Rogiers, A, Vanmolkot, FH, Kane, SA, ...
Vanmolkot, F H, Kane, S A, ...
AIMS: Part I: to establish the dose and appropriate application site of capsaicin on the human forearm in order to produce a robust and reproducible dermal blood flow (DBF) response. Part II: to...
Van Hecken, Anne; U0011994, De Lepeleire, I, Thach, C, Oeyen, M, Van Effen, J, ...
INTRODUCTION: Nasal congestion in allergic rhinitis results from tissue edema and vasodilatation in the nasal mucosa. Of the mediators released by mast cells in response to allergens, prostaglandin...
Effect of aprepitant on the pharmacokinetics and pharmacodynamics of warfarin (2005)
Oeyen, M, De Lepeleire, I, Laethem, T, Rothenberg, P, ...
OBJECTIVE: To examine the effect of aprepitant on the pharmacokinetics and pharmacodynamics of warfarin. Aprepitant is a neurokinin-1 (NK1)-receptor antagonist developed as an antiemetic for...
De Lepeleire, I, Laethem, T, ...
Effects of enteric-coated, low-dose aspirin on parameters of platelet function (2002)
Juliano, M L, De Lepeleire, I, Dynder, A, ...
BACKGROUND: Aspirin is widely used as an anti-thrombotic drug; however, it has been suggested that enteric-coated formulations of aspirin may be less bioavailable and less effective as...
Schwartz, J I, De Lepeleire, I, Dallob, A, Tanaka, W, ...
Steady-state inhibitory activity of rofecoxib (Vioxx) on COX-2 versus COX-1 was compared with that of commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in 76 healthy volunteers randomized...
De Lepeleire, I, Porras, A, Mukhopadhyay, S, ...
Merck & Co., Inc., Rahway, NJ 07065, USA. aimee_dallob@merck.com
Verbesselt, René; U0018460, Wynants, K, De Lepeleire, I, ...
Montelukast, a cysteinyl leukotriene receptor antagonist, is being developed for the treatment of asthma and related diseases. This study was designed to evaluate whether montelukast at clinically...
Dallob, A, De Lepeleire, I, Riendeau, D, Yuan, W, ...
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive (COX-1) and inducible (COX-2) isoforms of...
Murphy, G, De Lepeleire, I, Gould, R J, Panebianco, D, ...
MK-383 (L-tyrosine, N-(n-butylsulfonyl)-O-[4-butyl(4-piperidinyl)], monohydrochloride monohydrate) is a potent and specific platelet fibrinogen receptor antagonist that may be useful in preventing...
De Lepeleire, I, Goldberg, M, Farrell, D, Barrett, J, Hand, E, ...
BACKGROUND. Fibrinogen-dependent cross-linking of glycoprotein (GP) IIb/IIIa on activated platelets is the final mechanism leading to platelet aggregation. Inhibition of this mechanism may result in...
Van Daele, P, Van Den Elshout, F M, Buntinx, A, De Lepeleire, I, ...
The safety, tolerability and bronchodilator properties of inhaled verlukast (MK-0679), a new potent and selective LTD4-receptor antagonist, were studied in 12 asthmatic subjects with more than 15%...
De Lepeleire, I, Verbesselt, René; U0018460, Angehrn, J, Youngberg, C, ...
The effect of benazepril (CGS 14824), 20 mg/day orally, on the steady-state pharmaco-dynamics and plasma levels of the anticoagulants, warfarin and acenocoumarol, was studied in healthy volunteers....
De Lepeleire, I, Miyamoto, Y, Holmes, I, ...
1. The efficacy and tolerability of CV-3988, a selective PAF antagonist with structural analogies with PAF, were studied after intravenous infusion in man. 2. The compound, in doses from 750 to 2,000...
Comparative oral pharmacokinetics of fleroxacin and pefloxacin (1988)
De Lepeleire, I., Van Hecken, A., Verbesselt, R., Tjandra-Maga, T. B., De Schepper, P. J.
The pharmacokinetics of a single 400 mg oral dose of fleroxacin and pefloxacin were evaluated in ten healthy male volunteers in a randomized cross-over study. There were no significant differences in...
Laethem, T., De Lepeleire, I., McCrea, J., Zhang, J., Majumdar, A., Musson, D., ...
The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose....
Laethem, T., De Lepeleire, I., McCrea, J., Zhang, J., Majumdar, A., Musson, D., ...
The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose....
Arnout, J, Van Hecken, A, De Lepeleire, I, Miyamoto, Y, Holmes, I, De Schepper, P, ...
1. The efficacy and tolerability of CV-3988, a selective PAF antagonist with structural analogies with PAF, were studied after intravenous infusion in man. 2. The compound, in doses from 750 to 2,000...
Van Der Schueren, B J, De Hoon, J N, Vanmolkot, F H, Van Hecken, A, Depre, M, Kane, S A, ...
What is already known about this subjectCapsaicin rapidly produces local neurogenic inflammation (characterized by oedema and erythema) when locally administered to the human skin by binding to the...