HuR recruits let-7/RISC to repress c-Myc expression (2009)
Kim, Hyeon Ho, Kuwano, Yuki, Srikantan, Subramanya, Lee, Eun Kyung, Martindale, Jennifer L., Gorospe, Myriam
RNA-binding proteins (RBPs) and microRNAs (miRNAs) are potent post-transcriptional regulators of gene expression. Here, we show that the RBP HuR reduced c-Myc expression by associating with the c-Myc...
Nuclear HuR accumulation through phosphorylation by Cdk1 (2008)
Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Pullmann, Rudolf, Yang, Xiaoling, Galban, Stefanie, ...
A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs. Here,...
Pullmann, Rudolf, Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Martindale, Jennifer L., Yang, Xiaoling, ...
RNA-binding proteins (RBPs) that associate with specific mRNA sequences and function as mRNA turnover and translation regulatory (TTR) RBPs are emerging as pivotal posttranscriptional regulators of...
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
Jang, Hyeung-Jin, Kokrashvili, Zaza, Theodorakis, Michael J., Carlson, Olga D., Kim, Byung-Joon, Zhou, Jie, ...
Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically,...
p16INK4a Translation Suppressed by miR-24
Lal, Ashish, Kim, Hyeon Ho, Abdelmohsen, Kotb, Kuwano, Yuki, Pullmann, Rudolf, Srikantan, Subramanya, ...
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α▿ †
Galbán, Stefanie, Kuwano, Yuki, Pullmann, Rudolf, Martindale, Jennifer L., Kim, Hyeon Ho, Lal, Ashish, ...
The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa cells...
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90▿ †
Kuwano, Yuki, Kim, Hyeon Ho, Abdelmohsen, Kotb, Pullmann, Rudolf, Martindale, Jennifer L., Yang, Xiaoling, ...
The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated kinase (ERK), c-Jun...
Nuclear HuR accumulation through phosphorylation by Cdk1
Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Pullmann, Rudolf, Yang, Xiaoling, Galban, Stefanie, ...
A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs. Here,...