Differential inhibition of neuronal and extraneuronal monoamine oxidase (1996)
Kopin, I.J., Murphy, D.L., Zametkin, A., Ernst, M.F., Harvey-White, J., Lenders, J.W.M., ...
Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines (1995)
Lenders, J.W.M., Kopin, I.J., Dakak, N., Friberg, P., Aneman, A., ...
Goldstein, D.S., Kopin, I.J., Univerzita Karlova.
Přehledy lit
Catecholamines and stress / edited by Earl Usdin, Richard Kvetnansky and Irwin J. Kopin (1976)
Usdin, Earl, Kvetnansky, Richard, Kopin, I. J
"Proceedings of the International Symposium on Catecholamines and Stress, held in Bratislava, Czechoslovakia, July 27-30, 1975"
Nankova, B, Kvetnanský, R, McMahon, A, Viskupic, E, Hiremagalur, B, Frankle, G, ...
Stress stimulates the sympathoadrenal system, causing activation of the catecholamine biosynthetic enzymes. Here we examine the changes of gene expression of tyrosine hydroxylase (TH; EC 1.14.16.2),...
Porrino, L J, Burns, R S, Crane, A M, Palombo, E, Kopin, I J, Sokoloff, L
The quantitative 2-deoxy[14C]glucose autoradiographic method was used to map the distribution of alterations in local cerebral glucose utilization that accompanies clinically effective chronic L-dopa...
Oertel, W H, Mugnaini, E, Tappaz, M L, Weise, V K, Dahl, A L, Schmechel, D E, ...
Activity of glutamic acid decarboxylase GluDCase, the biosynthetic enzyme of gamma-aminobutyric acid (GABA) was measured in low-speed homogenate supernatant of the neural and intermediate...
Goldstein, D S, Horwitz, D, Keiser, H R, Polinsky, R J, Kopin, I J
We infused tracer-labeled l-[3H]-norepinephrine, d-[14C]norepinephrine, and d,l-[3H]-isoproterenol simultaneously into patients with essential hypertension and into normotensive control subjects, in...
Burns, R S, Chiueh, C C, Markey, S P, Ebert, M H, Jacobowitz, D M, Kopin, I J
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have...
Measurement of regional neuronal removal of norepinephrine in man.
Goldstein, D S, Zimlichman, R, Stull, R, Folio, J, Levinson, P D, Keiser, H R, ...
We describe here and validate an in vivo technique to measure the regional proportionate removal of norepinephrine (NE) by neuronal uptake (Uptake1) in man. The measurement is based on the...
Cizza, G, Pacak, K, Kvetnansky, R, Palkovits, M, Goldstein, D S, Brady, L S, ...
We investigated the effects of stress on central and peripheral sympatho-adrenal and sympatho-neural functions in healthy, intact young (3-4 mo) and aged (24 mo) male Fischer 344/N rats....
Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.
Goldstein, D S, Eisenhofer, G, Stull, R, Folio, C J, Keiser, H R, Kopin, I J
We examined plasma levels of the sympathetic neurotransmitter norepinephrine (NE) and its deaminated metabolite dihydroxyphenylglycol (DHPG) during supine rest in healthy human subjects and in...
Lenders, J W, Eisenhofer, G, Abeling, N G, Berger, W, Murphy, D L, Konings, C H, ...
Monoamine oxidase (MAO) exists as two isoenzymes and plays a central role in the metabolism of monoamine neurotransmitters. In this study we compared the neurochemical phenotypes of previously...
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes selective destruction of dopaminergic neurons of the nigrostriatal pathway in humans and other primates. It is less specific and much less...
Nankova, B, Kvetnanský, R, McMahon, A, Viskupic, E, Hiremagalur, B, Frankle, G, ...
Stress stimulates the sympathoadrenal system, causing activation of the catecholamine biosynthetic enzymes. Here we examine the changes of gene expression of tyrosine hydroxylase (TH; EC 1.14.16.2),...
Porrino, L J, Burns, R S, Crane, A M, Palombo, E, Kopin, I J, Sokoloff, L
The quantitative 2-deoxy[14C]glucose autoradiographic method was used to map the distribution of alterations in local cerebral glucose utilization that accompanies clinically effective chronic L-dopa...
Oertel, W H, Mugnaini, E, Tappaz, M L, Weise, V K, Dahl, A L, Schmechel, D E, ...
Activity of glutamic acid decarboxylase GluDCase, the biosynthetic enzyme of gamma-aminobutyric acid (GABA) was measured in low-speed homogenate supernatant of the neural and intermediate...
Goldstein, D S, Horwitz, D, Keiser, H R, Polinsky, R J, Kopin, I J
We infused tracer-labeled l-[3H]-norepinephrine, d-[14C]norepinephrine, and d,l-[3H]-isoproterenol simultaneously into patients with essential hypertension and into normotensive control subjects, in...
Burns, R S, Chiueh, C C, Markey, S P, Ebert, M H, Jacobowitz, D M, Kopin, I J
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have...
Measurement of regional neuronal removal of norepinephrine in man.
Goldstein, D S, Zimlichman, R, Stull, R, Folio, J, Levinson, P D, Keiser, H R, ...
We describe here and validate an in vivo technique to measure the regional proportionate removal of norepinephrine (NE) by neuronal uptake (Uptake1) in man. The measurement is based on the...
Cizza, G, Pacak, K, Kvetnansky, R, Palkovits, M, Goldstein, D S, Brady, L S, ...
We investigated the effects of stress on central and peripheral sympatho-adrenal and sympatho-neural functions in healthy, intact young (3-4 mo) and aged (24 mo) male Fischer 344/N rats....
Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.
Goldstein, D S, Eisenhofer, G, Stull, R, Folio, C J, Keiser, H R, Kopin, I J
We examined plasma levels of the sympathetic neurotransmitter norepinephrine (NE) and its deaminated metabolite dihydroxyphenylglycol (DHPG) during supine rest in healthy human subjects and in...
Lenders, J W, Eisenhofer, G, Abeling, N G, Berger, W, Murphy, D L, Konings, C H, ...
Monoamine oxidase (MAO) exists as two isoenzymes and plays a central role in the metabolism of monoamine neurotransmitters. In this study we compared the neurochemical phenotypes of previously...
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes selective destruction of dopaminergic neurons of the nigrostriatal pathway in humans and other primates. It is less specific and much less...
On the mechanism of tachyphylaxis to tyramine in the isolated rat heart
Axelrod, J., Gordon, Edna, Hertting, G., Kopin, I. J., Potter, L. T.
Tyramine was shown to release [3H]-catecholamines from an isolated rat heart previously perfused with [3H]-noradrenaline. With successive injections of tyramine the amount of [3H]-catecholamine...
Transport-P is an antidepressant-sensitive, proton-dependent, V-ATPase-linked uptake process for amines in peptidergic neurones of the hypothalamus. It is unusual in its anatomical location in...
Effects of amphetamine derivatives on brain dopamine and noradrenaline
Breese, G. R., Kopin, I. J., Weise, Virginia K.
1. Intracisternally administered metaraminol, α-methyl-octopamine, α-methyl-m-tyramine, and α-methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine.
Hanbauer, I., Kopin, I. J., Maengwyn-Davies, Gertrude D., Thoa, N. B., Weise, Virginia K.
1. The effect of vinblastine on the activities of dopamine-β-hydroxylase (DBH) in heart, superior cervical ganglion and adrenal glands of rats and tyrosine hydroxylase (TH) and...
Effects of vinblastine on noradrenergic axons
Hanbauer, I., Jacobowitz, D.M., Kopin, I.J.
1 The effects of vinblastine and 6-hydroxydopamine (6-OHDA) on various parameters of adrenergic neurone functions in the rat were examined and compared.
Functional properties of the uptake of amines in immortalised peptidergic neurones (transport-P).
1. Most neurotransmitters are inactivated by uptake into presynaptic nerve terminals and into glial cells. We recently provided evidence for uptake of amines in postsynaptic neurones. Uptake was...
1. We have provided evidence for a novel amine uptake process for which prazosin is a substrate in postsynaptic neurones, characterized by a paradoxical increase in accumulation of the radioligand...
Angus, J. A., Bobik, A., Jackman, G. P., Kopin, I. J., Korner, P. I.
Guinea-pig right atria were labelled with [3H]-noradrenaline or [3H]-dopamine before superfusion in a flow-cell. Choice of label did not significantly alter either the relationship between 3H-efflux...
Glycine stimulates striatal dopamine release in conscious rats.
Yadid, G., Pacak, K., Golomb, E., Harvey-White, J. D., Lieberman, D. M., Kopin, I. J., ...
1. Glycine is an inhibitory neurotransmitter in the spinal cord and brainstem. The mechanism of this inhibition is via binding of glycine to specific receptors, increasing transmembrane Cl-...
Higgins, J J, Harvey-White, J D, Nee, L E, Colli, M J, Grossi, T A, Kopin, I J
OBJECTIVES: To serially assess changes in lumbar CSF biogenic amines, radiographic characteristics, and neurological signs in 34 patients with dominantly inherited ataxia. METHODS: Mutational...
Gastrin responses in patients with adrenergic insufficiency.
Polinsky, R J, Taylor, I L, Weise, V, Kopin, I J
High basal gastrin levels in pure autonomic failure could result from peripheral vagus nerve involvement, whereas the increased response during hypoglycaemia may reflect adrenergic supersensitivity....
Polinsky, R J, Brown, R T, Burns, R S, Harvey-White, J, Kopin, I J
Low lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in patients with multiple system atrophy attended by autonomic failure (MSA) reflect decreased...