Somboon Leungwattanakij, Trinity J. Bivalacqua, Mustafa F. Usta, Dae-yul Yang, Jae-seog Hyun, Hunter C. Champion, ...
ABSTRACT: The etiologies of erectile dysfunction (ED) after nervesparing radical prostatectomy have not been clearly elucidated. The aim of this study was to evaluate the effects of cavernous nerve...
Phosphodiesterase regulation of nitric oxide signaling (2007)
Kass, David A., Takimoto, Eiki, Nagayama, Takahiro, Champion, Hunter C.
Nitric oxide regulation of the cardiovascular system involves both cGMP-dependent and independent mechanisms. The former directly interacts with the family of catabolic phosphodiesterases (PDEs) that...
Champion, Hunter C., Bivalacqua, Trinity J., Greenberg, Stanley S., Giles, Thomas D., Hyman, Albert L., Kadowitz, Philip J.
It has been shown that mice deficient in the gene coding for endothelial nitric-oxide synthase (eNOS) have increased pulmonary arterial pressure and pulmonary vascular resistance. In the present...
Paolocci, Nazareno, Katori, Tatsuo, Champion, Hunter C., St. John, Marcus E., Miranda, Katrina M., Fukuto, Jon M., ...
Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we tested whether...
Bivalacqua, Trinity J., Champion, Hunter C., Usta, Mustafa F., Cellek, Selim, Chitaley, Kanchan, Webb, R. Clinton, ...
Significant impairment in endothelial-derived nitric oxide is present in the diabetic corpus cavernosum. RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS). Here, we tested the...
Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
Champion, Hunter C., Bivalacqua, Trinity J., Takimoto, Eiki, Kass, David A., Burnett, Arthur L.
The molecular mechanism for priapism is not well characterized. Although the nitric oxide (NO) pathway is known to mediate penile erection under normal conditions, we hypothesized that the mechanism...
Takimoto, Eiki, Champion, Hunter C., Li, Manxiang, Ren, Shuxun, Rodriguez, E. Rene, Tavazzi, Barbara, ...
Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide synthase–3 (NOS3) plays...
Nagoshi, Tomohisa, Matsui, Takashi, Aoyama, Takuma, Leri, Annarosa, Anversa, Piero, Li, Ling, ...
Acute activation of the serine-threonine kinase Akt is cardioprotective and reduces both infarction and dysfunction after ischemia/reperfusion injury (IRI). However, less is known about the chronic...
Alternatively spliced neuronal nitric oxide synthase mediates penile erection
Hurt, K. Joseph, Sezen, Sena F., Champion, Hunter C., Crone, Julie K., Palese, Michael A., Huang, Paul L., ...
A key role for nitric oxide (NO) in penile erection is well established, but the relative roles of the neuronal NO synthase (nNOS) versus endothelial forms of NOS are not clear. nNOS- and endothelial...
Champion, Hunter C., Bivalacqua, Trinity J., Greenberg, Stanley S., Giles, Thomas D., Hyman, Albert L., Kadowitz, Philip J.
It has been shown that mice deficient in the gene coding for endothelial nitric-oxide synthase (eNOS) have increased pulmonary arterial pressure and pulmonary vascular resistance. In the present...
Paolocci, Nazareno, Katori, Tatsuo, Champion, Hunter C., St. John, Marcus E., Miranda, Katrina M., Fukuto, Jon M., ...
Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we tested whether...
Bivalacqua, Trinity J., Champion, Hunter C., Usta, Mustafa F., Cellek, Selim, Chitaley, Kanchan, Webb, R. Clinton, ...
Significant impairment in endothelial-derived nitric oxide is present in the diabetic corpus cavernosum. RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS). Here, we tested the...
Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
Champion, Hunter C., Bivalacqua, Trinity J., Takimoto, Eiki, Kass, David A., Burnett, Arthur L.
The molecular mechanism for priapism is not well characterized. Although the nitric oxide (NO) pathway is known to mediate penile erection under normal conditions, we hypothesized that the mechanism...
Takimoto, Eiki, Champion, Hunter C., Li, Manxiang, Ren, Shuxun, Rodriguez, E. Rene, Tavazzi, Barbara, ...
Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide synthase–3 (NOS3) plays...
Nagoshi, Tomohisa, Matsui, Takashi, Aoyama, Takuma, Leri, Annarosa, Anversa, Piero, Li, Ling, ...
Acute activation of the serine-threonine kinase Akt is cardioprotective and reduces both infarction and dysfunction after ischemia/reperfusion injury (IRI). However, less is known about the chronic...
Alternatively spliced neuronal nitric oxide synthase mediates penile erection
Hurt, K. Joseph, Sezen, Sena F., Champion, Hunter C., Crone, Julie K., Palese, Michael A., Huang, Paul L., ...
A key role for nitric oxide (NO) in penile erection is well established, but the relative roles of the neuronal NO synthase (nNOS) versus endothelial forms of NOS are not clear. nNOS- and endothelial...
Hsu, Lewis L., Champion, Hunter C., Campbell-Lee, Sally A., Bivalacqua, Trinity J., Manci, Elizabeth A., Diwan, Bhalchandra A., ...
Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary...
Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension
Zaiman, Ari L., Podowski, Megan, Medicherla, Satya, Gordy, Kimberley, Xu, Fang, Zhen, Lijie, ...
Rationale: Pulmonary arterial hypertension is a progressive disease characterized by an elevation in the mean pulmonary artery pressure leading to right heart failure and a significant risk of death....
Exposure to inhaled particulate matter impairs cardiac function in senescent mice
Tankersley, Clarke G., Champion, Hunter C., Takimoto, Eiki, Gabrielson, Kathleen, Bedja, Djahida, Misra, Vikas, ...
Daily exposure to particulate matter (PM) is known to adversely affect cardiac function and is also known to be exaggerated with senescence. This study tests the hypothesis that cardiac function is...
Sussan, Thomas E., Rangasamy, Tirumalai, Blake, David J., Malhotra, Deepti, El-Haddad, Hazim, Bedja, Djahida, ...
Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no...