Hubert Denise

Studies on the CPA cysteine peptidase in the Leishmania infantumgenome strain JPCM5 (2006)

Denise, Hubert, Poot, Jacqueline, Jiménez, Maribel, Ambit, Audrey, Herrmann, Daland C, Vermeulen, Arno N, ...

Abstract Background Visceral leishmaniasis caused by members of the Leishmania donovani complex is often fatal in the absence of treatment. Research has been hampered by the lack of good laboratory...

Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion

Basselin, Mireille, Denise, Hubert, Coombs, Graham H., Barrett, Michael P.

The uptake of [3H]pentamidine into wild-type and drug-resistant strains of Leishmania mexicana was compared. Uptake was carrier mediated. Pentamidine-resistant parasites showed cross-resistance to...

Expression of Multiple CPB Genes Encoding Cysteine Proteases Is Required for Leishmania mexicana Virulence In Vivo

Denise, Hubert, McNeil, Kathryn, Brooks, Darren R., Alexander, James, Coombs, Graham H., Mottram, Jeremy C.

Leishmania mexicana mutants deficient in the multicopy CPB gene array have reduced virulence, demonstrated by poor lesion growth in BALB/c mice and induction of a protective Th1 response. Reinsertion...

Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion

Basselin, Mireille, Denise, Hubert, Coombs, Graham H., Barrett, Michael P.

The uptake of [3H]pentamidine into wild-type and drug-resistant strains of Leishmania mexicana was compared. Uptake was carrier mediated. Pentamidine-resistant parasites showed cross-resistance to...

Expression of Multiple CPB Genes Encoding Cysteine Proteases Is Required for Leishmania mexicana Virulence In Vivo

Denise, Hubert, McNeil, Kathryn, Brooks, Darren R., Alexander, James, Coombs, Graham H., Mottram, Jeremy C.

Leishmania mexicana mutants deficient in the multicopy CPB gene array have reduced virulence, demonstrated by poor lesion growth in BALB/c mice and induction of a protective Th1 response. Reinsertion...