu-Val-betaPhe-Val-DPro-Gly-Leub Phe-Val-Val-methyl ester [bPhe; (S)-b3 homophenylalanine] by x-ray...

Peptide hybrids containing α- and β-amino acids: Structure of a decapeptide β-hairpin with two facing β-phenylalanine residues

Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan

A β-hairpin conformation has been characterized in crystals of the decapeptide t-butoxycarbonyl-Leu-Val-βPhe-Val-DPro-Gly-Leu-βPhe-Val-Val-methyl ester [βPhe; (S)-β3 homophenylalanine] by x-ray...

Infinite pleated β-sheet formed by the β-hairpin Boc-β-Phe-β-Phe-d-Pro-Gly-β-Phe-β-Phe-OMe

Karle, Isabella, Gopi, Hosahudya N., Balaram, Padmanabhan

A β-hairpin conformation and extended β-pleated sheet assembly have been characterized by single crystal x-ray diffraction for the synthetic peptide...

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located d amino acids

Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan

The design of the synthetic 19-residue peptide Boc-Leu-Aib-Val-Ala-Leu5-Aib-Val-d-Ala-d-Leu-Leu10-Val-Phe-Val-Aib-d-Val15-Leu-Phe-Val-Val-OMe (Aib, α-aminoisobutyric acid; OMe, methyl ester) was...

Peptide Hairpins with Strand Segments Containing α- and β- Amino Acid Residues : Cross – Strand Aromatic Interactions of Facing Phe Residues.

Roy, Rituparna S., Gopi, Hosahudya N., Raghothama, Srinivasarao, Gilardi, Richard D., Karle, Isabella L, Balaram, Padmanabhan

The incorporation of β-amino acid residues into the strand segments of designed β-hairpin leads to the formation of polar sheets, since in the case of β-peptide strands, all adjacent carbonyl...

Hybrid Peptide Hairpins Containing α- and ω-Amino Acids: Conformational Analysis of Decapeptides with Unsubstituted β-, γ-, and δ-Residues at Positions 3 and 8

Roy, Rituparna S., Gopi, Hosahudya N., Raghothama, Srinivasarao, Karle, Isabella L., Balaram, Padmanabhan

The effects of inserting un-substituted ω-amino acids into the strand segments of model β-hairpin peptides was investigated by using four synthetic decapeptides,...

Peptide hybrids containing α- and β-amino acids: Structure of a decapeptide β-hairpin with two facing β-phenylalanine residues

Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan

A β-hairpin conformation has been characterized in crystals of the decapeptide t-butoxycarbonyl-Leu-Val-βPhe-Val-DPro-Gly-Leu-βPhe-Val-Val-methyl ester [βPhe; (S)-β3 homophenylalanine] by x-ray...

Infinite pleated β-sheet formed by the β-hairpin Boc-β-Phe-β-Phe-d-Pro-Gly-β-Phe-β-Phe-OMe

Karle, Isabella, Gopi, Hosahudya N., Balaram, Padmanabhan

A β-hairpin conformation and extended β-pleated sheet assembly have been characterized by single crystal x-ray diffraction for the synthetic peptide...

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located d amino acids

Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan

The design of the synthetic 19-residue peptide Boc-Leu-Aib-Val-Ala-Leu5-Aib-Val-d-Ala-d-Leu-Leu10-Val-Phe-Val-Aib-d-Val15-Leu-Phe-Val-Val-OMe (Aib, α-aminoisobutyric acid; OMe, methyl ester) was...