I. A. Romero

Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells (2008)

András, I. E., Rha, G., Huang, W., Eum, S., Couraud, P. O., Romero, I. A., ...

Increased deposition of amyloid beta (Abeta) is characteristic for normal aging and human immunodeficiency virus-1 (HIV-1)-associated alterations of the central nervous system. In addition, both...

Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier (2008)

Förster, C., Burek, M., Romero, I. A., Weksler, B., Couraud, P. O., Drenckhahn, D.

Homeostasis of the central nervous system (CNS) microenvironment is maintained by the blood-brain barrier (BBB) which regulates the transport of molecules from blood into brain and back. Many...

Human Blood Brain Barrier Disruption by Retroviral Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization. (2007)

Afonso, P.V., Ozden, S., Prevost, M.C., Schmitt, C., Seilhan, D., Weksler, B.B., ...

The blood-brain barrier (BBB), which constitutes the interface between blood and cerebral parenchyma, has been shown to be disrupted during retroviral associated neuromyelopathies. Human T cell...

Human cerebral endothelial cells support infection by HTLV (2007)

Afonzo, P. V., Ceccaldi, P.-E., Ozdeni, S., Mason, S., Lambert, S., Seilhea, D., ...

Human Blood Brain Barrier Model (2006)

Couraud, P.O., Romero, I.A., Weksler, B.B.

The present invention relates to an immortalized human brain endothelial cell line that is useful as an in vitro model of the blood brain barrier. CLAIMS 1. An immortalized human brain endothelial...

Blood-brain barrier-specific properties of a human adult brain endothelial cell line (2005)

Weksler, B.B., Subileau, E.A., Perriere, N., Charneau, P., Holloway, K., Leveque, M., ...

Establishment of a human model of the blood-brain barrier has proven to be a difficult goal. Normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase...

Role of neurotrophic factors (NTF) and extracellular matrix components (ECM) on VIP expression in the rat enteric nervous system (ENS) (2005)

Xeniou, Ourania, Romero, I.A., Saffrey, M.J.

We studied changes in vasoactive intestinal peptide (VIP) and neuronal nitric oxide synthase (nNOS) expression by myenteric neurons during early postnatal development in parallel with maturation of...

Oxidative stress affects the junctional integrity of retinal pigment epithelial cells (2004)

Bailey, T. A., Kanuga, N., Romero, I. A., Greenwood, J., Luthert, P. J., Cheetham, M. E.

PURPOSE: Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration. The cell line ARPE-19 was therefore examined for response to oxidative stress and its effect on...

Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells (2003)

Romero, I.A., Radewicz, K., Jubin, E., Michel, C.C., Greenwood, J., Couraud, P.O., ...

The blood-brain barrier (BBB) plays an important role in controlling the passage of molecules from the blood to the extracellular fluid environment of the brain. An immortalised rat brain endothelial...

Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated (2002)

Romero, I.A., Amos, C.L., Greenwood, J., Adamson, P.

The precise mechanism by which ICAM-1 transduces signals from adherent lymphocytes remains elusive. The ERM proteins ezrin and moesin were found to strongly co-localise with both ICAM-1 and F-actin...