Serum bile acids in patients with hyperlipidaemia.
Pennington, C R, Ross, P E, Bateson, M C, Bouchier, I A
Individual serum bile acids were analysed by an improved gas liquid chromatography method in 12 patients with primary hyperlipidaemia. Total serum bile acid concentrations were raised in 10 subjects....
Influence of the gallbladder on serum bile acids.
Pennington, C R, Ross, P E, Bouchier, I A
Serum bile acids (SBA) were studied after a standard fatty meal in patients with gallbladder disease. Early postprandial bile acid values were found to be greater in patients with non-functioning...
Characteristics of cholesterol absorption by human gall bladder: relevance to cholesterolosis.
Jacyna, M R, Ross, P E, Bakar, M A, Hopwood, D, Bouchier, I A
The characteristics of cholesterol uptake by 83 human gall bladders (obtained at cholecystectomy) were studied with a modified Ussing technique. Real and artificial biles labelled with...
Radioimmunoassay of primary bile salts in serum.
Baqir, Y A, Murison, J, Ross, P E, Bouchier, I A
Rapid, sensitive radioimmunoassays have been developed for the conjugated primary bile salts, cholate and chenodeoxycholate, using immunogens prepared by the mixed anhydride procedure. Antibodies...
Measurement of serum primary bile acid ratio by gas liquid chromatography and radioimmunoassay.
Pennington, C R, Baqir, Y A, Ross, P E, Murison, J, Bouchier, I A
The application of a sensitive gas liquid chromatography (GLC) assay has enabled patients in different diagnostic groups to be differentiated on the basis of the ratio of the primary bile acids,...
A comparative trial of liver biopsy needles.
Bateson, M C, Hopwood, D, Duguid, H L, Bouchier, I A
A sheathed needle (Tru-Cut) was compared with a suction biopsy needle (Menghini) in a randomised prospective trial over 18 months to determine whether the former offered any special advantages in...
Fluctuations of serum bile acid concentrations during the menstrual cycle.
Pennington, C R, Ross, P E, Murison, J, Bouchier, I A
Fasting primary bile acid conjugates were measured in 44 women by radioimmunoassay methods. Bile acid values were significantly greater in the 21 women who were in the first half of the menstrual...
Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state.
Shepherd, A N, Bedford, G J, Hill, A, Bouchier, I A
Twenty five patients with primary biliary cirrhosis were studied for vitamin A state. In nine patients found to have low circulating vitamin A concentrations no abnormality was found on...
Diagnosis of inflammatory bowel disease: an international multicentre scoring system.
Clamp, S E, Myren, J, Bouchier, I A, Watkinson, G, De Dombal, F T
Inflammatory bowel disease is being studied by the World Organisation of Gastroenterology (OMGE) Research Committee in a survey (currently) affecting 1696 patients presenting to 30 hospitals in 16...
Calcification of radiolucent gall stone during treatment with ursodeoxycholic acid.
Bateson, M C, Bouchier, I A, Trash, D B, Maudgal, D P, Northfield, T C
During the decade in which the medical dissolution of gall stones has become feasible several drugs have been introduced but only the two listed in the British National Formulary have been...
Reversal of clofibrate-induced cholesterol oversaturation of bile with chenodeoxycholic acid.
Bateson, M C, Ross, P E, Murison, J, Bouchier, I A
Giving clofibrate 2 g daily to seven patients significantly increased the biliary cholesterol concentration while the proportion of bile acids fell. Five patients on established clofibrate treatment...
Serum bile acids in patients with hyperlipidaemia.
Pennington, C R, Ross, P E, Bateson, M C, Bouchier, I A
Individual serum bile acids were analysed by an improved gas liquid chromatography method in 12 patients with primary hyperlipidaemia. Total serum bile acid concentrations were raised in 10 subjects....
Influence of the gallbladder on serum bile acids.
Pennington, C R, Ross, P E, Bouchier, I A
Serum bile acids (SBA) were studied after a standard fatty meal in patients with gallbladder disease. Early postprandial bile acid values were found to be greater in patients with non-functioning...
Characteristics of cholesterol absorption by human gall bladder: relevance to cholesterolosis.
Jacyna, M R, Ross, P E, Bakar, M A, Hopwood, D, Bouchier, I A
The characteristics of cholesterol uptake by 83 human gall bladders (obtained at cholecystectomy) were studied with a modified Ussing technique. Real and artificial biles labelled with...
Radioimmunoassay of primary bile salts in serum.
Baqir, Y A, Murison, J, Ross, P E, Bouchier, I A
Rapid, sensitive radioimmunoassays have been developed for the conjugated primary bile salts, cholate and chenodeoxycholate, using immunogens prepared by the mixed anhydride procedure. Antibodies...
Measurement of serum primary bile acid ratio by gas liquid chromatography and radioimmunoassay.
Pennington, C R, Baqir, Y A, Ross, P E, Murison, J, Bouchier, I A
The application of a sensitive gas liquid chromatography (GLC) assay has enabled patients in different diagnostic groups to be differentiated on the basis of the ratio of the primary bile acids,...
A comparative trial of liver biopsy needles.
Bateson, M C, Hopwood, D, Duguid, H L, Bouchier, I A
A sheathed needle (Tru-Cut) was compared with a suction biopsy needle (Menghini) in a randomised prospective trial over 18 months to determine whether the former offered any special advantages in...
Fluctuations of serum bile acid concentrations during the menstrual cycle.
Pennington, C R, Ross, P E, Murison, J, Bouchier, I A
Fasting primary bile acid conjugates were measured in 44 women by radioimmunoassay methods. Bile acid values were significantly greater in the 21 women who were in the first half of the menstrual...
Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state.
Shepherd, A N, Bedford, G J, Hill, A, Bouchier, I A
Twenty five patients with primary biliary cirrhosis were studied for vitamin A state. In nine patients found to have low circulating vitamin A concentrations no abnormality was found on...
Diagnosis of inflammatory bowel disease: an international multicentre scoring system.
Clamp, S E, Myren, J, Bouchier, I A, Watkinson, G, De Dombal, F T
Inflammatory bowel disease is being studied by the World Organisation of Gastroenterology (OMGE) Research Committee in a survey (currently) affecting 1696 patients presenting to 30 hospitals in 16...
Calcification of radiolucent gall stone during treatment with ursodeoxycholic acid.
Bateson, M C, Bouchier, I A, Trash, D B, Maudgal, D P, Northfield, T C
During the decade in which the medical dissolution of gall stones has become feasible several drugs have been introduced but only the two listed in the British National Formulary have been...
Reversal of clofibrate-induced cholesterol oversaturation of bile with chenodeoxycholic acid.
Bateson, M C, Ross, P E, Murison, J, Bouchier, I A
Giving clofibrate 2 g daily to seven patients significantly increased the biliary cholesterol concentration while the proportion of bile acids fell. Five patients on established clofibrate treatment...
Acute effect of low dose theophylline on the circulatory disturbances of cirrhosis.
Forrest, E H, Bouchier, I A, Hayes, P C
BACKGROUND: Adenosine is a potent vasoactive substance that may be responsible for mediating the altered haemodynamics found in patients with cirrhosis. AIM: The administration of oral theophylline...
Computerised system for the continuous measurement of azygos venous blood flow.
Hayes, P C, Terrace, D, Peaston, I, Bouchier, I A, Redhead, D, Brash, H M
A computer assisted apparatus for the continuous measurement of azygos blood flow is described. The system was validated in vitro and changes in flow which occur with respiration and Valsalva...
Evidence of hydrogen ion secretion from the human gall bladder in vitro.
Plevris, J N, Hayes, P C, Harrison, D J, Bouchier, I A
Gall bladder bile is more acid that hepatic bile and this has been attributed to bicarbonate absorption by the gall bladder epithelium. The aim of this study was to investigate in vitro the acid base...
Simpson, K J, Chalmers, N, Redhead, D N, Finlayson, N D, Bouchier, I A, Hayes, P C
The insertion of a transjugular intrahepatic portasystemic stent shunt (TIPSS) was evaluated in 22 patients with recurrent upper gastrointestinal haemorrhage related to portal hypertension (bleeding...
Primary culture of bovine gall bladder epithelial cells.
Plevris, J N, Walker, S W, Harrison, D J, Dhariwal, A, Hayes, P C, Bouchier, I A
Gall bladder epithelial cells serve numerous biological functions and abnormalities in their function are important in the pathogenesis of several gall bladder diseases. Direct studies on cell...
Portal and systemic haemodynamic action of N-acetylcysteine in patients with stable cirrhosis.
Jones, A L, Bangash, I H, Bouchier, I A, Hayes, P C
The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one...
Exocrine pancreatic function in juvenile-onset diabetes mellitus.
Frier, B M, Saunders, J H, Wormsley, K G, Bouchier, I A
Exocrine pancreatic function was studied in 20 juvenile-onset diabetics, seven maturity-onset diabetics, and five patients with diabetes secondary to chronic pancreatitis. The results were compared...
Bateson, M C, Ross, P E, Murison, J, Bouchier, I A
Nineteen patients who received chenodeoxycholic acid 750 mg/day for six months had duodenal bile aspirated before and after treatment. In five patients with hypertriglyceridaemia but no gallstones...
Serum bile acids in the diagnosis of hepatobiliary disease.
Pennington, C R, Ross, P E, Bouchier, I A
The value of serum bile acids (SBA) in the diagnosis of hepatobiliary disease has been investigated. A modified GLC method was used, with an overall coefficient of variation of +/- 11% in the control...
Serum bile acids in hepatobiliary disease.
Bouchier, I A, Pennington, C R
We review the estimation of total and individual serum bile acids to detect the presence and nature of hepatobiliary disease. The different methods for measuring serum bile acids are discussed.
Changes in enzyme activity in normal and histologically inflamed oesophageal epithelium.
Hopwood, D, Ross, P E, Logan, K R, Nicholson, G, Bouchier, I A
Oesophageal biopsies were obtained from 74 patinets undergoing upper gastrointestinal fibreoptic endoscopy. Thirteen patients with histological evidence of inflammation had a raised alkaline...
Effects of bile acids and hydrogen ion on the fine structure of oesophageal epithelium.
Hopwood, D, Bateson, M C, Milne, G, Bouchier, I A
Oesophageal mucosal biopsies were incubated in 20, 0, and 0.2mM solutions of cholic, chenodeoxycholic, ursodeoxycholic, and deoxycholic bile acids. Both conjugated and unconjugated bile acids were...
Ursodeoxycholic acid therapy and biliary lipids--a dose-response study.
Bateson, M C, Ross, P E, Murison, J, Saunders, J H, Bouchier, I A
The effects of four different doses of ursodeoxycholic acid (250, 500, 750, and 1000 mg daily) on biliary lipids were studied in 24 patients with radiolucent gallbladder stones. There was a...
Liver membrane antibodies in alcoholic liver disease: 1. prevalence and immunoglobulin class.
Burt, A D, Anthony, R S, Hislop, W S, Bouchier, I A, MacSween, R N
Using an indirect immunofluorescence technique liver membrane antibodies of IgG and IgA class have been demonstrated in a statistically significant proportion of sera from patients with alcoholic...
Collagenous colitis associated with small intestinal villous atrophy.
Hamilton, I, Sanders, S, Hopwood, D, Bouchier, I A
Two patients diagnosed as having small intestinal hyperplastic villous atrophy and being treated with a gluten free diet were investigated because of persistent watery diarrhoea. Both were found to...
Hayes, P C, Harrison, D J, Bouchier, I A, McLellan, L I, Hayes, J D
Glutathione S-transferases are a group of drug metabolising and detoxification enzymes. We have studied the distribution of four isoenzymes, acidic, basic, neutral, and microsomal GST in human liver,...
Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.
Bateson, M C, Maclean, D, Evans, J R, Bouchier, I A
1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and...
The influence of captopril, the nitrates and propranolol on apparent liver blood flow.
Shepherd, A N, Hayes, P C, Jacyna, M, Morrison, L, Bouchier, I A
Indocyanine green estimated apparent liver blood flow was measured in normal volunteers following glyceryl trinitrate, propranolol, isosorbide mononitrate and captopril. Glyceryl trinitrate and...
Prospective study of a planned approach to the surgical management of bleeding oesophageal varices.
Connacher, A. A., Campbell, F. C., Bouchier, I. A., Cuschieri, A.
A policy of joint management of patients with acute variceal bleeding was constructed and applied prospectively to 37 consecutive patients. According to the protocol, every patient underwent an...
Mefenamic acid-induced bullous pemphigoid.
Shepherd, A. N., Ferguson, J., Bewick, M., Bouchier, I. A.
A 52 year old man developed bullous pemphigoid, Coombs' positive haemolytic anaemia and diarrhoea related to the use of mefenamic acid. Clinical manifestation of the bullous pemphigoid, haemolytic...
The association of oesophagitis with disease in the stomach and duodenum.
Bateson, M. C., Bouchier, I. A.
The records of all upper digestive endoscopies performed in one year in the Clinical Measurement Department of a teaching hospital serving a population of 250 000 were reviewed; 25% of patients had...
Jacyna, M. R., Ross, P. E., Hopwood, D., Bouchier, I. A.
Oral cholecystography is a well established method for studying the human gallbladder and radiological non-visualization of the gallbladder has been shown to correlate highly with the presence of...