Role of lipid trimming and CD1 groove size in cellular antigen presentation. (2006)
Cheng, T.Y., Relloso, M., Rhijn, I. Van, Young, D.C., Besra, G.S., Briken, V., ...
Cheng, H., Chong, Y.H., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I.A., ...
The synthesis and evaluation of 10-methanesulfonyl-DDACTHF (1), 10-methanesulfonyl-5-DACTHF (2), and 10-methylthio-DDACTHF (3) as potential inhibitors of glycinamide ribonucleotide transformylase...
Cheng, H., Hwang, I., Chong, Y.H., Tavassoli, A., Webb, M.E., Zhang, Y., ...
The synthesis and evaluation of N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl}-l-glutamic acid (2) as an inhibitor of glycinamide ribonucleotide...
Chong, Y., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I.A., Benkovic, S.J., ...
Structurally-related, but non-polyglutamylatable, derivatives of 10-CF3CO-DDACTHF (1), which incorporate l-glutamine (2) and l-isoglutamine (3) in place of l-glutamate, were prepared and evaluated as...
Marsilje, T.H., Hedrick, M.P., Desharnais, J., Capps, K., Tavassoli, A., Zhang, Y., ...
The design and synthesis of 10-(2-benzoxazolcarbonyl)-DDACTHF (1) as an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase)...
Desharnais, J., Hwang, I., Zhang, Y., Tavassoli, A., Baboval, J., Benkovic, S.J., ...
The synthesis and evaluation of analogues and key derivatives of 10-CF3CO-DDACTHF as inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase...
Marsilje, T.H., Hedrick, M.P., Desharnais, J., Tavassoli, A., Zhang, Y., Wilson, I.A., ...
A series of simplified -keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues lacking the benzoylglutamate subunit were prepared and examined as potential inhibitors of...
Zhang, Y., Desharnais, J., Marsilje, T.H., Li, C.L., Hedrick, M.P., Gooljarsingh, L.T., ...
Glycinamide ribonucleotide transformylase (GAR Tfase) has been the target of anti-neoplastic intervention for almost two decades. Here, we use a structure-based approach to design a novel folate...
Marsilje, T.H., Labroli, M.A., Hedrick, M.P., Jin, Q., Desharnais, J., Baker, S.J., ...
The synthesis of 10-formyl-DDACTHF (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) is...
Fremont, D H, Stura, E A, Matsumura, M, Peterson, P A, Wilson, I A
Sequence analysis of peptides naturally presented by major histocompatibility complex (MHC) class I molecules has revealed allele-specific motifs in which the peptide length and the residues observed...
Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association.
Fremont, D H, Anderson, D H, Wilson, I A, Dennis, E A, Xuong, N H
Phospholipase A2 (PLA2) from Indian cobra venom (Naja naja naja) was crystallized from ethanol in space group P4(3)2(1)2 in the presence of Ca2+. The x-ray crystal structure was determined to 2.3-A...
Rini, J M, Stanfield, R L, Stura, E A, Salinas, P A, Profy, A T, Wilson, I A
The crystal structure of the Fab fragment of a human immunodeficiency virus type 1 (HIV-1) neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex with a linear...
Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin.
Kemble, G W, Bodian, D L, Rosé, J, Wilson, I A, White, J M
At a low pH, the influenza virus hemagglutinin (HA) undergoes conformational changes that promote membrane fusion. While the critical role of fusion peptide release from the trimer interface has been...
Skehel, J J, Stevens, D J, Daniels, R S, Douglas, A R, Knossow, M, Wilson, I A, ...
A single amino acid substitution, Asp-63 to Asn-63, was detected in the hemagglutinin of an antigenic variant of the 1968 Hong Kong (H3) influenza virus that was selected by growth of the wild-type...
Skehel, J J, Bayley, P M, Brown, E B, Martin, S R, Waterfield, M D, White, J M, ...
A conformational change in the hemagglutinin glycoprotein of influenza virus has been observed to occur to pH values corresponding to those optimal for the membrane fusion activity of the virus. CD,...
Field, J, Nikawa, J, Broek, D, MacDonald, B, Rodgers, L, Wilson, I A, ...
We developed a method for immunoaffinity purification of Saccharomyces cerevisiae adenylyl cyclase based on creating a fusion with a small peptide epitope. Using oligonucleotide technology to encode...
Krystal, M, Young, J F, Palese, P, Wilson, I A, Skehel, J J, Wiley, D C
Comparative analysis of the amino acid sequences of hemagglutinins (HAs) of influenza B/Lee/40, B/Md/59, and B/HK/73 viruses has allowed examination of the molecular basis of antigenic variation in...
Niman, H L, Houghten, R A, Walker, L E, Reisfeld, R A, Wilson, I A, Hogle, J M, ...
Recent studies have shown that chemically synthesized small peptides can induce antibodies that often react with intact proteins regardless of their position in the folded molecule. These findings...
Wilson, I A, Haft, D H, Getzoff, E D, Tainer, J A, Lerner, R A, Brenner, S
The ability of antibodies raised against disordered short peptides to interact frequently with their cognate sequences in intact folded proteins has raised a major theoretical issue in protein...
Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.
Wilson, I A, Brindle, K M, Fulton, A M
Creatine kinase (CK) plays an important role in buffering ATP and ADP levels in tissues which have intermittently high and fluctuating energy demands, such as skeletal muscle. This buffering function...
Smith, S G, Lewis, M, Aschaffenburg, R, Fenna, R E, Wilson, I A, Sundaralingam, M, ...
The crystal structure of baboon alpha-lactalbumin has been determined at 6 A and at 4.5 A (0.6 nm and 0.45 nm) resolution by the method of isomorphous replacement. The principal derivative was...
Johnson, A G, Marshall, C E, Wilson, I A
1. The efficacies of some standard preparations of CCK were compared and the effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall-bladder to cholecystokinin...
Fremont, D H, Stura, E A, Matsumura, M, Peterson, P A, Wilson, I A
Sequence analysis of peptides naturally presented by major histocompatibility complex (MHC) class I molecules has revealed allele-specific motifs in which the peptide length and the residues observed...
Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association.
Fremont, D H, Anderson, D H, Wilson, I A, Dennis, E A, Xuong, N H
Phospholipase A2 (PLA2) from Indian cobra venom (Naja naja naja) was crystallized from ethanol in space group P4(3)2(1)2 in the presence of Ca2+. The x-ray crystal structure was determined to 2.3-A...
Rini, J M, Stanfield, R L, Stura, E A, Salinas, P A, Profy, A T, Wilson, I A
The crystal structure of the Fab fragment of a human immunodeficiency virus type 1 (HIV-1) neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex with a linear...
Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin.
Kemble, G W, Bodian, D L, Rosé, J, Wilson, I A, White, J M
At a low pH, the influenza virus hemagglutinin (HA) undergoes conformational changes that promote membrane fusion. While the critical role of fusion peptide release from the trimer interface has been...
Skehel, J J, Stevens, D J, Daniels, R S, Douglas, A R, Knossow, M, Wilson, I A, ...
A single amino acid substitution, Asp-63 to Asn-63, was detected in the hemagglutinin of an antigenic variant of the 1968 Hong Kong (H3) influenza virus that was selected by growth of the wild-type...
Skehel, J J, Bayley, P M, Brown, E B, Martin, S R, Waterfield, M D, White, J M, ...
A conformational change in the hemagglutinin glycoprotein of influenza virus has been observed to occur to pH values corresponding to those optimal for the membrane fusion activity of the virus. CD,...
Field, J, Nikawa, J, Broek, D, MacDonald, B, Rodgers, L, Wilson, I A, ...
We developed a method for immunoaffinity purification of Saccharomyces cerevisiae adenylyl cyclase based on creating a fusion with a small peptide epitope. Using oligonucleotide technology to encode...
Krystal, M, Young, J F, Palese, P, Wilson, I A, Skehel, J J, Wiley, D C
Comparative analysis of the amino acid sequences of hemagglutinins (HAs) of influenza B/Lee/40, B/Md/59, and B/HK/73 viruses has allowed examination of the molecular basis of antigenic variation in...
Niman, H L, Houghten, R A, Walker, L E, Reisfeld, R A, Wilson, I A, Hogle, J M, ...
Recent studies have shown that chemically synthesized small peptides can induce antibodies that often react with intact proteins regardless of their position in the folded molecule. These findings...
Wilson, I A, Haft, D H, Getzoff, E D, Tainer, J A, Lerner, R A, Brenner, S
The ability of antibodies raised against disordered short peptides to interact frequently with their cognate sequences in intact folded proteins has raised a major theoretical issue in protein...
Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts.
Wilson, I A, Brindle, K M, Fulton, A M
Creatine kinase (CK) plays an important role in buffering ATP and ADP levels in tissues which have intermittently high and fluctuating energy demands, such as skeletal muscle. This buffering function...
Smith, S G, Lewis, M, Aschaffenburg, R, Fenna, R E, Wilson, I A, Sundaralingam, M, ...
The crystal structure of baboon alpha-lactalbumin has been determined at 6 A and at 4.5 A (0.6 nm and 0.45 nm) resolution by the method of isomorphous replacement. The principal derivative was...
Johnson, A G, Marshall, C E, Wilson, I A
1. The efficacies of some standard preparations of CCK were compared and the effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall-bladder to cholecystokinin...
Stura, E A, Arevalo, J H, Feinstein, A, Heap, R B, Taussig, M J, Wilson, I A
Anti-progesterone monoclonal antibodies are being used for structural studies of antibody-antigen interaction, for their ability to block pregnancy shortly after fertilization, and for hormone...
Sequence, specificity and crystallization of an oestrone-3-glucuronide antibody (3910).
He, M, Gani, M, Livnah, O, Stura, E A, Beale, D, Coley, J, ...
We describe the specificity profile and V region sequences of a high-affinity monoclonal antibody (mAb), 3910, directed against oestrone-3-glucuronide (E3G). Inhibition studies show that the D-ring...
Scott, C. A., Garcia, K. C., Stura, E. A., Peterson, P. A., Wilson, I. A., Teyton, L.
Class II Major Histocompatibility (MHC) molecules are cell surface heterodimeric glycoproteins that play a central role in the immune response by presenting peptide antigens for surveillance by T...