The ADMA/DDAH pathway is a critical regulator of endothelial cell motility (2007)
Wojciak-Stothard, B., Torondel, B., Tsang, L.Y.F., Fleming, I., Fisslthaler, B., Leiper, J.M., ...
Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action of ADMA is not well understood....
Fisslthaler, B, Suzuki, M, ...
TRPV4 is a broadly expressed Ca2+-permeable cation channel in the vanilloid subfamily of transient receptor potential channels. TRPV4 gates in response to a large variety of stimuli, including cell...
Pokreisz, Peter; U0032789, Vermeersch, Pieter; U0035259, Szelid, Z, Falck, J. R, Hammock, B. D, Fleming, I, ...
Wang, S, Meades, C, Wood, G, Osnowski, A, Anderson, S, Yuill, R, ...
Fisslthaler, B., Boengler, K., Fleming, I., Schaper, W., Busse, R., Deindl, E.
Fluid shear stress exerts numerous effects on gene expression in endothelial cells. To investigate the regulatory mechanisms involved, we designed oligonucleotides composed of a 20-bp core containing...
Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery (2003)
Büssemaker, E., Popp, R., Fisslthaler, B., Larson, C.M., Fleming, I., Busse, R., ...
Objective: Hyperthyroidism has pronounced effects on vascular function and endothelium-dependent relaxation. The aim of the present study was to identify mechanisms underlying hyperthyroidism-induced...
Bauersachs, J., Christ, M., Ertl, G., Michaelis, U.R., Fisslthaler, B., Busse, R., ...
Objectives/methods: In addition to nitric oxide (NO) and prostacyclin, endothelium-dependent dilation is mediated by the endothelium-derived hyperpolarizing factor (EDHF) which, in the coronary...
MacKenzie, S, Fleming, I, Houslay, M D, Anderson, N G, Kilgour, E
Previous studies have shown that the activation of p44 and p42 mitogen-activated protein (MAP) kinases (ERK1 and ERK2) by growth hormone (GH) and phorbol esters, but not by epidermal growth factor,...
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
Fleming, I, MacKenzie, S J, Vernon, R G, Anderson, N G, Houslay, M D, Kilgour, E
In this study we first established, by immunoblotting with specific antibodies, the temporal changes in cellular levels of protein kinase C (PKC) isoforms during differentiation of 3T3-F442A...
Popp, R, Bauersachs, J, Hecker, M, Fleming, I, Busse, R
1. The vascular endothelium releases a hyperpolarizing factor (endothelium-derived hyperpolarizing factor, EDHF) tentatively identified as a cytochrome P450-derived arachidonic acid metabolite....
Popp, R, Bauersachs, J, Hecker, M, Fleming, I, Busse, R
1. The vascular endothelium releases a hyperpolarizing factor (endothelium-derived hyperpolarizing factor, EDHF) tentatively identified as a cytochrome P450-derived arachidonic acid metabolite....
MacKenzie, S, Fleming, I, Houslay, M D, Anderson, N G, Kilgour, E
Previous studies have shown that the activation of p44 and p42 mitogen-activated protein (MAP) kinases (ERK1 and ERK2) by growth hormone (GH) and phorbol esters, but not by epidermal growth factor,...
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
Fleming, I, MacKenzie, S J, Vernon, R G, Anderson, N G, Houslay, M D, Kilgour, E
In this study we first established, by immunoblotting with specific antibodies, the temporal changes in cellular levels of protein kinase C (PKC) isoforms during differentiation of 3T3-F442A...
Fleming, I, Schermer, B, Popp, R, Busse, R
The endogenous cannabinoid, anandamide, has been reported to induce an 'endothelium-derived hyperpolarizing factor (EDHF)-like' relaxation in vitro. We therefore investigated the effects of...
Brandes, R P, Popp, R, Ott, G, Bredenkötter, D, Wallner, C, Busse, R, ...
Cannabinoids are potent inhibitors of endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations. We set out to study the mechanism underlying this effect and the possible role of...
Fleming, I., Julou-Schaeffer, G., Gray, G. A., Parratt, J. R., Stoclet, J. C.
1. The aim of this investigation was to study the relationship between contractile responsiveness, activation of the L-arginine pathway and tissue levels of guanosine 3':5'cyclic monophosphate (cylic...
Gray, G. A., Schott, C., Julou-Schaeffer, G., Fleming, I., Parratt, J. R., Stoclet, J. C.
1. The effects on blood pressure and on pressor responses to noradrenaline (NA), of NG-monomethyl-L-arginine (L-NMMA) and NG-nitro-L-arginine methyl ester (L-NAME), inhibitors of the...