Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches (2009)
Rudy J. Castellani, Xiongwei Zhu, Hyoung-Gon Lee, Mark A. Smith, George Perry
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Molecular Pathogenesis of Alzheimer's Disease: Reductionist versus Expansionist Approaches. (2009)
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer's disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
The role of metabotropic glutamate receptors in Alzheimer’s disease (2008)
Neu Obiologi E, Hyoung-gon Lee, Xiongwei Zhu, Michael J. O’neill, Gemma Casadesus, ...
Abstract. While glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in Alzheimer’s disease (AD), the role of glutamate...
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Pathology's New Role: Defining Disease Process and Protective Responses. (2008)
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. (2007)
Evans, Teresa A., Raina, Arun K., Delacourte, Andr, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, ...
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many...
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! (2006)
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
Staying connected: synapses in Alzheimer disease. (2004)
Lee, Hyoung-gon, Moreira, Paula I., Zhu, Xiongwei, Smith, Mark A., Perry, George
A New Approach for Finite Capacity Planning in MRP Environment. (1970)
Hong-bum Na, Hyoung-Gon Lee, Jinwoo Park
MRP (Material Requirement Planning) process generates a production plan which guarantees an exact quantity of right materials on needed time but it sometimes causes capacity problems in the shop...
Staying Connected: Synapses in Alzheimer Disease
Lee, Hyoung-gon, Moreira, Paula I., Zhu, Xiongwei, Smith, Mark A., Perry, George
Amyloid-β Vaccination: Testing the Amyloid Hypothesis? : Heads We Win, Tails You Lose!
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease
Evans, Teresa A., Raina, Arun K., Delacourte, André, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, ...
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many...
Smith, Mark A., Zhu, Xiongwei, Lee, Hyoung-gon, Harris, Peggy L.R., Fortino, Anne E., Perry, George, ...
A number of recent studies have suggested that cardiac myocytes, previously considered post-mitotic, re-enter the cell cycle and possess the ability to proliferate with certain pathogenic stimuli. To...
Pathology's New Role: Defining Disease Process and Protective Responses
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...
The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
Lee, Hyoung-gon, Casadesus, Gemma, Nunomura, Akihiko, Zhu, Xiongwei, Castellani, Rudy J., Richardson, Sandy L., ...
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an...
Lee, Hyoung-gon, Chen, Qun, Wolfram, Julie A., Richardson, Sandy L., Liner, Anna, Siedlak, Sandra L., ...
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a “fetal re-expression” pattern, the functional role of Myc in...