Valés-Gómez, Mar, Browne, Helena, Reyburn, Hugh T
Abstract Background Human Cytomegalovirus (HCMV) has acquired through evolution a number of genes to try to evade immune recognition of the virus-infected cell. Many of these mechanisms act to...
Self and viral peptides can initiate lysis by autologous natural killer cells
Mandelboim, Ofer, Wilson, S. Brian, Valés-Gómez, Mar, Reyburn, Hugh T., Strominger, Jack L.
Natural killer (NK) cells are inhibited by specific allotypes of class I major histocompatibility complex ligands recognized by polymorphic inhibitory receptors (e.g., NKIR1 and NKIR2). NK1- and...
Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors
Valés-Gómez, Mar, Reyburn, Hugh T., Erskine, Robert A., Strominger, Jack
Natural killer (NK) cell cytotoxicity is regulated in large part by the expression of NK cell receptors able to bind class I major histocompatibility complex glycoproteins. The receptors associated...
The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins
Valés-Gómez, Mar, Erskine, Robert A., Deacon, Matthew P., Strominger, Jack L., Reyburn, Hugh T.
The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During...
Valés-Gómez, Mar, Shiroishi, Mitsunori, Maenaka, Katsumi, Reyburn, Hugh T.
Human cytomegalovirus carries a gene, UL18, that is homologous to cellular major histocompatibility complex (MHC) class I genes. Like MHC class I molecules, the protein product of the UL18 gene...
Chisholm, Susan E., Reyburn, Hugh T.
Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only...
Self and viral peptides can initiate lysis by autologous natural killer cells
Mandelboim, Ofer, Wilson, S. Brian, Valés-Gómez, Mar, Reyburn, Hugh T., Strominger, Jack L.
Natural killer (NK) cells are inhibited by specific allotypes of class I major histocompatibility complex ligands recognized by polymorphic inhibitory receptors (e.g., NKIR1 and NKIR2). NK1- and...
Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors
Valés-Gómez, Mar, Reyburn, Hugh T., Erskine, Robert A., Strominger, Jack
Natural killer (NK) cell cytotoxicity is regulated in large part by the expression of NK cell receptors able to bind class I major histocompatibility complex glycoproteins. The receptors associated...
The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins
Valés-Gómez, Mar, Erskine, Robert A., Deacon, Matthew P., Strominger, Jack L., Reyburn, Hugh T.
The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During...
Valés-Gómez, Mar, Shiroishi, Mitsunori, Maenaka, Katsumi, Reyburn, Hugh T.
Human cytomegalovirus carries a gene, UL18, that is homologous to cellular major histocompatibility complex (MHC) class I genes. Like MHC class I molecules, the protein product of the UL18 gene...
Chisholm, Susan E., Reyburn, Hugh T.
Natural Killer (NK) cells are important in the immune response to a number of viruses; however, the mechanisms used by NK cells to discriminate between healthy and virus-infected cells are only...
Roda-Navarro, Pedro, Vales-Gomez, Mar, Chisholm, Susan E., Reyburn, Hugh T.
Although transfer of membrane proteins has been shown to occur during immune cell interactions, the functional significance of this process is not well understood. Here we describe the intercellular...