Konstantinidis, A.K., Puddicombe, S.M., Mochizuki, A., Sheth, P.D., Yang, I.A., Yoshisue, H., ...
BACKGROUND: Interleukin (IL) 13 is a key cytokine in asthma, regulating fibrosis, airway remodeling, induction of immunoglobulin E synthesis by B cells, bronchial hyperresponsiveness, and mucus...
Genetic susceptibility to the respiratory effects of air pollution (2008)
Yang, I.A., Fong, K.M., Zimmerman , P.V., Holgate, S.T., Holloway, J.W.
Konstantinidis, A.K., Barton, S.J., Sayers, I., Yang, I.A., Lordan, J.L., Rorke, S., ...
Interleukin (IL)-13 plays a central role in asthma pathogenesis by binding to the IL-13 receptor, which is a heterodimer composed of the IL-13 receptor alpha1 subunit (IL-13Ralpha1) and IL-4Ralpha....
Gene-environmental interaction in asthma (2007)
Yang, I.A., Savarimuthu, S., Kim, S.T., Holloway, J.W., Bell, S.C., Fong, K.M.
Purpose of Review: Asthma is likely to result from the effects of environmental stimuli in genetically susceptible individuals. This review summarizes recent studies of gene-environmental interaction...
Chen, L., Meyers, D., Javorsky, G., Bursto, D., Lolekha, P., Lucas, M., ...
Objective: Administration of the beta-adrenergic receptor blocker carvedilol to patients with chronic heart failure leads to clinically significant benefits, including improvement in left ventricular...
Inhaled corticosteroids for stable chronic obstructive pulmonary disease (Review) (2007)
Yang, I. A., Fong, K. M., Sim, E. H. A., Black, P. N., Lasserson, T. J.
Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease ( COPD) has been the subject of much controversy. Major international guidelines recommend selective use...
Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement (2007)
Larsen, J.E., Pavey, S.J., Bowman, R., Yang, I.A., Clarke, B.E., Colosimo, M.L., ...
Tumour, node, metastasis staging is essential for lung cancer management. However, similarly staged cancers may have markedly different prognoses, indicating that stage cannot completely explain...
Gene-environmental interaction in asthma (2007)
Yang, I.A., Savarimuthu,S., Kim, S.T., Holloway, J.W, Bell, S.C., Fong, K.W.
Chen, L., Meyers, D., Javorsky, G., Bursto, D., Lolekha, P., Lucas, M., ...
Objective: Administration of the beta-adrenergic receptor blocker carvedilol to patients with chronic heart failure leads to clinically significant benefits, including improvement in left ventricular...
Inhaled corticosteroids for stable chronic obstructive pulmonary disease (Review) (2007)
Yang, I. A., Fong, K. M., Sim, E. H. A., Black, P. N., Lasserson, T. J.
Background The role of inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease ( COPD) has been the subject of much controversy. Major international guidelines recommend selective use...
Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement (2007)
Larsen, J.E., Pavey, S.J., Bowman, R., Yang, I.A., Clarke, B.E., Colosimo, M.L., ...
Tumour, node, metastasis staging is essential for lung cancer management. However, similarly staged cancers may have markedly different prognoses, indicating that stage cannot completely explain...
Gene-environmental interaction in asthma (2007)
Yang, I.A., Savarimuthu,S., Kim, S.T., Holloway, J.W, Bell, S.C., Fong, K.W.
Perfusion CT applications in lung cancer (2007)
Fong, K. M., Bowman, R. V., Yang, I. A., Miles, K. A.
This new text-atlas focuses on anatomy and procedural strategy for perfusion CT imaging in the diagnosis and management of cancer. It will use a combination of pictures and schematic diagrams that...
The role of Toll-like receptors and related receptors of the innate immune system in asthma (2006)
Yang, I.A., Fong, K.M., Holgate, S.T., Holloway, J.W.
Purpose of review: The biology of the innate immunity receptors is of central importance in the host response to the environment. Identifying genetic variants that alter the innate immune response is...
Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, K. M., Barton, S. J., Holloway, J. W., Yang, I. A., Cakebread, J. A., Cruikshank, W., ...
Association of asthma with a functional promoter polymorphism in the IL16 gene (2006)
Burkart, K. M., Barton, S. J., Holloway, J. W., Yang, I. A., Cakebread, J. A., Cruikshank, W., ...
Cochrane systematic reviews of treatments for lung cancer (2005)
Fong, K.M., Yang, I.A., Zimmerman, P.V., Bowman, R.V.
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic...
Toll-like receptor 4 polymorphism and severity of atopy in asthmatics (2004)
Yang, I.A., Barton, S.J., Rorke, S., Cakebread, J.A., Keith, T.P., Clough, J.B., ...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism in the Toll-like receptor 4 (TLR4) gene reduces responsiveness to endotoxin. This study determined...
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome (2003)
Child, N.J.A., Yang, I.A., Pulletz, M.C.K., Pappachan, V.J., ...
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4...
Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections (2003)
Yang, I. A., Seeney, S. L., Wolter, J. M., Anders, E. M., McCormack, J. G., Tunnicliffe, A. M., ...
Infection frequently causes exacerbations of chronic obstructive pulmonary disease (COPD). Mannose-binding lectin (MBL) is a pattern-recognition receptor that assists in clearing microorganisms....
Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections (2003)
Yang, I. A., Seeney, S. L., Wolter, J. M., Anders, E. M., McCormack, J. G., Tunnicliffe, A. M., ...
Infection frequently causes exacerbations of chronic obstructive pulmonary disease (COPD). Mannose-binding lectin (MBL) is a pattern-recognition receptor that assists in clearing microorganisms....
b2 adrenoceptor genotypes and life-threatening asthma (1999)
Rabnott, G. C., Tunnicliffe, A. M., Yang, I. A., Douglas, J. A., Shaw, J., McCarthy, J. B., ...
GSTM1 and GSTP1 polymorphisms in chronic obstructive pulmonary disease (COPD) (1999)
Yang, I. A., Gan, R., Tunnicliffe, A. M., Rabnott, G. C., Slaughter, R., Zimmerman, P.V., ...
GSTM1 and GSTT1 genotypes in Australians with NSCLC (1999)
Gan, R., Yang, I. A., Tunnicliffe, A. M., Rabnott, G. C., Fong, K. M.
b2 adrenoceptor genotypes and life-threatening asthma (1999)
Rabnott, G. C., Tunnicliffe, A. M., Yang, I. A., Douglas, J. A., Shaw, J., McCarthy, J. B., ...
b2 adrenoceptor genotypes and life-threatening asthma (1999)
Rabnott, G. C., Tunnicliffe, A. M., Yang, I. A., Douglas, J. A., Shaw, J., McCarthy, J. B., ...