Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity (2006)
R. Grace Zhai, Yu Cao, P. Robin Hiesinger, Yi Zhou, Sunil Q. Mehta, Karen L. Schulze, ...
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wlds) mice overexpress a chimeric protein containing the NAD synthase NMNAT...
The Nicotinic Acetylcholine Receptor Dα7 Is Required for an Escape Behavior in Drosophila (2006)
Amir Fayyazuddin, Mahira A. Zaheer, P. Robin Hiesinger, Hugo J. Bellen
The authors integrate behavioral, electrophysiological, anatomical, and genetic data to establish an essential role for the Dα7 nAChR in giant fiber-mediated escape in Drosophila.
The Nicotinic Acetylcholine Receptor Dα7 Is Required for an Escape Behavior in Drosophila (2006)
Amir Fayyazuddin, Mahira A. Zaheer, P. Robin Hiesinger, Hugo J. Bellen
Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the Dα7 nicotinic acetylcholine receptor (nAChR) of Drosophila shows that it is...
Mapping and identification of essential gene functions on the X chromosome of Drosophila (2002)
Peter, Annette, Schoettler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development (2000)
Prokopenko, Sergei N., Saint, Robert Bryce, Bellen, Hugo J.
pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses...
Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development (2000)
Prokopenko, Sergei N., Saint, Robert Bryce, Bellen, Hugo J.
pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses...
Mapping Drosophila mutations with molecularly defined P element insertions
Zhai, R. Grace, Hiesinger, P. Robin, Koh, Tong-Wey, Verstreken, Patrik, Schulze, Karen L., Cao, Yu, ...
The isolation of chemically induced mutations in forward genetic screens is one of the hallmarks of Drosophila genetics. However, mapping the corresponding loci and identifying the molecular lesions...
Senseless acts as a binary switch during sensory organ precursor selection
Jafar-Nejad, Hamed, Acar, Melih, Nolo, Riitta, Lacin, Haluk, Pan, Hongling, Parkhurst, Susan M., ...
During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor,...
Adams, Richard R., Tavares, Alvaro A.M., Salzberg, Adi, Bellen, Hugo J., Glover, David M.
Mutations in the Drosophila gene pavarotti result in the formation of abnormally large cells in the embryonic nervous system. In mitotic cycle 16, cells of pav mutant embryos undergo normal anaphase...
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
Prokopenko, Sergei N., Brumby, Anthony, O’Keefe, Louise, Prior, Leanne, He, Yuchun, Saint, Robert, ...
Cytokinesis ensures the successful completion of the cell cycle and distribution of chromosomes, organelles, and cytoplasm between daughter cells. It is accomplished by formation and constriction of...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
The Nicotinic Acetylcholine Receptor Dα7 Is Required for an Escape Behavior inDrosophila
Fayyazuddin, Amir, Zaheer, Mahira A, Hiesinger, P. Robin, Bellen, Hugo J
Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the Dα7 nicotinic acetylcholine receptor (nAChR) ofDrosophila shows that it is...
Shroyer, Noah F., Wallis, Deeann, Venken, Koen J.T., Bellen, Hugo J., Zoghbi, Huda Y.
Gfi1 is a transcriptional repressor implicated in lymphomagenesis, neutropenia, and hematopoietic development, as well as ear and lung development. Here, we demonstrate that Gfi1 functions downstream...
Sexual Hyperactivity and Reduced Longevity of dunce Females of Drosophila melanogaster
Bellen, Hugo J., Kiger, John A.
The dunce gene of Drosophila melanogaster codes for a cyclic adenosine-3',5'-monophosphate-specific phosphodiesterase. Mutations of dunce alter or abolish the activity of this enzyme, produce...
Bellen, Hugo J, Levis, Robert W, Liao, Guochun, He, Yuchun, Carlson, Joseph W, Tsang, Garson, ...
The Berkeley Drosophila Genome Project (BDGP) strives to disrupt each Drosophila gene by the insertion of a single transposable element. As part of this effort, transposons in >30,000 fly strains...
Mapping Drosophila mutations with molecularly defined P element insertions
Zhai, R. Grace, Hiesinger, P. Robin, Koh, Tong-Wey, Verstreken, Patrik, Schulze, Karen L., Cao, Yu, ...
The isolation of chemically induced mutations in forward genetic screens is one of the hallmarks of Drosophila genetics. However, mapping the corresponding loci and identifying the molecular lesions...
Senseless acts as a binary switch during sensory organ precursor selection
Jafar-Nejad, Hamed, Acar, Melih, Nolo, Riitta, Lacin, Haluk, Pan, Hongling, Parkhurst, Susan M., ...
During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor,...
Adams, Richard R., Tavares, Alvaro A.M., Salzberg, Adi, Bellen, Hugo J., Glover, David M.
Mutations in the Drosophila gene pavarotti result in the formation of abnormally large cells in the embryonic nervous system. In mitotic cycle 16, cells of pav mutant embryos undergo normal anaphase...
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
Prokopenko, Sergei N., Brumby, Anthony, O’Keefe, Louise, Prior, Leanne, He, Yuchun, Saint, Robert, ...
Cytokinesis ensures the successful completion of the cell cycle and distribution of chromosomes, organelles, and cytoplasm between daughter cells. It is accomplished by formation and constriction of...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Sexual Hyperactivity and Reduced Longevity of dunce Females of Drosophila melanogaster
Bellen, Hugo J., Kiger, John A.
The dunce gene of Drosophila melanogaster codes for a cyclic adenosine-3',5'-monophosphate-specific phosphodiesterase. Mutations of dunce alter or abolish the activity of this enzyme, produce...
Shroyer, Noah F., Wallis, Deeann, Venken, Koen J.T., Bellen, Hugo J., Zoghbi, Huda Y.
Gfi1 is a transcriptional repressor implicated in lymphomagenesis, neutropenia, and hematopoietic development, as well as ear and lung development. Here, we demonstrate that Gfi1 functions downstream...
The Nicotinic Acetylcholine Receptor Dα7 Is Required for an Escape Behavior inDrosophila
Fayyazuddin, Amir, Zaheer, Mahira A, Hiesinger, P. Robin, Bellen, Hugo J
Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the Dα7 nicotinic acetylcholine receptor (nAChR) ofDrosophila shows that it is...
Bellen, Hugo J, Levis, Robert W, Liao, Guochun, He, Yuchun, Carlson, Joseph W, Tsang, Garson, ...
The Berkeley Drosophila Genome Project (BDGP) strives to disrupt each Drosophila gene by the insertion of a single transposable element. As part of this effort, transposons in >30,000 fly strains...
Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity
Zhai, R. Grace, Cao, Yu, Hiesinger, P. Robin, Zhou, Yi, Mehta, Sunil Q, Schulze, Karen L, ...
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wlds) mice overexpress a chimeric protein containing the NAD synthase NMNAT...
Thirty-One Flavors of Drosophila Rab Proteins
Zhang, Jun, Schulze, Karen L., Hiesinger, P. Robin, Suyama, Kaye, Wang, Stream, Fish, Matthew, ...
Rab proteins are small GTPases that play important roles in transport of vesicle cargo and recruitment, association of motor and other proteins with vesicles, and docking and fusion of vesicles at...
Internalization is required for proper Wingless signaling in Drosophila melanogaster
Seto, Elaine S., Bellen, Hugo J.
The Wnt–Wingless (Wg) pathway regulates development through precisely controlled signaling. In this study, we show that intracellular trafficking regulates Wg signaling levels. In Drosophila...
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development
Koh, Tong-Wey, Korolchuk, Viktor I., Wairkar, Yogesh P., Jiao, Wei, Evergren, Emma, Pan, Hongling, ...
Epidermal growth factor receptor pathway substrate clone 15 (Eps15) is a protein implicated in endocytosis, endosomal protein sorting, and cytoskeletal organization. Its role is, however, still...
Dermaut, Bart, Norga, Koenraad K., Kania, Artur, Verstreken, Patrik, Pan, Hongling, Zhou, Yi, ...
Lysosomal storage is the most common cause of neurodegenerative brain disease in preadulthood. However, the underlying cellular mechanisms that lead to neuronal dysfunction are unknown. Here, we...
Ohyama, Tomoko, Verstreken, Patrik, Ly, Cindy V., Rosenmund, Tanja, Rajan, Akhila, Tien, An-Chi, ...
Posttranslational modification through palmitoylation regulates protein localization and function. In this study, we identify a role for the Drosophila melanogaster palmitoyl transferase...
Ly, Cindy V., Yao, Chi-Kuang, Verstreken, Patrik, Ohyama, Tomoko, Bellen, Hugo J.
In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an α2δ subunit of the voltage-gated calcium channel. stj mutant...