Hywel Williams

Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)

Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...

Analysis of copy number variation using quantitative interspecies competitive PCR (2008)

Williams, Nigel M., Williams, Hywel, Majounie, Elisa, Norton, Nadine, Glaser, Beate, Morris, Huw R., ...

Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, human phenotypic diversity and disease...

Homeostatic plasticity improves signal propagation in continuous time recurrent neural networks (2007)

Williams, Hywel, Noble, Jason

Continuous-time recurrent neural networks (CTRNNs) are potentially an excellent substrate for the generation of adaptive behaviour in artificial autonomous agents. However, node saturation effects in...

Homeostatic plasticity improves signal propagation in continuous time recurrent neural networks (2007)

Williams, Hywel, Noble, Jason

Continuous-time recurrent neural networks (CTRNNs) are potentially an excellent substrate for the generation of adaptive behaviour in artificial autonomous agents. However, node saturation effects in...

Homeostatic plasticity improves signal propagation in continuous time recurrent neural networks (2007)

Williams, Hywel, Noble, Jason

Continuous-time recurrent neural networks (CTRNNs) are potentially an excellent substrate for the generation of adaptive behaviour in artificial autonomous agents. However, node saturation effects in...

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis (2006)

Williams, Hywel, Flohr, Carsten

We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree,...

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis (2006)

Williams, Hywel, Flohr, Carsten

We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree,...

Evolution and the Regulation of Environmental Variables (2005)

Hywel Williams, Jason Noble

Abstract. The idea that the biota can regulate the abiotic components of their environment to levels suitable for life has attracted criticism from neo-Darwinian theorists but is still a viable...

New treatments for atopic dermatitis (2002)

Williams, Hywel

Atopic dermatitis now affects 15% to 20% of chilĀ­ dren in developed countries, and prevalence in cities in developing countries undergoing rapid demographic changes is quickly following suit.1 Most...

New treatments for atopic dermatitis (2002)

Williams, Hywel

Atopic dermatitis now affects 15% to 20% of chilĀ­ dren in developed countries, and prevalence in cities in developing countries undergoing rapid demographic changes is quickly following suit.1 Most...

Localization of the Gene for Distal Hereditary Motor Neuronopathy VII (dHMN-VII) to Chromosome 2q14

McEntagart, Meriel, Norton, Nadine, Williams, Hywel, Teare, M. Dawn, Dunstan, Melanie, Baker, Philip, ...

Distal hereditary motor neuronopathy type VII (dHMN-VII) is an autosomal dominant disorder characterized by distal muscular atrophy and vocal cord paralysis. We performed a genomewide linkage search...

Localization of the Gene for Distal Hereditary Motor Neuronopathy VII (dHMN-VII) to Chromosome 2q14

McEntagart, Meriel, Norton, Nadine, Williams, Hywel, Teare, M. Dawn, Dunstan, Melanie, Baker, Philip, ...

Distal hereditary motor neuronopathy type VII (dHMN-VII) is an autosomal dominant disorder characterized by distal muscular atrophy and vocal cord paralysis. We performed a genomewide linkage search...

Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia

Georgieva, Lyudmila, Moskvina, Valentina, Peirce, Tim, Norton, Nadine, Bray, Nicholas J., Jones, Lesley, ...

Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to...

Analysis of copy number variation using quantitative interspecies competitive PCR

Williams, Nigel M., Williams, Hywel, Majounie, Elisa, Norton, Nadine, Glaser, Beate, Morris, Huw R., ...

Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, human phenotypic diversity and disease...