I. Nicoletti

Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin (2005)

Martelli, M P, Dirks, W G, Bolli, N, Liso, A, Macleod, R A F, ...

We recently identified a new acute myeloid leukemia (AML) subtype characterized by mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic expression of NPM protein (NPMc+)....

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins (1994)

Salcini, AE, McGlade, J, Pelicci, G, Nicoletti, I, Pawson, Tony, Pelicci, PG

The mammalian SHC gene encodes three overlapping proteins which all contain a carboxy-terminal SH2 domain. Shc proteins are phosphorylated on tyrosine by a variety of receptor and cytoplasmic...

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins (1994)

Salcini, AE, McGlade, J, Pelicci, G, Nicoletti, I, Pawson, Tony, Pelicci, PG

The mammalian SHC gene encodes three overlapping proteins which all contain a carboxy-terminal SH2 domain. Shc proteins are phosphorylated on tyrosine by a variety of receptor and cytoplasmic...

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...

The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, ...

The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific...

IL-4 is able to reverse the CD2-mediated negative apoptotic signal to CD4-CD8- alpha beta and/or gamma delta T lymphocytes.

Spinozzi, F, Nicoletti, I, Agea, E, Belia, S, Moraca, R, Migliorati, G, ...

Activation of immature thymocytes or transformed T lymphocytes via T-cell receptor (TCR)/CD3 signalling can induce programmed cell death (apoptosis). Recent data indicate that anti-CD3/TCR monoclonal...

Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes.

Migliorati, G, Nicoletti, I, D'Adamio, F, Spreca, A, Pagliacci, C, Riccardi, C

Glucocorticoid hormones (GCH) induce apoptotic cell death in immature thymocytes through an active mechanism, characterized by extensive DNA fragmentation into oligonucleosomal subunits. This...

Reduced number of natural killer cells in patients with pathological hyperprolactinemia.

Gerli, R, Rambotti, P, Nicoletti, I, Orlandi, S, Migliorati, G, Riccardi, C

Human natural killer (NK) cell activity, as measured against K-562 target cells, was evaluated in 23 untreated and in 11 bromocriptine-treated hyperprolactinemic female patients and in 63 age-matched...

DHT-receptor in cultured human fibroblasts: binding study in a family with androgen insensitivity (complete testicular feminisation).

Donti, E, Nicoletti, I, Filipponi, P, Venti, G, Bocchini, V, Santeusanio, F

3H-DHT binding was examined in cultured skin fibroblasts from a patient with complete testicular feminisation (CTF), from his heterozygote mother, and his clinically normal sister, who menstruated...