Scientific Commons: I. K. Hariharan

Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster.

Hariharan, I K, Chuang, P T, Rubin, G M

We have cloned and characterized cDNAs coding for a receptor-class phosphotyrosine phosphatase gene from Drosophila melanogaster. The gene maps to the polytene chromosome bands 99A7-8. The cDNA...

Conformation and Segregation of Nucleoids Accompanying Cell Length Extension After Completion of a Single Round of DNA Replication in Germinated and Outgrowing Bacillus subtilis Spores

Hariharan, I. K., Czolij, R., Wake, R. G.

When germinating spores of the temperature-sensitive DNA initiation mutant of Bacillus subtilis TsB134 are shifted to the restrictive temperature at a time such that just one or two rounds of...

A vector for inducible production of retrovirus.

Hariharan, I K

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

Hariharan, I K, Harris, A W, Crawford, M, Abud, H, Webb, E, Cory, S, ...

In chronic myeloid leukemia and some cases of acute lymphoblastic leukemia, a 9;22 chromosome translocation has fused most of the c-abl oncogene to a gene designated bcr. To explore in vivo the...

Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.

Hariharan, I K, Hu, K Q, Asha, H, Quintanilla, A, Ezzell, R M, Settleman, J

The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely expressed members of this family from...

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

Johnson, G R, Gonda, T J, Metcalf, D, Hariharan, I K, Cory, S

Murine bone marrow cells infected with a novel recombinant retrovirus, MPZen(GM-CSF), were engrafted into lethally irradiated recipients. The transplanted animals developed extremely high circulating...

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

Hariharan, I K, Adams, J M

The hallmark of human chronic myeloid leukaemia is a 9;22 chromosome translocation that fuses most of the c-abl oncogene to the 5' portion of the breakpoint cluster region (bcr) gene, such that a...

The Rap1 GTPase functions as a regulator of morphogenesis in vivo.

Asha, H, De Ruiter, N D, Wang, M G, Hariharan, I K

The Ras-related Rap GTPases are highly conserved across diverse species but their normal biological function is not well understood. Initial studies in mammalian cells suggested a role for Rap as a...

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

Elefanty, A G, Hariharan, I K, Cory, S

The chromosome translocation forming the hybrid bcr-abl gene is thought to be the initiating event in chronic myeloid leukaemia (CML) and some cases of acute lymphoblastic leukaemia. To assess the...