Rockett, K A, Awburn, M M, Aggarwal, B B, Cowden, W B, Clark, I A
Tumor necrosis factor and related cytokines are thought to be implicated in cell-mediated immunity and pathophysiology in malaria, but their mechanism of action has not been ascertained. Tumor...
Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.
Rockett, K A, Awburn, M M, Cowden, W B, Clark, I A
We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not...
Production of luminol-reactive oxygen radicals during Plasmodium vinckei infection.
Stocker, R, Hunt, N H, Clark, I A, Weidemann, M J
We tested the ability of whole blood and enriched fractions of peripheral blood polymorphonuclear leukocytes obtained from mice during the course of infection with Plasmodium vinckei to produce...
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
A rapid reduction in parasitemia associated with damage to intraerythrocytic parasites was observed in Plasmodium vinckei-infected mice after they had received a single intravenous injection of...
Demonstration of a lipopolysaccharide-induced cytostatic effect on malarial parasites.
In an in vitro assay, malarial parasites (Plasmodium vinckei petteri) taken from mice 7 to 8 h after the injection of bacterial lipopolysaccharide (LPS) incorporated significantly less hypoxanthine...
Genetic control of Propionibacterium acnes-induced protection of mice against Babesia microti.
Using various strains of inbred mice, we found that Propionibacterium acnes-induced protection against the hemoprotozoan parasite Babesia microti was controlled by a dominant gene(s) not linked to...
Malarial parasites, Plasmodium vinckei petteri, taken from lipopolysaccharide (LPS) high-responder (C3H/HeJGiFWeHi) mice which had been injected 7 to 8 h previously with either Escherichia coli LPS B...
Possible importance of macrophage-derived mediators in acute malaria.
Clark, I A, Virelizier, J L, Carswell, E A, Wood, P R
Tumor necrosis factor, lymphocyte-activating factor, and enhanced levels of type I interferon were found in serum samples taken 2 h after mice infected with Plasmodium vinckei subsp. petteri received...
Oxidative stress and protective mechanisms in erythrocytes in relation to Plasmodium vinckei load.
Stocker, R, Hunt, N H, Buffinton, G D, Weidemann, M J, Lewis-Hughes, P H, Clark, I A
The protection of mouse erythrocytes (RBC) parasitized with Plasmodium vinckei vinckei against activated oxygen species was examined in relation to the intraerythrocytic parasite load. RBC from...
Mice injected intravenously with a commercially available extract of Coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for Q fever were subsequently...
Suppression of babesiosis in BCG-infected mice and its correlation with tumor inhibition.
Clark, I A, Wills, E J, Richmond, J E, Allison, A C
Infection of mice with Bacillus Calmette-Guérin (BCG) provided good protection against Babesia species. The intensity and duration of this protection was similar to that established after natural...
Buffinton, G D, Hunt, N H, Cowden, W B, Clark, I A
Reversed-phase h.p.l.c. was used to detect 2,4-dinitrophenylhydrazine-reactive carbonyl products, which excludes malonaldehyde, in malaria-parasite (Plasmodium vinckei)-infected murine red blood...
Rockett, K A, Awburn, M M, Aggarwal, B B, Cowden, W B, Clark, I A
Tumor necrosis factor and related cytokines are thought to be implicated in cell-mediated immunity and pathophysiology in malaria, but their mechanism of action has not been ascertained. Tumor...
Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.
Rockett, K A, Awburn, M M, Cowden, W B, Clark, I A
We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not...
Production of luminol-reactive oxygen radicals during Plasmodium vinckei infection.
Stocker, R, Hunt, N H, Clark, I A, Weidemann, M J
We tested the ability of whole blood and enriched fractions of peripheral blood polymorphonuclear leukocytes obtained from mice during the course of infection with Plasmodium vinckei to produce...
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
A rapid reduction in parasitemia associated with damage to intraerythrocytic parasites was observed in Plasmodium vinckei-infected mice after they had received a single intravenous injection of...
Demonstration of a lipopolysaccharide-induced cytostatic effect on malarial parasites.
In an in vitro assay, malarial parasites (Plasmodium vinckei petteri) taken from mice 7 to 8 h after the injection of bacterial lipopolysaccharide (LPS) incorporated significantly less hypoxanthine...
Genetic control of Propionibacterium acnes-induced protection of mice against Babesia microti.
Using various strains of inbred mice, we found that Propionibacterium acnes-induced protection against the hemoprotozoan parasite Babesia microti was controlled by a dominant gene(s) not linked to...
Malarial parasites, Plasmodium vinckei petteri, taken from lipopolysaccharide (LPS) high-responder (C3H/HeJGiFWeHi) mice which had been injected 7 to 8 h previously with either Escherichia coli LPS B...
Possible importance of macrophage-derived mediators in acute malaria.
Clark, I A, Virelizier, J L, Carswell, E A, Wood, P R
Tumor necrosis factor, lymphocyte-activating factor, and enhanced levels of type I interferon were found in serum samples taken 2 h after mice infected with Plasmodium vinckei subsp. petteri received...
Oxidative stress and protective mechanisms in erythrocytes in relation to Plasmodium vinckei load.
Stocker, R, Hunt, N H, Buffinton, G D, Weidemann, M J, Lewis-Hughes, P H, Clark, I A
The protection of mouse erythrocytes (RBC) parasitized with Plasmodium vinckei vinckei against activated oxygen species was examined in relation to the intraerythrocytic parasite load. RBC from...
Mice injected intravenously with a commercially available extract of Coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for Q fever were subsequently...
Suppression of babesiosis in BCG-infected mice and its correlation with tumor inhibition.
Clark, I A, Wills, E J, Richmond, J E, Allison, A C
Infection of mice with Bacillus Calmette-Guérin (BCG) provided good protection against Babesia species. The intensity and duration of this protection was similar to that established after natural...
Buffinton, G D, Hunt, N H, Cowden, W B, Clark, I A
Reversed-phase h.p.l.c. was used to detect 2,4-dinitrophenylhydrazine-reactive carbonyl products, which excludes malonaldehyde, in malaria-parasite (Plasmodium vinckei)-infected murine red blood...
Production of lymphocyte activating factor in vivo.
Wood, P R, Andrus, L, Clark, I A
Mice injected with Propionibacterium acnes, when challenged with lipopolysaccharide release a range of soluble mediators into their serum. Included among these is lymphocyte activating factor (LAF,...
Clark, I. A., MacMicking, J. D., Gray, K. M., Rockett, K. A., Cowden, W. B.
Because Plasmodium berghei ANKA induces cerebral malaria and P. vinckei does not, the former has often been studied as a model for human falciparum malaria. It lacks, however, many of the systemic...
Possible roles of tumor necrosis factor in the pathology of malaria.
Clark, I. A., Cowden, W. B., Butcher, G. A., Hunt, N. H.
The authors have earlier proposed that tumor necrosis factor (TNF) might contribute to the pathology of malaria. Here they report the outcome of injecting recombinant human TNF/cachectin into normal...
Clark, I A, Hunt, N H, Cowden, W B, Maxwell, L E, Mackie, E J
Intravenous injection of t-butyl hydroperoxide rapidly killed Plasmodium vinckei in mice, and caused haemolysis. The same dose seemed harmless to unparasitized mice. Many parasites disintegrated...
Protection of mice against haemoprotozoan Babesia microti with Brucella abortus strain 19.
Herod, E, Clark, I A, Allison, A C
When Brucella abortus strain 19 is given intraperitoneally to mice it protects them against subsequent infection with large doses of Babesia microti. The protection obtained was more effective when...
Proliferation in vitro of Lyt2-,L3T4- thymocytes shows responsiveness to interleukin 1.
Chaudhri, G, Clark, I A, Ceredig, R
The responsiveness of adult mouse thymocytes to interleukin 1 (IL-1) was investigated. When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature...