Hui Wang

Publication List Details

Period

1990 - 2009

Number

423

Co-Authors

1 WLAN-Based Pedestrian Tracking Using Particle Filters and Low-Cost MEMS Sensors (2009)

Hui Wang, Henning Lenz, Andrei Szabo, Joachim Bamberger, Uwe D. Hanebeck

Abstract — Indoor positioning systems based on Wireless LAN (WLAN) are being widely investigated in academia and industry. Meanwhile, the emerging low-cost MEMS sensors can also be used as another...

Enhancing the Map Usage for Indoor Location-Aware Systems (2009)

Hui Wang, Henning Lenz, Andrei Szabo, Joachim Bamberger, Uwe D. Hanebeck

Abstract. Location-aware systems are receiving more and more interest in both academia and industry due to their promising prospective in a broad category of so-called Location-Based-Services (LBS)....

A Fault-tolerant Structure for Reliable Multi-core Systems Based on Hardware-Software Co-design (2009)

Xia, Bingbing, Qiao, Fei, Yang, Huazhong, Wang, Hui

To cope with the soft errors and make full use of the multi-core system, this paper gives an efficient fault-tolerant hardware and software co-designed architecture for multi-core systems. And with a...

Interference with Symbol-misalignment (2009)

Zhang, Shengli, Liew, Soung-Chang, Lu, Lu, Wang, Hui

This paper studies the impact of interference asynchrony among different links in a wireless network. Without deliberate coordination and cooperation among the active links, there is a naturally...

RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study (2009)

Weber, Damien C, Wang, Hui, Cozzi, Luca, Dipasquale, Giovanna, Khan, Haleem G, Ratib, Osman, ...

Abstract Background A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent...

Resolving deconvolution ambiguity in gene alternative splicing (2009)

She, Yiyuan, Hubbell, Earl, Wang, Hui

Abstract Background For many gene structures it is impossible to resolve intensity data uniquely to establish abundances of splice variants. This was empirically noted by Wang et al . in which it was...

Ghost imaging without beam splitter (2009)

He, Shibei, Shen, Xia, Wang, Hui, Gong, Wenlin, Han, Shengsheng

Many significant results have been achieved in the fields of ghost imaging, in which the beam splitter is an indispensable optical component. This paper introduces a method to realize ghost imaging...

Methylglyoxal-Induced Increase in Peroxynitrite and Inflammation Related to Diabetes (2009)

Wang, Hui

Methylglyoxal (MG) is a reactive á-oxoaldehyde and a glucose metabolite. Previous studies in our laboratory have shown that MG induces the production of reactive oxygen species (ROS), such as...

Methylglyoxal-Induced Increase in Peroxynitrite and Inflammation Related to Diabetes (2009)

Wang, Hui

Methylglyoxal (MG) is a reactive á-oxoaldehyde and a glucose metabolite. Previous studies in our laboratory have shown that MG induces the production of reactive oxygen species (ROS), such as...

Coulomb blockade double-dot Aharonov-Bohm interferometer: harmonic decomposition of the interference pattern (2009)

Li, Feng, Jiao, HuJun, Wang, Hui, Luo, JunYan, Li, Xin-Qi

For the solid state double-dot interferometer, the phase shifted interference pattern induced by the interplay of inter-dot Coulomb correlation and multiple reflections is analyzed by harmonic...

Belief rule-based inference methodology to improve nuclear safeguards information evaluation (2009)

Ruan, Da, Carchon, Roland, Van Der Meer, Klaas, Liu, Jun, Wang, Hui, Martinez, Luis

A framework for modeling, analyzing and synthesizing nuclear safeguards information with various uncertainties is proposed by using a newly developed belief rule-base inference methodology (RIMER)....

A versatile simulation of slow moving vortex lattices (2009)

Dreyer, Michael, Lee, Jonghee, Wang, Hui, Barker, Barry

We designed and implemented our own versatile simulation software in order to understand the velocity changes and track patterns observed in slow moving vortex lattices. The data was obtained from...

Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population (2009)

Liu, Youning, Chen, Minjun, Zhao, Tiemei, Wang, Hui, Wang, Rui, Cai, Baiqiang, ...

Abstract Background Knowledge of predominant microbial patterns in community-acquired pneumonia (CAP) constitutes the basis for initial decisions about empirical antimicrobial treatment, so a...

Potential landscape of a clean superconductor mapped by pm/s-moving vortices (2009)

Lee, Jonghee, Wang, Hui, Dreyer, Michael, Berger, Helmuth, Barker, Barry I.

We investigated vortex dynamics in a pristine sample of type II superconductor NbSe$_{2}$ by scanning tunneling microscopy at 4.2 K. The decay of the magnetic field at $\sim$ nT/s in our...

The Effects of Interfering COX-2 Gene Expression on Malignant Proliferation of Human Lung Adenocarcinoma A2 Cell in vitro (2009)

Weiying LI, Hui WANG, Baitang LAI, Xuehui YANG, Chunyan ZHANG

Background and objective COX-2 was highly expressed in many tumor tissues and was involved in the initiation and development of tumors. The RNAi technique is a method to inhibit gene expression...

Distribution and mRNA Expression of BAMBI in Non-small-cell Lung Cancer (2009)

Shen MIAO, Lei ZHAO, Jian GAO, Hui WANG, Zeshi CUI

Background and objective BAMBI structure is similar with that of the receptor Ⅰof TGF-β, it broadly participates in the control of TGF-β signaling. The aim of this study is to investigate the...

2-(Benzo[d]thiazol-2-ylsulfanyl)-N-(6-methyl-2-pyridyl)acetamide (2009)

Bing Zhao, Hui Wang, Qiang Li, Yan Gao, Dong Liang

In the title compound, C15H13N3OS2, the pyridine ring and the benzo[d]thiazole unit subtend a dihedral angle of 57.7 (2)°. The length of the Csp2—S bond...

N-(2-Chlorophenyl)-2-(4,6-dimethylpyrimidin-2-ylsulfanyl)acetamide (2009)

Qiang Li, Wei Wang, Hui Wang, Yan Gao, Hong Qiu

In the title compound, C14H14ClN3OS, the 4,6-dimethylpyrimidine ring and the chlorobenzene ring subtend a dihedral angle of 80.0 (2)°. The length of the Csp2—S bond is significantly...

A Prelude to Design Biofriendly Nanostructural Arms using Biological Hinges as Models First Principle Conformational Analysis on the Ala -> Phe Point Mutation in Proline Environment (2009)

Hui Wang, Zoltan Mucsi, Imre G. Csizmadia, Gregory A. Chass, De C. Fang, Bela Viskolcz

Point mutation is an important bio-chemical process related to many genetically transmitted diseases. The presentwork focuses on Ala!Phe mutation through analysis of the geometric and energetic...

Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China (2009)

Chen, Wei, Chen, Weiqing, Wang, Hui, Dong, Xiuqing, Liu, Qinghua, Mao, Haiping, ...

Background. Population-based studies evaluating the prevalence of kidney damage in different communities have been limited in developing countries. We conducted a population-based screening study in...

Structural studies of actin and actin-binding proteins (2009)

Wang, Hui

Actin is involved in cell movement, maintaining cell shape and anchoring cytoskeletal proteins. These functions are regulated by many actin-binding proteins, including those of the gelsolin...

Physicochemical Factors Affecting Protein Aggregation: Biomolecular Engineering of Proteins for Enhanced Stability (2009)

Hui Wang

Protein aggregation is commonly encountered during the manufacture of protein-based bioproducts in processing such as protein expression, purification, refolding, shipping and storage (Volkin and...

5'-Transducing SVA retrotransposon groups spread efficiently throughout the human genome (2009)

Damert, Annette, Raiz, Julija, Horn, Axel V., Löwer, Johannes, Wang, Hui, Xing, Jinchuan, ...

SVA elements represent the youngest family of hominid non-LTR retrotransposons, which alter the human genome continuously. They stand out due to their organization as composite repetitive elements....

Existence of Global Attractors in Lp for m-Laplacian Parabolic Equation in RN (2009)

Caisheng Chen, Lanfang Shi, Hui Wang

We study the long-time behavior of solution for the m-Laplacian equation ut−div(|∇u|m−2∇u)+λ|u|m−2u+f(x,u)=g(x) in RN×R+, in which the nonlinear term f(x,u) is a function like...

Aqua{6,6′-dimethoxy-2,2′-[propane-1,3-diylbis(nitrilomethylidyne)]diphenolato}copper(II) (2009)

Hui Wang

In the asymmetric unit of the title compound, [Cu(C19H20N2O4)(H2O)], there are two independent mononuclear CuII complexes. The coordination environment of each CuII ion is square-pyramidal completed...

Existence of Global Attractors in Lp for m-Laplacian Parabolic Equation in RN (2009)

Caisheng Chen, Lanfang Shi, Hui Wang

We study the long-time behavior of solution for the m-Laplacian equation ut−div(|∇u|m−2∇u)+λ|u|m−2u+f(x,u)=g(x) in RN×R+, in which the nonlinear term...

Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods (2008)

Ach, Robert A, Wang, Hui, Curry, Bo

Abstract Background Determining the expression levels of microRNAs (miRNAs) is of great interest to researchers in many areas of biology, given the significant roles these molecules play in cellular...

Current efficiency in organic light-emitting diodes with a hole-injection layer (2008)

Wang, Hui, Klubek, Kevin P., Tang, C.W.

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ICSP2006 Proceedings Classification of Imbalanced Data by Using the SMOTE Algorithm and Locally Linear Embedding (2008)

Juanjuan Wang, Mantao Xu, Hui Wang, Jiwu Zhang

The classification of imbalanced data is a common practice in the context of medical imaging intelligence. The synthetic minority oversampling technique (SMOTE) is a powerful approach to tackling the...

Self-organized periodicity of protein clusters in growing bacteria (2008)

Wang, Hui, Wingreen, Ned S., Mukhopadhyay, Ranjan

Chemotaxis receptors in E. coli form clusters at the cell poles and also laterally along the cell body, and this clustering plays an important role in signal transduction. Recently, experiments using...

High-temperature AlN interlayer for crack-free AlGaN growth on GaN (2008)

Wang, Jianteng, Wang, Hui, Jin, Ruiqin, Jiang, Desheng, Zhu, Jianjun, ...

This paper presents a study of the transformation of high-temperature AlN (HT-AlN) interlayer (IL) and its effect on the strain relaxation of Al0.25Ga0.75N/HT-AlN/GaN. The HT-AlN IL capped with...

Metallic nanoparticle arrays: A common substrate for both surface-enhanced Raman scattering and surface-enhanced infrared absorption (2008)

Le, Fei, Brandl, Daniel W., Urzhumov, Yaroslav A., Wang, Hui, Kundu, Janardan, Halas, Naomi J., ...

Nanoshell arrays have recently been found to possess ideal properties as a substrate for combining surface enhanced raman scattering (SERS) and surface enhanced infrared absorption (SEIRA)...

Journal of Chinese Language and Computing, 15 (3):(149-160) Some Suggestions on How to Improve the Lexical Abstract Semantic Knowledge-Base (2008)

Su Xinchun, Wang Hui, Lu Weiqing, Qin Shaokang, Xinchun Su, Hui Wang, ...

Disambiguation, particularly that of lexical meanings is the key problem involved in natural language processing (NLP), and among many means of achieving this end, is to construct a language...

Multi-Platform Soccer Robot Development System (2008)

Hui Wang, Han Wang, Chunmiao Wang

Abstract. Robot soccer is a challenging research domain, which involves multiple agents (physical robots or ”softbots”) to work together in a dynamic, noisy, cooperative and adversarial...

Scheduling Control Tasks with Threshold-based Largest Dedication First (2008)

Hong Jin, Hongan Wang, Hui Wang, Danli Wang

Scheduling design of control tasks with fuzzy deadline is considered. By introducing the dedication concept to describe the scheduling criticality of a control task, the largest dedication first with...

Similarity-Based Data Reduction Techniques (2008)

Gongde Guo, Hui Wang, David Bell

The k-nearest neighbours (kNN) is a simple but effective method for classification. Its major drawbacks are (1) low efficiency, and (2) dependency on the selection of a “good value ” for k. In...

IOS Press Algebras of approximating regions (2008)

Ivo Düntsch, Ewa Orłowska, Hui Wang

It is rarely the case that spatial regions can be determined up to their true boundaries, if, indeed, they have such boundaries; in most cases, we can only observe regions up to a certain...

FROM CONCEPTUAL MODELLING TO ARCHITECTURAL MODELLING — A UCD METHOD FOR INTERACTIVE SYSTEMS (2008)

Qingyi Hua, Hui Wang, Claudio Muscogiuri, Claudia Niederée, Matthias Hemmje

Abstract. Software design is a process of transformation from problem domain to implementation domain based on two crucial models: conceptual and system models. User-Centred Design (UCD) differs from...

A Bucket-Based Approach to Query Rewriting Using Views in the Presence of Inclusion Dependencies* (2008)

Qingyuan Bai, Jun Hong, Michael F. Mctear, Hui Wang

A number of algorithms based on the use of either buckets or inverse rules have been proposed to address the problem of query rewriting using views. Some inverse rule-based algorithms have considered...

Puzzle J in Abstract (2008)

Hui Wang, Andrzej Skowron, Ivo Düntsch, Günther Gediga

A version space is a set of all hypotheses consistent with a given set of training examples, delimited by the specific boundary and the general boundary. In existing studies [5, 6, 8] a hypothesis is...

Abstract Conceptual Modeling for Interaction Design (2008)

Qingyi Hua, Hui Wang, Matthias Hemmje

A usable interactive system provides its users with presentation and manipulation of useful concepts for solving their problems at hand without becoming bogged down in accidental features of user...

Network Quotients: Structural Skeletons of Complex Systems (2008)

Xiao, Yanghua, MacArthur, Ben D., Wang, Hui, Xiong, Momiao, Wang, Wei

A defining feature of many large empirical networks is their intrinsic complexity. However, many networks also contain a large degree of structural repetition. An immediate question then arises: can...

ADivide-and-Conquer Algorithm for Irregular Redistribution in Parallelizing Compilers (2008)

Hui Wang, Minyi Guo, Daming Wei

Abstract. In order to achieve higher load balancing, it is necessary to solve irregular block redistribution problems, which are different from regular block-cyclic redistribution. High Performance...

A Hierarchical Approach to Multimodal Classification (2008)

Andrzej Skowron, Hui Wang, Arkadiusz Wojna, Jan Bazan

Abstract. Data models that are induced in classifier construction often consists of multiple parts, each of which explains part of the data. Classification methods for such models are called the...

MIC2003: The Fifth Metaheuristics International Conference HASTS-1 Solving Multi-Objective Multi-Constraint Optimization Problems using Hybrid Ants System and Tabu Search (2008)

Hoong Chuin Lau, Min Kwang Lim, Wee Chong Wan, Hui Wang, Xiaotao Wu

Many real-world optimization problems today are multi-objective multi-constraint generalizations of NP-hard problems. A classic case we study in this paper is the Inventory Routing Problem with Time...

Enhancing the Map Usage for Indoor Location-Aware Systems (2008)

Hui Wang, Henning Lenz, Andrei Szabo, Joachim Bamberger, Uwe D. Hanebeck

Abstract. Location-aware systems are receiving more and more interest in both academia and industry due to their promising prospective in a broad category of so-called Location-Based-Services (LBS)....

CONSIDERATIONS ON UNCERTAIN SPATIO-TEMPORAL REASONING IN SMART HOME SYSTEMS (2008)

Jun Liu, Juan C. Augusto, Hui Wang

Smart Homes are the subject of intensive research to explore different ways in which they can be used to provide home-based preventive and assistive technology to patients and other vulnerable...

Markov models for inferring Copy Number Variations from genotype data (2008)

Hui Wang, Jan Veldink, Roel Opoff, Sabatti, Chiara

We develop an algorithm to analyze data from Illumina genotyping arrays for the detection of copy number variations in a single individual or in a random sample of individuals. We use a Hidden Markov...

ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY (2008)

Wang, Hui

In this thesis, I first demonstrate three novel broad band light sources at above 1 µm for ultra-high resolution optical coherence tomography (OCT) based on multiple SLED combination and...

ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY (2008)

Wang, Hui

In this thesis, I first demonstrate three novel broad band light sources at above 1 µm for ultra-high resolution optical coherence tomography (OCT) based on multiple SLED combination and...

catena-Poly[[tetraaqua(μ-4,4′-bipyridine-κ2N:N′)zinc(II)] fumarate tetrahydrate] (2008)

Yong Tian, Ya-Pan Wu, Dong-Sheng Li, Hui Wang, Ji-Wu Wang

In the title compound, {[Zn(C10H8N2)(H2O)4](C4H2O4)·4H2O}n, the ZnII atom is coordinated by two N atoms from two μ-4,4′-bipyridine ligands and four water molecules in a distorted...

The relationship between genetic polymorphism of GSTM1 and the outcome of chemotherapy in Chinese patients with primary lung cancer (2008)

Weiying LI, Yanfei GU, Baitang LAI, Hui WANG

Background and objective GSTM1 takes part in the metabolism of environmental pollutants such as benzopyrene other polycyclic aromatic hydrocarbons and anticancer drugs and so on. The study aims to...

Effects of p53 gene on drug resistance in human lung cancer cell lines (2008)

Hong TAO, Yunzhong ZHU, Hui WANG, Baitang LAI, Xiuping ZHAN, Yue WANG, ...

Background and Objective Drug resistance of lung cancer cells is one of main factors which affect the outcome of chemotherapy. It has been reported that abnormal p53 gene is well assosiated with...

The Relationship between EGFR Mutations and Response and Prognosis of Tyrosine Kinase Inhibitors in Advanced Non-small-cell Lung Cancer (2008)

Xinyong ZHANG, Liyan XU, Hui WANG, Yunzhong ZHU, Zhe LIU, Wentao YUE, ...

Background and objectives It has been proven that epigermal growth factor receptor (EGFR) signal pathway plaied an important role in the oncogenesis and development of non-small cell lung cancer...

The Roles of a LIM Domain Protein, Hic-5/ARA55, in TGF-β Signaling in Prostate Cancer Cells (2008)

Wang, Hui

Findings from our laboratory as well as from others support that transforming growth factor beta (TGF-β) functions as a critical tumor suppressor of the prostate. During the progression of a variety...

The Roles of a LIM Domain Protein, Hic-5/ARA55, in TGF-β Signaling in Prostate Cancer Cells (2008)

Wang, Hui

Findings from our laboratory as well as from others support that transforming growth factor beta (TGF-β) functions as a critical tumor suppressor of the prostate. During the progression of a variety...

Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury (2008)

Xue, Xiang, Xiao, Ying, Zhu, Hongli, Wang, Hui, Liu, Yongzhen, Xie, Tianpei, ...

Background. Cytochrome P450 1A, an enzyme known to metabolize polycyclic aromatic hydrocarbons (PAHs), participates in the metabolism of aristolochic acid I (AAI) in liver and kidney microsomes...

Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women (2008)

Liang, Jie, Chen, Peizhan, Hu, Zhibin, Zhou, Xiaoyi, Chen, Lu, Li, Mian, ...

Fibroblast growth factor receptor 2 (FGFR2) belongs to the FGFR family, which plays an important role in cell growth, invasiveness, motility and angiogenesis. In human breast cancer, expression of...

Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity (2008)

Yang, Xiuna, Morita, Masahiro, Wang, Hui, Suzuki, Toru, Yang, Wen, Luo, Yunhai, ...

BTG2 is the prototypical member of the TOB family and is known to be involved in cell growth, differentiation and DNA repair. As a transcriptional co-regulator, BTG2 interacts with CCR4-associated...

Tunable plasmonic nanostructures: From fundamental nanoscale optics to surface-enhanced spectroscopies (2008)

Wang, Hui, Wang, Hui

In this thesis, I demonstrate the rational design and controllable fabrication of a series of novel plasmonic nanostructures with judiciously tailored optical properties including perfect nanoshells,...

An Algebraic and Logical Approach to the Approximation of Regions (Extended Abstract) (2007)

Ivo Düntsch, Hui Wang, Ewa Orlowska

To be presented at the 5th Seminar on Relational Methods in Computer Science Ivo Dntsch School of Information and Software Engineering University of Ulster at Jordanstown Newtownabbey, BT 37 0QB,...

Optimal stopping with random intervention times (2007)

Paul Dupuis, Hui Wang

We consider a class of optimal stopping problems where the ability to stop depends an exogenous Poisson signal process -- one can only stop at the Poisson jump times. Even though the time variable in...

¤ We are grateful to many people who o®ered insights into this work including John Birge, Mark Broadie, (2007)

S. C. Kou, Morris Cohen, Paul Glasserman, David Weinstein, Hui Wang, ...

The inability to predict the earnings of growth stocks, such as biotechnology and internet stocks, leads to the high volatility of share prices and di±culty in applying the traditional valuation...

Classification based on contextual probability (2007)

Hui Wang, Sally Mcclean

Data Mining is often concerned with large and complex datasets. However the data space may be sparse and contain regions that are poorly covered. In such cases we would like to make inferences about...

Data Reduction and Noise Filtering for Predicting Times Series (2007)

Gongde Guo, Hui Wang, David Bell

Abstract. In this paper we introduce a modification of the real discrete Fourier transform and its inverse transform to filter noise and perform reduction on the data whilst preserving the trend of...

Asymmetric Neighbourhood Selection and Support Aggregation for Effective Classification (2007)

Gongde Guo, Hui Wang, David Bell

Abstract: The k-Nearest-Neighbours (kNN) is a simple but effective method for classification. The success of kNN in classification depends on the selection of a “good value ” for k. To reduce the...

Lattice machine: Version space in hyper relations (Extended abstract (2007)

Hui Wang, Ivo Düntsch

A version space is a set of all hypotheses consistent with a given set of training examples, delimited by the specific boundary and the general boundary. In existing studies [4, 5, 3] a hypothesis is...

Time Series Data Analysis and Pre-process on Large Databases (2007)

Gongde Guo, Hui Wang, David Bell

In this paper we introduce a novel classification algorithm called MCC (Minimal Cover Classification), which works well for numerical data and categorical data. Given a new data tuple, it provides...

KNN Model-Based Approach in Classification (2007)

Gongde Guo, Hui Wang, David Bell, Yaxin Bi, Kieran Greer

Abstract. The k-Nearest-Neighbours (kNN) is a simple but effective method for classification. The major drawbacks with respect to kNN are (1) its low efficiency- being a lazy learning method...

Dynamic importance sampling for queueing networks (2007)

Dupuis, Paul, Sezer, Ali Devin, Wang, Hui

Importance sampling is a technique that is commonly used to speed up Monte Carlo simulation of rare events. However, little is known regarding the design of efficient importance sampling algorithms...

Symmetry based Structure Entropy of Complex Networks (2007)

Xiao, Yanghua, Wu, Wentao, Wang, Hui, Xiong, Momiao, Wang, Wei

Precisely quantifying the heterogeneity or disorder of a network system is very important and desired in studies of behavior and function of the network system. Although many degree-based entropies...

Emergence of Symmetry in Complex Networks (2007)

Xiao, Yanghua, Xiong, Momiao, Wang, Wei, Wang, Hui

Many real networks have been found to have a rich degree of symmetry, which is a very important structural property of complex network, yet has been rarely studied so far. And where does symmetry...

Heritability of alternative splicing in the human genome (2007)

Kwan, Tony, Benovoy, David, Dias, Christel, Gurd, Scott, Serre, David, Zuzan, Harry, ...

Alternative pre-mRNA splicing increases proteomic diversity and provides a potential mechanism underlying both phenotypic diversity and susceptibility to genetic disorders in human populations. To...

Homogeneous and heterogeneous nucleation of Lennard-Jones liquids (2007)

Wang, Hui, Gould, Harvey, Klein, W.

The homogeneous and heterogeneous nucleation of a Lennard-Jones liquid is investigated using the umbrella sampling method. The free energy cost of forming a nucleating droplet is determined as a...

Discovery of tissue-specific exons using comprehensive human exon microarrays (2007)

Clark, Tyson A, Schweitzer, Anthony C, Chen, Tina X, Staples, Michelle K, Lu, Gang, Wang, Hui, ...

Abstract Background Higher eukaryotes express a diverse population of messenger RNAs generated by alternative splicing. Large-scale methods for monitoring gene expression must adapt in order to...

Approaching equilibrium and the distribution of clusters (2007)

Wang, Hui, Barros, Kipton, Gould, Harvey, Klein, W.

We investigate the approach to stable and metastable equilibrium in Ising models using a cluster representation. The distribution of nucleation times is determined using the Metropolis algorithm and...

A mobile element-based evolutionary history of guenons (tribe Cercopithecini) (2007)

Xing, Jinchuan, Wang, Hui, Zhang, Yuhua, Ray, David A, Tosi, Anthony J, Disotell, Todd R, ...

Abstract Background Guenons (tribe Cercopithecini) are a species-rich group of primates that have attracted considerable attention from both primatologists and evolutionary biologists. The complex...

Paths to Modernity: China and India (2007)

Wang, Hui, Subrahmanyam, Sanjay

Wang Hui, editor of Dushu (Beijing), talked about the different historical narratives of China. He argued that the emergence of the modern nation state began in the Song Dynasty and thus the process...

Bilateral effect of unilateral electroacupuncture on muscle strength (2007)

Huang, Liping, Zhou, Shi, Lu, Zhen, Tian, Qiang, Li, Xia, Cao, Longjun, ...

Objectives: This study aimed to examine the bilateral effect of 4 weeks of unilateral electroacupuncture on leg muscle strength. Design: The effect of unilateral electroacupuncture at two selected...

Subsolutions of an Isaacs Equation and Efficient Schemes for Importance Sampling: Examples and Numerics (2007)

Dupuis, Paul, Wang, Hui

It has been established that importance sampling algorithms for estimating rare-event probabilities are intimately connected with two-person zero-sum differential games and the associated Isaacs...

Dynamic Importance Sampling for Queueing Networks (2007)

Dupuis, Paul, Sezer, Ali D., Wang, Hui

Importance sampling is a technique that is commonly used to speed up Monte Carlo simulation of rare events. However, little is known regarding the design of efficient importance sampling algorithms...

Importance Sampling for Sums of Random Variables With Regularly Varying Tails (2007)

Dupuis, Paul, Leder, Kevin, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. For random variables with heavy tails there is little consensus on how to...

Subsolutions of an Isaacs Equation and Efficient Schemes for Importance Sampling: Convergence Analysis (2007)

Dupuis, Paul, Wang, Hui

Previous papers by authors establish the connection between importance sampling algorithms for estimating rare-event probabilities, two-person zero-sum differential games, and the associated Isaacs...

Tuning DCDHF (dicyanomethylenedihydrofuran) Fluorophores and their applications in biological systems (2007)

Wang, Hui

The application of single molecule spectroscopy in living cells is one of the most active fields in this area. DCDHF (dicyanomethylenedihydrofuran) fluorophores have been successfully imaged at the...

Tuning DCDHF (dicyanomethylenedihydrofuran) Fluorophores and their applications in biological systems (2007)

Wang, Hui

The application of single molecule spectroscopy in living cells is one of the most active fields in this area. DCDHF (dicyanomethylenedihydrofuran) fluorophores have been successfully imaged at the...

DESIGN, SYNTHESIS, AND SUPRAMOLECULAR SURFACE CHEMISTRY OF BI- AND TRIDENTATE SURFACE ANCHORS FOR NANOSCIENCE AND NANOBIOTECHNOLOGY (2007)

Wang, Hui

This dissertation describes the design, synthesis, and supramolecular surface chemistry of bi- and tri-dentate surface anchors for nanoscience and nanobiotechnology. Molecular electronic device...

DESIGN, SYNTHESIS, AND SUPRAMOLECULAR SURFACE CHEMISTRY OF BI- AND TRIDENTATE SURFACE ANCHORS FOR NANOSCIENCE AND NANOBIOTECHNOLOGY (2007)

Wang, Hui

This dissertation describes the design, synthesis, and supramolecular surface chemistry of bi- and tri-dentate surface anchors for nanoscience and nanobiotechnology. Molecular electronic device...

Numerical Simulation of Dental Resurfacing of a Feldspar Porcelain with Coarse Diamond Burs (2007)

Song, Xiao-Fei, Yin, Ling, Han, Yi-Gang, Wang, Hui, Li, Jia

Dental bioceramics are more and more attractive to both dentists and patients due to their unique biocompatibility and esthetics; they can be fabricated efficiently using chair-side CAD/CAM dental...

Numerical Simulation of Dental Resurfacing of a Feldspar Porcelain with Coarse Diamond Burs (2007)

Song, Xiao-Fei, Yin, Ling, Han, Yi-Gang, Wang, Hui, Li, Jia

Dental bioceramics are more and more attractive to both dentists and patients due to their unique biocompatibility and esthetics; they can be fabricated efficiently using chair-side CAD/CAM dental...

Hanebeck: WLAN-Based Pedestrian Tracking Using Particle Filters and Low-Cost MEMS Sensors (2007)

Hui Wang, Henning Lenz, Andrei Szabo, Joachim Bamberger, Uwe D. Hanebeck

Abstract — Indoor positioning systems based on Wireless LAN (WLAN) are being widely investigated in academia and industry. Meanwhile, the emerging low-cost MEMS sensors can also be used as another...

MULTIPLE ROBOT GRAPH EXPLORATION (2007)

Hui Wang, Hui Wang

This report investigates the problem of exploration and mapping in an embedded graph-like world. Graph-like worlds provide a useful theoretical model within which to explore fundamental limits to...

Effect of diamond burs on process and damage involving in vitro dental resurfacing of a restorative porcelain (2007)

Yin, Ling, Han, Yi-Gang, Song, Xiao-Fei, Wang, Hui

This work reports on the effect of diamond burs with coarse, medium and fine grit sizes and nickel or chromium coatings on in vitro dental resurfacing of a restorative porcelain. Process parameters...

Bilateral effect of unilateral electroacupuncture on muscle strength (2007)

Huang, Liping, Zhou, Shi, Lu, Zhen, Tian, Qiang, Li, Xia, Cao, Longjun, ...

Objectives: This study aimed to examine the bilateral effect of 4 weeks of unilateral electroacupuncture on leg muscle strength. Design: The effect of unilateral electroacupuncture at two selected...

Direct and sensitive miRNA profiling from low-input total RNA (2007)

Wang, Hui, Ach, Robert A., Curry, Bo

We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling assay that is based on a highly efficient labeling method and novel microarray probe design. The probes provide...

Effect of Premature ACK Transmission Timing on Throughput in TCP with a Performance Enhancing Proxy (2007)

WANG, Hui, OSADA, Shigeyuki, YOKOHIRA, Tokumi, OKAYAMA, Kiyohiko, YAMAI, Nariyoshi

In order to improve TCP performance, the use of a PEP (Performance Enhancing Proxy) has been proposed. The PEP operates on a router along a TCP connection. When a data packet arrives at the PEP, it...

Bilateral effect of unilateral electroacupuncture on muscle strength (2007)

Huang, Liping, Zhou, Shi, Lu, Zhen, Tian, Qiang, Li, Xia, Cao, Longjun, ...

Objectives: This study aimed to examine the bilateral effect of 4 weeks of unilateral electroacupuncture on leg muscle strength. Design: The effect of unilateral electroacupuncture at two selected...

Plasmonic nanoparticle heterodimers in a semiembedded geometry fabricated by stepwise upright assembly (2006)

Wang, Hui, Halas, Naomi J.

We report the experimental realization of plasmonic heterodimers, pairs of directly adjacent, interacting metallic nanoparticles. A novel fabrication and positioning approach is utilized for the...

SVA Elements: Hominid Specific Retrotransposons (2006)

Wang, Hui

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. There are ~3000 SVA elements in the human genome. A genomic distribution analysis indicates that SVA...

SVA Elements: Hominid Specific Retrotransposons (2006)

Wang, Hui

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. There are ~3000 SVA elements in the human genome. A genomic distribution analysis indicates that SVA...

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication (2006)

Sara Cherry, Amit Kunte, Hui Wang, Carolyn Coyne, Robert B. Rawson, Norbert Perrimon

During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular...

Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer (2006)

Wang, Hui, Zhao, Li-Na, Li, Kai-Zong, Ling, Rui, Li, Xiao-Jun, Wang, Ling

Abstract Background Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous...

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity (2006)

Susanna Wang, Nadir Yehya, Eric E. Schadt, Hui Wang, Thomas A. Drake, Aldons J. Lusis

The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...

A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity. (2006)

Lee, Hane, Jen, Joanna C, Wang, Hui, Chen, Zugen, Mamsa, Hafsa, Sabatti, Chiara, ...

Benign recurrent vertigo (BRV) is a common disorder affecting up to 2% of the adult population and may be etiologically related to migraine because of similarities in the clinical spectrum of the...

Effect of unilateral electro-acupuncture on function of ipsilateral and contralateral tibialis anterior muscle (2006)

Huang, Liping, Zhou, Shi, Lu, Zhen, Brooks, Lyndon O, Tian, Qiang, Li, Xia, ...

AIMS: It is known that unilateral resistance exercise or electromyostimulation training can increase muscular strength not only in the trained limb, but also in the homologous muscle of the...

Fusion of Barometric Sensors, WLAN Signals and Building Information for 3--D Indoor/Campus Localization (2006)

Wang, Hui, Lenz, Henning, Szabo, Andrei, Hanebeck, Uwe D.

Location estimation in indoor/campus environments has attracted much interest for its broad applications. Many applications (e.g. personnel security) require not only the 2-D coordinate but also the...

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays (2006)

Charles W. Sugnet, Karpagam Srinivasan, Tyson A. Clark, Georgeann O'Brien, Melissa S. Cline, Hui Wang, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

SVA elements hominid specific retrotransposons / (2006)

Wang, Hui.

Thesis (Ph. D.)--Louisiana State University, Baton Rouge, 2006.

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. (2006)

Song, Kyung, Wang, Hui, Krebs, Tracy L, Danielpour, David

Insulin-like growth factor-I inhibits transforming growth factor-beta (TGF-beta) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt-dependent pathway. Here...

Fusion of Barometric Sensors, WLAN Signals and Building Information for 3-D Indoor/Campus Localization (2006)

Hui Wang, Henning Lenz, Andrei Szabo, Uwe D. Hanebeck, Joachim Bamberger

Abstract—Location estimation in indoor/campus environments has attracted much interest for its broad applications. Many applications (e.g. personnel security) require not only the 2-D coordinate...

Effect of unilateral electro-acupuncture on function of ipsilateral and contralateral tibialis anterior muscle (2006)

Huang, Liping, Zhou, Shi, Lu, Zhen, Brooks, Lyndon O, Tian, Qiang, Li, Xia, ...

AIMS: It is known that unilateral resistance exercise or electromyostimulation training can increase muscular strength not only in the trained limb, but also in the homologous muscle of the...

A proteomic approach to analysing responses of Arabidopsis thaliana callus cells to clinostat rotation (2006)

Wang, Hui, Zheng, Hui Qiong, Sha, Wei, Zeng, Rong, Xia, Qi Chang

Callus cells of Arabidopsis thaliana (cv. Landsberg erecta) were exposed for 8 h to a horizontal clinostat rotation (H, simulated weightlessness), a vertical clinostat rotation (V, clinostat...

A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity (2006)

Lee, Hane, Jen, Joanna C., Wang, Hui, Chen, Zugen, Mamsa, Hafsa, Sabatti, Chiara, ...

Benign recurrent vertigo (BRV) is a common disorder affecting up to 2% of the adult population and may be etiologically related to migraine because of similarities in the clinical spectrum of...

Direct and sensitive miRNA profiling from low-input total RNA (2006)

Wang, Hui, Ach, Robert A., Curry, Bo

We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling assay that is based on a highly efficient labeling method and novel microarray probe design. The probes provide...

Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)

Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...

We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....

Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)

Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...

We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....

A proteomic approach to analysing responses of Arabidopsis thaliana callus cells to clinostat rotation (2006)

Wang, Hui, Zheng, Hui Qiong, Sha, Wei, Zeng, Rong, Xia, Qi Chang

Callus cells of Arabidopsis thaliana (cv. Landsberg erecta) were exposed for 8 h to a horizontal clinostat rotation (H, simulated weightlessness), a vertical clinostat rotation (V, clinostat...

Message Scheduling for Irregular Data Redistribution in Parallelizing Compilers (2006)

WANG, Hui, GUO, Minyi, WEI, Daming

In parallelizing compilers on distributed memory systems, distributions of irregular sized array blocks are provided for load balancing and irregular problems. The irregular data redistribution is...

Genetic Analysis of Glutathione S-transferase A1 Polymorphism in the Chinese Population and the Influence of Genotype on Enzymatic Properties (2006)

Ping, Jie, Wang, Hui, Huang, Min, Liu, Zhi-su

Genetic polymorphisms of human glutathione S-transferases (hGSTs) have important implications for drug efficacy and cancer susceptibility. hGSTA1 is the most abundant subfamily of hGSTs. The aim of...

Effect of unilateral electro-acupuncture on function of ipsilateral and contralateral tibialis anterior muscle (2006)

Huang, Liping, Zhou, Shi, Lu, Zhen, Brooks, Lyndon O, Tian, Qiang, Li, Xia, ...

AIMS: It is known that unilateral resistance exercise or electromyostimulation training can increase muscular strength not only in the trained limb, but also in the homologous muscle of the...

A proteomic approach to analysing responses of Arabidopsis thaliana callus cells to clinostat rotation (2006)

Wang, Hui, Zheng, Hui Qiong, Sha, Wei, Zeng, Rong, Xia, Qi Chang

Callus cells of Arabidopsis thaliana (cv. Landsberg erecta) were exposed for 8 h to a horizontal clinostat rotation (H, simulated weightlessness), a vertical clinostat rotation (V, clinostat...

Direct and sensitive miRNA profiling from low-input total RNA (2006)

Wang, Hui, Ach, Robert A., Curry, Bo

We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling assay that is based on a highly efficient labeling method and novel microarray probe design. The probes provide...

Fusion of Barometric Sensors, WLAN Signals and Building Information for 3-D Indoor/Campus Localization (2006)

Hui Wang, Henning Lenz, Andrei Szabo, Uwe D. Hanebeck, Joachim Bamberger

Abstract—Location estimation in indoor/campus environments has attracted much interest for its broad applications. Many applications (e.g. personnel security) require not only the 2-D coordinate...

Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver (2005)

Wang, Hui, Qiu, Hongming, Qi, Ke, Orr, F William

Abstract Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells...

Unusual Intron Conservation Near Tissue-regulated Exons Found by Splicing Microarrays (2005)

Charles W Sugnet, Karpagam Srinivasan, Tyson A Clark, Georgeann O'Brien, Melissa S Cline, Hui Wang, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

On the convergence from discrete to continuous time in an optimal stopping problem (2005)

Dupuis, Paul, Wang, Hui

We consider the problem of optimal stopping for a one-dimensional diffusion process. Two classes of admissible stopping times are considered. The first class consists of all nonanticipating stopping...

On the convergence from discrete to continuous time in an optimal stopping problem (2005)

Dupuis, Paul, Wang, Hui

We consider the problem of optimal stopping for a one-dimensional diffusion process. Two classes of admissible stopping times are considered. The first class consists of all nonanticipating stopping...

Preparation of indium-tin oxide (ITO) nano-aciculae by a simple precipitation near boiling point and post-calcination method (2005)

Chen, Shu-Guang, Li, Chen-Hui, Xiong, Wei-Hao, Liu, Lang-Ming, Wang, Hui

ITO nano-aciculae (needle-like nanometer crystals) were prepared by post-calcination of ITO precursor nano-aciculae, which were synthesized by a simple precipitation near boiling point method....

Inferring genomic loss and location of tumor suppressor genes from high density genotypes (2005)

Wang, Hui, Lee, Yohan, Nelson, Stanley, Sabatti, Chiara

Novel technologies, such as the 10k Affymetrix genotyping array, allow scoring of genetic polymorphisms at a very high density across the genome. This allows researchers to conduct traditional...

Dynamic importance sampling for uniformly recurrent markov chains (2005)

Dupuis, Paul, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. In standard importance sampling schemes, the system is simulated using an a...

Dynamic importance sampling for uniformly recurrent Markov chains (2005)

Dupuis, Paul, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. In standard importance sampling schemes, the system is simulated using an a...

A new approach of detecting influential markers for complex phenotypes with genotype data (2005)

Wang, Hui

With the increase in the use of genomewide studies, large-scale genome scans have become common tools in search of susceptibility genes for complex human disorders. The statistical methods, developed...

Essays on two financial market anomalies / (2005)

Wang, Hui.

Thesis (Ph. D.)--Yale University, 2005.

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea (2005)

Paton, Adrienne W., Jennings, Michael P., Morona, Renato, Wang, Hui, Focareta, Antonio, Roddam, Louise F., ...

Background & Aims: We have developed a therapeutic strategy for gastrointestinal infections that is based on molecular mimicry of host receptors for bacterial toxins on the surface of harmless gut...

Pricing Path-Dependent Options with Jump Risk via Laplace Transforms (2005)

Kou, Steven, Petrella, Giovanni, Wang, Hui

We present analytical solutions for two-dimensional Laplace transforms of barrier option prices, as well as an approximation based on Laplace transforms for the prices of finite-time horizon American...

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea (2005)

Paton, Adrienne W., Jennings, Michael P., Morona, Renato, Wang, Hui, Focareta, Antonio, Roddam, Louise F., ...

Background & Aims: We have developed a therapeutic strategy for gastrointestinal infections that is based on molecular mimicry of host receptors for bacterial toxins on the surface of harmless gut...

Dynamic importance sampling for uniformly recurrent markov chains (2005)

Paul Dupuis, Hui Wang

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. In standard importance sampling schemes, the system is simulated using an a...

Characterizing the Performance and Stability Issues of the AS Path Prepending Method: Taxonomy, Measurement Study and Analysis (2005)

Hui Wang, Dah Ming Chiu, Chang Dah, Ming Chiu

We consider the autonomous system (AS) path prepending (ASPP) approach to perform load-balancing on inbound traffic for multihomed ASes. Although the ASPP approach has been practiced by many AS...

A flexible and robust similarity measure based on contextual probability (2005)

Hui Wang

Arguably, analogy is one of the most important aspects of intelligent reasoning. It has been hypothesized that, given suitable background knowledge, analogy can be viewed as a logical inference...

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition (2005)

Cherry, Sara, Doukas, Tammy, Armknecht, Susan, Whelan, Sean, Wang, Hui, Sarnow, Peter, ...

The widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation include poliovirus and Hepatitis C virus. To identify host factors required for IRES-dependent...

Under the genomic radar: The Stealth model of Alu amplification (2005)

Han, Kyudong, Xing, Jinchuan, Wang, Hui, Hedges, Dale J., Garber, Randall K., Cordaux, Richard, ...

Alu elements are the most successful SINEs (Short INterspersed Elements) in primate genomes and have reached more than 1,000,000 copies in the human genome. The amplification of most Alu elements is...

ANOSVA: a statistical method for detecting splice variation from expression data (2005)

Cline, Melissa S., Blume, John, Cawley, Simon, Clark, Tyson A., Hu, Jing-Shan, Lu, Gang, ...

Motivation: Many or most mammalian genes undergo alternative splicing, generating a variety of transcripts from a single gene. New information on splice variation is becoming available through...

Genetic Analysis of Glutathione S-Transferase A1 Polymorphism in Chinese and the Influence of Genotype on Enzymatic Properties (2005)

Ping, Jie, Wang, Hui, Huang, Min, Liu, Zhi-su

Genetic polymorphisms of human glutathione S-transferases (hGSTs) have important implications for drug efficacy and cancer susceptibility. hGSTA1 is the most abundant subfamily of hGSTs. The aim of...

Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer (2004)

Chen, Jianghao, Wang, Ling, Yao, Qing, Ling, Rui, Li, Kaizong, Wang, Hui

Abstract Background Lymph node status is one of the decisive prognostic factors in breast cancer. Chemotherapy targeting regional lymphatic tissues has emerged as a promising therapy for the...

Geminivirus AL2 and L2 proteins interact with and inactivate adenosine kinase (2004)

Wang, Hui

Geminivirus AL2 and L2 proteins are pathogenicity determinants that cause enhanced susceptibility when expressed in transgenic plants. To understand how geminiviruses defeat host, we found that the...

Binding of complement factor H to the nematode Nippostrongylus brasiliensis (2004)

Baker, S., Wang, Hui, Giacomin, Paul, Dent, Lindsay Agin, Gordon, D. L.

http://www.elsevier.com/wps/find/journaldescription.cws_home/253/description#description

Geminivirus AL2 and L2 proteins interact with and inactivate adenosine kinase [electronic resource] / (2004)

Wang, Hui.

Abstract: Geminivirus AL2 and L2 proteins are pathogenicity determinants that cause enhanced susceptibility when expressed in transgenic plants. To understand how geminiviruses defeat host, we found...

Behavioral Modeling and Simulation of Jitter and Phase Noise (2004)

Xiaojian Mao, Huazhong Yang, Hui Wang

A methodology is presented for predicting the phase noise and jitter of a fractional-N PLL based frequency synthesizer. Based on the phase/jitter properties extracted from transistor level through...

An kNN model-based approach and its application in text categorization (2004)

Gongde Guo, Hui Wang, Kieran Greer

investigati n has been c nducted n tw well kn wn similarity-based learning appr aches t text categ rizati n. This includes the k-nearest nei hbor (kNN) classifier and the Rocchio classifier. After...

Hyperrelations in Version Space (2004)

Hui Wang, Günther Gediga, Ivo Düntsch, Andrzej Skowron

A version space is a set of all hypotheses consistent with a given set of training examples, delimited by the specific boundary and the general boundary. In existing studies [5, 6, 8] a hypothesis is...

Extended k-Nearest Neighbours based on Evidence Theory (2004)

Wang, Hui, Bell, David

An evidence theoretic classification method is proposed in this paper. In order to classify a pattern we consider its neighbours, which are taken as parts of a single source of evidence to support...

First passage times of a jump diffusion process (2003)

Kou, S. G., Wang, Hui

This paper studies the first passage times to flat boundaries for a double exponential jump diffusion process, which consists of a continuous part driven by a Brownian motion and a jump part with...

NMR implementation of a quantum scheduling algorithm (2003)

Zhang, Jingfu, Lu, Zhiheng, Deng, Zhiwei, Wang, Hui

The improved quantum scheduling algorithm proposed by Grover has been generalized using the generalized quantum search algorithm, in which a unitary operator replaces the Walsh-Hadamard transform,...

Transportation shortest path search area model (2003)

Wang, Hui.

Thesis (Ph. D.)--University of Tennessee, Knoxville, 2003.

Mining novel Web user behavior models for access prediction / (2003)

Wang, Hui.

Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.

Transportation shortest path search area model [electronic resource] / (2003)

Wang, Hui.

Although many studies on shortest-path algorithms have been conducted in the past, few of them have considered the time and effort required to obtain and update the weight property of the network...

3-D image segmentation and rendering / (2003)

Wang, Hui.

A novel 3-D rendering has been developed by surface rendering approach. A new and easier rendering model has been invented under the assumptions that light comes from the same side as the viewer,...

Mining novel Web user behavior models for access prediction / (2003)

Wang, Hui.

Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.

Transportation shortest path search area model (2003)

Wang, Hui.

Thesis (Ph. D.)--University of Tennessee, Knoxville, 2003.

A study of the gas-liquid reaction system of hydrogen sulfide and sulfuric acid / (2003)

Wang, Hui.

A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemical Engineering, Department of Chemical...

A density based approach to classification (2003)

Hui Wang

This paper presents a novel method for classification, which is density based and makes use of the models built by the lattice machine (LM) [5, 7]. Density is a natural concept to use in clustering...

Using kNN Modelbased Approach for Automatic Text Categorization (2003)

Gongde Guo, Hui Wang, David Bell, Yaxin Bi, Kieran Greer

Abstract An investigation has been conducted on two well known similarity-based learning approaches to text categorization: the k-nearest neighbor (k-NN) classifier and the Rocchio classifier. After...

The semantic knowledge-base of contemporary Chinese and its applications (2003)

Hui Wang, Shiwen Yu

The Semantic Knowledge-base of Contemporary Chinese (SKCC) is a large scale Chinese semantic resource developed by the Institute of Computational Linguistics of Peking University. It provides a large...

The semantic knowledge-base of contemporary Chinese and its applications (2003)

Hui Wang

The Semantic Knowledge-base of Contemporary Chinese (SKCC) is a large scale Chinese semantic resource developed by the Institute of Computational Linguistics of Peking University. It provides a large...

Mining novel Web user behavior models for access prediction (2003)

Wang, Hui

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2003

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles (2003)

Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, ...

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed...

Gene structure-based splice variant deconvolution using a microarry platform (2003)

Wang, Hui, Hubbell, Earl, Hu, Jing-shan, Mei, Gangwu, Cline, Melissa, Lu, Gang, ...

Motivation: Alternative splicing allows a single gene to generate multiple mRNAs, which can be translated into functionally and structurally diverse proteins. One gene can have multiple variants...

Mechanisms and inhibition of HIV-1 capsid assembly. (2002)

Wang, Hui.

The human immunodeficiency virus type 1 (HIV-1) initially assembles as a spherical, immature particle organized by the Gag polyprotein. As the virus buds, Gag is cleaved into three structural...

Mechanisms and inhibition of HIV-1 capsid assembly. (2002)

Wang, Hui.

The human immunodeficiency virus type 1 (HIV-1) initially assembles as a spherical, immature particle organized by the Gag polyprotein. As the virus buds, Gag is cleaved into three structural...

Optimal stopping with random intervention times (2002)

Dupuis, Paul, Wang, Hui

We consider a class of optimal stopping problems where the ability to stop depends on an exogenous Poisson signal process - we can only stop at the Poisson jump times. Even though the time variable...

Mechanisms and inhibition of HIV-1 capsid assembly /--by Hui Wang. (2002)

Wang, Hui

Thesis (Ph. D.)--Dept. of Biochemistry, University of Utah, 2002.

Injection of brain-derived neurotrophic factor in the rostral ventrolateral medulla increases arterial blood pressure in anaesthetized rats (2002)

Wang, Hui, Zhou, X-F.

Brain-derived neurotrophic factor (BDNF) is a unique neurotrophin which not only supports the development of neurons but also modulates the synaptic activity in a number of neuronal systems. BDNF is...

Injection of brain-derived neurotrophic factor in the rostral ventrolateral medulla increases arterial blood pressure in anaesthetized rats (2002)

Wang, Hui, Zhou, X-F.

Brain-derived neurotrophic factor (BDNF) is a unique neurotrophin which not only supports the development of neurons but also modulates the synaptic activity in a number of neuronal systems. BDNF is...

Feature Articles (2002)

Computational Intelligence Bulletin, Web-log Mining, Quantitative Temporal-event, Prediction Qiang Yang, Hui Wang, Wei Zhang, ...

The web log data embed much of web users' browsing behavior. From the web logs, one can discover patterns that predict the users' future requests based on their current behavior. These web...

Some control problems with random intervention times (2001)

Wang, Hui

We consider the problem of optimally tracking a Brownian motion by a sequence of impulse controls, in such a way as to minimize the total expected cost that consists of a quadratic deviation cost and...

The linkage role of LMX : a mediating effect of LMX on the relationship between transformational leadership and followers’ performance and OCB (2001)

Wang, Hui, Law, Kenneth S., Wang, Duan Xu, Chen, Zhen Xiong

In this study, we developed a model that captured the mediating role of leader-member exchange (LMX) on the relationship between transformational leadership and followers’ performance and...

A lack-of-fit test for linear models /--by Hui Wang. (2001)

Wang, Hui.

Thesis (M.S.)--Kansas State University, 2001.

A Relation-Algebraic Approach to the Region Connection Calculus (2001)

Ivo Düntsch, Hui Wang, Steve McCloskey

We explore the relation--algebraic aspects of the region connection calculus (RCC) of Randell et al. (1992a). In particular, we present a refinement of the RCC8 table which shows that the axioms...

Discretization of deflated bond prices (2000)

Glasserman, Paul, Wang, Hui

This paper proposes and analyzes discrete-time approximations to a class of diffusions, with an emphasis on preserving certain important features of the continuous-time processes in the...

Topics in stochastic control with discretionary stopping (2000)

Wang, Hui

This thesis addresses two stochastic control problems with discretionary stopping. The first one is a finite-fuel, singular stochastic control problem of optimally tracking the standard Brownian...

Utility maximization in incomplete markets with random endowment (2000)

Cvitanic, Jaksa, Schachermayer, Walter, Wang, Hui

This paper solves a long-standing open problem in mathematical finance: to find a solution to the problem of maximizing utility from terminal wealth of an agent with a random endowment process, in...

Multiple shrinkage estimator / (2000)

Wang, Hui.

Thesis (Ph. D. in Statistics)--University of California, Berkeley, Fall 2000.

Utility Maximization in Incomplete Markets with Random Endowment (2000)

Jaksa Cvitanic, Walter Schachermayer, Hui Wang

This paper solves a long-standing open problem in mathematical nance: to nd a solution to the problem of maximizing utility from terminal wealth of an agent with a random endowment process, in the...

Efficient Refreshment of Materialized Views With Multiple Sources (1999)

Hui Wang, Maria Orlowska

hva.ngQcsee.uq.edu.au mariaksee.uq.edu.au A data warehouse collects and maintains a large amount of data from multiple distributed and autonomous data sources. Often the data in it is stored in the...

Relation algebras in qualitative spatial reasoning (1999)

Ivo Düntsch, Hui Wang, Stephen Mccloskey

The formalization of the “part – of ” relationship goes back to the mereology of S. Le´sniewski, subsequently taken up by Leonard & Goodman (1940), and Clarke (1981). In this paper we...

Text classification using Lattice Machine (1999)

Hui Wang, Nguyen Hung Son

. A novel approach to supervised learning, called Lattice Machine, was proposed in [5]. In the Lattice Machine, it was assumed that data are structured as relations. In this paper we investigate the...

Utility Maximization in Incomplete Markets with Random Endowment (1999)

Jaksa Cvitanic, Walter Schachermayer, Hui Wang

This paper solves a long-standing open problem in mathematical finance: to find a solution to the problem of maximizing utility from terminal wealth of an agent with a random endowment process, in...

On Optimal Terminal Wealth Under Transaction Costs (1999)

Jaksa Cvitanic, Hui Wang

In this note we show that the modern approach to the problem of maximizing expected utility from terminal wealth in financial markets, namely martingale/duality methodology, works also in the...

Axiomatic Approach to Feature Subset Selection Based on Relevance (1999)

Hui Wang, David Bell, Fionn Murtagh

In this paper an axiomatic characterisation of feature subset selection is presented. Two axioms are presented: sufficiency axiom --- preservation of learning information, and necessity axiom ---...

A lattice machine approach to automated casebase design: Marrying lazy and eager learning (1999)

Hui Wang, Werner Dubitzky, Ivo Diintsch, David Bell

Case-based reasoning (CBR) is concerned with solving new problems by adapting solutions that worked for similar problems in the past. Years of experience in building and fielding CBR systems have...

Computer Simulation of X-Ray Capillary Optics for Digital Mammography (1998)

Wang, Hui

Mammography is the most widely used modality for breast cancer detection. The detection of tiny micro-calcifications and low contrast tissue is essential for mammography. Polycapillary optics provide...

Computer Simulation of X-Ray Capillary Optics for Digital Mammography (1998)

Wang, Hui, MacDonald, Carolyn

The objective of this proposal is to develop a digital mammographic imaging system with high contrast, good resolution, and low patient dose. A new technology, polycapillary optics, has been shown to...

Simulation, Measurements and Image Processing for Capillary Optical Digital Mammorgraphy (96 Breast) (1998)

Wang, Hui

Capillary optics, which use total external reflection to transmit x rays, have been proved to have great advantages in scatter reduction and resolution improvement in mammography application. The...

Function-Oriented Material Design of Joints for Advance Armors Under Ballistic Impact (1998)

Ma, Zheng-Dong, Wang, Hui, Raju, Basavaraju

The objective of this research is to develop a system of software tools based on a new design methodology for the efficient composite armor structural design under ballistic impact loading conditions...

Fine Structure Characterization of Stress-Strain Curves for Deformed Austenitic Stainless Steels. (1998)

Teng, Zhenyu, Wang, Hui, Li, Ji-Xue, Shan, Feng-Lan, Teng, Feng-En

This paper concerned metals in some important way and contained information about, utilized, or discussed these subjects: basic topics: experimental materials related terms: 18-8 stainless steel,...

Effects of Parton Intrinsic Transverse Momentum on Photon Production in Hard-Scattering Processes (1998)

Wong, Cheuk-Yin, Wang, Hui

We calculate the photon production cross section arising from the hard scattering of partons in nucleon-nucleon collisions by taking into account the intrinsic parton transverse momentum distribution...

Surface acoustic wave-induced birefringent multiple quantum well modulators for optical system applications (1998)

Wang, Hui

This dissertation presents the first verification of Surface Acoustic Wave (SAW) induced QCSE in the InGaAs-GaAs Multiple Quantum Wells. This work also describes novel strain induced birefringent...

A Barrier Option Of American Type (1998)

Ioannis Karatzas, Hui Wang

We obtain closed--form expressions for the prices and optimal hedging strategies of American put--options in the presence of an "up--and--out" barrier, both with and without constraints on...

Nanotechnology 9 (1998) 257–273. Printed in the UK PII: S0957-4484(98)90835-2 New motifs in DNA nanotechnology (1998)

Nadrian C Seeman, Hui Wang, Xiaoping Yang, Furong Liu, Chengde Mao, Weiqiong Sun, ...

Abstract. Recently, we have invested a great deal of effort to construct molecular building blocks from unusual DNA motifs. DNA is an extremely favorable construction medium. The sticky-ended...

Photoluminescence in the InAlAs/InP heterojunction interface (1997)

Wang, Hui

Enhanced photoluminescence (PL) from the InAlAs/InP interface was observed at temperatures between 100 and 220 K in an aluminum rich InAlAs/InP lattice mismatched type II heterostructure...

Control-oriented modeling of dynamic systems in fuzzy logic frameworks: Entropy approach (1997)

Wang, Hui

This dissertation introduces a novel systematic approach for control-oriented modeling of dynamic systems in fuzzy logic frameworks. The concepts of entropy and mutual information are employed to...

Phosphorylation of human plasma plasminogen / (1997)

Wang, Hui.

Thesis (M.S.)--University of Notre Dame, 1997.

Towards a unified framework of relevance. (1996)

Wang, Hui.

Thesis (Ph. D.)--University of Ulster, 1996.

Characterization of the physical interactions between chea-short with the other chemotaxis proteins / (1995)

Wang, Hui.

Thesis (Ph. D. in microbiology and immunology)--University of Illinois at Chicago, 1995.

Evaluation of tofu from selected soy cultivars and breeding lines / (1993)

Wang, Hui.

Thesis (M.S.)--Michigan State University. Dept. of Food Science and Human Nutrition, 1993.

Evaluation of tofu from selected soy cultivars and breeding lines [microform] / (1993)

Wang, Hui.

Thesis (M.S.)--Michigan State University. Dept. of Food Science and Human Nutrition, 1993.

Geminivirus AL2 and L2 proteins interact with and inactivate adenosine kinase

Wang, Hui

Geminivirus AL2 and L2 proteins are pathogenicity determinants that cause enhanced susceptibility when expressed in transgenic plants. To understand how geminiviruses defeat host, we found that the...

Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization

Wang, Hui, Griffiths, Michelle N., Burton, Dennis R., Ghazal, Peter

We have compared the kinetics of antibody responses in conventional and dendritic cell-targeted immunization by using a model antigen in mice. Targeting was achieved by linking the reporter antigen...

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration

Wang, Hui, Cai, Qiuyin, Zeng, Xiaofei, Yu, Dong, Agrawal, Sudhir, Zhang, Ruiwen

Overexpression of the RIα subunit of cAMP-dependent protein kinase (PKA) has been demonstrated in various human cancers. PKA has been suggested as a potential target for cancer therapy. The goal of...

Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical Escherichia coli Strains from China: Role of acrR Mutations

Wang, Hui, Dzink-Fox, Joann L., Chen, Minjun, Levy, Stuart B.

The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated...

Antibiotic Susceptibility Patterns of Streptococcus pneumoniae in China and Comparison of MICs by Agar Dilution and E-Test Methods

Wang, Hui, Huebner, Robin, Chen, Minjun, Klugman, Keith

Beta-lactam resistance by Streptococcus pneumoniae is becoming a significant threat to public health worldwide. However, data concerning antibiotic susceptibility patterns in China have not been...

Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...

The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...

Increased CCR5 Affinity and Reduced CCR5/CD4 Dependence of a Neurovirulent Primary Human Immunodeficiency Virus Type 1 Isolate

Gorry, Paul R., Taylor, Joann, Holm, Geoffrey H., Mehle, Andrew, Morgan, Tom, Cayabyab, Mark, ...

Most human immunodeficiency virus type 1 (HIV-1) viruses in the brain use CCR5 as the principal coreceptor for entry into a cell. However, additional phenotypic characteristics are necessary for...

Positive and negative regulation of APP amyloidogenesis by sumoylation

Li, Yonghong, Wang, Hui, Wang, Su, Quon, Diana, Liu, Yu-Wang, Cordell, Barbara

Amyloid β peptide (Aβ) generated from amyloid precursor protein (APP) is central to Alzheimer's disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis...

Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases: Prevalence of CTX-M-3 at a Hospital in China

Wang, Hui, Kelkar, Swathi, Wu, Weiyuan, Chen, Minjun, Quinn, John P.

The prevalence of extended-spectrum β-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae,...

Geminivirus AL2 and L2 Proteins Interact with and Inactivate SNF1 Kinase

Hao, Linhui, Wang, Hui, Sunter, Garry, Bisaro, David M.

Geminivirus AL2 and L2 proteins cause enhanced susceptibility, characterized primarily by an increase in viral infectivity, when expressed in transgenic plants. Here, we present genetic and...

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, ...

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed...

T lymphoid differentiation in human bone marrow

Klein, Florian, Feldhahn, Niklas, Lee, Sanggyu, Wang, Hui, Ciuffi, Fiammetta, Von Elstermann, Mirko, ...

The unique role of the thymus in the development of T cells was established >4 decades ago. To elucidate how uncommitted lymphoid progenitor cells are instructed to migrate from bone marrow to the...

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

Zhang, Zhuo, Li, Mao, Wang, Hui, Agrawal, Sudhir, Zhang, Ruiwen

This study was undertaken to investigate the role of mouse double minute 2 (MDM2) oncogene in prostate cancer growth and the potential of MDM2 as a target for prostate cancer therapy. An antisense...

Adenosine Kinase Is Inactivated by Geminivirus AL2 and L2 Proteins

Wang, Hui, Hao, Linhui, Shung, Chia-Yi, Sunter, Garry, Bisaro, David M.

AL2 and L2 are related proteins encoded by geminiviruses of the Begomovirus and Curtovirus genera, respectively. Both are pathogenicity determinants that cause enhanced susceptibility when expressed...

Alternative Gene Form Discovery and Candidate Gene Selection from Gene Indexing Projects

Burke, John, Wang, Hui, Hide, Winston, Davison, Daniel B.

Several efforts are under way to partition single-read expressed sequence tag (EST), as well as full-length transcript data, into large-scale gene indices, where transcripts are in common index...

Simultaneous Detection and Identification of Common Cell Culture Contaminant and Pathogenic Mollicutes Strains by Reverse Line Blot Hybridization

Wang, Hui, Kong, Fanrong, Jelfs, Peter, James, Gregory, Gilbert, Gwendolyn L.

We have developed a reverse line blot (RLB) hybridization assay to detect and identify the commonest mollicutes causing cell line contamination (Mycoplasma arginini, Mycoplasma fermentans, Mycoplasma...

DNA heterogeneity and phosphorylation unveiled by single-molecule electrophoresis

Wang, Hui, Dunning, James E., Huang, Albert P.-H., Nyamwanda, Jacqueline A., Branton, Daniel

Broad-spectrum analysis of DNA and RNA samples is of increasing importance in the growing field of biotechnology. We show that nanopore measurements may be used to assess the purity, phosphorylation...

Effect of Direct Electric Current on the Cell Surface Properties of Phenol-Degrading Bacteria

Luo, Qishi, Wang, Hui, Zhang, Xihui, Qian, Yi

The change in cell surface properties in the presence of electric currents is of critical concern when the potential to manipulate bacterial movement with electric fields is evaluated. In this study,...

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition

Cherry, Sara, Doukas, Tammy, Armknecht, Susan, Whelan, Sean, Wang, Hui, Sarnow, Peter, ...

The widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation include poliovirus and Hepatitis C virus. To identify host factors required for IRES-dependent...

Under the genomic radar: The Stealth model of Alu amplification

Han, Kyudong, Xing, Jinchuan, Wang, Hui, Hedges, Dale J., Garber, Randall K., Cordaux, Richard, ...

Alu elements are the most successful SINEs (Short INterspersed Elements) in primate genomes and have reached more than 1,000,000 copies in the human genome. The amplification of most Alu elements is...

Adenosine Kinase Inhibition and Suppression of RNA Silencing by Geminivirus AL2 and L2 Proteins

Wang, Hui, Buckley, Kenneth J., Yang, Xiaojuan, Buchmann, R. Cody, Bisaro, David M.

Most plant viruses are initiators and targets of RNA silencing and encode proteins that suppress this adaptive host defense. The DNA-containing geminiviruses are no exception, and the AL2 protein...

Loss of Complement Activation and Leukocyte Adherence as Nippostrongylus brasiliensis Develops within the Murine Host

Giacomin, Paul R., Wang, Hui, Gordon, David L., Botto, Marina, Dent, Lindsay A.

Complement activation and C3 deposition on the surface of parasitic helminths may be important for recruitment of leukocytes and for damage to the target organism via cell-mediated mechanisms....

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays

Sugnet, Charles W, Srinivasan, Karpagam, Clark, Tyson A, O'Brien, Georgeann, Cline, Melissa S, Wang, Hui, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

Simultaneous Detection of Nine Antibiotic Resistance-Related Genes in Streptococcus agalactiae Using Multiplex PCR and Reverse Line Blot Hybridization Assay†

Zeng, Xianyu, Kong, Fanrong, Wang, Hui, Darbar, Archie, Gilbert, Gwendolyn L.

Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal and maternal sepsis. Penicillin is recommended for intrapartum prophylaxis, but erythromycin or clindamycin is...

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity

Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J

The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...

Reduced Virulence of an fliC Mutant of Shiga-Toxigenic Escherichia coli O113:H21

Rogers, Trisha J., Paton, James C., Wang, Hui, Talbot, Ursula M., Paton, Adrienne W.

The contribution of flagellin to the virulence of the O113:H21 Shiga-toxigenic Escherichia coli (STEC) strain 98NK2 was investigated in the streptomycin-treated mouse model. Groups of mice were...

Simultaneous Detection and Identification of Candida, Aspergillus, and Cryptococcus Species by Reverse Line Blot Hybridization

Playford, E. Geoffrey, Kong, Fanrong, Sun, Ying, Wang, Hui, Halliday, Catriona, Sorrell, Tania C.

We report on a reverse line blot (RLB) assay, utilizing fungal species-specific oligonucleotide probes to hybridize with internal transcribed spacer 2 region sequences amplified using a nested...

Bayesian Shrinkage Estimation of Quantitative Trait Loci Parameters

Wang, Hui, Zhang, Yuan-Ming, Li, Xinmin, Masinde, Godfred L., Mohan, Subburaman, Baylink, David J., ...

Mapping multiple QTL is a typical problem of variable selection in an oversaturated model because the potential number of QTL can be substantially larger than the sample size. Currently, model...

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication

Cherry, Sara, Kunte, Amit, Wang, Hui, Coyne, Carolyn, Rawson, Robert B, Perrimon, Norbert

During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular...

Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization

Wang, Hui, Griffiths, Michelle N., Burton, Dennis R., Ghazal, Peter

We have compared the kinetics of antibody responses in conventional and dendritic cell-targeted immunization by using a model antigen in mice. Targeting was achieved by linking the reporter antigen...

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration

Wang, Hui, Cai, Qiuyin, Zeng, Xiaofei, Yu, Dong, Agrawal, Sudhir, Zhang, Ruiwen

Overexpression of the RIα subunit of cAMP-dependent protein kinase (PKA) has been demonstrated in various human cancers. PKA has been suggested as a potential target for cancer therapy. The goal of...

Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical Escherichia coli Strains from China: Role of acrR Mutations

Wang, Hui, Dzink-Fox, Joann L., Chen, Minjun, Levy, Stuart B.

The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated...

Antibiotic Susceptibility Patterns of Streptococcus pneumoniae in China and Comparison of MICs by Agar Dilution and E-Test Methods

Wang, Hui, Huebner, Robin, Chen, Minjun, Klugman, Keith

Beta-lactam resistance by Streptococcus pneumoniae is becoming a significant threat to public health worldwide. However, data concerning antibiotic susceptibility patterns in China have not been...

Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...

The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...

Increased CCR5 Affinity and Reduced CCR5/CD4 Dependence of a Neurovirulent Primary Human Immunodeficiency Virus Type 1 Isolate

Gorry, Paul R., Taylor, Joann, Holm, Geoffrey H., Mehle, Andrew, Morgan, Tom, Cayabyab, Mark, ...

Most human immunodeficiency virus type 1 (HIV-1) viruses in the brain use CCR5 as the principal coreceptor for entry into a cell. However, additional phenotypic characteristics are necessary for...

Positive and negative regulation of APP amyloidogenesis by sumoylation

Li, Yonghong, Wang, Hui, Wang, Su, Quon, Diana, Liu, Yu-Wang, Cordell, Barbara

Amyloid β peptide (Aβ) generated from amyloid precursor protein (APP) is central to Alzheimer's disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis...

Clinical Isolates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases: Prevalence of CTX-M-3 at a Hospital in China

Wang, Hui, Kelkar, Swathi, Wu, Weiyuan, Chen, Minjun, Quinn, John P.

The prevalence of extended-spectrum β-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae,...

Geminivirus AL2 and L2 Proteins Interact with and Inactivate SNF1 Kinase

Hao, Linhui, Wang, Hui, Sunter, Garry, Bisaro, David M.

Geminivirus AL2 and L2 proteins cause enhanced susceptibility, characterized primarily by an increase in viral infectivity, when expressed in transgenic plants. Here, we present genetic and...

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Zhu, Fu-Gang, Tang, Jimmy, ...

Unmethylated CpG dinucleotides present within certain specific sequence contexts in bacterial and synthetic DNA stimulate innate immune responses and induce cytokine secretion. Recently, we showed...

T lymphoid differentiation in human bone marrow

Klein, Florian, Feldhahn, Niklas, Lee, Sanggyu, Wang, Hui, Ciuffi, Fiammetta, Von Elstermann, Mirko, ...

The unique role of the thymus in the development of T cells was established >4 decades ago. To elucidate how uncommitted lymphoid progenitor cells are instructed to migrate from bone marrow to the...

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

Zhang, Zhuo, Li, Mao, Wang, Hui, Agrawal, Sudhir, Zhang, Ruiwen

This study was undertaken to investigate the role of mouse double minute 2 (MDM2) oncogene in prostate cancer growth and the potential of MDM2 as a target for prostate cancer therapy. An antisense...

Adenosine Kinase Is Inactivated by Geminivirus AL2 and L2 Proteins

Wang, Hui, Hao, Linhui, Shung, Chia-Yi, Sunter, Garry, Bisaro, David M.

AL2 and L2 are related proteins encoded by geminiviruses of the Begomovirus and Curtovirus genera, respectively. Both are pathogenicity determinants that cause enhanced susceptibility when expressed...

Alternative Gene Form Discovery and Candidate Gene Selection from Gene Indexing Projects

Burke, John, Wang, Hui, Hide, Winston, Davison, Daniel B.

Several efforts are under way to partition single-read expressed sequence tag (EST), as well as full-length transcript data, into large-scale gene indices, where transcripts are in common index...

Simultaneous Detection and Identification of Common Cell Culture Contaminant and Pathogenic Mollicutes Strains by Reverse Line Blot Hybridization

Wang, Hui, Kong, Fanrong, Jelfs, Peter, James, Gregory, Gilbert, Gwendolyn L.

We have developed a reverse line blot (RLB) hybridization assay to detect and identify the commonest mollicutes causing cell line contamination (Mycoplasma arginini, Mycoplasma fermentans, Mycoplasma...

DNA heterogeneity and phosphorylation unveiled by single-molecule electrophoresis

Wang, Hui, Dunning, James E., Huang, Albert P.-H., Nyamwanda, Jacqueline A., Branton, Daniel

Broad-spectrum analysis of DNA and RNA samples is of increasing importance in the growing field of biotechnology. We show that nanopore measurements may be used to assess the purity, phosphorylation...

Effect of Direct Electric Current on the Cell Surface Properties of Phenol-Degrading Bacteria

Luo, Qishi, Wang, Hui, Zhang, Xihui, Qian, Yi

The change in cell surface properties in the presence of electric currents is of critical concern when the potential to manipulate bacterial movement with electric fields is evaluated. In this study,...

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition

Cherry, Sara, Doukas, Tammy, Armknecht, Susan, Whelan, Sean, Wang, Hui, Sarnow, Peter, ...

The widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation include poliovirus and Hepatitis C virus. To identify host factors required for IRES-dependent...

Under the genomic radar: The Stealth model of Alu amplification

Han, Kyudong, Xing, Jinchuan, Wang, Hui, Hedges, Dale J., Garber, Randall K., Cordaux, Richard, ...

Alu elements are the most successful SINEs (Short INterspersed Elements) in primate genomes and have reached more than 1,000,000 copies in the human genome. The amplification of most Alu elements is...

Adenosine Kinase Inhibition and Suppression of RNA Silencing by Geminivirus AL2 and L2 Proteins

Wang, Hui, Buckley, Kenneth J., Yang, Xiaojuan, Buchmann, R. Cody, Bisaro, David M.

Most plant viruses are initiators and targets of RNA silencing and encode proteins that suppress this adaptive host defense. The DNA-containing geminiviruses are no exception, and the AL2 protein...

Loss of Complement Activation and Leukocyte Adherence as Nippostrongylus brasiliensis Develops within the Murine Host

Giacomin, Paul R., Wang, Hui, Gordon, David L., Botto, Marina, Dent, Lindsay A.

Complement activation and C3 deposition on the surface of parasitic helminths may be important for recruitment of leukocytes and for damage to the target organism via cell-mediated mechanisms....

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays

Sugnet, Charles W, Srinivasan, Karpagam, Clark, Tyson A, O'Brien, Georgeann, Cline, Melissa S, Wang, Hui, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

Simultaneous Detection of Nine Antibiotic Resistance-Related Genes in Streptococcus agalactiae Using Multiplex PCR and Reverse Line Blot Hybridization Assay†

Zeng, Xianyu, Kong, Fanrong, Wang, Hui, Darbar, Archie, Gilbert, Gwendolyn L.

Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal and maternal sepsis. Penicillin is recommended for intrapartum prophylaxis, but erythromycin or clindamycin is...

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity

Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J

The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...

Simultaneous Detection and Identification of Candida, Aspergillus, and Cryptococcus Species by Reverse Line Blot Hybridization

Playford, E. Geoffrey, Kong, Fanrong, Sun, Ying, Wang, Hui, Halliday, Catriona, Sorrell, Tania C.

We report on a reverse line blot (RLB) assay, utilizing fungal species-specific oligonucleotide probes to hybridize with internal transcribed spacer 2 region sequences amplified using a nested...

Reduced Virulence of an fliC Mutant of Shiga-Toxigenic Escherichia coli O113:H21

Rogers, Trisha J., Paton, James C., Wang, Hui, Talbot, Ursula M., Paton, Adrienne W.

The contribution of flagellin to the virulence of the O113:H21 Shiga-toxigenic Escherichia coli (STEC) strain 98NK2 was investigated in the streptomycin-treated mouse model. Groups of mice were...

Bayesian Shrinkage Estimation of Quantitative Trait Loci Parameters

Wang, Hui, Zhang, Yuan-Ming, Li, Xinmin, Masinde, Godfred L., Mohan, Subburaman, Baylink, David J., ...

Mapping multiple QTL is a typical problem of variable selection in an oversaturated model because the potential number of QTL can be substantially larger than the sample size. Currently, model...

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication

Cherry, Sara, Kunte, Amit, Wang, Hui, Coyne, Carolyn, Rawson, Robert B, Perrimon, Norbert

During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular...

Human Genomic Deletions Mediated by Recombination between Alu Elements

Sen, Shurjo K., Han, Kyudong, Wang, Jianxin, Lee, Jungnam, Wang, Hui, Callinan, Pauline A., ...

Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of...

Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation

Song, Kyung, Wang, Hui, Krebs, Tracy L, Danielpour, David

Insulin-like growth factor-I inhibits transforming growth factor-β (TGF-β) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt-dependent pathway. Here we...

Symmetry breaking in individual plasmonic nanoparticles

Wang, Hui, Wu, Yanpeng, Lassiter, Britt, Nehl, Colleen L., Hafner, Jason H., Nordlander, Peter, ...

The plasmon resonances of a concentric metallic nanoshell arise from the hybridization of primitive plasmon modes of the same angular momentum on its inner and outer surfaces. For a nanoshell with an...

Tissue-specific expression and regulation of sexually dimorphic genes in mice

Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...

We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....

Emergence of primate genes by retrotransposon-mediated sequence transduction

Xing, Jinchuan, Wang, Hui, Belancio, Victoria P., Cordaux, Richard, Deininger, Prescott L., Batzer, Mark A.

Gene duplication is one of the most important mechanisms for creating new genes and generating genomic novelty. Retrotransposon-mediated sequence transduction (i.e., the process by which a...

Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas

Lu, Peirong, Nakamoto, Yasunari, Nemoto-Sasaki, Yoko, Fujii, Chifumi, Wang, Hui, Hashii, Minako, ...

Hepatoma cell lines can produce a massive amount of chemokines in response to various stimuli including hepatitis viruses and their products. However, it remains elusive on the types of chemokine...

Discovery of tissue-specific exons using comprehensive human exon microarrays

Clark, Tyson A, Schweitzer, Anthony C, Chen, Tina X, Staples, Michelle K, Lu, Gang, Wang, Hui, ...

Comprehensive exon microarrays with a simple intra-gene normalization algorithm were used to detect human tissue-specific alternative splicing events, suggesting significant expression outside of...

Direct and sensitive miRNA profiling from low-input total RNA

Wang, Hui, Ach, Robert A., Curry, Bo

We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling assay that is based on a highly efficient labeling method and novel microarray probe design. The probes provide...

Purification, crystallization and preliminary X-ray diffraction analysis of human enolase-phosphatase E1

Wang, Hui, Pang, Hai, Ding, Yi, Li, Yi, Wu, Xiao’ai, Rao, Zihe

Recombinant human E1 enzyme has been crystallized using the hanging-drop vapour-diffusion method and diffraction-quality crystals were grown at 291 K using PEG 4000 as precipitant.

Role for CD47-SIRPα signaling in xenograft rejection by macrophages

Ide, Kentaro, Wang, Hui, Tahara, Hiroyuki, Liu, Jianxiang, Wang, Xiaoying, Asahara, Toshimasa, ...

We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological...

Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms.

Wang, Hui, Nan, Li, Yu, Dong, Lindsey, J. Russell, Agrawal, Sudhir, Zhang, Ruiwen

BACKGROUND: The MDM2 oncogene is amplified or overexpressed in many human cancers and MDM2 levels are associated with poor prognosis. MDM2 not only serves as a negative regulator of p53 but also has...

Attenuation of phagocytosis of xenogeneic cells by manipulating CD47

Wang, Hui, VerHalen, Jon, Madariaga, Maria Lucia, Xiang, Shuanglin, Wang, Shumei, Lan, Ping, ...

Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPα, prevents autologous phagocytosis. We hypothesized...

Heritability of alternative splicing in the human genome

Kwan, Tony, Benovoy, David, Dias, Christel, Gurd, Scott, Serre, David, Zuzan, Harry, ...

Alternative pre-mRNA splicing increases proteomic diversity and provides a potential mechanism underlying both phenotypic diversity and susceptibility to genetic disorders in human populations. To...

Purification and bioactivity of exendin-4, a peptide analogue of GLP-1, expressed in Pichia pastoris

Zhou, Jin, Chu, Ju, Wang, Yong-Hong, Wang, Hui, Zhuang, Ying-Ping, Zhang, Si-Liang

Exendin-4, a peptide analogue of glucagon-like peptide-1 (GLP-1), has been developed for treatment of type 2 diabetes. Herein, the secretive exendin-4 fusion protein, expressed by methanol induction...

Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals▿

Wang, Hui, Guo, Ping, Sun, Hongli, Wang, He, Yang, Qiwen, Chen, Minjun, ...

Carbapenem resistance in Acinetobacter spp. is an emerging problem in China. We investigated the molecular epidemiology and carbapenemase genes of 221 nonrepetitive imipenem-resistant clinical...

Functional Modulation of the Geminivirus AL2 Transcription Factor and Silencing Suppressor by Self-Interaction▿

Yang, Xiaojuan, Baliji, Surendranath, Buchmann, R. Cody, Wang, Hui, Lindbo, John A., Sunter, Garry, ...

The DNA genomes of geminiviruses have a limited coding capacity that is compensated for by the production of small multifunctional proteins. The AL2 protein encoded by members of the genus...

Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells

Wang, Hui, Madariaga, Maria Lucia, Wang, Shumei, Van Rooijen, Nico, Oldenborg, Per-Arne, Yang, Yong-Guang

Macrophages recognize CD47 as a marker of “self” and phagocytose CD47null hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against...

Tumor cell α3β1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis

Wang, Hui, Fu, Weili, Im, Jae Hong, Zhou, Zengyi, Santoro, Samuel A., Iyer, Vandana, ...

Arrest of circulating tumor cells in distant organs is required for hematogenous metastasis, but the tumor cell surface molecules responsible have not been identified. Here, we show that the tumor...

The BCR-ABL1 Kinase Bypasses Selection for the Expression of a Pre–B Cell Receptor in Pre–B Acute Lymphoblastic Leukemia Cells

Klein, Florian, Feldhahn, Niklas, Harder, Lana, Wang, Hui, Wartenberg, Maria, Hofmann, Wolf-Karsten, ...

The BCR-ABL1 kinase expressed in acute lymphoblastic leukemia (ALL) drives malignant transformation of human pre–B cells. Comparing genome-wide gene expression profiles of BCR-ABL1+ pre–B ALL and...

A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli

Paton, Adrienne W., Srimanote, Potjanee, Talbot, Ursula M., Wang, Hui, Paton, James C.

The Shiga toxigenic Escherichia coli (STEC) O113:H21 strain 98NK2, which was responsible for an outbreak of hemolytic uremic syndrome, secretes a highly potent and lethal subtilase cytotoxin that is...

Silencing of B Cell Receptor Signals in Human Naive B Cells

Feldhahn, Niklas, Schwering, Ines, Lee, Sanggyu, Wartenberg, Maria, Klein, Florian, Wang, Hui, ...

To identify changes in the regulation of B cell receptor (BCR) signals during the development of human B cells, we generated genome-wide gene expression profiles using the serial analysis of gene...

WEIGHTED LEAST ABSOLUTE DEVIATIONS ESTIMATION FOR ARMA MODELS WITH INFINITE VARIANCE

Pan, Jiazhu, Wang, Hui, Yao, Qiwei

For autoregressive moving average (ARMA) models with infinite variance innovations, quasi-likelihood-based estimators (such as Whittle estimators) suffer from complex asymptotic distributions...

Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes

Hao, Miao, Zhao, Yuqing, Chen, Peizhan, Huang, He, Liu, Hong, Jiang, Hualiang, ...

Ginseng, a traditional herbal medicine, may interact with several co-administered drugs in clinical settings, and ginsenosides, the major active components of ginseng, may be responsible for these...

Serological Reactivity and Biochemical Characterization of Methylated and Unmethylated Forms of a Recombinant Protein Fragment Derived from Outer Membrane Protein B of Rickettsia typhi▿

Chao, Chien-Chung, Zhang, Zhiwen, Wang, Hui, Alkhalil, Abdulnaser, Ching, Wei-Mei

Rickettsia typhi, an obligate intracellular bacterium that causes murine typhus, possesses a heavily methylated outer membrane protein B (OmpB) antigen. This immunodominant antigen is responsible for...

HSP90-buffered genetic variation is common in Arabidopsis thaliana

Sangster, Todd A., Salathia, Neeraj, Lee, Hana N., Watanabe, Etsuko, Schellenberg, Kurt, Morneau, Keith, ...

HSP90 is a protein chaperone particularly important in the maturation of a diverse set of proteins that regulate key steps in a multitude of biological processes. Alterations in HSP90 function...

ESCRT factors restrict mycobacterial growth

Philips, Jennifer A., Porto, Maura C., Wang, Hui, Rubin, Eric J., Perrimon, Norbert

Nearly 1.7 billion people are infected with Mycobacterium tuberculosis. Its ability to survive intracellularly is thought to be central to its success as a pathogen, but how it does this is poorly...

DEVELOPMENT OF HYDROXYAPATITE COATING PREPARED BY SOLâGEL TECHNIQUE

HUI WANG, CHUANZHONG CHEN, DIANGANG WANG

Metallic biomaterial, as a kind of composite materials, has been applied extensively in medical field due to its mechanical advantages and biological affinity. The solâgel technique, as a new method...

Practical Method for Detection and Identification of Candida, Aspergillus, and Scedosporium spp. by Use of Rolling-Circle Amplification▿

Zhou, Xiaoyong, Kong, Fanrong, Sorrell, Tania C., Wang, Hui, Duan, Yiqun, Chen, Sharon C. A.

A sensitive rolling-circle amplification (RCA)-based method utilizing species-specific padlock probes targeted to the internal transcribed spacer 2 region of the fungal ribosomal DNA gene complex was...

Use of Phenotypic and Molecular Serotype Identification Methods To Characterize Previously Nonserotypeable Group B Streptococci▿

Kong, Fanrong, Lambertsen, Lotte Munch, Slotved, Hans-Christian, Ko, Danny, Wang, Hui, Gilbert, Gwendolyn L.

Among 1,762 isolates of Streptococcus agalactiae (group B streptococcus [GBS]), 207 (12%) initially nonserotypeable isolates were tested by improved conventional serotyping methods (Lancefield...

Antiviral activities of extracts from Hong Kong seaweeds*

Wang, Hui, Ooi, Engchoon Vincent, Ang Jr., Put O.

We extracted six Hong Kong brown seaweed species with hot water for their antiviral properties. The cytotoxicity and antiviral activity of these extracts were tested by MTT...

WEIGHTED LEAST ABSOLUTE DEVIATIONS ESTIMATION FOR ARMA MODELS WITH INFINITE VARIANCE

Pan, Jiazhu, Wang, Hui, Yao, Qiwei

For autoregressive moving average (ARMA) models with infinite variance innovations, quasi-likelihood-based estimators (such as Whittle estimators) suffer from complex asymptotic distributions...

Model of For3p-Mediated Actin Cable Assembly in Fission Yeast

Wang, Hui, Vavylonis, Dimitrios

Formin For3p nucleates actin cables at the tips of fission yeast cells for polarized cell growth. The results of prior experiments have suggested a possible mechanism for actin cable assembly that...

Trading Land Development Rights under a Planned Land Use System: The "Zhejiang Model"

Hui Wang, Ran Tao, Juer Tong

China's state planned land use system, including regulations such as setting planned quotas for land use, basic cropland preservation, and pursuing a balance between the conversion of arable land...

Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity

Yang, Xiuna, Morita, Masahiro, Wang, Hui, Suzuki, Toru, Yang, Wen, Luo, Yunhai, ...

BTG2 is the prototypical member of the TOB family and is known to be involved in cell growth, differentiation and DNA repair. As a transcriptional co-regulator, BTG2 interacts with CCR4-associated...

Cell-permeable Tat-NBD peptide attenuates rat pancreatitis and acinus cell inflammation response

Long, You-Ming, Chen, Ken, Liu, Xue-Jin, Xie, Wen-Rui, Wang, Hui

AIM: To investigate the effects of Tat-NEMO-binding domain (NBD) peptide on taurocholate-induced pancreatitis and lipopolysaccharide (LPS)-stimulated AR42J acinus cells inflammatory response in rats.

A system for screening agonists targeting β2-adrenoceptor from Chinese medicinal herbs*

Wang, Hui, Li, Shi-you, Zhao, Chuan-ke, Zeng, Xin

In order to develop a model for screening the agonists of human β2-adrenoceptor from Chinese medicinal herbs extracts, we used a cell-based functional assay based on a common G protein-coupled...

Tropomyosin Dynamics in Cardiac Thin Filaments: A Multisite Förster Resonance Energy Transfer and Anisotropy Study

Wang, Hui, Mao, Shu, Chalovich, Joseph M., Marriott, Gerard

Cryoelectron microscopy studies have identified distinct locations of tropomyosin (Tm) within the Ca2+-free, Ca2+-saturated, and myosin-S1-saturated states of the thin filament. On the other hand,...

High Prevalence of Plasmid-Mediated Quinolone Resistance Genes qnr and aac(6′)-Ib-cr in Clinical Isolates of Enterobacteriaceae from Nine Teaching Hospitals in China ▿

Yang, Hong, Chen, Hongbin, Yang, Qiwen, Chen, Minjun, Wang, Hui

Quinolone resistance is an emerging problem in China. To investigate the prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6′)-Ib-cr, a total of 265 clinical isolates of...

Over-expressed and truncated midkines promote proliferation of BGC823 cells in vitro and tumor growth in vivo

Wang, Qing-Ling, Wang, Hui, Zhao, Shu-Li, Huang, Ya-Hong, Hou, Ya-Yi

AIM: To determine whether midkine (MK) and its truncated form (tMK) contribute to gastric tumorigenesis using in vitro and in vivo models.

Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy

Abuzeid, Waleed M., Jiang, Xiaoling, Shi, Guoli, Wang, Hui, Paulson, David, Araki, Koji, ...

Platinum-based drugs that induce DNA damage are commonly used first-line chemotherapy agents for testicular, bladder, head and neck, lung, esophageal, stomach, and ovarian cancers. The inherent...

Molecular Evidence for Spread of Two Major Methicillin-Resistant Staphylococcus aureus Clones with a Unique Geographic Distribution in Chinese Hospitals▿

Liu, Yudong, Wang, Hui, Du, Na, Shen, Enhua, Chen, Hongbin, Niu, Junqi, ...

Methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) is a serious problem worldwide. To investigate the molecular epidemiology of MRSA isolates in China, a total of 702 MRSA isolates...

Government Protection and Corporate Risk Management in China

Jianbing Huang, Hui Wang

Corporate finance theory holds that risk management increases firm value by reducing the costs of financial distress, agency costs, and taxes. This hypothesis is examined by conducting empirical...

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

Nag, Shalini, Ma, Qing, Wang, Hui, Chumnarnsilpa, Sakesit, Lee, Wei Lin, Larsson, Mårten, ...

Gelsolin consists of six homologous domains (G1–G6), each containing a conserved Ca-binding site. Occupation of a subset of these sites enables gelsolin to sever and cap actin filaments in a...

Effect of Des-acyl Ghrelin on Adiposity and Glucose Metabolism

Zhang, Weizhen, Chai, Biaoxin, Li, Ji-yao, Wang, Hui, Mulholland, Michael W.

Ghrelin, a gastric peptide hormone, has been reported to regulate GH secretion and energy homeostasis. Here, we examined the effect of des-acyl ghrelin driven from the fatty acid-binding protein-4...

Mutations in SPATA7 Cause Leber Congenital Amaurosis and Juvenile Retinitis Pigmentosa

Wang, Hui, Den Hollander, Anneke I., Moayedi, Yalda, Abulimiti, Abuduaini, Li, Yumei, Collin, Rob W.J., ...

Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP) are the most common hereditary causes of visual impairment in infants and children. Using homozygosity mapping, we narrowed...

Substitution Effects in Parental Investments

Brandt, Loren, Siow, Aloysius, Wang, Hui

The paper estimates how parents adjust bride-prices and land divisions to compensate their sons for differences in their schooling investments in rural China. The main estimate implies that when a...

Agricultural origins and the isotopic identity of domestication in northern China

Barton, Loukas, Newsome, Seth D., Chen, Fa-Hu, Wang, Hui, Guilderson, Thomas P., Bettinger, Robert L.

Stable isotope biochemistry (δ13C and δ15N) and radiocarbon dating of ancient human and animal bone document 2 distinct phases of plant and animal domestication at the Dadiwan site in northwest...

Financial caps for oil pollution damage: A historical mistake?

Faure, Michael, Wang, Hui

The limitation of liability (known as financial caps) of the ship owner has a long tradition in maritime law in general and in the marine oil pollution compensation regime in particular. This paper...

Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma

Ma, Hai-Qing, Liang, Xiao-Ting, Zhao, Jing-Jing, Wang, Hui, Sun, Jian-Cong, Chen, Yi-Bing, ...

AIM: To investigate the expression of Neurensin-2 (NRSN2) in hepatocellular carcinoma (HCC) and its prognostic values in predicting survival.

A Drosophila Resource of Transgenic RNAi Lines for Neurogenetics

Ni, Jian-Quan, Liu, Lu-Ping, Binari, Richard, Hardy, Robert, Shim, Hye-Seok, Cavallaro, Amanda, ...

Conditional expression of hairpin constructs in Drosophila is a powerful method to disrupt the activity of single genes with a spatial and temporal resolution that is impossible, or exceedingly...

High-Throughput Multiplex Sequencing to Discover Copy Number Variants in Drosophila

Daines, Bryce, Wang, Hui, Li, Yumei, Han, Yi, Gibbs, Richard, Chen, Rui

Copy number variation (CNV) contributes in phenotypically relevant ways to the genetic variability of many organisms. Cost-effective genomewide methods for identifying copy number variation are...