Rogers, H.J., Bradbrook, I.D., Morrison, P.J., Spector, R.G., Cox, D.A., Lees, L.J.
Sultamicillin is an orally absorbed double ester of sulbactam (penicillanic acid sulphone, a semisynthetic inhibitor of the &eegr;-lactamases of many Gram-positive and Gram-negative species) and...
Effect of cimetidine on oral absorption of ampicillin and cotrimoxazole (1980)
ROGERS, H. J., JAMES, C. A., MORRISON, P. J., BRADBROOK, I. D.
ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man.
Bradbrook, I D, Magnani, H N, Moelker, H C, Morrison, P J, Robinson, J, Rogers, H J, ...
ORG 10172 is a heparinoid with mean molecular weight 6500 daltons. Intravenous bolus injections of ORG 10172 were compared with placebo and heparin injections in 91 separate studies in 83 healthy...
Effects of single and multiple doses of ketoconazole on adrenal function in normal subjects.
Bradbrook, I D, Gillies, H C, Morrison, P J, Robinson, J, Rogers, H J, Spector, R G
The plasma cortisol response to 0.25 mg tetracosactrin given by intramuscular injection was suppressed by nine oral doses of 200 mg ketoconazole given 12 hourly to nine normal female subjects. No...
Bradbrook, I D, Babiker, M, Crome, P, Gillies, H C, Morrison, P J, Rogers, H J, ...
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young...
Pharmacokinetics of single doses of sulphinpyrazone and its major metabolites in plasma and urine.
Bradbrook, I D, John, V A, Morrison, P J, Rogers, H J, Spector, R G
1 High pressure liquid chromatographic assays for the estimation of sulphinpyrazone and its sulphide, sulphone and p-hydroxy metabolites in plasma and urine are described. 2 Five normal volunteers...
Effect of pirprofen on glibenclamide kinetics and response.
Morrison, P J, Rogers, H J, Spector, R G, Bradbrook, I D, John, V A
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose...
Pharmacokinetic observations on piroxicam in young adult, middle-aged and elderly patients.
Woolf, A D, Rogers, H J, Bradbrook, I D, Corless, D
Nineteen out of 21 patients with painful conditions of the locomotor system aged between 27 and 94 years completed a study in which they received 20 mg piroxicam daily for 14 days. Plasma piroxicam...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A quantitative thin layer chromatographic technique for the estimation of plasma prednisolone levels has been devised with a minimum level of estimation of 10 ng/ml. 2 A comparative study of the...
Morrison, P J, Bradbrook, I D, Rogers, H J
1 A gas chromatographic assay for the estimation of therapeutic concentrations of cinnarizine in plasma is described. 2 Cinnarizine (75 mg) was administered orally to twelve healthy subjects in the...
Comparison of the effect of drugs upon some commonly used measures of bowel transit time.
Rogers, H J, House, F R, Morrison, P J, Bradbrook, I D
1 To study the effect of drugs on methods of assessment of gut transit time a double-blind study of the effect of single doses of placebo, oxyphenisatin, anthracene purgatives, (+)-norpseudoephedrine...
Effect of cimetidine on the absorption of orally administered tetracycline.
Fisher, P, House, F, Inns, P, Morrison, P J, Rogers, H J, Bradbrook, I D
1 Six healthy female subjects received orally two 250 mg tetracycline tablets either with 400 mg cimetidine or placebo. In a separate experiment six healthy female volunteers received 500 mg...
Bradbrook, I. D., John, V. A., Morrison, P. J., Rogers, H. J., Spector, R. G.
1 The absorption kinetics of oxprenolol have been investigated in eight healthy volunteers after single dosing with 16/260 Oros drug delivery systems. Oxprenolol disposition kinetics in individual...