Hui-Chun Cheng

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation (2009)

Vingadassalom, Didier F., Kazlauskas, Arunas, Skehan, Brian M., Cheng, Hui-Chun, Magoun, Loranne, Robbins, Douglas, ...

Enterohemorrhagic Escherichia coli O157:H7 translocates 2 effectors to trigger localized actin assembly in mammalian cells, resulting in filamentous actin "pedestals." One effector, the...

Hierarchical regulation of WASP/WAVE proteins (2008)

Padrick, Shae B., Cheng, Hui-Chun, Ismail, Ayman M., Panchal, Sanjay C., Doolittle, Lynda K., Kim, Soyeon, ...

Members of the Wiskott-Aldrich syndrome protein (WASP) family control actin dynamics in eukaryotic cells by stimulating the actin nucleating activity of the Arp2/3 complex. The prevailing paradigm...

Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly (2008)

Campellone, Kenneth Geno, Cheng, Hui-Chun, Robbins, Douglas, Siripala, Anosha D., McGhie, Emma J., Hayward, Richard D., ...

Enterohemorrhagic Escherichia coli (EHEC) generate F-actin-rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along...

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U) (2008)

Cheng, Hui-Chun, Skehan, Brian M., Campellone, Kenneth Geno, Leong, John M., Rosen, Michael K.

During infection, enterohaemorrhagic Escherichia coli (EHEC) takes over the actin cytoskeleton of eukaryotic cells by injecting the EspF(U) protein into the host cytoplasm. EspF(U) controls actin by...

Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa (2004)

Cheng, Hui-Chun, Cheng, Pei-Tsung, Peng, Peiyu, Lyu, Ping-Chiang, Sun, Yuh-Ju

Nonspecific lipid transfer proteins (nsLTPs) facilitate the transfer of phospholipids, glycolipids, fatty acids and steroids between membranes, with wide-ranging binding affinities. Three crystal...

Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa (2004)

Cheng, Hui-Chun, Cheng, Pei-Tsung, Peng, Peiyu, Lyu, Ping-Chiang, Sun, Yuh-Ju

Nonspecific lipid transfer proteins (nsLTPs) facilitate the transfer of phospholipids, glycolipids, fatty acids and steroids between membranes, with wide-ranging binding affinities. Three crystal...

Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa

Cheng, Hui-Chun, Cheng, Pei-Tsung, Peng, Peiyu, Lyu, Ping-Chiang, Sun, Yuh-Ju

Nonspecific lipid transfer proteins (nsLTPs) facilitate the transfer of phospholipids, glycolipids, fatty acids and steroids between membranes, with wide-ranging binding affinities. Three crystal...

Arp2/3-independent assembly of actin by Vibrio type III effector VopL

Liverman, Amy D. B., Cheng, Hui-Chun, Trosky, Jennifer E., Leung, Daisy W., Yarbrough, Melanie L., Burdette, Dara L., ...

Microbial pathogens use a variety of mechanisms to disrupt the actin cytoskeleton during infection. Vibrio parahaemolyticus (V. para) is a Gram-negative bacterium that causes gastroenteritis, and new...

Repetitive N-WASP–Binding Elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly

Campellone, Kenneth G., Cheng, Hui-Chun, Robbins, Douglas, Siripala, Anosha D., McGhie, Emma J., Hayward, Richard D., ...

Enterohemorrhagic Escherichia coli (EHEC) generate F-actin–rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along...

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspFU during pedestal formation

Vingadassalom, Didier, Kazlauskas, Arunas, Skehan, Brian, Cheng, Hui-Chun, Magoun, Loranne, Robbins, Douglas, ...

Enterohemorrhagic Escherichia coli O157:H7 translocates 2 effectors to trigger localized actin assembly in mammalian cells, resulting in filamentous actin “pedestals.” One effector, the...