C. Hermann, J. Hermann, U. Munzel, R. Ruchel, Mycoses 42, 619 (1999). (2008)
C. Hermann, J. Hermann, U. Munzel, R. Ruchel, I. Brook, E. H. Frazier, ...
S. Mahajan-Miklos, M. W. Tan, L. G. Rahme, F. M. Ausubel, Cell 96, 47 (1999). 28. M. W. Tan, L. G. Rahme, J. A. Sternberg, R. G. Tompkins, F. M. Ausubel, Proc. Natl. Acad. Sci. U.S.A. 96, 2408...
Brook, I., Tom, S. P., Ledney, G. D.
The effects of increased does of mixed-field neutron-gamma-photon irradiation on bacterial translocation and subsequent sepsis, and the influence of antimicrobial therapy on these events, were...
Brook, I., Germana, A., Giraldo, D. E., Camp-Hyde, T. D., Bolduc, D. L., Foriska, M. A., ...
Objectives: Sublethal ionizing doses of radiation increase the susceptibility of mice to Bacillus anthracis Sterne infection. In this study, we investigated the efficacy of clindamycin in...
Brook, I., Germana, A., Giraldo, D. E., Camp-Hyde, T. D., Bolduc, D. L., Foriska, M. A., ...
Objectives: Sublethal ionizing doses of radiation increase the susceptibility of mice to Bacillus anthracis Sterne infection. In this study, we investigated the efficacy of clindamycin in...
Rhinosinusitis: Establishing definitions for clinical research and patient care (2004)
MELTZER, EO, HAMILOS, DL, HADLEY, JA, LANZA, DC, MARPLE, BF, NICKLAS, RA, ...
Mixed Infections and their Control (2003)
The necessity for treating all components of mixed infections has now been adequately documented in both experimental and clinical studies. The importance of synergistic antimicrobial therapy that...
Antimicrobials in the Management of Post-Irradiation Infection (1998)
Brook, I., Elliott, T. B., Shoemaker, M. O., Ledney, G. D.
Ionizing radiation depresses host defenses and enhances susceptibility to local and systemic infection due to endogenous or exogenous microorganisms. Giving mice a lethal dose of ionizing 60Co-gamma...
Brook, I, Gober, A E, Leyva, F
Encapsulation of group A beta-hemolytic streptococci (GABHS) is an important virulence factor. The changes that occur in the frequency of encapsulation of GABHS during pharyngotonsillitis, in 20...
Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation.
Death subsequent to whole-body irradiation is associated with gram-negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa...
Brook, I, Coolbaugh, J C, Walker, R I, Weiss, E
Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or...
Therapy with ofloxacin, ciprofloxacin, and lomefloxacin (alone or in combination with clindamycin) and therapy with sparfloxacin, clinafloxacin, and temafloxacin alone were given to mice with...
The in vivo effects of penicillin and cefprozil therapy on the interaction between organisms commonly recovered from inflamed tonsils were studied by using a subcutaneous abscess model in mice. These...
Use of cephalosporins for prophylaxis and therapy of polymicrobial infection in mice.
Cefoxitin, cefotetan, and cefmetazole were compared in 10-day therapy of intra-abdominal and subcutaneous infections caused by three organisms: Bacteroides fragilis and Bacteroides thetaiotaomicron...
Adverse effects of pefloxacin in irradiated C3H/HeN mice: correction with glucan therapy.
Patchen, M L, Brook, I, Elliott, T B, Jackson, W E
Opportunistic bacterial infections are the predominant cause of death following myelosuppressive radiation exposure. When used alone, a variety of immunomodulators and antibiotics have been reported...
Microbiology of secondary bacterial infection in scabies lesions.
Aerobic and anaerobic bacteria were grown from specimens obtained from 30 children with secondarily infected scabies lesions. Aerobic or facultative bacteria only were present in 14 (47%) patients,...
Clinical and microbiological features of necrotizing fasciitis.
The microbiological and clinical characteristics of 83 patients with necrotizing fasciitis (NF) treated over a period of 17 years are presented. Bacterial growth was noted in 81 of 83 (98%) of...
Veillonella infections in children.
From 1974 to 1994, 2,033 specimens from children were submitted for cultures for anaerobic bacteria. Eighty-three Veillonella spp. were recovered from 83 children (4%). Most Veillonella species were...
The aerobic and anaerobic bacteriology of perirectal abscesses.
The microbiology of perirectal abscesses in 144 patients was studied. Aerobic or facultative bacteria only were isolated in 13 (9%) instances, anaerobic bacteria only were isolated in 27 (19%)...
The efficacies of 40 mg of ofloxacin per kg/day given orally and 250 mg of penicillin per kg/day given intramuscularly, alone or in combination, were evaluated in the prevention of mortality of...
Adherence of Bacteroides fragilis group species.
The ability of piliated and capsulated Bacteroides fragilis and Bacteroides ovatus to adhere to intestinal cells and mucus was investigated. The adherence of piliated and capsulated strains was at...
The potential for mutual enhancement of growth of the Bacteroides fragilis and B. melaninogenicus groups and the aerobic and facultative organisms commonly isolated with them in mixed infections was...
Recovery of aerobic and anaerobic bacteria from irradiated mice.
Brook, I, MacVittie, T J, Walker, R I
Anaerobic and aerobic bacteria were often found as mixed infections in 225 lethally irradiated mice. Of a total of 57 mice that were sacrificed, aerobic bacteria were recovered exclusively in 9 (27%)...
Pathogenicity of anaerobic gram-positive cocci.
The pathogenicity of 20 strains of facultative or anaerobic gram-positive cocci (AGPC) was investigated by injecting them alone or mixed with other flora into mice, utilizing the subcutaneous abscess...
Organisms of the Bacteroides melaninogenicus and Bacteroides fragilis groups are often found mixed with facultatively anaerobic organisms in infections. The relative importance of these Bacteroides...
Infectivity of organisms recovered from polymicrobial abscesses.
The ability to cause subcutaneous abscesses in mice was used to identify the pathogens among the bacteria recovered from 13 clinical abscesses. A total of 35 isolates (30 anaerobes and 5 aerobes), 16...
Aerobic and anaerobic bacteriology of purulent nasopharyngitis in children.
Cultures of aerobic and anaerobic bacteria were obtained from the inferior nasal meatus of 25 children with purulent nasopharyngitis and from 25 controls. Microorganisms were isolated from all...
Recovery of anaerobic bacteria from clinical specimens in 12 years at two military hospitals.
Examination of 15,844 clinical specimens submitted over 12 years (1973 to 1985) to the anaerobic microbiology laboratories in two military hospitals demonstrated the recovery of anaerobic bacteria in...
Aerobic and anaerobic microbiology of biliary tract disease.
A retrospective analysis of the experiences of two military hospitals over 4 years in the recovery of organisms from biliary tract specimens was done. Bacterial growth was obtained in 123 bile...
Microbiology of postthoractomy sternal wound infection.
Specimens from 74 patients with postthoractomy sternal wound infection were studied for aerobic and anaerobic bacteria. Bacterial growth was obtained in specimens from 65 patients (88%). Aerobic or...
Jacob, E, Arendt, D M, Brook, I, Durham, L C, Falk, M C, Schaberg, S J
An enzyme-linked immunosorbent assay was used to evaluate and compare the immunoglobulin G antibody response to Staphylococcus aureus cell walls of rabbits with either chronic staphylococcal...
Comparison of two transport systems for recovery of aerobic and anaerobic bacteria from abscesses.
An evaluation of two commercially available swab transport systems, Port-A-Cul (PAC; BBL Microbiology Systems, Cockeysville, Md.) and Anaerobic Specimen Collector (ASC; Becton Dickinson Vacutainer...
Effect of diving and diving hoods on the bacterial flora of the external ear canal and skin.
Brook, I, Coolbaugh, J C, Williscroft, R G
The bacterial flora of the external ear canals and posterior auricular skin surfaces were investigated in a group of 26 divers after 25 dry-suit dives in harbor water and 20 dry-suit dives in clear...
Quantitative nephelometric determination of Haemophilus influenzae antigen in body fluids.
Caceci, T, Brook, I, Daniel, A
Nephelometry, an immunological technique widely used for the quantification of blood proteins, was adapted to provide a quantitative method of detecting Haemophilus influenzae capsular antigen in...
The Monotest Lactate Kit (MLT) was compared with gas-liquid chromatography (GLC) for the rapid detection of septic arthritis. A total of 36 joint fluids were tested. Specimens were obtained from...
Beta-lactamase-producing isolates of Bacteroides species from children.
Brook, I, Calhoun, L, Yocum, P
Two hundred twenty-four isolates of Bacteroides sp. were recovered from recurrently inflamed tonsils, infected peritoneal fluid, abscesses, wounds, and burns of hospitalized children. Isolates were...
Trehalose dimycolate enhances resistance to infection in neutropenic animals.
Madonna, G S, Ledney, G D, Elliott, T B, Brook, I, Ulrich, J T, Myers, K R, ...
Bacterial infections are lethal complications of neutropenia, and antibiotics alone are inadequate therapy for these infections. Irradiated mice become severely neutropenic and remain susceptible to...
Rapid method for detecting beta-lactamase producing bacteria in clinical specimens.
The use of liquid media to detect the production of beta-lactamase by beta-lactamase producing organisms has been compared with the conventional method of inoculation on to agar media. Pharyngeal...
Microbiology of infected pilonidal sinuses.
Aspirates of pus from infected pilonidal sinuses in 75 patients showed bacterial growth. Anaerobic bacteria only were recovered in 58 (77%) specimens, aerobic bacteria only in three (4%), and mixed...
Arizona hinshawii bacteraemia and meningitis in a child: a case report.
Ichord, R, Brook, I, Controni, G
An 8-week-old infant presented with Arizona hinshawii meningitis and bacteraemia. The child responded well to the administration of parenteral ampicillin and chloramphenicol. However, chloramphenicol...
Bullous impetigo caused by Streptococcus salivarius: a case report.
A 19-month-old child presented with bullous impetigo around the perineal region, penis, and left foot. Streptococcus salivarius was the only isolate recovered from the lesions. The child was treated...
Brook, I, Gober, A E, Leyva, F
Encapsulation of group A beta-hemolytic streptococci (GABHS) is an important virulence factor. The changes that occur in the frequency of encapsulation of GABHS during pharyngotonsillitis, in 20...
Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation.
Death subsequent to whole-body irradiation is associated with gram-negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa...
Brook, I, Coolbaugh, J C, Walker, R I, Weiss, E
Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or...
Therapy with ofloxacin, ciprofloxacin, and lomefloxacin (alone or in combination with clindamycin) and therapy with sparfloxacin, clinafloxacin, and temafloxacin alone were given to mice with...
The in vivo effects of penicillin and cefprozil therapy on the interaction between organisms commonly recovered from inflamed tonsils were studied by using a subcutaneous abscess model in mice. These...
Use of cephalosporins for prophylaxis and therapy of polymicrobial infection in mice.
Cefoxitin, cefotetan, and cefmetazole were compared in 10-day therapy of intra-abdominal and subcutaneous infections caused by three organisms: Bacteroides fragilis and Bacteroides thetaiotaomicron...
Adverse effects of pefloxacin in irradiated C3H/HeN mice: correction with glucan therapy.
Patchen, M L, Brook, I, Elliott, T B, Jackson, W E
Opportunistic bacterial infections are the predominant cause of death following myelosuppressive radiation exposure. When used alone, a variety of immunomodulators and antibiotics have been reported...
Microbiology of secondary bacterial infection in scabies lesions.
Aerobic and anaerobic bacteria were grown from specimens obtained from 30 children with secondarily infected scabies lesions. Aerobic or facultative bacteria only were present in 14 (47%) patients,...
Clinical and microbiological features of necrotizing fasciitis.
The microbiological and clinical characteristics of 83 patients with necrotizing fasciitis (NF) treated over a period of 17 years are presented. Bacterial growth was noted in 81 of 83 (98%) of...
Veillonella infections in children.
From 1974 to 1994, 2,033 specimens from children were submitted for cultures for anaerobic bacteria. Eighty-three Veillonella spp. were recovered from 83 children (4%). Most Veillonella species were...
The aerobic and anaerobic bacteriology of perirectal abscesses.
The microbiology of perirectal abscesses in 144 patients was studied. Aerobic or facultative bacteria only were isolated in 13 (9%) instances, anaerobic bacteria only were isolated in 27 (19%)...
The efficacies of 40 mg of ofloxacin per kg/day given orally and 250 mg of penicillin per kg/day given intramuscularly, alone or in combination, were evaluated in the prevention of mortality of...
Adherence of Bacteroides fragilis group species.
The ability of piliated and capsulated Bacteroides fragilis and Bacteroides ovatus to adhere to intestinal cells and mucus was investigated. The adherence of piliated and capsulated strains was at...
The potential for mutual enhancement of growth of the Bacteroides fragilis and B. melaninogenicus groups and the aerobic and facultative organisms commonly isolated with them in mixed infections was...
Recovery of aerobic and anaerobic bacteria from irradiated mice.
Brook, I, MacVittie, T J, Walker, R I
Anaerobic and aerobic bacteria were often found as mixed infections in 225 lethally irradiated mice. Of a total of 57 mice that were sacrificed, aerobic bacteria were recovered exclusively in 9 (27%)...
Pathogenicity of anaerobic gram-positive cocci.
The pathogenicity of 20 strains of facultative or anaerobic gram-positive cocci (AGPC) was investigated by injecting them alone or mixed with other flora into mice, utilizing the subcutaneous abscess...
Organisms of the Bacteroides melaninogenicus and Bacteroides fragilis groups are often found mixed with facultatively anaerobic organisms in infections. The relative importance of these Bacteroides...
Infectivity of organisms recovered from polymicrobial abscesses.
The ability to cause subcutaneous abscesses in mice was used to identify the pathogens among the bacteria recovered from 13 clinical abscesses. A total of 35 isolates (30 anaerobes and 5 aerobes), 16...
Aerobic and anaerobic bacteriology of purulent nasopharyngitis in children.
Cultures of aerobic and anaerobic bacteria were obtained from the inferior nasal meatus of 25 children with purulent nasopharyngitis and from 25 controls. Microorganisms were isolated from all...
Recovery of anaerobic bacteria from clinical specimens in 12 years at two military hospitals.
Examination of 15,844 clinical specimens submitted over 12 years (1973 to 1985) to the anaerobic microbiology laboratories in two military hospitals demonstrated the recovery of anaerobic bacteria in...
Aerobic and anaerobic microbiology of biliary tract disease.
A retrospective analysis of the experiences of two military hospitals over 4 years in the recovery of organisms from biliary tract specimens was done. Bacterial growth was obtained in 123 bile...
Microbiology of postthoractomy sternal wound infection.
Specimens from 74 patients with postthoractomy sternal wound infection were studied for aerobic and anaerobic bacteria. Bacterial growth was obtained in specimens from 65 patients (88%). Aerobic or...
Jacob, E, Arendt, D M, Brook, I, Durham, L C, Falk, M C, Schaberg, S J
An enzyme-linked immunosorbent assay was used to evaluate and compare the immunoglobulin G antibody response to Staphylococcus aureus cell walls of rabbits with either chronic staphylococcal...
Comparison of two transport systems for recovery of aerobic and anaerobic bacteria from abscesses.
An evaluation of two commercially available swab transport systems, Port-A-Cul (PAC; BBL Microbiology Systems, Cockeysville, Md.) and Anaerobic Specimen Collector (ASC; Becton Dickinson Vacutainer...
Effect of diving and diving hoods on the bacterial flora of the external ear canal and skin.
Brook, I, Coolbaugh, J C, Williscroft, R G
The bacterial flora of the external ear canals and posterior auricular skin surfaces were investigated in a group of 26 divers after 25 dry-suit dives in harbor water and 20 dry-suit dives in clear...
Quantitative nephelometric determination of Haemophilus influenzae antigen in body fluids.
Caceci, T, Brook, I, Daniel, A
Nephelometry, an immunological technique widely used for the quantification of blood proteins, was adapted to provide a quantitative method of detecting Haemophilus influenzae capsular antigen in...
The Monotest Lactate Kit (MLT) was compared with gas-liquid chromatography (GLC) for the rapid detection of septic arthritis. A total of 36 joint fluids were tested. Specimens were obtained from...
Beta-lactamase-producing isolates of Bacteroides species from children.
Brook, I, Calhoun, L, Yocum, P
Two hundred twenty-four isolates of Bacteroides sp. were recovered from recurrently inflamed tonsils, infected peritoneal fluid, abscesses, wounds, and burns of hospitalized children. Isolates were...
Trehalose dimycolate enhances resistance to infection in neutropenic animals.
Madonna, G S, Ledney, G D, Elliott, T B, Brook, I, Ulrich, J T, Myers, K R, ...
Bacterial infections are lethal complications of neutropenia, and antibiotics alone are inadequate therapy for these infections. Irradiated mice become severely neutropenic and remain susceptible to...
Rapid method for detecting beta-lactamase producing bacteria in clinical specimens.
The use of liquid media to detect the production of beta-lactamase by beta-lactamase producing organisms has been compared with the conventional method of inoculation on to agar media. Pharyngeal...
Microbiology of infected pilonidal sinuses.
Aspirates of pus from infected pilonidal sinuses in 75 patients showed bacterial growth. Anaerobic bacteria only were recovered in 58 (77%) specimens, aerobic bacteria only in three (4%), and mixed...
Arizona hinshawii bacteraemia and meningitis in a child: a case report.
Ichord, R, Brook, I, Controni, G
An 8-week-old infant presented with Arizona hinshawii meningitis and bacteraemia. The child responded well to the administration of parenteral ampicillin and chloramphenicol. However, chloramphenicol...
Bullous impetigo caused by Streptococcus salivarius: a case report.
A 19-month-old child presented with bullous impetigo around the perineal region, penis, and left foot. Streptococcus salivarius was the only isolate recovered from the lesions. The child was treated...
Brook, I, Reza, M J, Bricknell, K S, Bluestone, R, Finegold, S M
Gas liquid chromatography was performed on synovial fluid of 94 patients with exudative arthritis. A relatively constant pattern of peaks was obtained in all synovial fluid samples. Lactic acid was...
Aerobic and anaerobic microbiology of infections after trauma in children.
OBJECTIVE: To review the recovery of aerobic and anaerobic bacteria from infections after trauma in children over a 20 year period. METHODS: Only specimens that were studied for both aerobic and...