Individualizing the risks and benefits of postmenopausal hormone therapy (2008)
Van Staa, Tjeerd P., Cooper, Cyrus, Barlow, David, Leufkens, Hubert G.M.
OBJECTIVE: The objective was to develop an individualized risk-benefit model quantifying the impact of combined use of estrogen and progestogen on chronic diseases. DESIGN: The study population...
Van Staa, Tjeerd-Peter, Kanis, John A., Geusens, Piet, Boonen, Annelies, Leufkens, Hubert G.M., Cooper, Cyrus
OBJECTIVES: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study (2007)
De Vries, Frank, Pouwels, Sander, Bracke, Madelon, Leufkens, Hubert G.M., Cooper, Cyrus, Lammers, Jan-Willem J., ...
INTRODUCTION: Administration of beta-2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. OBJECTIVES: To...
Van Staa, Tjeerd-Peter, Kanis, John A., GEUSENS, Piet, Boonen, Annelies, Leufkens, Hubert G. M., Cooper, Cyrus
Objectives: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
Van Staa, Tjeerd-Peter, Kanis, John A., GEUSENS, Piet, Boonen, Annelies, Leufkens, Hubert G. M., Cooper, Cyrus
Objectives: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
Are inhaled corticosteroids associated with an increased risk of fracture in children? (2004)
Van Staa, Tjeerd P., Bishop, Nick, Leufkens, Hubert G.M., Cooper, Cyrus
Inhaled corticosteroids are widely used in the long-term management of asthma in children. Data on the relationship between inhaled corticosteroid therapy and osteoporotic fracture are inconsistent....
Inhaled corticosteroids and hip fracture: disease or drugs? (2003)
Van Staa, Tjeerd P., Leufkens, Hubert G. M., Cooper, Cyrus
Hubbard and colleagues report a study using the General Practice Research Database exploring the relationship between inhaled corticosteroids and the risk of hip fracture. In so doing, they replicate...
Functional foods: the case for closer evaluation
De Jong, Nynke, Klungel, Olaf H, Verhagen, Hans, Wolfs, Marion C J, Ocké, Marga C, Leufkens, Hubert G M
Current regulations focus on the mandatory safety evaluation of functional foods before they come to market, but Nynke de Jongand colleagues argue that the effects of such foods should also be...
Association between antidepressant drug use and hyponatraemia: a case-control study
Movig, Kris L L, Leufkens, Hubert G M, Lenderink, Albert W, Hodiamont, Paul P G, Goldschmidt, Henk M J, ...
Drug reimbursement: Indicators of inappropriate resource allocation
Bégaud, Bernard, Bergman, Ulf, Eichler, Hans-Georg, Leufkens, Hubert G M, Meier, Peter J
In-hospital cardiac arrest is associated with use of non-antiarrhythmic QTc-prolonging drugs
De Bruin, Marie L, Langendijk, Pim N J, Koopmans, Richard P, Wilde, Arthur A M, Leufkens, Hubert G M, Hoes, Arno W
Prescribing patterns in patients using new antidepressants
Meijer, Welmoed E E, Heerdink, Eibert R, Pepplinkhuizen, Lolke P, Van Eijk, Jacques ThM, Leufkens, Hubert G M
Determinants of signal selection in a spontaneous reporting system for adverse drug reactions
Van Puijenbroek, Eugène P, Van Grootheest, Kees, Diemont, Willem L, Leufkens, Hubert G M, Egberts, Antoine C G
Non-puerperal lactation associated with antidepressant drug use
Egberts, Antoine C. G., Meyboom, Ronald H. B., Bakker, Albert, Leufkens, Hubert G. M.
Aims The aim of the present study was to estimate the relative risk of non-puerperal lactation in patients using antidepressants in general, and specifically for serotonergic (selective serotonin...