Ancliff, P.J., Blundell, M.P., Cory, G.O., Calle, Y., Worth, A., Kempski, H., ...
Severe congenital neutropenia (SCN) is characterized by neutropenia, recurrent bacterial infections, and maturation arrest in the bone marrow. Although many cases have mutations in the ELA2 gene...
Gibson, B.E., Wheatley, K., Hann, I.M., Stevens, R.F., Webb, D., Hills, R.K., ...
Between 1988 and 2002, 758 children with acute myeloid leukaemia (AML) were treated on Medical Research Council (MRC) AML 10 and AML 12. MRC AML 10 tested the role of bone marrow transplantation...
MRC trials in childhood acute myeloid leukaemia (2004)
Hann, I. M., Webb, D.K., Gibson, B.E., Harrison, C.J.
The modern approach to therapy for acute myeloid leukaemia (AML) in children began in the late 80's and in the MRC series led to a 30% improvement in survival, up to levels of about 50%. Since 1995...
Ancliff, P.J., Gale, R.E., Watts, M.J., Liesner, R., Hann, I.M., Strobel, S., ...
Heterozygous mutations in neutrophil elastase have been detected in many sporadic cases of congenital neutropenia. However, a convincing pathogenetic mechanism has not been established, and it is...
Chessells, J.M., Harrison, C.J., Kempski, H., Webb, D.K., Wheatley, K., Hann, I.M., ...
The clinical features, cytogenetics and response to treatment have been examined in 180 infants (aged
Ancliff, P.J., Gale, R.E., Liesner, R., Hann, I.M., Linch, D.C.
Severe congenital neutropenia (SCN) was originally described as an autosomal recessive disorder. Subsequently, autosomal dominant and sporadic forms of the disease have been recognized. All forms are...
Paediatric myelodysplasia (1996)
Myelodysplastic syndromes (MDS) in childhood comprise a heterogeneous group of disorders, many of which respond poorly to intensive chemotherapy; the only curative treatment for these is bone marrow...
ANTIVIRAL THERAPY IN THE IMMUNOCOMPROMISED PATIENT (1985)
The viral infections encountered in the compromised host are remarkable for the relatively small number of causative organisms. Although children with acuto leukaemia may suffer fatal measles...
The pharmacokinetics of ketoconazole in severely immunocompromised patients (1982)
Hann, I. M., Prentice, H. G., Keaney, M., Corringham, R., Blacklock, H. A., Fox, J., ...
Forty patients severely immunocompromised because of the nature of their underlying disease (marrow aplasia, acute leukaemia or solid tumour) and/or the treatment they were receiving, received...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Stevens, R F, Hann, I M, Gibson, B E, Britton, J A, Darbyshire, P J, ...
AIMS--Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the...
Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
Hann, I M, Evans, D I, Marsden, H B, Jones, P M, Palmer, M K
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary...
Hermansky-Pudlak syndrome presenting with subdural haematoma and retinal haemorrhages in infancy.
Russell-Eggitt, I M, Thompson, D A, Khair, K, Liesner, R, Hann, I M
Gray, M M, Hann, I M, Glass, S, Eden, O B, Jones, P M, Stevens, R F
Measles is a major cause of mortality and morbidity in children receiving treatment for leukaemia. A review was made of all the documented cases of measles in children in first remission from acute...
Hann, I M, Prentice, H G, Blacklock, H A, Ross, M G, Brigden, D, Rosling, A E, ...
Twenty patients undergoing allogeneic bone marrow transplantation and 39 patients receiving remission induction chemotherapy for acute leukaemia were entered into a double blind, placebo controlled...
Philadelphia-chromosome-positive childhood chronic myeloid leukaemia.
Saffhill, R, Dexter, T M, Testa, N, Morris-Jones, P H, Hann, I M
Psychological disturbance in children with haemophilia.
Logan, F A, Maclean, A, Howie, C A, Gibson, B, Hann, I M, Parry-Jones, W L
OBJECTIVE--To assess the need for formal psychotherapeutic intervention in children attending a children's haemophilia clinic after some of them had been diagnosed as positive for HIV....
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Stevens, R F, Hann, I M, Gibson, B E, Britton, J A, Darbyshire, P J, ...
AIMS--Children in a United Kingdom national trial for relapsed non-B lymphoblastic leukaemia (ALL) had their diagnostic and relapse marrow cytomorphology compared to see what changes occur during the...
Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood.
Hann, I M, Evans, D I, Marsden, H B, Jones, P M, Palmer, M K
A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary...
Gray, M M, Hann, I M, Glass, S, Eden, O B, Jones, P M, Stevens, R F
Measles is a major cause of mortality and morbidity in children receiving treatment for leukaemia. A review was made of all the documented cases of measles in children in first remission from acute...
Hermansky-Pudlak syndrome presenting with subdural haematoma and retinal haemorrhages in infancy.
Russell-Eggitt, I M, Thompson, D A, Khair, K, Liesner, R, Hann, I M
Hann, I M, Prentice, H G, Blacklock, H A, Ross, M G, Brigden, D, Rosling, A E, ...
Twenty patients undergoing allogeneic bone marrow transplantation and 39 patients receiving remission induction chemotherapy for acute leukaemia were entered into a double blind, placebo controlled...
Philadelphia-chromosome-positive childhood chronic myeloid leukaemia.
Saffhill, R, Dexter, T M, Testa, N, Morris-Jones, P H, Hann, I M
Psychological disturbance in children with haemophilia.
Logan, F A, Maclean, A, Howie, C A, Gibson, B, Hann, I M, Parry-Jones, W L
OBJECTIVE--To assess the need for formal psychotherapeutic intervention in children attending a children's haemophilia clinic after some of them had been diagnosed as positive for HIV....
Connor, J M, Pettigrew, A F, Hann, I M, Forbes, C D, Lowe, G D, Affara, N A
Total ascertainment revealed 28 families with haemophilia B in the west of Scotland (prevalence 1/26 870 males). In 12 of these families more than one person was affected and 26 living obligate...
Application of three intragenic DNA polymorphisms for carrier detection in haemophilia B.
Connor, J M, Pettigrew, A F, Shiach, C, Hann, I M, Lowe, G D, Forbes, C D
In the west of Scotland use of a single intragenic restriction fragment length polymorphism (F9(VIII)/TaqI) allowed definitive genetic counselling for 45% of females at risk of being carriers for...
Visceral leishmaniasis: rapid response to AmBisome treatment.
Smith, O P, Hann, I M, Cox, H, Novelli, V
There appears to be an increase in imported cases of visceral leishmaniasis in Northern Europe; many are children infected on holiday in the Mediterranean. Making the diagnosis in young children can...
Late functioning adrenocortical carcinoma in a 5-year-old girl.
Marsden, H B, Jones, P M, Lees, P D, Hann, I M
A 5-year-old with adrenocortical carcinoma presented with acute paraplegia. The tumour was initially nonfunctioning but finally showed rapid dissemination and the patient then developed Cushingoid...
Use of the diving reflex to treat supraventricular tachycardia in an infant.
A simple method for treating supraventricular tachycardias is described--ice cubes are applied to the nose and upper lip. It should be particularly useful in younger children and depends on a sound...
Recurrent thrombocytopenic purpura associated with accessory spleen.
In the case of a boy with a relapsed thrombocytopenic purpura removal of a splenunculus, shown by radioisotope scanning, resulted in a partial remission. The significance of the association of...
Testicular function after combination chemotherapy in childhood for acute lymphoblastic leukaemia.
Shalet, S M, Hann, I M, Lendon, M, Morris Jones, P H, Beardwell, C G
We have assessed testicular function with luteinising hormone-releasing hormone (LH-RH) and human chorionic gonadotrophin stimulation tests in 44 boys previously treated with, or currently receiving,...
Haemoglobin and prognosis in childhood acute lymphoblastic leukaemia.
Hann, I M, Scarffe, J H, Palmer, M K, Evans, D I, Jones, P H
Two hundred and nine children presenting consecutively with acute lymphoblastic leukaemia to a regional paediatric oncology unit were investigated to determine the prognostic significance of various...
Carcinoid syndrome: an unusual cause of diarrhoea.
King, M D, Young, D G, Hann, I M, Patrick, W J
A 9 year old girl underwent laparotomy because of intermittent diarrhoea, present since infancy. Histology of a mass at the head of pancreas and multiple hepatic nodules suggested an apudoma. Plasma...
Acquired aplastic anaemia: still a serious disease.
Webb, D K, Hann, I M, Chessells, J M
Over 15 years, 42 children aged 2-14 years were diagnosed as having acquired aplastic anaemia. Adequate clinical details were available for 38 children who were categorised as very severe (n = 13),...
The c-ets-1 proto-oncogene is rearranged in some cases of acute lymphoblastic leukaemia.
Goyns, M. H., Hann, I. M., Stewart, J., Gegonne, A., Birnie, G. D.
Low IgG or IgA: a further indicator of poor prognosis in childhood acute lymphoblastic leukaemia.
Hann, I. M., Jones, P. H., Evans, D. I., Addison, G. M., Palmer, M. K., Scarffe, J. H.
Scarffe, J. H., Hann, I. M., Evans, D. I. K., Jones, P. Morris, Palmer, M. K., Lilleyman, J. S., ...
Pretreatment marrow blast cells were studied in 38 boys and 27 girls (aged 1-14) with acute lymphoblastic leukaemia by flow cytometry after staining with propidium iodide.
A score at diagnosis for predicting length of remission in childhood acute lymphoblastic leukaemia.
Palmer, M. K., Hann, I. M., Jones, P. M., Evans, D. I.
Thirty-two variables at diagnosis of acute lymphoblastic leukaemia (ALL) were studied in an unselected population-bases series of 209 children. Twelve variables had individually a statistically...
A tumour spheroid model for antibody-targeted therapy of micrometastases.
Walker, K. A., Murray, T., Hilditch, T. E., Wheldon, T. E., Gregor, A., Hann, I. M.
Human neuroblastoma cells grown as tumour spheroids were briefly incubated with a conjugate of 131I and an anti-human neuroectodermal monoclonal antibody UJ13A. Unbound 131I was removed by washing...
Atra, A, Imeson, J D, Hobson, R, Gerrard, M, Hann, I M, Eden, O B, ...
From July 1990 to March 1996, 112 children with stage III or IV B-cell non-Hodgkin's lymphoma (B-NHL) with up to 70% FAB L3-type blasts (n= 42) in the bone marrow without central nervous system (CNS)...